| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B T Gaudette, B Dwivedi, K S Chitta, S Poulain, D Powell, P Vertino, X Leleu, S Lonial, A A Chanan-Khan, J Kowalski, L H Bois. Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia. Oncogene. vol 35. issue 4. 2016-06-20. PMID:25893290. |
three wm cell lines expressed pro-apoptotic bcl-2 family members bim or bax and bak at low levels, which determined their sensitivity to inducers of intrinsic apoptosis. |
2016-06-20 |
2023-08-13 |
Not clear |
| Lirui Zhang, Xiaofeng Yang, Xu Li, Chen Li, Le Zhao, Yuanyuan Zhou, Huilian Ho. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310353. |
foxo3a target genes involved in cell cycle progression and apoptosis were also investigated, and combined treatment with butein and cisplatin resulted in the downregulation of cyclin d1 and bcl-2 and the upregulation of p27 and bax. |
2016-06-20 |
2023-08-13 |
mouse |
| Raquel Salvador-Gallego, Markus Mund, Katia Cosentino, Jale Schneider, Joseph Unsay, Ulrich Schraermeyer, Johann Engelhardt, Jonas Ries, Ana J García-Sáe. Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. The EMBO journal. vol 35. issue 4. 2016-06-20. PMID:26783362. |
bax is a key regulator of apoptosis that, under cell stress, accumulates at mitochondria, where it oligomerizes to mediate the permeabilization of the mitochondrial outer membrane leading to cytochrome c release and cell death. |
2016-06-20 |
2023-08-13 |
Not clear |
| Raquel Salvador-Gallego, Markus Mund, Katia Cosentino, Jale Schneider, Joseph Unsay, Ulrich Schraermeyer, Johann Engelhardt, Jonas Ries, Ana J García-Sáe. Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. The EMBO journal. vol 35. issue 4. 2016-06-20. PMID:26783362. |
our data identify the supramolecular organization of bax during apoptosis and support a molecular mechanism in which bax fully or partially delineates pores of different sizes to permeabilize the mitochondrial outer membrane. |
2016-06-20 |
2023-08-13 |
Not clear |
| Lena Große, Christian A Wurm, Christian Brüser, Daniel Neumann, Daniel C Jans, Stefan Jakob. Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis. The EMBO journal. vol 35. issue 4. 2016-06-20. PMID:26783364. |
bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis. |
2016-06-20 |
2023-08-13 |
Not clear |
| Lena Große, Christian A Wurm, Christian Brüser, Daniel Neumann, Daniel C Jans, Stefan Jakob. Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis. The EMBO journal. vol 35. issue 4. 2016-06-20. PMID:26783364. |
during apoptosis, bax translocates to the mitochondria and mediates the permeabilization of the outer membrane, thereby facilitating the release of pro-apoptotic proteins. |
2016-06-20 |
2023-08-13 |
Not clear |
| Tomasz Olszowski, Irena Baranowska-Bosiacka, Izabela Gutowska, Katarzyna Piotrowska, Katarzyna Mierzejewska, Jan Korbecki, Mateusz Kurzawski, Maciej Tarnowski, Dariusz Chlube. The Effects of Cadmium at Low Environmental Concentrations on THP-1 Macrophage Apoptosis. International journal of molecular sciences. vol 16. issue 9. 2016-06-17. PMID:26370970. |
the decrease in mitochondrial membrane potential, increased ros production, increased bax and decreased bcl-2 mrna expression are mitochondrial events involved in cadmium-induced apoptosis. |
2016-06-17 |
2023-08-13 |
Not clear |
| Wenfa Yu, Guozheng Zhang, Baocai Lu, Jing Li, Zhiyan Wu, Huimin Ma, Huimin Wang, Rong Lia. MiR-340 impedes the progression of laryngeal squamous cell carcinoma by targeting EZH2. Gene. vol 577. issue 2. 2016-06-17. PMID:26656176. |
in addition, mir-340 transfection induced cell apoptosis with concomitant enhancement of bax, increase of caspase-3 expression and activity, and reduction of bcl-2 expression in hep-2 cells. |
2016-06-17 |
2023-08-13 |
Not clear |
| Chengqiu Li, Ting Wang, Chunyuan Zhang, Jichang Xuan, Changjiang Su, Yuqi Wan. Quercetin attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways. Gene. vol 577. issue 2. 2016-06-17. PMID:26680104. |
furthermore, the effect of que, sp600125 (jnk inhibitor) and sb203580 (p38 inhibitor) on mitogen-activated protein kinases (mapks) and the expression of apoptosis related proteins (bcl-2, bax and caspase-3) was determined by western blotting. |
2016-06-17 |
2023-08-13 |
Not clear |
| Grant Dewso. Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death. Molecular & cellular oncology. vol 2. issue 1. 2016-06-16. PMID:27308408. |
recent studies have revolutionized our understanding of how the crucial apoptosis effectors bax and bak target mitochondria to kill cells. |
2016-06-16 |
2023-08-13 |
Not clear |
| Frank Edlic. The great migration of Bax and Bak. Molecular & cellular oncology. vol 2. issue 3. 2016-06-16. PMID:27308479. |
the bcl-2 proteins bcl-2-associated x protein (bax) and bcl-2 antagonist killer 1 (bak) can commit cells to apoptosis. |
2016-06-16 |
2023-08-13 |
Not clear |
| A M ElKeeb, M E W Collier, A Maraveyas, C Ettelai. Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis. vol 114. issue 2. 2016-06-14. PMID:25903973. |
cell proliferation, apoptosis and the expression of cyclin d1, p53, bax and p21 were measured following activation of cells with par2-agonist peptide. |
2016-06-14 |
2023-08-13 |
Not clear |
| A M ElKeeb, M E W Collier, A Maraveyas, C Ettelai. Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis. vol 114. issue 2. 2016-06-14. PMID:25903973. |
finally, sirna-mediated suppression of p38α, or inhibition using sb202190 significantly reduced the p53 protein levels, p53 nuclear localisation and transcriptional activity, suppressed bax expression and prevented cellular apoptosis. |
2016-06-14 |
2023-08-13 |
Not clear |
| Song-Tao Xu, Xiang Ding, Qing-Feng Ni, Shao-Ju Ji. Targeting MACC1 by RNA interference inhibits proliferation and invasion of bladder urothelial carcinoma in T24 cells. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-06-14. PMID:26339359. |
the expression of apoptosis proteins (caspase-3, caspase-8 and bax) increased significantly due to the macc1 rnai. |
2016-06-14 |
2023-08-13 |
human |
| H-C Liu, Y Zhang, S Zhang, T Xin, W-H Li, W-L Wu, Q Pang, Y-Z Che. Correlation research on the protein expression (p75NTR, bax, bcl-2, and caspase-3) and cortical neuron apoptosis following mechanical injury in rat. European review for medical and pharmacological sciences. vol 19. issue 18. 2016-06-14. PMID:26439043. |
correlation research on the protein expression (p75ntr, bax, bcl-2, and caspase-3) and cortical neuron apoptosis following mechanical injury in rat. |
2016-06-14 |
2023-08-13 |
rat |
| Muthuraman Pandurangan, Gansukh Enkhtaivan, Bhupendra Mistry, Murugesan Chandrasekaran, Rafi Noorzai, Doo Hwan Ki. Investigation of role of aspartame on apoptosis process in HeLa cells -->. Saudi journal of biological sciences. vol 23. issue 4. 2016-06-14. PMID:27298583. |
aspartame suppresses apoptosis process in cancer cells by down-regulation of mrna expression of tumor suppressor gene p53, and pro-apoptotic gene bax. |
2016-06-14 |
2023-08-13 |
Not clear |
| Chaoxiang Chen, Xiang Zhang, Shuyue Zhang, Shaobin Zhu, Jingyi Xu, Yan Zheng, Jinyan Han, Jin-Zhang Zeng, Xiaomei Ya. Quantification of protein copy number in single mitochondria: The Bcl-2 family proteins. Biosensors & bioelectronics. vol 74. 2016-06-13. PMID:26176207. |
bcl-2 family proteins, represented by antiapoptotic protein bcl-2 and proapoptotic protein bax, are key regulators of mitochondria-mediated apoptosis pathway. |
2016-06-13 |
2023-08-13 |
Not clear |
| Chaoxiang Chen, Xiang Zhang, Shuyue Zhang, Shaobin Zhu, Jingyi Xu, Yan Zheng, Jinyan Han, Jin-Zhang Zeng, Xiaomei Ya. Quantification of protein copy number in single mitochondria: The Bcl-2 family proteins. Biosensors & bioelectronics. vol 74. 2016-06-13. PMID:26176207. |
we observed an approximately 4.4 fold increase of bax copy number per mitochondrion upon 9h of apoptosis stimulation while the abundance of bcl-2 remained almost unchanged. |
2016-06-13 |
2023-08-13 |
Not clear |
| Maria Galuppo, Antonietta Rossi, Sabrina Giacoppo, Simona Pace, Placido Bramanti, Lidia Sautebin, Emanuela Mazzo. Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids. Pharmacological research. vol 99. 2016-06-13. PMID:26192346. |
in detail, mice sacrificed seven days after induction of sci trauma resulted not only in tissue damage, cellular infiltration, fibrosis, astrocyte activation, inos expression, extracellular signal regulated kinase 1/2 phosphorylation in injured tissue, poly (adp-ribose) polymerase 1 (parp-1) activation but also apoptosis (bax and bcl-2 expression). |
2016-06-13 |
2023-08-13 |
mouse |
| Peng Wu, Yuandai Luo, Lifang Zhen, Xianda Hu, Ying Shang, Yinuo Liao, Huiyuan Xue, Fukai Huang, Wei Xia. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-06-13. PMID:27293454. |
moreover, western blot and quantitative pcr (q-pcr) results indicated that the rsnp could suppress the apoptosis in the hippocampus of the vd animals by increasing the expression ratio of b-cell lymphoma-2 (bcl-2) to bcl-2-associated x protein (bax). |
2016-06-13 |
2023-08-13 |
rat |