| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Jen Liu, Hsueh-Hsia Wu, Tzu-Ho Chen, Wan Leung, Yu-Chih Lian. 15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies. International journal of molecular sciences. vol 16. issue 8. 2016-05-24. PMID:26287183. |
we found that treatment with 1.5 μg/ml dhts increased proapoptotic bax and bad protein expressions and activated caspases-3, -8, and -9, thus leading to poly adp ribose polymerase (parp) cleavage and resulting in cell apoptosis. |
2016-05-24 |
2023-08-13 |
mouse |
| Qiusheng Lan, Shoufeng Li, Wei Lai, Heyang Xu, Yang Zhang, Yujie Zeng, Wenjian Lan, Zhonghua Ch. Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. International journal of molecular sciences. vol 16. issue 8. 2016-05-24. PMID:26287184. |
culture studies found that methyl sartortuoate inhibited colon cancer cell (lovo and rko) growth and caused apoptotic death in a concentration- and time-dependent manner, by activation of caspase-8, caspase-9, caspase-3, p53 and bax, and inactivation of b-cell lymphoma 2 (bcl-2) apoptosis regulating proteins. |
2016-05-24 |
2023-08-13 |
mouse |
| Wei Wang, Hong-jie Wang, Bing Wang, Ying Li, Yan Qin, Li-shuang Zheng, Jin-sa Zhou, Peng-huan Qu, Jian-hong Shi, Hai-song Zhan. The Role of the Y Box Binding Protein 1 C-Terminal Domain in Vascular Endothelial Cell Proliferation, Apoptosis, and Angiogenesis. DNA and cell biology. vol 35. issue 1. 2016-05-24. PMID:26430912. |
yb1 ctd overexpression also increased bax and active caspase 3 expression, decreased bcl-2 expression, and induced apoptosis in ea.hy926 cells. |
2016-05-24 |
2023-08-13 |
Not clear |
| Wen-feng Gou, Dao-fu Shen, Xue-feng Yang, Shuang Zhao, Yun-peng Liu, Hong-zhi Sun, Rong-Jian Su, Jun-sheng Luo, Hua-chuan Zhen. ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression. Oncotarget. vol 6. issue 23. 2016-05-23. PMID:25980581. |
the induction of bax hypoexpression, bcl-2, survivin, 14-3-3, pi3k, p-akt and p70s6k overexpression by ing5 decreased apoptosis in sgc-7901 cells. |
2016-05-23 |
2023-08-13 |
Not clear |
| Rama P Kotipatruni, Xuan Ren, Dinesh Thotala, Jerry J Jaboi. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26053091. |
we show that apoptosis caused by p53 upregulation, phosphorylation at ser15, bax activation, bcl-2 and bcl-xl downregulation, mitochondrial cytochrome c release and execution of caspases following ndrg4 depletion. |
2016-05-20 |
2023-08-13 |
Not clear |
| Rama P Kotipatruni, Xuan Ren, Dinesh Thotala, Jerry J Jaboi. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26053091. |
sub-cellular distribution of bax and cytochrome c indicated mitochondrial-mediated apoptosis. |
2016-05-20 |
2023-08-13 |
Not clear |
| Federica Ghersa, Juan Burdisso, Sandra S Vallcaneras, Federico Fuentes, Magalí de la Vega, Silvia M Delgado, Carlos M Telleria, Marilina Casai. Neuromodulation of the luteal regression: presence of progesterone receptors in coeliac ganglion. Experimental physiology. vol 100. issue 8. 2016-05-20. PMID:26084725. |
the luteal structural regression was evaluated through a study of apoptosis measured by tunel assay and the expression of apoptotic factors, such as bcl-2, bax, fas and fas ligand (fasl) by rt-pcr. |
2016-05-20 |
2023-08-13 |
rat |
| Elisa Fernández-Millán, Isabel Cordero-Herrera, Sonia Ramos, Fernando Escrivá, Carmen Alvarez, Luis Goya, María Angeles Martí. Cocoa-rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis. Molecular nutrition & food research. vol 59. issue 4. 2016-05-19. PMID:25559866. |
at the molecular level, cocoa-rich diet prevented beta-cell apoptosis by increasing the levels of bcl-xl and decreasing bax levels and caspase-3 activity. |
2016-05-19 |
2023-08-13 |
rat |
| Yunyao Jiang, Jingpei Piao, Hyun-Jong Cho, Wie-Soo Kang, Hye-Young Ki. Improvement in antiproliferative activity of Angelica gigas Nakai by solid dispersion formation via hot-melt extrusion and induction of cell cycle arrest and apoptosis in HeLa cells. Bioscience, biotechnology, and biochemistry. vol 79. issue 10. 2016-05-19. PMID:26057458. |
agn-sd decreased cell viability, induced apoptosis, increased the production of reactive oxygen species, regulated the expression of bcl-2 and bax, and induced g2/m phase arrest in hela cells. |
2016-05-19 |
2023-08-13 |
Not clear |
| Jin-Ping Li, Yin-Xue Yang, Qi-Lun Liu, Shu-Ting Pan, Zhi-Xu He, Xueji Zhang, Tianxin Yang, Xiao-Wu Chen, Dong Wang, Jia-Xuan Qiu, Shu-Feng Zho. The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells. Drug design, development and therapy. vol 9. 2016-05-17. PMID:25834401. |
als induced mitochondria-mediated apoptosis in mcf7 and mda-mb-231 cells; als significantly decreased the expression of b-cell lymphoma 2 (bcl-2), but increased the expression of b-cell lymphoma 2-associated x protein (bax) and p53-upregulated modulator of apoptosis (puma), and increased the expression of cleaved caspases 3 and 9. |
2016-05-17 |
2023-08-13 |
human |
| Xuexue Huang, Yuan Xu, Yanyi Liu, Hong Xie, Jiachun Wang, Zhigang W. Extracellular Ca(2+) Selectively Enhances Adriamycin-induced Cell Death in Human Hepatoma Cells. Current cancer drug targets. vol 15. issue 6. 2016-05-17. PMID:26282547. |
to further elucidate the mechanisms involved in the selective promotion of [ca(2+)]e in hepg2 and l02 cells, the levels of these apoptosis regulatory proteins (bcl-2, bax and procaspase-3) and the caspase-3 activity following treatment of hepg2 and l02 cells with adm or/and [ca(2+)]a were investigated. |
2016-05-17 |
2023-08-13 |
human |
| Xuexue Huang, Yuan Xu, Yanyi Liu, Hong Xie, Jiachun Wang, Zhigang W. Extracellular Ca(2+) Selectively Enhances Adriamycin-induced Cell Death in Human Hepatoma Cells. Current cancer drug targets. vol 15. issue 6. 2016-05-17. PMID:26282547. |
the mechanism of this intensive pro-apoptotic effect can be ascribed to up-regulation of bax and the simultaneous down-regulation of bcl-2, followed by the switch from procaspase-3 to caspase-3, which executed apoptosis. |
2016-05-17 |
2023-08-13 |
human |
| Onyinyechukwu Uchime, Zhou Dai, Nikolaos Biris, David Lee, Sachdev S Sidhu, Sheng Li, Jonathan R Lai, Evripidis Gavathioti. Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. The Journal of biological chemistry. vol 291. issue 1. 2016-05-17. PMID:26565029. |
pro-apoptotic bcl-2-associated x protein (bax) is an executioner protein of the bcl-2 family that represents the gateway to mitochondrial apoptosis. |
2016-05-17 |
2023-08-13 |
Not clear |
| Onyinyechukwu Uchime, Zhou Dai, Nikolaos Biris, David Lee, Sachdev S Sidhu, Sheng Li, Jonathan R Lai, Evripidis Gavathioti. Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. The Journal of biological chemistry. vol 291. issue 1. 2016-05-17. PMID:26565029. |
following cellular stresses that induce apoptosis, cytosolic bax is activated and translocates to the mitochondria, where it inserts into the mitochondrial outer membrane to form a toxic pore. |
2016-05-17 |
2023-08-13 |
Not clear |
| Shuangmei Yang, Jun Liu, Xiaoran Zhang, Jianmin Tian, Zhichao Zuo, Jingjing Liu, Xiuqin Yu. Anesthetic isoflurane attenuates activated microglial cytokine-induced VSC4.1 motoneuronal apoptosis. American journal of translational research. vol 8. issue 3. 2016-05-17. PMID:27186270. |
conditioned medium (cm) from activated bv-2 cells treated by iso directly prevented vsc4.1 motoneurons from lps-cm-induced neuronal apoptosis, as determined by the following: reductions in caspase-8, caspase-9, and caspase-3 activities; downregulation of pro-apoptotic procaspase-8, cleaved (cl)-caspase-8, procaspase-9, cl-caspase-9, caspase-3, cl-caspase-3, bid, bax, and cytochrome c expression; and upregulation of anti-apoptotic bcl-2 expression in lps-cm-cultured vsc4.1 motoneurons. |
2016-05-17 |
2023-08-13 |
Not clear |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
the activity of caspase 3 (casp3) and level changes of several apoptosis factors including b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), phosphatase and tensin homolog (pten) and v-akt murine thymoma viral oncogene homolog 1 (akt1) were detected. |
2016-05-17 |
2023-08-13 |
rat |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
it also caused the corresponding changes in casp3 activity and other apoptosis factors, with cleaved casp3, bax and pten inhibited and bcl2 and phosphorylated akt1 promoted, while mir-22 antagomir had the opposite effects. |
2016-05-17 |
2023-08-13 |
rat |
| Feng-Lian Xiao, Wei-Jie Gao, Cheng-Yi Liu, Xiao-Ping Wang, Tong-Sheng Che. Artemisinin induces caspase-8/9-mediated and Bax/Bak-independent apoptosis in human lung adenocarcinoma (ASTC-a-1) cells. Journal of X-ray science and technology. vol 19. issue 4. 2016-05-16. PMID:25214386. |
interestingly, silencing bax and bak by rna interference (rnai) did not attenuate arte-induced apoptosis. |
2016-05-16 |
2023-08-13 |
human |
| Wipawan Thangnipon, Nirut Suwanna, Chanati Jantrachotechatchawan, Sukonthar Ngampramuan, Patoomratana Tuchinda, Saksit Nobsathia. Protective roles of N-benzylcinnamide on cortex and hippocampus of aged rat brains. Archives of pharmacal research. vol 38. issue 7. 2016-05-16. PMID:25840686. |
pt-3 treatment improved spatial learning and memory of aged rats and caused significant changes in brain frontal cortex, hippocampus, and temporal cortex in parameters associated with oxidative stress (decreased reactive oxygen species production and inos and nnos levels), inflammation (reduced levels of il-1β and il-6), apoptosis (reduced levels of bax and activated caspase-3, and elevated level of bcl-2), and signaling pathways related to inflammation and apoptosis (decreased amounts of phospho-jnk and -p38, increased phospho-akt level and no change in phospho-erk1/2 content) compared to controls. |
2016-05-16 |
2023-08-13 |
rat |
| Sima Hajiahmadi, Mojtaba Panjehpour, Mahmoud Aghaei, Mahdi Shaban. Activation of A2b adenosine receptor regulates ovarian cancer cell growth: involvement of Bax/Bcl-2 and caspase-3. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 93. issue 4. 2016-05-16. PMID:25877700. |
detection of apoptosis was conducted using annexin v-fitc/pi staining, caspase-3 activation assay, and the expression of bax and bcl-2 proteins analysis. |
2016-05-16 |
2023-08-13 |
Not clear |