| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumit Kumar, Ashu Bhan Tik. Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits. Journal of agricultural and food chemistry. vol 64. issue 8. 2016-10-13. PMID:26881453. |
although naringenin induces apoptosis in cancer cells we found that it can protect against radiation-induced apoptosis in normal cells by modulating the expression of p53, bax, and bcl-2. |
2016-10-13 |
2023-08-13 |
mouse |
| Tsu-Tuan Wu, Chien-Lin Lu, Hen-I Lin, Bing-Fang Chen, Guey-Mei Jo. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion. Oncology reports. vol 35. issue 1. 2016-10-12. PMID:26530631. |
the death of human a549 lung cancer cells was caused by apoptosis induced by activation of ros activity, increase in the sub-g1 proportion, downregulation of bcl-2 expression, upregulation of bax expression and inhibition of the mapk signaling pathways. |
2016-10-12 |
2023-08-13 |
human |
| Jie Wu, Yanbo Zhu, Chun Xu, Hong Xu, Xiumin Zhou, Jicheng Yang, Yufeng Xie, Min Ta. Adenovirus-mediated p53 and ING4 gene co-transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer. Oncology reports. vol 35. issue 1. 2016-10-12. PMID:26530780. |
we demonstrated that adving4/p53-mediated p53 and ing4 co-expression induced synergistic growth inhibition and apoptosis as well as enhanced effects on upregulation of acetylated p53, p21, bax, puma, noxa, cleaved caspase-9, cleaved caspase-3 and cleaved parp, and downregulation of bcl-2, cd31 and microvessel density (mvd) in mda-mb-231 breast cancer in vitro and/or in vivo subcutaneous (s.c.) xenografted tumors. |
2016-10-12 |
2023-08-13 |
human |
| Zhengwu Sun, Xiaoyan Lan, Anil Ahsan, Yalin Xi, Shumin Liu, Zonghui Zhang, Peng Chu, Yushu Song, Fengyuan Piao, Jinyong Peng, Yuan Lin, Guozhu Han, Zeyao Tan. Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation. Apoptosis : an international journal on programmed cell death. vol 21. issue 3. 2016-10-12. PMID:26708229. |
pcr protected huvecs against lps-induced apoptosis by suppressing the mitochondrial permeability transition, cytosolic release of cytochrome c (cyt c), ca(2+), reactive oxygen species and subsequent activation of caspases, and increasing bcl2 expression, while suppressing bax expression. |
2016-10-12 |
2023-08-13 |
human |
| P F Zhao, M J Su. Aquaporin in the proliferation and apoptosis of diabetic myocardial cells. Genetics and molecular research : GMR. vol 14. issue 4. 2016-10-12. PMID:26782377. |
aquaporin was found to inhibit the proliferation of diabetic myocardial cells in a concentration-dependent manner; the increase in aquaporin concentration led to an increase in bax (apoptosis protein) expression, decrease in bcl-2 expression (anti-apoptosis protein), increase in the bax/bcl-2 ratio, and a decrease in caspase-3 and survivin expression (p < 0.05). |
2016-10-12 |
2023-08-13 |
human |
| Xiaochao Huang, Rizheng Huang, Zhixin Liao, Yingming Pan, Shaohua Gou, Hengshan Wan. Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. European journal of medicinal chemistry. vol 108. 2016-10-11. PMID:26706349. |
elevated level of ros generation, activation of caspase-3, caspase-8, caspase-9, and fas, higher expression of bax, lower expression of bcl-2, and increased level of bax/bcl-2 ratio identified 6e as a promising inducer of apoptosis that follows both of the mitochondria dependent pathway and the death receptor-mediated pathway. |
2016-10-11 |
2023-08-13 |
Not clear |
| Yunpeng Fan, Yuede Jiang, Jianjun Liu, Yongxiang Kang, Ruiqiao Li, Jingyu Wan. The anti-tumor activity and mechanism of alkaloids from Aconitum szechenyianum Gay. Bioorganic & medicinal chemistry letters. vol 26. issue 2. 2016-10-11. PMID:26711147. |
in addition, asa could led to a loss in the mitochondrial out membrane potential, up-regulate p53, phosphorylated p53 and bax, down-regulate bcl-2, release cytochrome c from the mitochondria to the cytoplasm, and activate caspase-9 and caspase-3 in a549 cells, which revealed that asa could also induce apoptosis through the mitochondria mediated pathway. |
2016-10-11 |
2023-08-13 |
human |
| Ying Zhang, Ruoyu Zhang, Song Qiao, Jing Fa. Effect of FK506 on apoptosis of facial motor neurons in rats and its possible mechanism. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 273. issue 3. 2016-10-10. PMID:25784181. |
fk506 could inhibit apoptosis of facial motor neurons after facial nerve transection, possibly via up-regulation of bcl-2 expression and down-regulation of bax expression. |
2016-10-10 |
2023-08-13 |
rat |
| Fang Ye, Xiaoyi Li, Lili Li, Jing Yuan, Jun Che. t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway. Oxidative medicine and cellular longevity. vol 2016. 2016-10-10. PMID:26798413. |
furthermore, neuronal apoptosis was detected by nissl staining, and bax expression was inhibited in the t-bhq-treated group. |
2016-10-10 |
2023-08-13 |
rat |
| Jialin Duan, Ying Yin, Jia Cui, Jiajia Yan, Yanrong Zhu, Yue Guan, Guo Wei, Yan Weng, Xiaoxiao Wu, Chao Guo, Yanhua Wang, Miaomiao Xi, Aidong We. Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25636683. |
apoptosis was analyzed by caspase-3, bax, and bcl-2 expression. |
2016-10-07 |
2023-08-13 |
mouse |
| Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowsk. Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer. Oncology reports. vol 35. issue 1. 2016-10-06. PMID:26530886. |
the material was tested against changes in expression level of genes encoding factors involved in apoptosis: bcl2, bax and birc5. |
2016-10-06 |
2023-08-13 |
human |
| Sivagami Gunasekaran, Karthikkumar Venkatachalam, Nalini Namasivaya. p-Methoxycinnamic acid, an active phenylpropanoid induces mitochondrial mediated apoptosis in HCT-116 human colon adenocarcinoma cell line. Environmental toxicology and pharmacology. vol 40. issue 3. 2016-10-05. PMID:26546748. |
the induction of apoptosis by p-mca was accompanied by an increase in caspase 3 and caspase 9 activities, increased expression of bax and decreased expression of bcl-2. |
2016-10-05 |
2023-08-13 |
human |
| Luiz Gustavo A Chuffa, Michelly S Alves, Marcelo Martinez, Isabel Cristina C Camargo, Patricia F F Pinheiro, Raquel F Domeniconi, Luiz Antonio L Júnior, Francisco Eduardo Martine. Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma. Endocrine-related cancer. vol 23. issue 2. 2016-10-05. PMID:26555801. |
to accomplish oc-related apoptosis, we first observed that p53, bax, caspase-3, and cleaved caspase-3 were downregulated in oc tissue while bcl-2 and survivin were overexpressed. |
2016-10-05 |
2023-08-13 |
rat |
| Luiz Gustavo A Chuffa, Michelly S Alves, Marcelo Martinez, Isabel Cristina C Camargo, Patricia F F Pinheiro, Raquel F Domeniconi, Luiz Antonio L Júnior, Francisco Eduardo Martine. Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma. Endocrine-related cancer. vol 23. issue 2. 2016-10-05. PMID:26555801. |
notably, mel therapy and etoh intake promoted apoptosis along with the upregulation of p53, bax, and cleaved caspase-3. |
2016-10-05 |
2023-08-13 |
rat |
| Ruchi Saxena, Garima Gupta, Murli Manohar, Utsab Debnath, Pooja Popli, Yenamandra S Prabhakar, Rituraj Konwar, Sandeep Kumar, Atul Kumar, Anila Dwived. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. The international journal of biochemistry & cell biology. vol 70. 2016-10-05. PMID:26556313. |
the activation of p53 led to upregulation of p53 dependent pro-apoptotic proteins, bax, pumaα and noxa and enhanced interaction of p53 with bcl2 member proteins thus triggering both transcription-dependent and transcription-independent apoptosis, respectively. |
2016-10-05 |
2023-08-13 |
Not clear |
| Jing Wu, Aimei Li, Yujun Li, Xiaoguang Li, Qingmeng Zhang, Wuqi Song, Yao Wang, James O Ogutu, Jindong Wang, Jianbo Li, Renkuan Tang, Fengmin Zhan. Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor. The international journal of biochemistry & cell biology. vol 70. 2016-10-05. PMID:26592196. |
furthermore, in another independent rat model of apoptosis, compared with the group administrated with alcohol only, the brains of the cpz-pretreated rats showed lower expression of cleaved caspase-3, cytochrome c and bax, but higher expression of bcl-2 and tf. |
2016-10-05 |
2023-08-13 |
rat |
| Tatjana Srdic-Rajic, Katarina Nikolic, Milena Cavic, Ivana Djokic, Branislava Gemovic, Vladimir Perovic, Nevena Veljkovi. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 81. 2016-10-05. PMID:26598394. |
we demonstrated that the antihypertensive drug rilmenidine, a selective imidazoline i1 receptor agonist, modulates proliferation and stimulates the proapoptotic protein bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic k562 cells. |
2016-10-05 |
2023-08-13 |
human |
| Mei-Hua Bao, Jian-Ming Li, Qi-Liang Zhou, Guang-Yi Li, Jie Zeng, Juan Zhao, Yi-Wen Zhan. Effects of miR‑590 on oxLDL‑induced endothelial cell apoptosis: Roles of p53 and NF‑κB. Molecular medicine reports. vol 13. issue 1. 2016-10-05. PMID:26648441. |
the overexpression of mir‑590 inhibited oxldl‑induced endothelial cell apoptosis, expression of p53 and bax, reduction of bcl‑2 and activation of caspase‑3. |
2016-10-05 |
2023-08-13 |
Not clear |
| Hun Seok Lee, Juthika Kundu, Ryong Nam Kim, Young Kee Shi. Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective. International journal of molecular sciences. vol 16. issue 12. 2016-10-05. PMID:26694352. |
tob1 antagonizes the v-akt murine thymoma viral oncogene (akt) signaling and induces cancer cell apoptosis by activating bcl2-associated x (bax) protein and inhibiting the bcl-2 and bcl-xl expressions. |
2016-10-05 |
2023-08-13 |
mouse |
| Ya-Hui Ding, Xue Gao, Jing Long, Bei-Jia Kuang, Yue Chen, Quan Zhan. Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. Bioorganic & medicinal chemistry letters. vol 26. issue 4. 2016-10-05. PMID:26832219. |
further study suggested that ddl induced apoptosis mainly through the up-regulation of apoptosis related protein bax, followed by the cleavage of caspase-3, caspase-9, and parp. |
2016-10-05 |
2023-08-13 |
mouse |