| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Xie, Wen Qin, Yalin Kang, Ziyan Zhou, Aiping Qi. MicroRNA-340 Inhibits Tumor Cell Proliferation and Induces Apoptosis in Endometrial Carcinoma Cell Line RL 95-2. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2016-12-26. PMID:27153225. |
the underlying mechanisms involved in cell proliferation and apoptosis were explored by measuring the protein levels of cell cycle regulators (p27 kinase inhibition protein (kip) 1 and p21) and apoptosis-related factors (b-cell lymphoma-2 (bcl-2), bax, pro-caspase 3, and active-caspase-3). |
2016-12-26 |
2023-08-13 |
human |
| Lili Du, Wen Sun, Huili Zhang, Dunjin Che. BDE-209 inhibits pluripotent genes expression and induces apoptosis in human embryonic stem cells. Journal of applied toxicology : JAT. vol 36. issue 5. 2016-12-23. PMID:26206603. |
the downregulation of birc5/bcl2 and upregulation of bax were related to apoptosis of hescs induced by bde-209 exposure. |
2016-12-23 |
2023-08-13 |
human |
| Yihao Zhu, Shu Li, Xiaohua Ten. The involvement of the mitochondrial pathway in manganese-induced apoptosis of chicken splenic lymphocytes. Chemosphere. vol 153. 2016-12-23. PMID:27035383. |
our research indicated that excess mn induced ros and mda content, inhibited mn-sod and gsh-px activities, induced bax and p53 mrna expression, inhibited bcl-2 and cam mrna expression, induced caspase-3 mrna and protein expression, upregulated [ca(2+)]i, inhibited ΔΨm, and induced apoptosis in a dose effect. |
2016-12-23 |
2023-08-13 |
chicken |
| H Kauser, S Sahu, U Panjwan. Guanfacine promotes neuronal survival in medial prefrontal cortex under hypobaric hypoxia. Brain research. vol 1636. 2016-12-21. PMID:26854138. |
further, change in bax to bcl2 ratio was in correlation with caspase3 expression in layer ii of the medial pfc, indicating that caspase3 is responsible for bcl2 cleavage and hence modulation of apoptosis. |
2016-12-21 |
2023-08-13 |
rat |
| Pratiksha H Roham, Kiran R Kharat, Priyanka Mungde, Mahadev A Jadhav, Surinder J Makhij. Induction of Mitochondria Mediated Apoptosis in Human Breast Cancer Cells (T-47D) by Annona reticulata L. Leaves Methanolic Extracts. Nutrition and cancer. vol 68. issue 2. 2016-12-21. PMID:26908199. |
the downregulation of bcl-2 and upregulation of bax and bak, and caspases activation suggested induction of apoptosis in t-47d cells by arme through mitochondrial pathway. |
2016-12-21 |
2023-08-13 |
human |
| D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie, H Wan. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell death & disease. vol 7. 2016-12-21. PMID:27031958. |
elevated p53 expression raised up puma expression, which initiated mitochondrial apoptosis by downregulating antiapoptotic bcl-2, followed by upregulation of proapoptotic bax, resulting in translocation of cytochrome c (cyto c), an apoptogenic factor, from the mitochondria to cytoplasm and activation of caspase-dependent pathways. |
2016-12-21 |
2023-08-13 |
human |
| D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie, H Wan. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell death & disease. vol 7. 2016-12-21. PMID:27031958. |
as a result, the ratio of dissociative bcl-2 to bax was also significantly decreased, which led to translocation of cyto c and initiated more drastic apoptosis. |
2016-12-21 |
2023-08-13 |
human |
| Yan Wang, Yanmei Chen, Yi Yan, Xinzhong Li, Guojun Chen, Nvqin He, Shuxin Shen, Gangbin Chen, Chuanxi Zhang, Wangjun Liao, Yulin Liao, Jianping Bi. Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis. Scientific reports. vol 6. 2016-12-20. PMID:26911181. |
in cultured nrcs exposed to hypoxia, recombinant human ceacam1 (rhceacam1) reduced mitochondrial membrane potential, upregulated mitochondrial bax, increased cytosolic cytochrome c and cleaved caspase-3, and consequently increased apoptosis. |
2016-12-20 |
2023-08-13 |
mouse |
| Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Masahiko Sato. Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. Scientific reports. vol 6. 2016-12-20. PMID:26912277. |
double knockdown of ube2d2 and ube2d4 caused an increase in p53 protein levels, and knockdown of p53 attenuated not only cd-induced apoptosis, but also cd-induced apoptosis-related gene expression (bax and puma). |
2016-12-20 |
2023-08-13 |
mouse |
| Wei Wang, Xiao Li, Xiang-Zhen Han, Fan-Bin Meng, Zhen-Xing Wang, Yong-Qing Zhai, Dong-Sheng Zho. Transglutaminase-2 is Involved in Cell Apoptosis of Osteosarcoma Cell Line U2OS Under Hypoxia Condition. Cell biochemistry and biophysics. vol 72. issue 1. 2016-12-19. PMID:25561282. |
we further investigated the mechanism of cell apoptosis and found bax protein is significantly increased after depletion of tg2 under hypoxia. |
2016-12-19 |
2023-08-13 |
Not clear |
| Wei Wang, Xiao Li, Xiang-Zhen Han, Fan-Bin Meng, Zhen-Xing Wang, Yong-Qing Zhai, Dong-Sheng Zho. Transglutaminase-2 is Involved in Cell Apoptosis of Osteosarcoma Cell Line U2OS Under Hypoxia Condition. Cell biochemistry and biophysics. vol 72. issue 1. 2016-12-19. PMID:25561282. |
our results suggest that tg2 can inhibit tumor cell apoptosis through down-regulation of bax and prevention of release cyt c from mitochondria into cytoplasm. |
2016-12-19 |
2023-08-13 |
Not clear |
| Shouyu Guo, Mingzhi Long, Xiuzhen Li, Shushu Zhu, Min Zhang, Zhijian Yan. Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway. Molecular medicine reports. vol 13. issue 3. 2016-12-19. PMID:26781771. |
oxidative stress resulted in a significant increase in the rate of cell apoptosis, which was accompanied by an increase in the expression levels of caspase‑3 and b‑cell lymphoma 2 (bcl‑2)‑associated x protein (bax), and a decrease in the expression levels of bcl‑2. |
2016-12-19 |
2023-08-13 |
Not clear |
| Shouyu Guo, Mingzhi Long, Xiuzhen Li, Shushu Zhu, Min Zhang, Zhijian Yan. Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway. Molecular medicine reports. vol 13. issue 3. 2016-12-19. PMID:26781771. |
treatment with curcumin (5 or 20 µmol/l) significantly inhibited apoptosis, and reversed the alterations in caspase‑3, bcl‑2 and bax expression. |
2016-12-19 |
2023-08-13 |
Not clear |
| Min Li, Jing-Jing Li, Qi-Hua Gu, Jian An, Li-Ming Cao, Hua-Ping Yang, Cheng-Ping H. EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation. Oncology reports. vol 35. issue 4. 2016-12-19. PMID:26794417. |
treatment of a549 cells with egcg-induced apoptosis via increased expression of cleaved caspase-3 and bax, but decreased expression of bcl-xl. |
2016-12-19 |
2023-08-13 |
Not clear |
| Min Li, Jing-Jing Li, Qi-Hua Gu, Jian An, Li-Ming Cao, Hua-Ping Yang, Cheng-Ping H. EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation. Oncology reports. vol 35. issue 4. 2016-12-19. PMID:26794417. |
our results established a role of egcg in inducing cell apoptosis by suppressing bax activity. |
2016-12-19 |
2023-08-13 |
Not clear |
| Min Li, Jing-Jing Li, Qi-Hua Gu, Jian An, Li-Ming Cao, Hua-Ping Yang, Cheng-Ping H. EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation. Oncology reports. vol 35. issue 4. 2016-12-19. PMID:26794417. |
regulating ku70 acetylation by egcg, that block the interaction between ku70 and bax, will result in lung cancer cell apoptosis. |
2016-12-19 |
2023-08-13 |
Not clear |
| Sheng-Qi Wang, Bo-Xin Zhao, Yuan Liu, Ya-Tian Wang, Qian-Ying Liang, Yun Cai, Yun-Qi Zhang, Jiang-Hong Yang, Zhi-Hua Song, Guo-Feng L. New application of an old drug: Antitumor activity and mechanisms of doxycycline in small cell lung cancer. International journal of oncology. vol 48. issue 4. 2016-12-16. PMID:26846275. |
rt-pcr and western blot assays proved that apoptosis induction effect of doxycycline was achieved via inducing the expression of caspase-3 and bax, as well as attenuating the expression of survivin and bcl-2. |
2016-12-16 |
2023-08-13 |
Not clear |
| Jianhai Zhang, Yunfei Xia, Zifeng Xu, Xiaoming Den. Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK. Oxidative medicine and cellular longevity. vol 2016. 2016-12-16. PMID:27057270. |
propofol suppressed hypoxia/reoxygenation-induced apoptosis in hbvsmc by regulation of the expression of bcl-2, bax, caspase3, kir6.1, and p-jnk. |
2016-12-16 |
2023-08-13 |
Not clear |
| Jianhai Zhang, Yunfei Xia, Zifeng Xu, Xiaoming Den. Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK. Oxidative medicine and cellular longevity. vol 2016. 2016-12-16. PMID:27057270. |
these findings suggested that the protective effect of propofol against h/r injury in the hbvsmc was through the inhibition of apoptosis by inducing the expression of bcl-2 and p-mtor as well as inhibiting the expression levels of bax, caspase3, kir6.1, and p-jnk. |
2016-12-16 |
2023-08-13 |
Not clear |
| Shinpei Kadowaki, Tetsuro Shishido, Toshiki Sasaki, Takayuki Sugai, Taro Narumi, Yuki Honda, Yoichiro Otaki, Daisuke Kinoshita, Tetsuya Takahashi, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Akihiko Ishigami, Yasuchika Takeishi, Isao Kubot. Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion. International journal of molecular sciences. vol 17. issue 4. 2016-12-16. PMID:27077846. |
in cardiomyocytes, silencing of smp30 expression attenuated akt and gsk-3β phosphorylation, and increased bax to bcl-2 ratio and cardiomyocyte apoptosis induced by hydrogen peroxide. |
2016-12-16 |
2023-08-13 |
mouse |