| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Zhao, Bin Deng, Yichong Li, Lihua Zhou, Lei Yang, Xingchun Gou, Qiang Wang, Guozhong Chen, Hao Xu, Lixian X. Electroacupuncture Pretreatment Attenuates Cerebral Ischemic Injury via Notch Pathway-Mediated Up-Regulation of Hypoxia Inducible Factor-1α in Rats. Cellular and molecular neurobiology. vol 35. issue 8. 2016-07-28. PMID:25976178. |
the results showed ea pretreatment enhanced the neuronal expression of hif-1α, reduced infarct volume, improved neurological outcome, inhibited neuronal apoptosis, up-regulated expression of bcl-2, and down-regulated expression of bax after reperfusion in the penumbra, while the beneficial effects were attenuated by 2me2. |
2016-07-28 |
2023-08-13 |
rat |
| Amal H Hamza, Hanaa M Abdulfattah, Rasha H Mahmoud, Wagdy K B Khalil, Hanaa H Ahme. Current concepts in pathophysiology and management of hepatocellular carcinoma. Acta biochimica Polonica. vol 62. issue 3. 2016-07-27. PMID:26345095. |
regarding the apoptotic pathways of gse, we found a significant down regulation of apoptosis enhancing nuclease (aen), bcl2-associated x protein (bax), b-cell translocation gene 2(btg2), cyclin g1 (ccng1) and cyclin-dependent kinase inhibitor 1a (cdkn1a) gene expression in hcc+gse groups as compared to hcc bearing group. |
2016-07-27 |
2023-08-13 |
Not clear |
| Giuliana Castello Coatti, Juliana Cristina Marcarini, Daniele Sartori, Queli Cristina Fidelis, Dalva Trevisan Ferreira, Mário Sérgio Mantovan. Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:25894792. |
there was no significant modulation of the expression of the following genes: gstp1 and gpx1 (xenobiotic metabolism); cat (oxidative stress); tp53 and ccna2 (cell cycle); hspa5, ern1, eif2ak3 and traf2 (endoplasmic reticulum stress); casp8, casp9, casp3, casp7, bcl-2, bcl-xl bax and bax (apoptosis); and pcbp4, ercc4, ogg1, rad21 and mlh1 (dna repair). |
2016-07-26 |
2023-08-13 |
human |
| C-L Song, H Tang, L-K Ran, B C B Ko, Z-Z Zhang, X Chen, J-H Ren, N-N Tao, W-Y Li, A-L Huang, J Che. Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway. Oncogene. vol 35. issue 5. 2016-07-26. PMID:25915842. |
mechanistic studies revealed that sirt3 deacetylated and activated glycogen synthase kinase-3β (gsk-3β), which subsequently induced expression and mitochondrial translocation of the pro-apoptotic protein bcl2-associated x protein (bax) to promote apoptosis. |
2016-07-26 |
2023-08-13 |
Not clear |
| C-L Song, H Tang, L-K Ran, B C B Ko, Z-Z Zhang, X Chen, J-H Ren, N-N Tao, W-Y Li, A-L Huang, J Che. Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway. Oncogene. vol 35. issue 5. 2016-07-26. PMID:25915842. |
gsk-3β inhibitor or gene silencing of bax reversed sirt3-induced growth inhibition and apoptosis. |
2016-07-26 |
2023-08-13 |
Not clear |
| Sadeesh Em, Fozia Shah, Meena Kataria, P S Yada. A comparative study on expression profile of developmentally important genes during pre-implantation stages in buffalo hand-made cloned embryos derived from adult fibroblasts and amniotic fluid derived stem cells. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:26224482. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling, and imprinting (igf2, igf2r), apoptosis (bax, bcl2), oxidative stress (mnsod), metabolism (glut1) regulation were observed in cloned embryos. |
2016-07-26 |
2023-08-13 |
Not clear |
| Robert M Hughes, David J Freeman, Kelsey N Lamb, Rebecca M Pollet, Weston J Smith, David S Lawrenc. Optogenetic apoptosis: light-triggered cell death. Angewandte Chemie (International ed. in English). vol 54. issue 41. 2016-07-26. PMID:26418181. |
an optogenetic bax has been designed that facilitates light-induced apoptosis. |
2016-07-26 |
2023-08-13 |
Not clear |
| Robert M Hughes, David J Freeman, Kelsey N Lamb, Rebecca M Pollet, Weston J Smith, David S Lawrenc. Optogenetic apoptosis: light-triggered cell death. Angewandte Chemie (International ed. in English). vol 54. issue 41. 2016-07-26. PMID:26418181. |
mutagenesis of a key phosphorylatable residue or modification of the c-terminus mitigates background (dark) levels of apoptosis that result from bax overexpression. |
2016-07-26 |
2023-08-13 |
Not clear |
| Cheng Bi, Yinong Jiang, Tingting Fu, Yu Hao, Xifang Zhu, Yan L. Naringin inhibits lipopolysaccharide-induced damage in human umbilical vein endothelial cells via attenuation of inflammation, apoptosis and MAPK pathways. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:27006302. |
moreover, nar significantly down-regulated the protein or mrna levels of il-1, il-6, tnf-α, vcam-1, icam-1, nf-κb, ap-1, cleaved-3,-7,-9, p53, bak and bax, and up-regulated the expressions of bcl-xl, bcl-2 to suppress inflammation and apoptosis. |
2016-07-26 |
2023-08-13 |
human |
| Jixiao Niu, Aimin Xue, Yayun Chi, Jingyan Xue, Wei Wang, Ziqin Zhao, Meiyun Fan, Chuan He Yang, Zhi-Ming Shao, Lawrence M Pfeffer, Jiong Wu, Zhao-Hui W. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene. vol 35. issue 10. 2016-07-25. PMID:26028030. |
we further identified bax as a direct functional target of mir-181a, whose suppression decreased apoptosis and increased invasion of tnbc cells upon dox treatment. |
2016-07-25 |
2023-08-13 |
Not clear |
| Mingming Liu, Zihao Qi, Bingzhi Liu, Yi Ren, Hanbin Li, Gong Yang, Qian Zhan. RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway. Oncotarget. vol 6. issue 28. 2016-07-25. PMID:26325371. |
in the present study, we show that ry-2f, a chemically synthesized isoflavone analog, inhibited ovarian cancer cell proliferation, blocked cell cycle in g2/m phase and induced cellular apoptosis through up-regulation of p21, cyclin b1, bax, bad and cleaved-parp, and suppression of cyclin a, cdk2 and bcl-2. |
2016-07-25 |
2023-08-13 |
Not clear |
| Juan Li, Ran-ran Sun, Zu-jiang Yu, Hongxia Liang, Shen Shen, Quancheng Ka. Galectin-1 Modulates the Survival and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Sensitivity in Human Hepatocellular Carcinoma Cells. Cancer biotherapy & radiopharmaceuticals. vol 30. issue 8. 2016-07-24. PMID:26348206. |
the authors found that sirna-mediated downregulation of galectin-1 caused apoptosis in hcc cells, which was coupled with reduced bcl-2 and survivin and increased bax expression. |
2016-07-24 |
2023-08-13 |
human |
| Chuhai Xie, Boyi Wu, Binwei Chen, Qunwei Shi, Jianhong Guo, Ziwen Fan, Yan Huan. Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2-p53 signaling. OncoTargets and therapy. vol 9. 2016-07-22. PMID:27445491. |
then, cell proliferation and apoptosis were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and flow cytometry assays, respectively; the expression of ki67, bax, bcl-2, mdm2, and p53 proteins was determined by using western blot assay. |
2016-07-22 |
2023-08-13 |
mouse |
| Jie Song, Na Li, Yang Xia, Zhong Gao, Sa-Feng Zou, Liang Kong, Ying-Jia Yao, Ya-Nan Jiao, Yu-Hui Yan, Shao-Heng Li, Zhen-Yu Tao, Guan Lian, Jing-Xian Yang, Ting-Guo Kan. Arctigenin Treatment Protects against Brain Damage through an Anti-Inflammatory and Anti-Apoptotic Mechanism after Needle Insertion. Frontiers in pharmacology. vol 7. 2016-07-22. PMID:27445818. |
gene levels of inflammation (tnf-α, il-6, and il-10) and apoptosis (caspase-3, bax and bcl-2) were detected by reverse transcription-polymerase chain reaction (rt-pcr). |
2016-07-22 |
2023-08-13 |
mouse |
| Jian He, Yaoyun Tang, Yongquan Tia. MicroRNA‑214 promotes proliferation and inhibits apoptosis via targeting Bax in nasopharyngeal carcinoma cells. Molecular medicine reports. vol 12. issue 4. 2016-07-21. PMID:26239171. |
microrna‑214 promotes proliferation and inhibits apoptosis via targeting bax in nasopharyngeal carcinoma cells. |
2016-07-21 |
2023-08-13 |
human |
| Jian He, Yaoyun Tang, Yongquan Tia. MicroRNA‑214 promotes proliferation and inhibits apoptosis via targeting Bax in nasopharyngeal carcinoma cells. Molecular medicine reports. vol 12. issue 4. 2016-07-21. PMID:26239171. |
sirna‑induced bax inhibition attenuated the promoting effect of mir‑214 downregulation on nasopharyngeal carcinoma cell apoptosis, suggesting that bax acts as a downstream effector in mir‑214‑mediated nasopharyngeal carcinoma cell proliferation and apoptosis. |
2016-07-21 |
2023-08-13 |
human |
| Naoshad Mohammad, Shivendra Vikram Singh, Parmanand Malvi, Balkrishna Chaube, Dipti Athavale, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bipin Nair, Manoj Kumar Bha. Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complex. Scientific reports. vol 5. 2016-07-19. PMID:26149967. |
mcd sensitizes mcf-7 and hepa1-6 cells to dox, combination of mcd and marginal dose of dox reduces the cell viability, and promoted apoptosis through induction of pro-apoptotic protein, bax, activation of caspase-8 and caspase-7, down regulation of anti-apoptotic protein bcl-2 and finally promoting parp cleavage. |
2016-07-19 |
2023-08-13 |
mouse |
| Stuart Duncan Morton, Massimiliano Cadamuro, Simone Brivio, Marta Vismara, Tommaso Stecca, Marco Massani, Nicolò Bassi, Alberto Furlanetto, Ruth Elizabeth Joplin, Annarosa Floreani, Luca Fabris, Mario Strazzabosc. Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation. Oncotarget. vol 6. issue 28. 2016-07-19. PMID:26296968. |
in cholangiocarcinoma cells, we tested lif effects on proliferation, invasion, stem cell-like phenotype, chemotherapy-induced apoptosis (gemcitabine+cisplatin), expression levels of pro-apoptotic (bax) and anti-apoptotic (mcl-1) proteins, with/without pi3k inhibition, and of pstat3, perk1/2, pakt. |
2016-07-19 |
2023-08-13 |
human |
| Kun-Yuan Chiu, Chun-Chi Wu, Chi-Hao Chia, Shih-Lan Hsu, Yew-Min Tzen. Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms. Cancer letters. vol 373. issue 2. 2016-07-19. PMID:26679052. |
both antrocin-induced intrinsic and extrinsic apoptosis is through upregulation of pro-apoptotic proteins, including bax, fas, and dr5. |
2016-07-19 |
2023-08-13 |
human |
| Victoria Belén Ayala-Peña, Fiorella Pilotti, Yanel Volonté, Nora P Rotstein, Luis E Politi, Olga Lorena Germa. Protective effects of retinoid x receptors on retina pigment epithelium cells. Biochimica et biophysica acta. vol 1863. issue 6 Pt A. 2016-07-19. PMID:26883505. |
h2o2 induced apoptosis of d407 cells, promoting p65nfκb nuclear translocation, increasing bax mrna expression, activating caspase-3 and altering cell morphology. |
2016-07-19 |
2023-08-13 |
rat |