| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Machado Ferreira, Marcos Roberto Chiaratti, Carolina Habermann Macabelli, Carlos Alberto Rodrigues, Márcio Leão Ferraz, Yeda Fumie Watanabe, Lawrence Charles Smith, Flávio Vieira Meirelles, Pietro Sampaio Barusell. The Infertility of Repeat-Breeder Cows During Summer Is Associated with Decreased Mitochondrial DNA and Increased Expression of Mitochondrial and Apoptotic Genes in Oocytes. Biology of reproduction. vol 94. issue 3. 2016-12-13. PMID:26843447. |
therefore, oocytes collected from heifers, non-rbs in peak lactation (pls), and rbs were used to evaluate mtdna amounts as well as the expression levels of genes associated with the mitochondria (mt-co1, nrf1, polg, polg2, ppargc1a, and tfam), apoptosis (bax, bcl2, and itm2b), and oocyte maturation (bmp15, fgf8, fgf10, fgf16, fgf17, and gdf9). |
2016-12-13 |
2023-08-13 |
Not clear |
| Yun Liu, Min Gao, Ming-Ming Ma, Yong-Bo Tang, Jia-Guo Zhou, Guan-Lei Wang, Yan-Hua Du, Yong-Yuan Gua. Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells. Journal of molecular and cellular cardiology. vol 92. 2016-12-13. PMID:26854628. |
endophilin a2 protects h2o2-induced apoptosis by blockade of bax translocation in rat basilar artery smooth muscle cells. |
2016-12-13 |
2023-08-13 |
rat |
| Hailong Yu, Peipei Liu, Hui Tang, Jian Jing, Xiang Lv, Lanlan Chen, Li Jiang, Jun Xu, Jun L. Oleuropein, a natural extract from plants, offers neuroprotection in focal cerebral ischemia/reperfusion injury in mice. European journal of pharmacology. vol 775. 2016-12-13. PMID:26872990. |
finally, we explored the role of ole in providing anti-apoptotic effects through the increased expression of bcl-2 and the decreased expression of bax, which are important markers in apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Guoqian He, Wenming Xu, Linyan Tong, Shuaishuai Li, Shiceng Su, Xiaodan Tan, Changqing L. Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26882903. |
neuron apoptosis was monitored by expression of bcl-2, bax, cleaved caspase3, p53 and tunel assay. |
2016-12-13 |
2023-08-13 |
rat |
| Weihua Yu, Xiaodi Zhang, Jiangzheng Liu, Xin Wang, Shuang Li, Rui Liu, Nai Liao, Tao Zhang, Chunxu Ha. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884717. |
moreover, gox induced typical apoptosis characteristics including, mitochondrial dysfunction, accumulation of bax and release of cytochrome c in mitochondria, accompanied with activation of caspase-9 and caspase-3. |
2016-12-13 |
2023-08-13 |
mouse |
| Siao-Ru Jhong, Ching-Yu Li, Tai-Ching Sung, Yu-Jing Lan, Kuo-Jung Chang, Yun-Wei Chian. Evidence for an Induced-Fit Process Underlying the Activation of Apoptotic BAX by an Intrinsically Disordered BimBH3 Peptide. The journal of physical chemistry. B. vol 120. issue 10. 2016-12-13. PMID:26913490. |
apoptotic bax protein functions as a critical gateway to mitochondria-mediated apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Zih-Ying Li, Wen-Chung Huang, Rong-Syuan Tu, Pei-Yu Gu, Chwan-Fwu Lin, Chian-Jiun Lio. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation. The American journal of Chinese medicine. vol 44. issue 1. 2016-12-13. PMID:26916921. |
sg also upregulated bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway. |
2016-12-13 |
2023-08-13 |
human |
| Ahmet Kağan Özkaya, Embiya Dilber, Seren Gülşen Gürgen, Ömer Kutlu, Ali Cansu, Yusuf Gedi. Effects of chronic amiodarone treatment on rat testis. Acta histochemica. vol 118. issue 3. 2016-12-13. PMID:26947592. |
immunohistochemical staining showed evidence of apoptosis, including caspase-3, caspase-9, bax and increased dna fragmentation was detected via a terminal deoxynucleotidyl transferase dutp nick-end labeling assay. |
2016-12-13 |
2023-08-13 |
rat |
| Jianyu Feng, Yang Yang, Yajun Zhou, Bodong Wang, Hongyan Xiong, Chongxi Fan, Shuai Jiang, Jun Liu, Zhiqiang Ma, Wei Hu, Tian Li, Xiao Feng, Jianjun Xu, Zhenxiao Ji. Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1. Apoptosis : an international journal on programmed cell death. vol 21. issue 5. 2016-12-13. PMID:27000151. |
bak exerted cardioprotective effects, as evidenced by the improvements noted in cardiac function following ischemia, attenuated myocardial apoptosis, and changes in several biochemical parameters (including increases in the level of the anti-apoptotic protein bcl2, decreases in the level of the pro-apoptotic protein bax, and decreases in the cleaved caspase 3 level). |
2016-12-13 |
2023-08-13 |
rat |
| Rui-Jun Ju, Fan Zeng, Lei Liu, Li-Min Mu, Hong-Jun Xie, Yao Zhao, Yan Yan, Jia-Shuan Wu, Ying-Jie Hu, Wan-Liang L. Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma. International journal of nanomedicine. vol 11. 2016-12-13. PMID:27042063. |
the induction of apoptosis was related to the activation of caspase-8- and -3-signaling pathways, the activation of the proapoptotic protein bax, and the suppression of the antiapoptotic protein mcl-1. |
2016-12-13 |
2023-08-13 |
mouse |
| Di Hu, Hui Zou, Tao Han, Junze Xie, Nannan Dai, Liling Zhuo, Jianhong Gu, Jianchun Bian, Yan Yuan, Xuezhong Liu, Zongping Li. Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells. Journal of veterinary science. vol 17. issue 1. 2016-12-13. PMID:27051341. |
gap junction blockage pretreatment with 18β-glycyrrhizic acid (ga) promoted cd-induced apoptosis, involving changes in expression of bax, bcl-2, caspase-3 and the mitochondrial transmembrane electrical potential (Δψm). |
2016-12-13 |
2023-08-13 |
rat |
| Noha F Abdelkader, Marwa M Safar, Hesham A Sale. Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson's Disease: Modulation of Mitochondrial Perturbations. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25502462. |
furthermore, udca amended alterations in bax and bcl-2 and reduced the activities of caspase-8, caspase-9, and caspase-3, indicating that it suppressed rotenone-induced apoptosis via modulating both intrinsic and extrinsic pathways. |
2016-11-14 |
2023-08-13 |
human |
| Min Wang, Yu-Jiao Li, Yi Ding, Hui-Nan Zhang, Ting Sun, Kun Zhang, Le Yang, Yan-Yan Guo, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25561437. |
slb reversed the decreased level of procaspase-3 and balanced bcl-2 and bax expression upon h2o2 insult to inhibit cell apoptosis. |
2016-11-14 |
2023-08-13 |
mouse |
| Qin Chen, Lianyun Chen, Xiafei Wu, Feng Zhang, Huanhuan Jin, Chunfeng Lu, Jiangjuan Shao, Desong Kong, Li Wu, Shizhong Zhen. Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K/Akt pathway. IUBMB life. vol 68. issue 3. 2016-11-14. PMID:26865509. |
dha also induced apoptosis of hscs in such liver, as demonstrated by reduced distribution of α-sma-positive cells and the presence of high number of cleaved-caspase-3-positive cells in vivo, as well as by down-regulation of bcl-2 and up-regulation of bax. |
2016-11-14 |
2023-08-13 |
rat |
| Juan Sun, Li-Qun Mao, Kenneth S Polonsky, De-Cheng Re. Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak. The Journal of biological chemistry. vol 291. issue 26. 2016-11-10. PMID:27137932. |
these results suggest that bax mediates β-cell apoptosis in pdx1-deficient diabetes. |
2016-11-10 |
2023-08-13 |
mouse |
| Mona Samy Guida, Ali Abd El-Aal, Yehya Kafafy, Safwat Farid Salama, Badr Mohamed Badr, Gamal Bad. Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 38. issue 2. 2016-11-08. PMID:26872132. |
thymoquinone rescues t lymphocytes from gamma irradiation-induced apoptosis and exhaustion by modulating pro-inflammatory cytokine levels and pd-1, bax, and bcl-2 signaling. |
2016-11-08 |
2023-08-13 |
rat |
| Deepti Chopra, Lipika Ray, Ashish Dwivedi, Shashi Kant Tiwari, Jyoti Singh, Krishna P Singh, Hari Narayan Kushwaha, Sadaf Jahan, Ankita Pandey, Shailendra K Gupta, Rajnish Kumar Chaturvedi, Aditya Bhushan Pant, Ratan Singh Ray, Kailash Chand Gupt. Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. Biomaterials. vol 84. 2016-11-07. PMID:26803409. |
molecular docking studies suggested that intact curcumin from nanoparticles, bind with bax in bim sahb site and attenuate it to undergo apoptosis while upregulating anti-apoptotic genes like bcl2. |
2016-11-07 |
2023-08-13 |
mouse |
| Yan Ding, Xuefei Hou, Li Chen, Hua Zhou, Yanju Gong, Liqun Dai, Yu Zhen. Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats. Journal of the neurological sciences. vol 361. 2016-11-04. PMID:26810525. |
the morphological changes of neurons in the hypoglossal nucleus (12n), the nucleus ambiguus (amb), the nucleus tractus solitarius (nts), and the pre-bötzinger complex (pre-bötc) were investigated by nissl staining; the malondialdehyde (mda) content and superoxide dismutase (sod) activity were measured to evaluate the anti-oxidant effect; some apoptosis parameters, bax mrna and bcl-2 mrna, were tested; and the double immunochemistry staining of active caspase-3/neun was performed. |
2016-11-04 |
2023-08-13 |
rat |
| M Yue, X J Shen, Y X Liu, X Y Lin, S Q Zhou, Y H Son. Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro. Genetics and molecular research : GMR. vol 14. issue 4. 2016-11-01. PMID:26634500. |
wilfortrine can induce liver cancer cell hepg2 apoptosis, but with no effect on the cell cycle, mainly by promoting bax expression and inhibiting anti-apoptotic protein bcl-2 expression. |
2016-11-01 |
2023-08-13 |
human |
| Ángela Puig, Lisa Rancan, Sergio D Paredes, Adrián Carrasco, Germaine Escames, Elena Vara, Jesús A F Tresguerre. Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. Experimental gerontology. vol 75. 2016-11-01. PMID:26656745. |
this study aimed to investigate the effect of chronic administration of melatonin on the expression of inflammation markers (tnf-α, il-1β, nfκb2, ho-1) and apoptosis parameters (bad, bax, aif) in the lung tissue of male senescence-accelerated prone mice (samp8). |
2016-11-01 |
2023-08-13 |
mouse |