| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taolan Zhang, Yingying Shao, Tang-Yuan Chu, Hsuan-Shun Huang, Yu-Ligh Liou, Qing Li, Honghao Zho. MiR-135a and MRP1 play pivotal roles in the selective lethality of phenethyl isothiocyanate to malignant glioma cells. American journal of cancer research. vol 6. issue 5. 2016-06-13. PMID:27293991. |
moreover, peitc activated the mir-135a-mitochondria dependent apoptosis pathway as demonstrated by downregulation of stat6, smad5 and bcl-xl while upregulation of bax expression and cytochrome-c release in malignant glioma cell lines but not in the immortalized human normal glial heb cells. |
2016-06-13 |
2023-08-13 |
human |
| Maria Fernanda Hornos Carneiro, Christudas Morais, David M Small, David A Vesey, Fernando Barbosa, Glenda C Gob. Thimerosal induces apoptotic and fibrotic changes to kidney epithelial cells in vitro. Environmental toxicology. vol 30. issue 12. 2016-06-10. PMID:24942245. |
human kidney proximal tubular epithelial (hk2) cells were exposed for 24 h to thimerosal (0-2 µm), and assessed for cell viability, apoptosis, and cell proliferation; expression of proteins bax, nuclear factor-κb subunits, and transforming growth factor-β1 (tgfβ1); mitochondrial health (jc-1, mitotracker red cmxros); and fibronectin levels (enzyme-linked immunosorbent assay). |
2016-06-10 |
2023-08-13 |
human |
| Maria Fernanda Hornos Carneiro, Christudas Morais, David M Small, David A Vesey, Fernando Barbosa, Glenda C Gob. Thimerosal induces apoptotic and fibrotic changes to kidney epithelial cells in vitro. Environmental toxicology. vol 30. issue 12. 2016-06-10. PMID:24942245. |
thimerosal diminished hk2 cell viability and mitosis, promoted apoptosis, impaired the mitochondrial permeability transition, enhanced bax and tgfβ1 expression, and augmented fibronectin secretion. |
2016-06-10 |
2023-08-13 |
human |
| Maria Fernanda Hornos Carneiro, Christudas Morais, David M Small, David A Vesey, Fernando Barbosa, Glenda C Gob. Thimerosal induces apoptotic and fibrotic changes to kidney epithelial cells in vitro. Environmental toxicology. vol 30. issue 12. 2016-06-10. PMID:24942245. |
collectively, these in vitro results demonstrate that (1) thimerosal induces kidney epithelial cell apoptosis via upregulating bax and the mitochondrial apoptotic pathway, and (2) thimerosal is a potential pro-fibrotic agent in human kidney cells. |
2016-06-10 |
2023-08-13 |
human |
| Muhammad Noman Khan, Bing Wang, Jing Wei, Yingqiu Zhang, Qiang Li, Xuelin Luan, Jya-Wei Cheng, John R Gordon, Fang Li, Han Li. CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26087179. |
g31p also enhanced apoptosis in lung cancer cells as determined by elevated levels of cleaved parp, caspase-8, and bax, together with a reduced expression of the anti-apoptotic protein bcl-2. |
2016-06-10 |
2023-08-13 |
mouse |
| Jun Zeng, Jing Yang, Deng-bang Chen, Kang Ca. [The Mechanisms by which Bax Induces the Apoptosis of Human Ovarian Cancer Cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 46. issue 5. 2016-06-10. PMID:26619538. |
[the mechanisms by which bax induces the apoptosis of human ovarian cancer cells]. |
2016-06-10 |
2023-08-13 |
human |
| Yanxia Sui, Ya Yang, Ji Wang, Yi Li, Hongbing Ma, Hui Cai, Xiaoping Liu, Yong Zhang, Shufeng Wang, Zongfang Li, Xiaozhi Zhang, Jiansheng Wang, Rui Liu, Yanli Yan, Chaofan Xue, Xiaowei Shi, Li Tan, Juan Re. Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells. BioMed research international. vol 2015. 2016-06-09. PMID:26366416. |
our study found that cisplatin induced apoptosis of hela cell through inhibiting expression of bcl-2, upregulating the expression of bax, fas-l, and the enzyme activity of caspase-3 (p < 0.05); lpa significantly provided protection against the apoptosis induced by cisplatin by inhibiting the above alterations in apoptotic factor caused by cisplatin (p < 0.05). |
2016-06-09 |
2023-08-13 |
Not clear |
| Biswajit Chakraborty, Debasmita Dutta, Sanjukta Mukherjee, Supriya Das, Nakul C Maiti, Padma Das, Chinmay Chowdhur. Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29). European journal of medicinal chemistry. vol 102. 2016-06-08. PMID:26248310. |
elevated level of ros generation, activation of caspase 3 and caspase 9, dna fragmentation, higher expression of bax and bad, lower expression of bcl2 and bcl-xl, and increased level of bax/bcl-xl ratio identified 2c as a promising inducer of apoptosis that follows a mitochondria dependent pathway. |
2016-06-08 |
2023-08-13 |
human |
| Juliana Noguti, Tathiana A Alvarenga, Patrícia Marchi, Celina T F Oshima, Monica L Andersen, Daniel A Ribeir. The influence of sleep restriction on expression of apoptosis regulatory proteins p53, Bcl-2 and Bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 44. issue 3. 2016-06-07. PMID:25169245. |
the influence of sleep restriction on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. |
2016-06-07 |
2023-08-13 |
rat |
| Xiaolong Gu, Rongrong Chen, Guoliang Hu, Yu Zhuang, Junrong Luo, Caiying Zhang, Xiaoquan Guo, Aiming Huang, Huabin Ca. Cell apoptosis of caprine spleen induced by toxicity of cadmium with different levels of molybdenum. Environmental toxicology and pharmacology. vol 40. issue 1. 2016-06-07. PMID:26068552. |
spleen tissues were taken from individual goat at different time intervals to measure the levels of apoptosis genes including bcl-2, bax, cyt c, caspase-3, smac and ceruloplasmin (cp). |
2016-06-07 |
2023-08-13 |
Not clear |
| Ah Young Lee, Young-Ah Han, Ji-Eun Kim, Seong-Ho Hong, Eun-Jung Park, Myung-Haing Ch. Saururus chinensis Baill induces apoptosis through endoplasmic reticulum stress in HepG2 hepatocellular carcinoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 83. 2016-06-07. PMID:26116884. |
sc-e also caused ccaat-enhancer-binding protein homologous protein (chop) activation by dissociating the binding immunoglobulin protein (bip) from inositol-requiring 1α (ire1α) in the endoplasmic reticulum (er) and induced bax, cytochrome c release to cytosol, caspase-3 activation, and poly adp ribose polymerase (parp) cleavage, resulting in hepg2 cell apoptosis. |
2016-06-07 |
2023-08-13 |
Not clear |
| Lauryn R Werner, Shyhmin Huang, David M Francis, Eric A Armstrong, Fang Ma, Chunrong Li, Gopal Iyer, Jude Canon, Paul M Harar. Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors. Molecular cancer therapeutics. vol 14. issue 9. 2016-06-07. PMID:26162687. |
several molecules involved in senescence, autophagy, and apoptosis were specifically modulated following the combined amg 232/radiation treatment, including foxm1, ulk-1, dram, and bax. |
2016-06-07 |
2023-08-13 |
human |
| Hongwei Pu, Xuemei Wang, Jianlong Zhang, Chuang Ma, Yinxia Su, Xiujuan Li, Xiaoshan Liu, Liping S. Cerebellar neuronal apoptosis in heroin-addicted rats and its molecular mechanism. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-06-07. PMID:26339395. |
the overall objective of this study was to investigate neuronal apoptosis and expression of apoptosis related proteins (c-jun, cytc and bax) in the cerebellum of rates with heroin addiction. |
2016-06-07 |
2023-08-13 |
rat |
| Srilatha Nalluri, Sampa Ghoshal-Gupta, Ammar Kutiyanawalla, Sitaram Gayatri, Byung Rho Lee, Shahanawaz Jiwani, Amyn M Rojiani, Mumtaz V Rojian. TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2. PloS one. vol 10. issue 9. 2016-06-07. PMID:26366732. |
finally, we demonstrate that timp-1 dependent inhibition of apoptosis occurs through p90rsk, with phosphorylation of the pro-apoptotic protein bad at serine 112, ultimately reducing bax levels and increasing mitochondrial permeability. |
2016-06-07 |
2023-08-13 |
Not clear |
| Eveline A I F Queiroz, Zuleica B Fortes, Mário A A da Cunha, Aneli M Barbosa, Neelam Khaper, Robert F H Dekke. Antiproliferative and pro-apoptotic effects of three fungal exocellular β-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a. The international journal of biochemistry & cell biology. vol 67. 2016-06-06. PMID:26255117. |
exposure to β-glucans increased apoptosis, necrosis, oxidative stress, mrna expression of p53, p27 and bax; the activity of amp-activated protein-kinase, forkhead transcription factor foxo3a, bax and caspase-3; and decreased the activity of p70s6k in mcf-7 cells. |
2016-06-06 |
2023-08-13 |
Not clear |
| J F Ji, X H M. Effect of baculovirus P35 protein on apoptosis in brain tissue of rats with acute cerebral infarction. Genetics and molecular research : GMR. vol 14. issue 3. 2016-06-06. PMID:26345869. |
the levels of caspase-3, bcl-2, and bax mrna, the brain cell apoptosis index, and the infarct size were determined. |
2016-06-06 |
2023-08-13 |
human |
| B Ni, F F Bai, Y Wei, M J Liu, Z X Feng, Q Y Xiong, L Z Hua, G Q Sha. Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway. Genetics and molecular research : GMR. vol 14. issue 3. 2016-06-06. PMID:26436384. |
this study demonstrated that lamps from m. hyopneumoniae can induce apoptosis in sjpl cells through the activation of caspase 3, caspase 8, cyt c, bax, and p38 mapk, thereby contributing to our understanding of the pathogenesis of m. hyopneumoniae, which should improve the treatment of m. hyopneumoniae infections. |
2016-06-06 |
2023-08-13 |
Not clear |
| Guanghong Yang, Zhiwei Zhou, Yanli Cen, Xiaolin Gui, Qibing Zeng, Yunxia Ao, Qian Li, Shiran Wang, Jun Li, Aihua Zhan. Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water. Drug design, development and therapy. vol 9. 2016-06-03. PMID:26316710. |
treatment of rats with organic extraction also induced mitochondria-mediated apoptosis via increasing the expression level of proapoptotic protein, bax, but decreasing the expression level of antiapoptotic protein, bcl-2, resulting in an upregulation of cytochrome c and activation of caspase cascade at both transcriptional and post-transcriptional levels. |
2016-06-03 |
2023-08-13 |
human |
| Umut Fahrioğlu, Yavuz Dodurga, Levent Elmas, Mücahit Seçm. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. vol 576. issue 1 Pt 3. 2016-06-03. PMID:26516023. |
expression profiles of certain cell cycle and apoptosis genes such as ccnd1 (cyclin d1),cdk4, cdk6, rb, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, bcl-2, bcl-xl,bid, dr4,dr5,fadd,tradd,parp, apaf, bax, akt, pten, puma, noxa, mmp2, mmp9, timp1 and timp2 were determined by real-time pcr. |
2016-06-03 |
2023-08-13 |
human |
| Yong Tian, Song-Xue Guo, Jian-Ru Li, Hang-Gen Du, Chao-Hui Wang, Jian-Min Zhang, Qun W. Topiramate attenuates early brain injury following subarachnoid haemorrhage in rats via duplex protection against inflammation and neuronal cell death. Brain research. vol 1622. 2016-06-02. PMID:26086367. |
in addition, tpm ameliorated sah-induced cortical neuronal apoptosis by influencing bax, bcl-2 and cleaved caspase-3 protein expression, and the effect of tpm was enhanced in a dose-dependent manner. |
2016-06-02 |
2023-08-13 |
rat |