| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manel Boussabbeh, Intidhar Ben Salem, Karima Rjiba-Touati, Chedy Bouyahya, Fadwa Neffati, Mohamed Fadhel Najjar, Hassen Bacha, Salwa Abid-Essef. The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect? Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26619846. |
this effect was evidenced by the activation of apoptosis which is supported by the increase in p53 and bax expressions, the downregulation of the protein levels of bcl2, and the increase in caspase-3 activity. |
2017-02-06 |
2023-08-13 |
mouse |
| Wei Dai, Quangen Gao, Jianping Qiu, Jianmao Yuan, Guoliang Wu, Genhai She. Quercetin induces apoptosis and enhances 5-FU therapeutic efficacy in hepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26628295. |
our results showed that q effectively inhibited human hcc cell proliferation and induced apoptosis by upregulating the expression of bad and bax and downregulating the expression of bcl-2 and survivin in vitro. |
2017-02-06 |
2023-08-13 |
mouse |
| Xiangrong Liu, Jun Kang, Fang Liu, Shaohong Wen, Xianwei Zeng, Kuan Liu, Yumin Luo, Xunming Ji, Shangfeng Zha. Overexpression of iASPP-SV in glioma is associated with poor prognosis by promoting cell viability and antagonizing apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26628298. |
overexpression of iaspp-sv promoted the cell viability and downregulated the expression of pro-apoptosis genes (bax, puma, p21, and noxa) to inhibit apoptosis induced by tmz. |
2017-02-06 |
2023-08-13 |
human |
| Syed Kazim Hasan, Aisha Siddiqi, Sana Nafees, Nemat Ali, Summya Rashid, Rashid Ali, Ayaz Shahid, Sarwat Sultan. Chemopreventive effect of 18β-glycyrrhetinic acid via modulation of inflammatory markers and induction of apoptosis in human hepatoma cell line (HepG2). Molecular and cellular biochemistry. vol 416. issue 1-2. 2017-02-06. PMID:27116616. |
in the present study, 18β-ga increased the formation of reactive oxygen species, nitric oxide production, and loss of mitochondrial membrane potential, suggesting the involvement of 18β-ga in apoptosis which was also confirmed by assessing the markers involved in apoptosis like caspase-3, caspase-9, bax:bcl-2 ratio, and cleaved parp. |
2017-02-06 |
2023-08-13 |
human |
| Jian-Hua Qu, Chun-Cheng Lu, Cheng Xu, Gang Chen, Liang-Lin Qiu, Jun-Kang Jiang, Shuai Ben, Yu-Bang Wang, Ai-Hua Gu, Xin-Ru Wan. Perfluorooctane sulfonate-induced testicular toxicity and differential testicular expression of estrogen receptor in male mice. Environmental toxicology and pharmacology. vol 45. 2017-02-06. PMID:27310206. |
in relation to increased apoptosis, bax, cleaved caspase-9 and cleaved caspase-3 levels elevated significantly, indicating that pfos induced germ cell apoptosis by activating the mitochondrial pathway. |
2017-02-06 |
2023-08-13 |
mouse |
| Sayantanee Das, Scott M Filippone, Denise S Williams, Anindita Das, Rakesh C Kukrej. Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Molecular and cellular biochemistry. vol 421. issue 1-2. 2017-02-06. PMID:27565811. |
in contrast, brj significantly increased dox-mediated apoptosis in cancer cells with activation of poly(adp-ribose) polymerase (parp) and increased the bax:bcl-2 ratio. |
2017-02-06 |
2023-08-13 |
rat |
| Yali Li, Bin Liu, Fangfang Yang, Yang Yu, Anqi Zeng, Tinghong Ye, Wenya Yin, Yongmei Xie, Zhengyan Fu, Chengjian Zha. Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS- mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-06. PMID:27565846. |
western blot analysis also demonstrated that the occurrence of its apoptosis was associated with activation of cleaved caspase-3 and bax, downregulation of bcl-2. |
2017-02-06 |
2023-08-13 |
human |
| Niannian Fan, Jiantao Wan. MicroRNA 34a contributes to virus-mediated apoptosis through binding to its target gene Bax in influenza A virus infection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-06. PMID:27610823. |
microrna 34a contributes to virus-mediated apoptosis through binding to its target gene bax in influenza a virus infection. |
2017-02-06 |
2023-08-13 |
Not clear |
| Peiyan Hua, Mei Sun, Guangxin Zhang, Yifan Zhang, Ge Song, Zhenyu Liu, Xin Li, Xingyi Zhang, Bingjin L. Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells. Journal of biochemical and molecular toxicology. vol 30. issue 9. 2017-02-03. PMID:27078502. |
costunolide triggered apoptosis in esophageal cancer cells via the upregulation of bax, downregulation of bcl-2, and significant activation of caspase-3 and poly adp-ribose polymerase. |
2017-02-03 |
2023-08-13 |
human |
| Andrei Alexandru Constantinescu, Malak Abbas, Mohamad Kassem, Céline Gleizes, Guillaume Kreutter, Valerie Schini-Kerth, Ioan Liviu Mitrea, Florence Toti, Laurence Kessle. Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27344165. |
cleaved caspase-3, bax apoptosis indicators, and p53, p21 cell cycle regulators were detected by western blot. |
2017-02-02 |
2023-08-13 |
human |
| Andrei Alexandru Constantinescu, Malak Abbas, Mohamad Kassem, Céline Gleizes, Guillaume Kreutter, Valerie Schini-Kerth, Ioan Liviu Mitrea, Florence Toti, Laurence Kessle. Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27344165. |
apoptosis was associated with up-regulated bax (threefold) and cleaved caspase-3 (fivefold) but only in panc-1, while p53 and p21 were up-regulated (twofold) in both cell lines. |
2017-02-02 |
2023-08-13 |
human |
| A V Sirotkin, M Mészárosová, A H Harrath, R Grossman. Obestatin directly controls chicken ovarian cell functions. Journal of biological regulators and homeostatic agents. vol 30. issue 3. 2017-02-02. PMID:27655483. |
we identified the effect of obestatin addition (0.1, 10 or 100 ng/ml medium) on the accumulation of markers of proliferation (pcna, cyclin b1, mapk/erk1,2) and nuclear (tdt) and cytoplasmic (bax, caspase 3) apoptosis, as well as the release of progesterone (p), testosterone (t) and estradiol (e) by cultured chicken granulosa cells. |
2017-02-02 |
2023-08-13 |
chicken |
| A V Sirotkin, M Mészárosová, A H Harrath, R Grossman. Obestatin directly controls chicken ovarian cell functions. Journal of biological regulators and homeostatic agents. vol 30. issue 3. 2017-02-02. PMID:27655483. |
it was observed that obestatin addition could inhibit the accumulation of proliferation markers (pcna and cyclin b1, but not of mapk/erk1,2), promote the expression of nuclear (tdt) and cytoplasmic (bax, caspase 3) apoptosis markers and suppress p, t, and e release by cultured granulosa cells. |
2017-02-02 |
2023-08-13 |
chicken |
| Shao-Zhen Yan, Xiao-Li Wang, Hai-Yu Wang, Peng Dong, Yan-Song Zha. [Effects of umbilical cord blood mononuclear cells transplantation via lateral ventricle on the neural apoptosis and the expression of Bax and Bcl-2 proteins in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 18. issue 9. 2017-02-02. PMID:27655545. |
[effects of umbilical cord blood mononuclear cells transplantation via lateral ventricle on the neural apoptosis and the expression of bax and bcl-2 proteins in neonatal rats with hypoxic-ischemic brain damage]. |
2017-02-02 |
2023-08-13 |
rat |
| Shao-Zhen Yan, Xiao-Li Wang, Hai-Yu Wang, Peng Dong, Yan-Song Zha. [Effects of umbilical cord blood mononuclear cells transplantation via lateral ventricle on the neural apoptosis and the expression of Bax and Bcl-2 proteins in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 18. issue 9. 2017-02-02. PMID:27655545. |
to explore the effects of umbilical cord blood mononuclear cells (ucbmc) transplantation on the neuronal apoptosis and the expression of bcl-2 and bax proteins in neonatal rats with hypoxic-ischemic brain damage (hibd). |
2017-02-02 |
2023-08-13 |
rat |
| Yu-Zhen Du, Xiao-Hua Gu, Shao-Fei Cheng, Li Li, Hua Liu, Liu-Ping Hu, Feng Ga. The oncogenetic role of stanniocalcin 1 in lung adenocarcinoma: a promising serum candidate biomarker for tracking lung adenocarcinoma progression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-01. PMID:26577859. |
additionally, studies in the stc1-overexpressing or stc1-silenced stable cell lines showed that stc1 increased cell proliferation by promoting g1/s transition in cell cycle progression via up-regulating cyclin b1 and cyclin e. moreover, studies in the stc1-overexpressing or stc1-silenced stable cell lines also showed that stc1 inhibited cell apoptosis by up-regulating the expression of anti-apoptosis proteins bcl-2 and bcl-xl and down-regulating the expression of pro-apoptosis proteins bax, bak, and bid via the activation of the erk and jnk signaling pathway. |
2017-02-01 |
2023-08-13 |
human |
| Wei-Ting Tseng, Ya-Wen Hsu, Tzu-Ming Pa. Neuroprotective effects of dimerumic acid and deferricoprogen from Monascus purpureus NTU 568-fermented rice against 6-hydroxydopamine-induced oxidative stress and apoptosis in differentiated pheochromocytoma PC-12 cells. Pharmaceutical biology. vol 54. issue 8. 2017-02-01. PMID:26794209. |
dma and dfc inhibited 6-ohda-induced apoptosis and decreased activation of caspase-3 via regulation of bcl-2-associated x protein (bax) and bcl-2 protein expression in differentiated pc-12 cells. |
2017-02-01 |
2023-08-13 |
Not clear |
| Min Li, Chuan Liu, Lingling Yang, Lei Zhang, Chunhai Chen, Mindi He, Yonghui Lu, Wei Feng, Huifeng Pi, Yanwen Zhang, Min Zhong, Zhengping Yu, Zhou Zho. G9a-mediated histone methylation regulates cadmium-induced male fertility damage in pubertal mice. Toxicology letters. vol 252. 2017-01-31. PMID:27060504. |
our data showed that cd exposure decreased the numbers of impregnated females and litter sizes, which was concomitant with sperm count reduction, histological changes in the cauda epididymal ducts and seminiferous epithelium, and testicular cell apoptosis as evaluated by terminal dutp nick-end labeling (tunel) assay and immunoblotting with increased levels of cleaved caspase 3, parp and bax and a decreased level of bcl-2. |
2017-01-31 |
2023-08-13 |
mouse |
| Xin Sui, Xiao-Hua Li, Ming-Hua Duan, Ai-Ling Jia, Ye Wang, Da Liu, Yi-Ping Li, Zhi-Dong Qi. Investigation of the anti-glioma activity of Oviductus ranae protein hydrolysate. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 81. 2017-01-31. PMID:27261592. |
in addition, the results of western blotting also demonstrated that orph effectively regulated the expression of the apoptosis related proteins, cleaved caspase-3, bax and bcl-2, dna staining and flow cytometry analysis demonstrated that orph significantly promoted apoptosis in this cell line, a finding that was confirmed in vivo using terminal deoxynucleotidyl transferase dutp nick end labeling. |
2017-01-31 |
2023-08-13 |
human |
| Gang Li, Longfeng Sun, Zhongyi Mu, Yan Huang, Cheng Fu, Bin H. Ectopic WWOX Expression Inhibits Growth of 5637 Bladder Cancer Cell In Vitro and In Vivo. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-31. PMID:27352332. |
constitutive expression of ectopic wwox in 5637 cells suppressed cell proliferation and cell cycle progression, which was associated with downregulation of cyclin b, d1, and e. moreover, wwox overexpression promoted apoptosis in 5637 cells and resulted in upregulation of bax, downregulation of bcl-2, and elevated levels of cleaved caspase-3 and cleaved parp, indicating activation of the intrinsic apoptosis pathway. |
2017-01-31 |
2023-08-13 |
mouse |