| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mukesh K Jaiswal, Varkha Agrawal, Gajendra K Katara, Sahithi Pamarthy, Arpita Kulshrestha, Gerard Chaouat, Alice Gilman-Sachs, Kenneth D Beama. Male fertility and apoptosis in normal spermatogenesis are regulated by vacuolar-ATPase isoform a2. Journal of reproductive immunology. vol 112. 2016-08-29. PMID:26226211. |
the expression of pro-apoptotic molecules (bax, p53, and p21) and molecules involved in the intrinsic pathway of apoptosis (caspase-9, caspase-3, and parp), which are crucial for normal spermatogenesis was significantly reduced in testes from anti-a2v-treated males compared with the control. |
2016-08-29 |
2023-08-13 |
mouse |
| Daniel Förster, Georg Reise. Supportive or detrimental roles of P2Y receptors in brain pathology?--The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26407872. |
the mechanisms reported to underlie the protection in vitro include increased expression of oxidoreductase genes, like carbonyl reductase and thioredoxin reductase; increased expression of inhibitor of apoptosis protein-2; extracellular signal-regulated kinase- and akt-mediated antiapoptotic signaling; increased expression of bcl-2 proteins, neurotrophins, neuropeptides, and growth factors; decreased bax expression; non-amyloidogenic app shedding; and increased neurite outgrowth in neuronal cells. |
2016-08-29 |
2023-08-13 |
mouse |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
growth-inhibitory effect and apoptosis induction of hepg2 cells were evidenced by mtt assay, cell morphology alteration, apoptosis enzyme-linked immunosorbent assay, flow cytometric analysis, caspase-3 activity, and expression of p53, proapoptotic protein, bax, and proliferating cell nuclear antigen (pcna) after (100 ∼ 500 μg/ml) fce treatment for 48 h. furthermore, fce was analyzed by chromatography-mass spectrometry (gc/ms). |
2016-08-29 |
2023-08-13 |
Not clear |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
our results revealed that fce treatment for 48 h showed a cytotoxic effect and apoptosis induction in a dose-dependent manner that was mediated by upregulation of p53, bax, pcna, and caspase-3 activation in hepg2 cells. |
2016-08-29 |
2023-08-13 |
Not clear |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
our data introduced fce as a promising nontoxic herbal with therapeutic potential to induce apoptosis in hepg2 cells through p53, bax, and pcna upregulation in caspase-3 dependent manner. |
2016-08-29 |
2023-08-13 |
Not clear |
| Zhiqiang Wang, He Huang, Wangwei He, Bin Kong, He Hu, Yang Fan, Jiafen Liao, Lei Wang, Yang Mei, Wanli Liu, Xiaoju Xiong, Jianye Peng, Yali Xiao, Dan Huang, Dajun Quan, Qi Li, Liang Xiong, Peng Zhong, Guangji Wan. Regulator of G-protein signaling 5 protects cardiomyocytes against apoptosis during in vitro cardiac ischemia-reperfusion in mice by inhibiting both JNK1/2 and P38 signaling pathways. Biochemical and biophysical research communications. vol 473. issue 2. 2016-08-29. PMID:27021681. |
our results revealed that compared with either wt or ko mice, tg mice showed inhibition of cardiomyocyte apoptosis as indicated by a greater increase of b cell lymphoma/lewkmia-2 (bcl-2), and an obvious reduction in the positive expression of the terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel), bcl-2 associated x protein (bax), and active caspase-3. |
2016-08-29 |
2023-08-13 |
mouse |
| Hakan Savlı, Saadet Özdemir, Balint Nag. Rapid Detection of the Apoptosis Related Genes (BCL-2, BAD, BAX) in 12 Hours 1,25 (OH)2D3 Treated HL-60 Cells Using Real-Time Quantitative RT-PCR. Turkish journal of haematology : official journal of Turkish Society of Haematology. vol 21. issue 1. 2016-08-29. PMID:27263643. |
rapid detection of the apoptosis related genes (bcl-2, bad, bax) in 12 hours 1,25 (oh)2d3 treated hl-60 cells using real-time quantitative rt-pcr. |
2016-08-29 |
2023-08-13 |
Not clear |
| Bo Xu, Zhilei Mao, Xiaoli Ji, Mengmeng Yao, Minjian Chen, Xuemei Zhang, Bo Hang, Yi Liu, Wei Tang, Qiusha Tang, Yankai Xi. miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells. Scientific reports. vol 5. 2016-08-26. PMID:26263183. |
the mrna and protein levels of apoptosis markers (bax, caspase-3, caspase-9) in gc-2 cells were significantly increased, while bcl-2 was decreased. |
2016-08-26 |
2023-08-13 |
Not clear |
| Min Hee Sung, Ok-Kyoung Kwon, Sei-Ryang Oh, Joongku Lee, Sang-Hong Park, Sang Bae Han, Kyung-Seop Ah. Azorella compacta methanolic extract induces apoptosis via activation of mitogen-activated protein kinase. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26397193. |
the increases in apoptosis were also associated with decreases of the apoptosis-inhibitor b-cell lymphoma 2 (bcl‑2), upregulation of pro‑apoptotic bcl-2-associated x (bax) protein and downregulation of anti‑apoptotic bcl extra large protein. |
2016-08-26 |
2023-08-13 |
human |
| Huixia Lu, Feng Gao, Guofang Shu, Guohua Xia, Zeye Shao, Hangqin Lu, Keping Chen. Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26398525. |
notably, the data in the present study revealed that wogonin upregulated the expression of p21cip1 and p27kip1, and downregulated the expression of cyclin d1 and cyclin‑dependent kinase 4, causing a g0/g1 phase arrest, halting cell cycle progression, and inducing apoptosis in the mds cells, which was mediated by the mitochondrial pathway through a modulation of the ratio of bcl‑2 to bax. |
2016-08-26 |
2023-08-13 |
Not clear |
| Waleed Arafat, Tong Zhou, George E Naoum, Donald J Buchsbau. Targeted radiotherapy potentiates the cytotoxicity of a novel anti-human DR5 monoclonal antibody and the adenovirus encoding soluble TRAIL in prostate cancer. Journal of the Egyptian National Cancer Institute. vol 27. issue 4. 2016-08-24. PMID:26385392. |
mechanistic studies showed that the killing effect was due to induction of apoptosis mostly by increased expression of bax in tra-8 or ad/trail treated cells. |
2016-08-24 |
2023-08-13 |
human |
| Jin Wu, Zhida Chen, Qingjun Liu, Wenrong Zeng, Xinyu Wu, Bin Li. Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells. International journal of molecular sciences. vol 16. issue 11. 2016-08-24. PMID:26569226. |
silencing kv1.5 expression in the osteosarcoma cells significantly inhibited the proliferation of osteosarcoma cells, induced cell cycle arrest at g0/g1 phase, and induced cell apoptosis through up-regulation of p21, p27, bax, bcl-xl and caspase-3 and down-regulation of cyclins a, cyclins d1, cyclins e, bcl-2 and bik. |
2016-08-24 |
2023-08-13 |
Not clear |
| Kiyoko Setoguchi, Tara TeSlaa, Carla M Koehler, Michael A Teitel. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. Journal of molecular biology. vol 428. issue 7. 2016-08-23. PMID:26239243. |
also, bax activation and pro-apoptotic mitochondrial intermembrane space protein release, which are required to initiate the mitochondria-mediated apoptosis pathway, are more rapid in hpscs than in retinoic-acid-differentiated hpscs. |
2016-08-23 |
2023-08-13 |
human |
| Kiyoko Setoguchi, Tara TeSlaa, Carla M Koehler, Michael A Teitel. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. Journal of molecular biology. vol 428. issue 7. 2016-08-23. PMID:26239243. |
surprisingly, bak and not bax is essential for actinomycin-d-induced apoptosis in human embryonic stem cells. |
2016-08-23 |
2023-08-13 |
human |
| Y Zhang, S Chiu, X Liang, F Gao, Z Zhang, S Liao, Y Liang, Y-H Chai, D J H Low, H-F Tse, V Tergaonkar, Q Lia. Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction. Cell death discovery. vol 1. 2016-08-23. PMID:27551443. |
compared with bm-mscs, rap1(-/-)-bm-mscs displayed a significantly reduced ratio of phosphorylated nf-κb to nf-κb-p65 and of bax to bcl-2, and increased resistance to hypoxia-induced apoptosis by the terminal deoxynucleotidal transferase-mediated dutp nick end labeling (tunel) assay. |
2016-08-23 |
2023-08-13 |
Not clear |
| M A G de Castro, G Bunt, F S Wouter. Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes. Cell death discovery. vol 2. 2016-08-23. PMID:27551506. |
we used förster resonance energy transfer (fret)-based biosensors to image the real-time degradation of the bcl-2-family members, bcl-xl, bax and bid, in living cells undergoing lysosomal lysis and identified an early chain of proteolytic events, initiated by the release of cathepsin b, which directs cells toward apoptosis. |
2016-08-23 |
2023-08-13 |
Not clear |
| Yijia Li, Xiaoyun He, Xuan Yang, Kunlun Huang, Yunbo Luo, Liye Zhu, Yuzhe Li, Wentao X. Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells. Scientific reports. vol 5. 2016-08-22. PMID:26395757. |
meanwhile, two different zincs inhibited the zea-induced loss of mitochondrial membrane potential and elevation of late-stage apoptosis via activating the mitochondrial apoptotic pathway by recovering the mrna and protein expression of pro-apoptotic genes (bax, casp3, casp9). |
2016-08-22 |
2023-08-13 |
Not clear |
| Chun-Fu Hong, Shu-Yu Lin, Yu-Ting Chou, Cheng-Wen W. MicroRNA-7 Compromises p53 Protein-dependent Apoptosis by Controlling the Expression of the Chromatin Remodeling Factor SMARCD1. The Journal of biological chemistry. vol 291. issue 4. 2016-08-22. PMID:26542803. |
additionally, upon chemotherapy drug treatment, mir-7 down-regulated p53-dependent apoptosis-related gene bax (bcl2-associated x protein) and p21 expression by interfering with the interaction between smarcd1 and p53, thereby reducing caspase3 cleavage and the downstream apoptosis cascades. |
2016-08-22 |
2023-08-13 |
Not clear |
| Wei Jiang, Tao Luo, Sheng Li, Yue Zhou, Xiu-Yin Shen, Feng He, Jie Xu, Hua-Qiao Wan. Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons. PloS one. vol 11. issue 4. 2016-08-22. PMID:27050422. |
moreover, pre-treatment with quercetin not only inhibited oa-induced apoptosis via the reduction of bax, and up-regulation of cleaved caspase 3, but also via the inhibition of pi3k/akt/gsk3β, mapks and activation of nf-κb p65. |
2016-08-22 |
2023-08-13 |
mouse |
| Cheng-Lei Tian, Qian Wen, Ting-Jun Fa. Cytotoxicity of atropine to human corneal epithelial cells by inducing cell cycle arrest and mitochondrion-dependent apoptosis. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 67. issue 10. 2016-08-19. PMID:26296992. |
furthermore, atropine could also induce activations of caspase-2, -3 and -9, disruption of mitochondrial transmembrane potential, downregulation of bcl-2 and bcl-xl, upregulation of bax and bad, and upregulation of cytoplasmic cytochrome c and apoptosis-inducing factor, implying a death receptor-mediated mitochondrion-dependent pathway is most probably involved in the apoptosis of hcep cells induced by atropine. |
2016-08-19 |
2023-08-13 |
human |