| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunfeng Hu, Yuetang Ma, Shi Wu, Tianfeng Chen, Yong He, Jianxia Sun, Rui Jiao, Xinwei Jiang, Yadong Huang, Liehua Deng, Weibin Ba. Protective Effect of Cyanidin-3-O-Glucoside against Ultraviolet B Radiation-Induced Cell Damage in Human HaCaT Keratinocytes. Frontiers in pharmacology. vol 7. 2016-09-22. PMID:27656146. |
furthermore, expression of the proapoptotic proteins bcl-2-associated x (bax) and the key apoptosis executer cleaved caspase-3 were increased in uvb-irradiated cells and decreased in uvb/cyanidin-3-o-glucoside-treated cells. |
2016-09-22 |
2023-08-13 |
human |
| Joo Hwan Roh, Il-Gyu Ko, Sung-Eun Kim, Jae-Min Lee, Eun-Sang Ji, Ju Ho Kim, Hyun-Kyung Chang, Seung Kyu Lee, Khae Hawn Ki. Treadmill exercise ameliorates intracerebral hemorrhage-induced depression in rats. Journal of exercise rehabilitation. vol 12. issue 4. 2016-09-22. PMID:27656626. |
apoptosis in the hippocampus was detected using terminal deoxynucleotidyl transferase-mediated dutp nick end labeling assay, immunohistochemistry for caspase-3, and western blot for bcl-2 and bax. |
2016-09-22 |
2023-08-13 |
rat |
| Yi Sun, Amina Fu, Wu Xu, Jyh-Rong Chao, Simon Moshiach, Stephan W Morri. Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3. Journal of physiology and biochemistry. vol 71. issue 4. 2016-09-21. PMID:26563351. |
these data, taken together, strongly suggested that in response to the stresses, up-regulated mlf1 promoted its association with bcl-xl and reduced the available bcl-xl for associating with bax, which resulted in releasing bax from the bcl-xl and apoptosis in turn. |
2016-09-21 |
2023-08-13 |
mouse |
| Won Kyung Kim, Yuna Pyee, Hwa-Jin Chung, Hyen Joo Park, Ji-Young Hong, Kun Ho Son, Sang Kook Le. Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. Journal of natural products. vol 79. issue 4. 2016-09-21. PMID:27064730. |
apoptosis induced by 1 was associated with the regulation of apoptotic proteins including bcl-2, bax, and bid, the release of cytochrome c into the cytosol, and the accumulation of cleaved poly-adp-ribose polymerase (parp). |
2016-09-21 |
2023-08-13 |
mouse |
| Florian Engert, Cornelius Schneider, Lilly Magdalena Weiβ, Marie Probst, Simone Fuld. PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. Molecular cancer therapeutics. vol 14. issue 12. 2016-09-20. PMID:26438158. |
overexpression of a nondegradable mcl-1 mutant or bcl-2, knockdown of noxa or bax and bak, or the caspase inhibitor n-benzyloxycarbonyl-val-ala-asp-fluoromethylketone (zvad.fmk) all significantly reduce olaparib/tmz-mediated apoptosis. |
2016-09-20 |
2023-08-13 |
Not clear |
| Ulrike Heinicke, Johanna Kupka, Simone Fuld. JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis. Oncotarget. vol 6. issue 35. 2016-09-20. PMID:26473375. |
also, jnj-26481585 and doxorubicin cooperate to stimulate activation of bax and bak, which is required for jnj-26481585/doxorubicin-induced apoptosis, since silencing of bax or bak protects against apoptosis. |
2016-09-20 |
2023-08-13 |
Not clear |
| Jung-Hoo Hwang, Jong Cheon Joo, Dae Joon Kim, Eunbi Jo, Hwa-Seung Yoo, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jan. Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells. American journal of cancer research. vol 6. issue 8. 2016-09-20. PMID:27648363. |
the decreased bax activation markedly protected against cordycepin-induced apoptosis. |
2016-09-20 |
2023-08-13 |
human |
| Jung-Hoo Hwang, Jong Cheon Joo, Dae Joon Kim, Eunbi Jo, Hwa-Seung Yoo, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jan. Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells. American journal of cancer research. vol 6. issue 8. 2016-09-20. PMID:27648363. |
bax subfamily proteins induced apoptosis through caspase-3. |
2016-09-20 |
2023-08-13 |
human |
| Jung-Hoo Hwang, Jong Cheon Joo, Dae Joon Kim, Eunbi Jo, Hwa-Seung Yoo, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jan. Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells. American journal of cancer research. vol 6. issue 8. 2016-09-20. PMID:27648363. |
taken together, we show that jnk signaling activation by cordycepin mediated erk inhibition, which might have induced bax translocation and caspase-3 activation via regulation of dusp5 in tk-10 cells, thereby promoting the apoptosis of tk-10 cells. |
2016-09-20 |
2023-08-13 |
human |
| Xiaolin Zhang, Hao Y. Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression. Iranian journal of pharmaceutical research : IJPR. vol 15. issue 2. 2016-09-19. PMID:27642320. |
western blot analysis of p53, bax, cleaved caspase-3 and myosin light chain kinase (mlck) revealed that matrine induced tumor cell apoptosis by controlling anoikis. |
2016-09-19 |
2023-08-13 |
rat |
| Ambily Ravindran Nair, Wing-Kee Lee, Karen Smeets, Quirine Swennen, Amparo Sanchez, Frank Thévenod, Ann Cuyper. Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney. Archives of toxicology. vol 89. issue 12. 2016-09-16. PMID:25388156. |
in vivo, active caspase-3, and hence apoptosis, was detected by flivo injection in the kidney cortex of cd(2+)-treated rats together with an increase in bax mrna. |
2016-09-16 |
2023-08-13 |
rat |
| Sadeesh Em, Fozia Shah, P S Yada. Differential developmental competence and gene expression patterns in buffalo (Bubalus bubalis) nuclear transfer embryos reconstructed with fetal fibroblasts and amnion mesenchymal stem cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26660476. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling and imprinting (igf2, igf2r), apoptosis (bax, bcl2), metabolism (glut1) and oxidative stress (mnsod) regulation were observed in cloned embryos. |
2016-09-16 |
2023-08-13 |
Not clear |
| Canan Eroğlu, Mücahit Seçme, Pelin Atmaca, Oğuzhan Kaygusuz, Kutret Gezer, Gülseren Bağcı, Yavuz Dodurg. Extract of Calvatia gigantea inhibits proliferation of A549 human lung cancer cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26820971. |
c. gigantea extract induced cell cycle arrest and apoptosis by decreasing the ccnd1, ccnd2, cdk4, akt and bcl-2 expression and by increasing bax, p53, caspase-3 and caspase-9 expression in a549 cells. |
2016-09-16 |
2023-08-13 |
human |
| Hai-Jun Bao, Hai-Yang Qiu, Jin-Xia Kuai, Cheng-Jie Song, Shao-Xian Wang, Chao-Qun Wang, Hua-Bin Peng, Wen-Can Han, Yong-Ping W. Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury. Neural regeneration research. vol 11. issue 7. 2016-09-16. PMID:27630697. |
here, we found that apelin-13 significantly decreases cerebral water content, mitigates blood-brain barrier destruction, reduces aquaporin-4 expression, diminishes caspase-3 and bax expression in the cerebral cortex and hippocampus, and reduces apoptosis. |
2016-09-16 |
2023-08-13 |
Not clear |
| Ling-Ling Zhao, Yuan-Fang Liu, Li-Jun Peng, Ai-Mei Fei, Wen Cui, Sheng-Chao Miao, Olivier Hermine, Remy Gressin, Saadi Khochbin, Sai-Juan Chen, Jin Wang, Jian-Qing M. Arsenic trioxide rewires mantle cell lymphoma response to bortezomib. Cancer medicine. vol 4. issue 11. 2016-09-15. PMID:26310857. |
furthermore, the interaction of noxa and mcl-1 leads bak to release from mcl-1 or from bcl-xl, which could further activate bak and bax and then induce cell apoptosis. |
2016-09-15 |
2023-08-13 |
mouse |
| Xiang-ru Li, Jia Guo, Xin-ming L. [The expression and changes of apoptosis protein Bcl-2 and Bax in oral lichen planus]. Shanghai kou qiang yi xue = Shanghai journal of stomatology. vol 24. issue 4. 2016-09-15. PMID:26383573. |
[the expression and changes of apoptosis protein bcl-2 and bax in oral lichen planus]. |
2016-09-15 |
2023-08-13 |
Not clear |
| Xiang-ru Li, Jia Guo, Xin-ming L. [The expression and changes of apoptosis protein Bcl-2 and Bax in oral lichen planus]. Shanghai kou qiang yi xue = Shanghai journal of stomatology. vol 24. issue 4. 2016-09-15. PMID:26383573. |
to analyze the changes in epithelial cells, and observe the expression of bcl-2, bax and apoptosis in oral lichen planus. |
2016-09-15 |
2023-08-13 |
Not clear |
| Zhen-Gang Zhang, Jie Zou, Ying Huang, Liang W. Kinetin inhibits proliferation of hepatic stellate cells by interrupting cell cycle and induces apoptosis by down-regulating ratio of Bcl-2/Bax. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 35. issue 5. 2016-09-15. PMID:26489620. |
the kinetin-induced apoptosis of hscs was positively correlated with the expression of bax, and negatively with the expression of bcl-2. |
2016-09-15 |
2023-08-13 |
human |
| Z T Shen, X H Wu, L Wang, B Li, X X Zh. Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice. Genetics and molecular research : GMR. vol 14. issue 4. 2016-09-15. PMID:26634526. |
effects of gemcitabine on radiosensitization, apoptosis, and bcl-2 and bax protein expression in human pancreatic cancer xenografts in nude mice. |
2016-09-15 |
2023-08-13 |
mouse |
| Z T Shen, X H Wu, L Wang, B Li, X X Zh. Effects of gemcitabine on radiosensitization, apoptosis, and Bcl-2 and Bax protein expression in human pancreatic cancer xenografts in nude mice. Genetics and molecular research : GMR. vol 14. issue 4. 2016-09-15. PMID:26634526. |
the apoptotic index was determined by terminal deoxynucleotidyl transferase dutp nick end-labeling assay, and apoptosis inhibitory protein bcl-2 and apoptosis-related protein bax expression were detected by immunohistochemistry. |
2016-09-15 |
2023-08-13 |
mouse |