| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria Belén Ayala-Peña, Fiorella Pilotti, Yanel Volonté, Nora P Rotstein, Luis E Politi, Olga Lorena Germa. Protective effects of retinoid x receptors on retina pigment epithelium cells. Biochimica et biophysica acta. vol 1863. issue 6 Pt A. 2016-07-19. PMID:26883505. |
we show, for the first time, that hx630, a rxr pan-agonist, protected d407 cells from h2o2-induced apoptosis, preventing p65nfκb nuclear translocation, increasing bclxl and pparγ mrna levels and simultaneously decreasing bax mrna levels and caspase-3 activation. |
2016-07-19 |
2023-08-13 |
rat |
| Xiaoxia Hu, Fei Zhang, Dongwei Luo, Na Li, Qian Wang, Zhonghai Xu, Huiqin Bian, Yuting Liang, Yaojuan Lu, Qiping Zheng, Junxia G. URI promotes gastric cancer cell motility, survival, and resistance to adriamycin in vitro. American journal of cancer research. vol 6. issue 6. 2016-07-19. PMID:27429854. |
conversely, cells treated with uri sirna showed increased adriamycin induced apoptosis, along with reduced bcl-2, but increased bax, cleaved parp-1 and cleaved caspase-3 expression. |
2016-07-19 |
2023-08-13 |
Not clear |
| Tai-Ching Sung, Ching-Yu Li, Yei-Chen Lai, Chien-Lun Hung, Orion Shih, Yi-Qi Yeh, U-Ser Jeng, Yun-Wei Chian. Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion. Structure (London, England : 1993). vol 23. issue 10. 2016-07-18. PMID:26299946. |
we show that this soluble oligomer undergoes a direct conversion into membrane-inserted oligomer, which has the ability of inducing apoptosis and structurally resembles a membrane-embedded oligomer formed from bax monomers in lipid environment. |
2016-07-18 |
2023-08-13 |
Not clear |
| Tai-Ching Sung, Ching-Yu Li, Yei-Chen Lai, Chien-Lun Hung, Orion Shih, Yi-Qi Yeh, U-Ser Jeng, Yun-Wei Chian. Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion. Structure (London, England : 1993). vol 23. issue 10. 2016-07-18. PMID:26299946. |
our data suggest an alternative pathway of apoptosis in which bax oligomer formation occurs prior to membrane insertion. |
2016-07-18 |
2023-08-13 |
Not clear |
| Yung Hyun Cho. Induction of apoptosis by an ethanol extract of Poria cocos Wolf. in human leukemia U937 cells. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26353048. |
eepc-induced apoptosis of u937 cells was associated with an increase in the bax:bcl-2 ratio, the release of cytochrome c to the cytosol, and a decrease in the expression of an inhibitor of the apoptosis family of proteins. |
2016-07-18 |
2023-08-13 |
human |
| Mohamed Ben-Eltriki, Subrata Deb, Hans Adomat, Emma S Tomlinson Gun. Calcitriol and 20(S)-protopanaxadiol synergistically inhibit growth and induce apoptosis in human prostate cancer cells. The Journal of steroid biochemistry and molecular biology. vol 158. 2016-07-18. PMID:26709138. |
then, we determined the potential pharmacodynamic interaction mechanisms as follows: the protein expression levels of the genes those are known to control cell cycle (cyclin d1 and cdk2); apoptosis (bcl-2, bax, and capspases 3), androgen receptor and vitamin d receptors were examined upon combinational treatment. |
2016-07-18 |
2023-08-13 |
human |
| Jia-An Teng, San-Gang Wu, Jia-Xin Chen, Qiang Li, Fang Peng, Zhou Zhu, Jian Qin, Zhen-Yu H. The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901856. |
treatment with erk1/2 or jnk inhibitor in the presence of insulin and igf-1 significantly decreased b-cell lymphoma 2 (bcl-2) and increased bcl-2-associated x protein (bax) expression and finally increased apoptosis and inhibited the proliferation. |
2016-07-18 |
2023-08-13 |
mouse |
| Baiyan Wang, Qianqian Han, Yanqin Zh. Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells. Bio-medical materials and engineering. vol 26 Suppl 1. 2016-07-14. PMID:26405930. |
the a549 cells inhibition rate, apoptosis, and the expression of bcl-2 and bax were examined by mtt method, annexin v/pi double staining method, real-time quantitative pcr and western blot, respectively. |
2016-07-14 |
2023-08-13 |
human |
| Baiyan Wang, Qianqian Han, Yanqin Zh. Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells. Bio-medical materials and engineering. vol 26 Suppl 1. 2016-07-14. PMID:26405930. |
oxymatrine can induce apoptosis of the a549 cells by regulating the expression of bcl-2 and bax. |
2016-07-14 |
2023-08-13 |
human |
| S Y James, A Turner, K W Colsto. Induction of Apoptosis in Human Leukaemia Cells is Differentially Regulated by Vitamin D Derivatives and Retinoids. Hematology (Amsterdam, Netherlands). vol 2. issue 4. 2016-07-14. PMID:27405232. |
western analysis of bcl-2 and bax protein levels revealed that combinations of the vitamin d and retinoid compounds decreased bcl-2 in hl-60 but not u937 cells, suggesting a change in the bcl-2/bax heterodimeric ratio in the former which would favour apoptosis. |
2016-07-14 |
2023-08-13 |
human |
| Reem T Attia, Mai F Tolba, Ruchit Trivedi, Mariane G Tadros, Hossam M M Arafa, Ashraf B Abdel-Nai. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. vol 4. 2016-07-14. PMID:27413637. |
subsequent mechanistic studies included β-glucosidase activity assay, glucose uptake and apoptosis studies, namely annexin v-fitc assay and the protein expression of mitochondrial pathway signals including bcl-2, bax, caspase 9 and 3 were assessed. |
2016-07-14 |
2023-08-13 |
Not clear |
| Dongqiang Wang, Pingping Zhang, Zhijun Li, Ying Li. [Effects of mecobalamin on Bax and Bcl-2 in neurons after peripheral nerve injury]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 33. issue 11. 2016-07-12. PMID:26887269. |
to observe the effects of mecobalamin on the expression of apoptosis-related proteins, bax and bcl-2, in neurons after peripheral nerve injury, and to explore the role of neuron apoptosis in peripheral nerve regeneration after injury. |
2016-07-12 |
2023-08-13 |
Not clear |
| C Loreto, A Psaila, G Musumeci, S Castorina, R Leonard. Apoptosis activation in human carious dentin. An immunohistochemical study. European journal of histochemistry : EJH. vol 59. issue 3. 2016-07-11. PMID:26428882. |
this ex vivo immunohistochemical study explored the localization of trail, dr5, bcl-2 and bax, the main proteins involved in apoptosis, in teeth with advanced caries. |
2016-07-11 |
2023-08-13 |
human |
| M Sumitani, T Sakurai, K Kasashima, S Kobayashi, K Uchino, R Kanzaki, T Tamura, H Sezuts. Establishment of a specific cell death induction system in Bombyx mori by a transgene with the conserved apoptotic regulator, mouse Bcl-2-associated X protein (mouse Bax). Insect molecular biology. vol 24. issue 6. 2016-07-08. PMID:26426866. |
b-cell leukaemia/lymphoma 2-associated x protein (bax) functions as a pro-apoptotic factor and induces apoptosis in several organisms. |
2016-07-08 |
2023-08-13 |
mouse |
| Agnieszka Gornowicz, Anna Bielawska, Robert Czarnomysy, Halina Gabryel-Porowska, Anna Muszyńska, Krzysztof Bielawsk. The combined treatment with novel platinum(II) complex and anti-MUC1 increases apoptotic response in MDA-MB-231 breast cancer cells. Molecular and cellular biochemistry. vol 408. issue 1-2. 2016-07-06. PMID:26112902. |
finally, the influence of novel platinum(ii) complex (pt12) used with anti-muc1 on the concentration of selected markers of apoptosis such as bax, caspase-8, -9, and caspase-3 was performed using elisa. |
2016-07-06 |
2023-08-13 |
human |
| Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer biology & therapy. vol 16. issue 9. 2016-07-06. PMID:26252178. |
following a genotoxic stress, the tumor suppressor p53 translocates to mitochondria to take part in direct induction of apoptosis, via interaction with bcl-2 family members such as bak and bax. |
2016-07-06 |
2023-08-13 |
Not clear |
| V Marschall, S Fuld. Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death. Cell death & disease. vol 6. 2016-07-06. PMID:26379193. |
moreover, bv6 and tmz cooperate to transcriptionally upregulate the proapoptotic b-cell lymphoma 2 family proteins bax (bcl-2-associated x protein) or puma (p53-upregulated modulator of apoptosis). |
2016-07-06 |
2023-08-13 |
Not clear |
| V Marschall, S Fuld. Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death. Cell death & disease. vol 6. 2016-07-06. PMID:26379193. |
knockdown of bax or puma significantly decreases bv6/tmz-induced apoptosis, showing that both proteins are necessary for apoptosis. |
2016-07-06 |
2023-08-13 |
Not clear |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
motor function of the lower limbs was evaluated according to the tarlov score at 72 and 168 h. for each rat, spinal cord samples were taken at 6, 24, 72 h, and 1 week to evaluate the histopathological changes, neuronal apoptosis, and bax and bcl2 expression levels. |
2016-07-06 |
2023-08-13 |
rat |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
group c exhibited greater neuronal apoptosis, higher bax expression, but lower bcl2 expression than the other groups. |
2016-07-06 |
2023-08-13 |
rat |