| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Yang, Xiang-Jian Zhang, Li-Tao Li, Hai-Ying Cui, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Mia. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. vol 75. 2016-10-24. PMID:26631263. |
apelin-13, with the co-administration of saline, reduced apoptosis cells, down-regulated bax and cleaved-caspase3 and up-regulated bcl2. |
2016-10-24 |
2023-08-13 |
mouse |
| Yi Yang, Xiang-Jian Zhang, Li-Tao Li, Hai-Ying Cui, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Mia. Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke. Peptides. vol 75. 2016-10-24. PMID:26631263. |
however, with the co-administration of compound c, apelin-13 was inefficient in affecting apoptosis and bax, bcl2 and cleaved-caspase3. |
2016-10-24 |
2023-08-13 |
mouse |
| Yang Yang, Chongxi Fan, Chao Deng, Lin Zhao, Wei Hu, Shouyin Di, Zhiqiang Ma, Yu Zhang, Zhigang Qin, Zhenxiao Jin, Xiaolong Yan, Shuai Jiang, Yang Sun, Wei Y. Melatonin reverses flow shear stress-induced injury in bone marrow mesenchymal stem cells via activation of AMP-activated protein kinase signaling. Journal of pineal research. vol 60. issue 2. 2016-10-24. PMID:26707568. |
melatonin markedly reduced bmsc apoptotic death in a concentration-dependent manner while increasing the levels of transforming growth factor β (tgf-β), basic fibroblast growth factor (bfgf), vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf) and b-cell lymphoma 2 (bcl2), and decreasing those of bcl-2-associated x protein (bax), p53 upregulated modulator of apoptosis (puma), and caspase 3. |
2016-10-24 |
2023-08-13 |
Not clear |
| Daniel Radin, Arnold Lippa, Parth Patel, Donna Leonard. Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 77. 2016-10-24. PMID:26796280. |
cisplatin may initiate p73-dependent apoptosis in p53 mutant cell lines through fas trimerization and caspase-8 activation and bax up regulation and subsequent caspase-9 activation. |
2016-10-24 |
2023-08-13 |
Not clear |
| Eunyoung Lee, Chung Gi Lee, Joung-Han Yim, Hong-Kum Lee, Suhkneung Py. Ramalin-Mediated Apoptosis Is Enhanced by Autophagy Inhibition in Human Breast Cancer Cells. Phytotherapy research : PTR. vol 30. issue 3. 2016-10-21. PMID:26676298. |
moreover, the inhibition of autophagy by 3-methyladenine or atg5 sirna significantly enhanced ramalin-induced apoptosis, which was accompanied by a decrease in bcl-2 levels and an increase in bax levels. |
2016-10-21 |
2023-08-13 |
human |
| Xu-guang Chen, Yan-xia Lv, Dan Zhao, Lei Zhang, Fei Zheng, Jian-Ye Yang, Xiao-lin Li, Lu Wang, Lin-Yun Guo, Ya-mu Pan, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tang, Yu Wa. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and cellular biochemistry. vol 413. issue 1-2. 2016-10-21. PMID:26769665. |
24 h later, the myocardial infarction size, the number of tunel-positive cardiomyocytes, the levels of creatine kinase (ck), ck-mb, cardiac troponin, malondialdehyde (mda) content, and apoptosis protein bax expression were decreased, while bcl2 and pakt expression were increased in vegf-c-treated myocardium as compared to the saline-treated i/r hearts. |
2016-10-21 |
2023-08-13 |
human |
| Xu-guang Chen, Yan-xia Lv, Dan Zhao, Lei Zhang, Fei Zheng, Jian-Ye Yang, Xiao-lin Li, Lu Wang, Lin-Yun Guo, Ya-mu Pan, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tang, Yu Wa. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and cellular biochemistry. vol 413. issue 1-2. 2016-10-21. PMID:26769665. |
in the h2o2-induced h9c2 cardiomyocytes, which mimicked the i/r injury in vivo, vegf-c pre-treatment decreased the ldh release and mda content, blocked h2o2-induced apoptosis by inhibiting the pro-apoptotic protein bax expression and its translocation to the mitochondrial membrane, and consequently attenuated h2o2-induced decrease of mitochondrial membrane potential and increase of cytochrome c release from mitochondria. |
2016-10-21 |
2023-08-13 |
human |
| Xin-shang Wang, Zhen Tian, Nan Zhang, Jing Han, Hong-liang Guo, Ming-gao Zhao, Shui-bing Li. Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death. Phytotherapy research : PTR. vol 30. issue 3. 2016-10-20. PMID:26643508. |
furthermore, gastrodin protected astrocytes from apoptosis through bcl-2 and bax signaling pathway. |
2016-10-20 |
2023-08-13 |
Not clear |
| Joohyun Lee, Min Kyung Jung, Hyun Jeong Park, Kyung Eun Kim, Daeho Ch. Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis. International journal of molecular sciences. vol 17. issue 1. 2016-10-20. PMID:26784177. |
overall, data demonstrate that erdr1 induced murine melanoma apoptosis through the regulation of bcl-2 and bax. |
2016-10-20 |
2023-08-13 |
mouse |
| Tahereh Haghpanah, Mohammad Salehi, Marefat Ghaffari Novin, Reza Masteri Farahani, Fatemeh Fadaei-Fathabadi, Maryam Dehghani-Mohammadabadi, Hadi Azim. Does sperm DNA fragmentation affect the developmental potential and the incidence of apoptosis following blastomere biopsy? Systems biology in reproductive medicine. vol 62. issue 1. 2016-10-19. PMID:26678043. |
the frequency of apoptosis in biopsied embryos was assayed by tunel and the level of bcl-2, bax, hsa-mir-15a, and hsa-mir-16-1 were assessed by quantitative real-time polymerase chain reaction (qrt-pcr). |
2016-10-19 |
2023-08-13 |
human |
| Goran Gajski, Ana-Marija Domijan, Bojana Žegura, Alja Štern, Marko Gerić, Ivana Novak Jovanović, Ivana Vrhovac, Josip Madunić, Davorka Breljak, Metka Filipič, Vera Garaj-Vrhova. Melittin induced cytogenetic damage, oxidative stress and changes in gene expression in human peripheral blood lymphocytes. Toxicon : official journal of the International Society on Toxinology. vol 110. 2016-10-19. PMID:26704293. |
mel also modulated the expression of selected genes involved in dna damage response (tp53, cdkn1a, gadd45α, mdm), oxidative stress (cat, sod1, gpx1, gsr and gclc) and apoptosis (bax, bcl-2, cas-3 and cas-7). |
2016-10-19 |
2023-08-13 |
human |
| Seo-Hee Kang, Yon-Suk Kim, Eun-Kyung Kim, Jin-Woo Hwang, Jae-Hyun Jeong, Xin Dong, Jae-Woong Lee, Sang-Ho Moon, Byong-Tae Jeon, Pyo-Jam Par. Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells. Journal of microbiology and biotechnology. vol 26. issue 1. 2016-10-18. PMID:26437948. |
in this study, we discovered that thymol exerts anticancer effects by suppressing cell growth, inducing apoptosis, producing intracellular reactive oxygen species, depolarizing mitochondrial membrane potential, and activating the proapoptotic mitochondrial proteins bax, cysteine aspartases (caspases), and poly adp ribose polymerase in human gastric ags cells. |
2016-10-18 |
2023-08-13 |
human |
| Andréia Ferreira Eduardo da Costa, João Alfredo Moraes, Jessica Silva Santos de Oliveira, Michelle Hanthequeste Bittencourt Dos Santos, Gabriela da Silva Santos, Christina Barja-Fidalgo, Ana Luiza Mattos-Guaraldi, Prescilla Emy Naga. Reactive oxygen species involved in apoptosis induction of human respiratory epithelial (A549) cells by Streptococcus agalactiae. Microbiology (Reading, England). vol 162. issue 1. 2016-10-18. PMID:26490153. |
the apoptosis of a549 cells by gbs was dependent on the activation of caspase-3 and caspase-9 with increased pro-apoptotic bim and bax molecules and decreased bcl-2 pro-survival protein. |
2016-10-18 |
2023-08-13 |
human |
| Chang-Chi Lai, Po-Hsung Huang, An-Han Yang, Shu-Chiung Chiang, Chia-Yu Tang, Kuo-Wei Tseng, Cheng-Hsiung Huan. Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion. Planta medica. vol 82. issue 3. 2016-10-18. PMID:26550790. |
the underlying mechanisms might be related to the inhibition of apoptosis, possibly through the reduction of tumor necrosis factor-α production, the modulation of bcl-2 and bax, and the activation of akt and extracellular signal-regulated kinases 1 and 2. |
2016-10-18 |
2023-08-13 |
rat |
| Feng Zhang, Li Chen, Huanhuan Jin, Jiangjuan Shao, Li Wu, Yin Lu, Shizhong Zhen. Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity. Environmental toxicology and pharmacology. vol 41. 2016-10-18. PMID:26645133. |
furthermore, ssd treatment induced massive hepatocyte apoptosis, and significantly downregulated bcl-2 but upregulated bax in mouse liver. |
2016-10-18 |
2023-08-13 |
mouse |
| Laura San-Segundo, Laura Guimarães, Carlos Fernández Torija, Eulalia M Beltrán, Lúcia Guilhermino, María Victoria Pablo. Alterations in gene expression levels provide early indicators of chemical stress during Xenopus laevis embryo development: A case study with perfluorooctane sulfonate (PFOS). Ecotoxicology and environmental safety. vol 127. 2016-10-18. PMID:26802562. |
at 24 and 96h post-exposure (hpe), the mrna expression levels of the genetic markers involved in general stress responses (hsp70, hsp47, crh-a and ucn1), oxidative stress (cat.2 and sod), lipid metabolism (ppard) and apoptosis (tp53 and bax) were analyzed by rt-qpcr. |
2016-10-18 |
2023-08-13 |
xenopus_laevis |
| Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Che. Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances. Oncology reports. vol 35. issue 2. 2016-10-17. PMID:26717974. |
the results of cck-8, flow cytometry and western blot assays indicated that uvangoletin showed the cytotoxic effect on hl-60 cells and induced the apoptosis of hl-60 cells by downregulating the expression levels of anti-apoptotic proteins (survivin, bcl-xl and bcl-2), upregulating the expression levels of pro-apoptotic proteins (smac, bax, bad, c-caspase-3 and c-caspase-9), and promoting the release of cytochrome c from mitochondria to cytoplasm. |
2016-10-17 |
2023-08-13 |
mouse |
| Ping-An Peng, Le Wang, Qian Ma, Yi Xin, Ou Zhang, Hong-Ya Han, Xiao-Li Liu, Qing-Wei Ji, Yu-Jie Zhou, Ying-Xin Zha. Valsartan protects HK-2 cells from contrast media-induced apoptosis by inhibiting endoplasmic reticulum stress. Cell biology international. vol 39. issue 12. 2016-10-13. PMID:26248489. |
an angiotensin ii type 1 receptor (at1r) antagonist can alleviate er stress-induced renal apoptosis in streptozotocin (stz)-induced diabetic mice and can reduce cm-induced renal apoptosis by reducing oxidative stress and reversing the enhancement of bax mrna and the reduction of bcl-2 mrna, but the effect of the at1r blocker on er stress in the pathogenesis of ci-aki is still unknown. |
2016-10-13 |
2023-08-13 |
mouse |
| Wenqian Yu, Guochuang Chen, Pengying Zhang, Kaoshan Che. Purification, partial characterization and antitumor effect of an exopolysaccharide from Rhizopus nigricans. International journal of biological macromolecules. vol 82. 2016-10-13. PMID:26449531. |
eps1-1 caused dissipation of mitochondrial membrane potential, accumulation of reactive oxygen species, up-regulation of bax and p53 mrna expression and down-regulation of bcl-2 mrna expression, which suggested that mitochondrial pathway was involved in the eps1-1-induced apoptosis. |
2016-10-13 |
2023-08-13 |
human |
| Banudevi Sivanantham, Swaminathan Sethuraman, Uma Maheswari Krishna. Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways. ACS combinatorial science. vol 18. issue 1. 2016-10-13. PMID:26505786. |
treatment with 5-fu or dox in combination with curcumin induced apoptosis by inhibiting bcl-2 and increasing bax, caspase-3, and poly-adp ribose polymerase (parp) in nt8e cells. |
2016-10-13 |
2023-08-13 |
Not clear |