| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuntao Wu, Jinji Zhang, Tienan Liu, Guimei Jiao, Changzai Li, Baoshan H. [Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via blocking JAK1/STAT3 pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 6. 2017-01-06. PMID:27371847. |
the viability of a549 cells was detected by cck-8 assay; cell cycle and apoptosis were observed by flow cytometry; and the expressions of b-cell lymphoma-2 (bcl-2), bcl-2 associated x protein (bax), signal transducers and activators of transcription 3 (stat3), and janus kinase 1 (jak1) were evaluated by western blotting. |
2017-01-06 |
2023-08-13 |
Not clear |
| Muyuan Ma, Jie Bai, Ye Ling, Weilong Chang, Gengchen Xie, Ruidong Li, Guobin Wang, Kaixiong Ta. Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26847687. |
b‑cell lymphoma 2 (bcl‑2) and bcl‑2‑associated x protein (bax) are key proteins in apoptosis. |
2017-01-03 |
2023-08-13 |
Not clear |
| Muyuan Ma, Jie Bai, Ye Ling, Weilong Chang, Gengchen Xie, Ruidong Li, Guobin Wang, Kaixiong Ta. Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26847687. |
these results indicated that jzl184 may induce tumor cell apoptosis by regulating the expression of bcl‑2 and bax. |
2017-01-03 |
2023-08-13 |
Not clear |
| Tianjiao Xu, Yong Liu, Yating Deng, Jin Meng, Ping Li, Xiaoli Xu, Jurong Zen. [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363274. |
results insulin in combination with selenium significantly inhibited cardiomyocyte apoptosis, increased bcl-2 levels and decreased bax, cyclin d1, cyclin e, p38mapk, p-p38mapk, cbp, ku70 and acetylated ku70 levels. |
2017-01-03 |
2023-08-13 |
rat |
| Meng Lu, Yi Miao, Lan Qi, Mingzhu Bai, Jiarong Zhang, Youji Fen. RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells. Oncology research. vol 23. issue 6. 2017-01-02. PMID:27931282. |
moreover, knockdown of fkbp14 induced cell apoptosis via increasing the ratio of bax to bcl-2. |
2017-01-02 |
2023-08-13 |
human |
| Miao-Miao Ma, Xiao-Li Zhu, Li Wang, Xiao-Fang Hu, Zhong Wang, Jin Zhao, Yi-Tong Ma, Yi-Ning Yang, Bang-Dang Chen, Fen Li. β3-adrenoceptor impacts apoptosis in cultured cardiomyocytes via activation of PI3K/Akt and p38MAPK. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838732. |
furthermore, we investigated the ne-induced expression of the apoptosis marker genes akt and p38mapk, their phosphorylated counterparts p-akt and p-p38mapk, caspase-3, bcl-2, and bax. |
2016-12-30 |
2023-08-13 |
human |
| Qian Lv, Ying Yao, Wei Wang, Wei Xiong, Wen-Hui Lia. Biliverdin protects against cisplatin-induced apoptosis of renal tubular epithelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838739. |
the results showed that cisplatin induced the apoptosis of nrk-52e cells, decreased cell viability, and increased the formation of ros by upregulating the expression of cleaved caspase3 and bax and decreasing bcl-2 protein expression. |
2016-12-30 |
2023-08-13 |
rat |
| Kai-Xuan Sun, Ying Chen, Shuo Chen, Bo-Liang Liu, Miao-Xiao Feng, Zhi-Hong Zong, Yang Zha. The correlation between microRNA490-3p and TGFα in endometrial carcinoma tumorigenesis and progression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26843615. |
mir-490-3p overexpression reduced proliferation; promoted g1 arrest and apoptosis; suppressed migration and invasion; and reduced tgfα, nf-kb, cyclin d1, survivin, matrix metalloproteinase 2 (mmp2) mrna and protein expression, and improved bax mrna and protein expression. |
2016-12-30 |
2023-08-13 |
mouse |
| Hui Chen, Dong-Liang Wang, Yu-Ling Li. Poly (I:C) transfection induces mitochondrial-mediated apoptosis in cervical cancer. Molecular medicine reports. vol 13. issue 3. 2016-12-30. PMID:26848042. |
the results showed that poly (i:c) transfection markedly induced hela apoptosis, increased the protein levels of pro‑apoptotic b cell lymphoma‑2 (bcl‑2)‑associated x protein (bax) and bh3 interacting‑domain death agonist (bid), and suppressed the protein expression levels of anti‑apoptotic bcl‑2 and survivin. |
2016-12-30 |
2023-08-13 |
human |
| Yang Lu, DongMei Hu, ShanBo Ma, Xian Zhao, Shan Wang, Guo Wei, XiFang Wang, AiDong Wen, JingWen Wan. Protective effect of wedelolactone against CCl4-induced acute liver injury in mice. International immunopharmacology. vol 34. 2016-12-30. PMID:26921731. |
moreover, results showed that wel significantly inhibited ccl4-induced hepatocytes apoptosis, markedly suppressed the down-regulation of bax and active caspase-3 expression and accelerated the expression of bcl-2. |
2016-12-30 |
2023-08-13 |
mouse |
| Keyou Li, Wenhua Yang, Zhe Li, Wangwang Jia, Jiazhou Li, Pengfei Zhang, Tiancun Xia. Bitter apricot essential oil induces apoptosis of human HaCaT keratinocytes. International immunopharmacology. vol 34. 2016-12-30. PMID:26971222. |
also, increased bax and decreased bcl-2 levels suggest that baeo-induced apoptosis is mediated through both death receptor and mitochondrial pathways. |
2016-12-30 |
2023-08-13 |
human |
| Shihong Ma, Wenhua Tan, Botao Du, Wei Liu, Weijia Li, Dehong Che, Guangmei Zhan. Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935490. |
downregulated expression levels of bcl‑2 and upregulated the expression of bax protein were demonstrated by western blot analysis, further indicating increased apoptosis. |
2016-12-28 |
2023-08-13 |
human |
| Chengguo Zhao, Fanxin Meng, Lulu Geng, Xi Zhao, Hui Zhou, Yao Zhang, Shuzhi Qi. Cardiac-protective effects and the possible mechanisms of alatamine during acute myocardial ischemia. Canadian journal of physiology and pharmacology. vol 94. issue 4. 2016-12-27. PMID:26863576. |
meanwhile, alatamine decreased bax and increased bcl-2 expressions both in vivo and in vitro, therefore inhibiting cardiac myocyte apoptosis and preventing cardiac dysfunction caused by ami at the cellular level. |
2016-12-27 |
2023-08-13 |
rat |
| Kadry Sadek, Tarek Abouzed, Sherif Nas. Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model. Canadian journal of physiology and pharmacology. vol 94. issue 4. 2016-12-27. PMID:26900785. |
furthermore, msg induced apoptosis in brain tissues reflected in upregulation of pro-apoptotic bax while lycopene upregulated the anti-apoptotic bcl-2. |
2016-12-27 |
2023-08-13 |
rat |
| Ruixuan Wang, Lijie Ma, Dan Weng, Jiahui Yao, Xueying Liu, Faguang Ji. Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:26987028. |
the results showed that both ga and cisplatin changed the morphology, inhibited the growth and induced apoptosis in the h446 cells by inducing generation of ros, disruption of mmp, downregulation of xiap expression, and upregulation of bax, apaf-1, diablo and p53 expression. |
2016-12-27 |
2023-08-13 |
human |
| Pu Chen, Beili Wang, Baishen Pan, Wei Gu. Resveratrol-4‑O-D‑(2'-galloyl)-glucopyranoside exerts an anticancer effect on leukemia cells via inducing apoptosis. Molecular medicine reports. vol 13. issue 3. 2016-12-26. PMID:26781500. |
furthermore, flow cytometric analysis demonstrated that reg can induce the apoptosis of hl‑60 cells, as well as increase the levels of cytochrome c, c‑caspases‑3 and ‑9, and bax, as well as downregulate the expression of bcl‑2. |
2016-12-26 |
2023-08-13 |
mouse |
| Takamitsu Shimizu, Junya Kawai, Kenji Ouchi, Haruhisa Kikuchi, Yoshiteru Osima, Rikiishi Hidem. Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. International journal of oncology. vol 48. issue 4. 2016-12-26. PMID:26893131. |
further mechanistic studies revealed that induction of apoptosis is associated with increased generation of ros, reduced ∆ψm, release of apoptosis-inducing factor (aif) from the mitochondria to the cytosol, upregulation of bax, and downregulation of bcl-2. |
2016-12-26 |
2023-08-13 |
human |
| Sheng-Wei Luo, Wei-Na Wang, Zuo-Ming Sun, Fu-Xing Xie, Jing-Rong Kong, Yuan Liu, Chang-Hong Chen. Molecular cloning, characterization and expression analysis of (B-cell lymphoma-2 associated X protein) Bax in the orange-spotted grouper (Epinephelus coioides) after the Vibrio alginolyticus challenge. Developmental and comparative immunology. vol 60. 2016-12-26. PMID:26905633. |
bax is a pro-apoptotic member of bcl-2 like superfamily, playing an important role in regulating the apoptosis. |
2016-12-26 |
2023-08-13 |
Not clear |
| Feng Jin, Chong Qiao, Nannan Luan, Hui L. Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis. International journal of molecular medicine. vol 37. issue 4. 2016-12-26. PMID:26935516. |
in addition, phlda2 significantly induced apoptosis, as evidenced by annexin v-fitc/propidium iodide (pi) and hoechst staining, along with activation of bax and caspase-3 and also decreased bcl-2 expression. |
2016-12-26 |
2023-08-13 |
human |
| Kapil Suchal, Salma Malik, Nanda Gamad, Rajiv Kumar Malhotra, Sameer N Goyal, Uma Chaudhary, Jagriti Bhatia, Shreesh Ojha, Dharamvir Singh Ary. Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury. Oxidative medicine and cellular longevity. vol 2016. 2016-12-26. PMID:27087891. |
additionally, it also attenuated apoptosis by reducing the expression of proapoptotic proteins (bax and caspase-3), tunel positive cells, and increased level of antiapoptotic proteins (bcl-2). |
2016-12-26 |
2023-08-13 |
rat |