| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilaria Penna, Alessandra Molla, Giulia Grazia, Loredana Cleris, Gabriella Nicolini, Federica Perrone, Benedetta Picciani, Michele Del Vecchio, Filippo de Braud, Roberta Mortarini, Andrea Anichin. Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade. Oncotarget. vol 7. issue 4. 2016-11-01. PMID:26678033. |
compared to co-targeting of mutant braf and pi3k/mtor, the association of a mek1/2 and a pi3k/mtor inhibitor was more effective in the activation of bax and of caspase-3 and in the induction of caspase-dependent melanoma apoptosis. |
2016-11-01 |
2023-08-13 |
Not clear |
| Oscar Teijido, Yogesh Tengarai Ganesan, Raul Llanos, Ashley Peton, Jean-Baptiste Urtecho, Adauri Soprani, Aimee Villamayor, Bruno Antonsson, Stéphen Manon, Laurent Dejea. A sandwich ELISA for the conformation-specific quantification of the activated form of human Bax. Analytical biochemistry. vol 497. 2016-11-01. PMID:26748144. |
n-terminal exposure can be detected using specific monoclonal and/or polyclonal antibodies, and the onset of activated bax has extensively been used as an early marker of apoptosis. |
2016-11-01 |
2023-08-13 |
human |
| Naghmeh Aali, Gholamreza Motalle. The effect of nicotine on the expressions of the α7 nicotinic receptor gene and Bax and Bcl-2 proteins in the mammary gland epithelial-7 breast cancer cell line and its relationship to drug resistance. Cellular & molecular biology letters. vol 20. issue 5. 2016-11-01. PMID:26812869. |
the biochemical parameters of apoptosis, including the expressions of bax, bcl-2 and α7 nicotinic receptor proteins were determined via western blotting, and the α7 nicotinic receptor gene expression level was assessed via real-time qpcr using the 2(-ΔΔct) method. |
2016-11-01 |
2023-08-13 |
human |
| Zhiqing Liu, Ye Ding, Na Ye, Christopher Wild, Haiying Chen, Jia Zho. Direct Activation of Bax Protein for Cancer Therapy. Medicinal research reviews. vol 36. issue 2. 2016-10-31. PMID:26395559. |
bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the b-cell lymphoma 2 (bcl-2) family proteins that control apoptosis in normal and cancer cells. |
2016-10-31 |
2023-08-13 |
Not clear |
| S Davoodi, R F Cooke, A C C Fernandes, B I Cappellozza, J L M Vasconcelos, R L A Cerr. Expression of estrus modifies the gene expression profile in reproductive tissues on Day 19 of gestation in beef cows. Theriogenology. vol 85. issue 4. 2016-10-31. PMID:26525398. |
genes related to apoptosis, p4 synthesis, and prostaglandin receptor were downregulated (cyp11a, bax, and fpr; p < 0.05) in the cl tissue of cows that expressed estrus. |
2016-10-31 |
2023-08-13 |
Not clear |
| Man Luo, Lian Li, Cheng Xiao, Yu Sun, Gen-Lin Wan. Heat stress impairs mice granulosa cell function by diminishing steroids production and inducing apoptosis. Molecular and cellular biochemistry. vol 412. issue 1-2. 2016-10-31. PMID:26602771. |
we analyzed gcs apoptosis and evaluated the expression of apoptosis-related genes (caspase-3, bax, bcl-2) after heat treatment. |
2016-10-31 |
2023-08-13 |
mouse |
| Man Luo, Lian Li, Cheng Xiao, Yu Sun, Gen-Lin Wan. Heat stress impairs mice granulosa cell function by diminishing steroids production and inducing apoptosis. Molecular and cellular biochemistry. vol 412. issue 1-2. 2016-10-31. PMID:26602771. |
besides, our results indicated that heat treatment-induced apoptosis of gcs through the mitochondrial pathway, which involved caspase-3 and bax. |
2016-10-31 |
2023-08-13 |
mouse |
| Ajeet K Srivastav, Syed Faiz Mujtaba, Ashish Dwivedi, Saroj K Amar, Shruti Goyal, Ankit Verma, Hari N Kushwaha, Rajnish K Chaturvedi, Ratan Singh Ra. Photosensitized rose Bengal-induced phototoxicity on human melanoma cell line under natural sunlight exposure. Journal of photochemistry and photobiology. B, Biology. vol 156. 2016-10-31. PMID:26866294. |
we propose a p53-mediated apoptosis via increased expression of bax gene and protein. |
2016-10-31 |
2023-08-13 |
human |
| Qingliang Shao, Wei Jiang, Yan Ji. MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823764. |
western blot was applied to detect apoptosis related protein caspase-3, bcl-2 and bax expression. |
2016-10-28 |
2023-08-13 |
mouse |
| Qingliang Shao, Wei Jiang, Yan Ji. MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823764. |
further western blot results revealed that apoptosis inhibition might be related to down-regulating activated caspase-3 and bax levels, and up-regulating tumor-suppressor gene bcl-2 expression. |
2016-10-28 |
2023-08-13 |
mouse |
| Xiao-Hang Che, Chun-Lin Chen, Xiao-Lei Ye, Guo-Bin Weng, Xian-Zhi Guo, Wen-Ying Yu, Jin Tao, Yi-Chen Chen, Xiaodong Che. Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. Oncology reports. vol 35. issue 3. 2016-10-27. PMID:26707712. |
furthermore, the activation of caspase-3 and -9, upregulation of bax and downregulation of bcl-2 demonstrated the occurrence of apoptosis by darbufelone. |
2016-10-27 |
2023-08-13 |
Not clear |
| Yinli Yang, Cuiping Li, Yun Fu, Youxun Liu, Yu Zhang, Yanfang Zhang, Pingxin Zhou, Yanbin Yuan, Sufeng Zhou, Shaoshan Li, Changzheng L. Redox cycling of a copper complex with benzaldehyde nitrogen mustard-2-pyridine carboxylic acid hydrazone contributes to its enhanced antitumor activity, but no change in the mechanism of action occurs after chelation. Oncology reports. vol 35. issue 3. 2016-10-27. PMID:26718494. |
the results showed that both bnmph and its copper complex induced reactive oxygen species (ros) generation, and caused upregulation of caspase 8 and bax as well as the downregulation of bcl-2, indicating that apoptosis was involved in the cytotoxic effects. |
2016-10-27 |
2023-08-13 |
Not clear |
| Feng Gao, Suxia Pan, Bing Liu, Huanzhi Zhan. TFF3 knockout in human pituitary adenoma cell HP75 facilitates cell apoptosis via mitochondrial pathway. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-26. PMID:26823779. |
apoptosis related protein bcl-2 and caspase-3 levels were remarkably depressed after sirna transfection, while bax and cleaved caspase-3 levels were elevated. |
2016-10-26 |
2023-08-13 |
human |
| Meng-Ya Sun, Kai-Jie Cui, Mao-Min Yu, Hui Zhang, Xiang-Li Peng, Hong Jian. Bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic-ischemic brain damage. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-26. PMID:26823794. |
bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic-ischemic brain damage. |
2016-10-26 |
2023-08-13 |
rat |
| Haijun Li, Xiujuan Li, Meiling Bai, Yueer Suo, Guohui Zhang, Xueyuan Ca. Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-26. PMID:26823806. |
matrine inhibited proliferation and increased apoptosis in human breast cancer mcf-7 cells via upregulation of bax and downregulation of bcl-2. |
2016-10-26 |
2023-08-13 |
human |
| Y Wang, L-L Jiang, J-F Wu, Z Li. Protective effect of Honokiol against endometriosis in Rats via attenuating Survivin and Bcl-2: A mechanistic study. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 1. 2016-10-26. PMID:26828978. |
moreover, it also inhibits the mrna levels of survivin gene and bcl-2 (b-cell lymphoma 2) in qpcr and western blot analysis together with increases the mrna level of apoptosis promoting factor bax. |
2016-10-26 |
2023-08-13 |
rat |
| Voja Pavlovic, Snezana Cekic, Milan Ciric, Dane Krtinic, Jelena Jovanovi. Curcumin attenuates Mancozeb-induced toxicity in rat thymocytes through mitochondrial survival pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 88. 2016-10-25. PMID:26763609. |
rat thymocytes were treated with man(0.01 μg/ml) and/or increasing cur(0.3, 1, 3 μm) concentrations and levels of cell viability, apoptosis, mitochondrial membrane potential (mmp),bcl-2, bax protein expression, caspase-3 and -9 activity and p38 mapk signaling involvement were examined. |
2016-10-25 |
2023-08-13 |
rat |
| Voja Pavlovic, Snezana Cekic, Milan Ciric, Dane Krtinic, Jelena Jovanovi. Curcumin attenuates Mancozeb-induced toxicity in rat thymocytes through mitochondrial survival pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 88. 2016-10-25. PMID:26763609. |
application of increasing cur (1, 3 μm) concentrations resulted with significantly reduced cytotoxicity, apoptosis, caspase-3, -9 activity, bax protein expression, together with increased mmp and bcl-2 protein expression in rat thymocytes. |
2016-10-25 |
2023-08-13 |
rat |
| Miao Li, Miao Song, Li-Min Ren, Chun-Yu Xiu, Jian-Yu Liu, Yan-zhu Zhu, Yan-Fei L. AlCl3 induces lymphocyte apoptosis in rats through the mitochondria-caspase dependent pathway. Environmental toxicology. vol 31. issue 4. 2016-10-24. PMID:25263842. |
mitochondrial transmembrane potential (ΔΨm), cytochrome c (cyt c) protein expression in cytoplasm, caspase-3 and caspase-9 activity, bcl-2, bax, caspase-3 and caspase-9 mrna expressions, dna ladder and lymphocytes apoptosis index were detected. |
2016-10-24 |
2023-08-13 |
rat |
| Miao Li, Miao Song, Li-Min Ren, Chun-Yu Xiu, Jian-Yu Liu, Yan-zhu Zhu, Yan-Fei L. AlCl3 induces lymphocyte apoptosis in rats through the mitochondria-caspase dependent pathway. Environmental toxicology. vol 31. issue 4. 2016-10-24. PMID:25263842. |
the results showed that cyt c protein expression in cytoplasm, caspase-3 and caspase-9 activity, bcl-2, bax, caspase-3 and caspase-9 mrna expressions, the ratio of bcl-2 and bax mrna expression, lymphocytes apoptosis index increased, while ΔΨm decreased in the alcl3-treated groups compared with those in cg. |
2016-10-24 |
2023-08-13 |
rat |