| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhong Wu, Pengfei Zan, Shaohua Li, Jie Liu, Jianguang Wang, Dong Chen, Hua Wang, Yongqiang Qian, Linjie Luo, Xiang Huan. Knockdown of WWP1 inhibits growth and invasion, but induces apoptosis of osteosarcoma cells. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-12-14. PMID:26339351. |
furthermore, knocking down wwp1 affected the protein levels of apoptosis (bcl2 and bax) and invasion related factor (mmp2, mmp9, β-catenin and e-cadherin). |
2016-12-14 |
2023-08-13 |
Not clear |
| Li Song, Jiao Chang, Zhuoyu L. A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food & function. vol 7. issue 2. 2016-12-14. PMID:26673746. |
the loss of mitochondrial membrane potential, upregulation of cytochrome c and bax, downregulation of bcl-2, and activation of caspase-9 and -3 were observed, indicating mitochondria-dependent apoptosis induced by tkp. |
2016-12-14 |
2023-08-13 |
human |
| Li Song, Jiao Chang, Zhuoyu L. A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food & function. vol 7. issue 2. 2016-12-14. PMID:26673746. |
treatment with pi3k inhibitor ly294003 increased the impact of tkp on mitochondria-related apoptosis proteins (cytochrome c, bcl-2, bax, caspase-9 and caspase-3) and cell apoptosis. |
2016-12-14 |
2023-08-13 |
human |
| Yongyao Yang, Hongming Zhang, Xiaoyan Li, Tianhe Yang, Qingan Jian. Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro. International journal of clinical and experimental pathology. vol 8. issue 10. 2016-12-14. PMID:26722406. |
severe apoptosis in doxorubicin group was verified by a set of markers including bax, bcl-2, cytosolic cytochrome c and caspase-3 up-regulation expression. |
2016-12-14 |
2023-08-13 |
mouse |
| Huilian Qiao, Hao Chen, Yuhang Dong, He Ma, Guangchao Zhao, Fakuan Tang, Zhen L. Polydatin Attenuates H2O2-Induced Oxidative Stress via PKC Pathway. Oxidative medicine and cellular longevity. vol 2016. 2016-12-14. PMID:26881030. |
tunel, fluorometric assays, and western blotting showed that osi upregulated the apoptosis ratio, the activity of caspase-3 and the level of proapoptotic protein bax and decreased the level of antiapoptotic protein bcl-2. |
2016-12-14 |
2023-08-13 |
human |
| Shiwei Zhou, Yingying Wang, Jun-Jie Zh. Simultaneous Detection of Tumor Cell Apoptosis Regulators Bcl-2 and Bax through a Dual-Signal-Marked Electrochemical Immunosensor. ACS applied materials & interfaces. vol 8. issue 12. 2016-12-14. PMID:26946947. |
simultaneous detection of tumor cell apoptosis regulators bcl-2 and bax through a dual-signal-marked electrochemical immunosensor. |
2016-12-14 |
2023-08-13 |
Not clear |
| Shiwei Zhou, Yingying Wang, Jun-Jie Zh. Simultaneous Detection of Tumor Cell Apoptosis Regulators Bcl-2 and Bax through a Dual-Signal-Marked Electrochemical Immunosensor. ACS applied materials & interfaces. vol 8. issue 12. 2016-12-14. PMID:26946947. |
b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) are often used to monitor the apoptosis of tumor cells and evaluate cancer drug effect. |
2016-12-14 |
2023-08-13 |
Not clear |
| Shiwei Zhou, Yingying Wang, Jun-Jie Zh. Simultaneous Detection of Tumor Cell Apoptosis Regulators Bcl-2 and Bax through a Dual-Signal-Marked Electrochemical Immunosensor. ACS applied materials & interfaces. vol 8. issue 12. 2016-12-14. PMID:26946947. |
with the increase of drug dosage and incubation time, the up-regulation for bax and down-regulation for bcl-2 were observed, which indicated that the apoptosis level of k562 cells could be regulated by bcl-2 family. |
2016-12-14 |
2023-08-13 |
Not clear |
| Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells. Integrative cancer therapies. vol 13. issue 3. 2016-12-13. PMID:22505597. |
fnq-induced apoptosis was accompanied by bax and bad upregulation, and the downregulation of bcl-2, bcl-xl, mcl-1, and x-linked inhibitor of apoptosis (xiap), resulting in cytochrome c release and sequential activation of caspase-9 and caspase-3. |
2016-12-13 |
2023-08-12 |
human |
| Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells. Integrative cancer therapies. vol 13. issue 3. 2016-12-13. PMID:22505597. |
the combined treatment of fnq with pp2 enhanced the cell cycle arrest and apoptosis and also led to the downregulation of bcl-xl, mcl-1, xiap, cyclin a, cyclin b, cdk1, and cdk2 and upregulation of p27, bax, and bad. |
2016-12-13 |
2023-08-12 |
human |
| Yue She, Hansong Zhao, Yanzhu Zhu, Yanfei Han, Shiliang Xia, Chongsheng Bai, Jihong Zhang, Yanfei L. Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats. Cell biochemistry and biophysics. vol 71. issue 3. 2016-12-13. PMID:25578489. |
the serum total bile acid (tba) concentration, the early and total hepatocyte apoptosis indexes, and protein and mrna expression of bcl-2 and bax were determined. |
2016-12-13 |
2023-08-13 |
rat |
| Yue She, Hansong Zhao, Yanzhu Zhu, Yanfei Han, Shiliang Xia, Chongsheng Bai, Jihong Zhang, Yanfei L. Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats. Cell biochemistry and biophysics. vol 71. issue 3. 2016-12-13. PMID:25578489. |
the results showed that the serum tba concentration, the early and total hepatocyte apoptosis indexes, and protein and mrna expression of bax increased, while protein and mrna expression of bcl-2 decreased in alcl3-treated rats. |
2016-12-13 |
2023-08-13 |
rat |
| Ali Zekri, Seyed H Ghaffari, Marjan Yaghmaie, Mehrdad Asghari Estiar, Kamran Alimoghaddam, Mohammad Hossein Modarressi, Ardeshir Ghavamzade. Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA. Molecular neurobiology. vol 53. issue 3. 2016-12-13. PMID:25752998. |
furthermore, lower concentrations of azd1152-hqpa profoundly induced apoptosis in u87gm (p53/p73 wild type) cells in parallel with an upregulation of p53 and its target genes bax, bad, apaf1, and puma. |
2016-12-13 |
2023-08-13 |
Not clear |
| Bor-Tsang Wu, Ming-Chang Chiang, Ching-Yi Tasi, Chia-Hua Kuo, Woei-Cherng Shyu, Chung-Lan Kao, Chih-Yang Huang, Shin-Da Le. Cardiac Fas-Dependent and Mitochondria-Dependent Apoptotic Pathways in a Transgenic Mouse Model of Huntington's Disease. Cardiovascular toxicology. vol 16. issue 2. 2016-12-13. PMID:25800750. |
the key components of fas-dependent apoptosis (tnf-alpha, tnfr1, fas ligand, fas death receptors, fadd, activated caspase-8, and activated caspase-3) and the key components of mitochondria-dependent apoptosis (bax, bax-to-bcl-2 ratio, cytosolic cytochrome c, activated caspase-9, and activated caspase-3) increased significantly in the hearts of the hd group. |
2016-12-13 |
2023-08-13 |
mouse |
| Diego F M Mühlbeier, Vera A Saddi, Élbio C de Paula, Isabela W Cunha, José H T G Fregnani, Maria A Barbosa, Wilmar J Manoe. Prognostic Significance of Apoptosis-related Markers in Patients With Soft-Tissue Sarcomas of Extremities. Applied immunohistochemistry & molecular morphology : AIMM. vol 24. issue 4. 2016-12-13. PMID:25906122. |
bcl-2 and bax proteins are key regulators of apoptosis, a process that is deregulated in many human diseases, particularly cancer. |
2016-12-13 |
2023-08-13 |
human |
| Jiamin Zhang, Shiyuan Zhou, Yi Zhou, Feier Feng, Qianming Wang, Xiaolu Zhu, Jingzhong Zhao, Haixia Fu, Meng Lv, Huisheng Ai, Xiaojun Huang, Xiaohui Zhan. Adipose-Derived Mesenchymal Stem Cells (ADSCs) With the Potential to Ameliorate Platelet Recovery, Enhance Megakaryopoiesis, and Inhibit Apoptosis of Bone Marrow Cells in a Mouse Model of Radiation-Induced Thrombocytopenia. Cell transplantation. vol 25. issue 2. 2016-12-13. PMID:25975417. |
administration of adscs upregulated protein expression of phosphorylated akt and bcl-xl, whereas the expression of bax, a protein related to apoptosis, was significantly lower in the adsc group. |
2016-12-13 |
2023-08-13 |
mouse |
| N Saini, M K Singh, S M Shah, K P Singh, R Kaushik, R S Manik, S K Singla, P Palta, M S Chauha. Developmental competence of different quality bovine oocytes retrieved through ovum pick-up following in vitro maturation and fertilization. Animal : an international journal of animal bioscience. vol 9. issue 12. 2016-12-13. PMID:26165355. |
to analyze whether the developmental potential of the cocs bears a relation to morphological appearance, relative expression of a panel of genes associated with; (a) cumulus-oocyte interaction (cx43, cx37, gdf9 and bmp15), (b) fertilization (zp2 and zp3), (c) embryonic development (hsf1, zar1 and bfgf) and (d) apoptosis and survival (bax, bid and bcl-xl, mcl-1, respectively) was studied at two stages: germinal vesicle (gv) stage and after in vitro maturation. |
2016-12-13 |
2023-08-13 |
cattle |
| Zheng Zhenzhong, Yu Yafa, Liang Ji. Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved. Bioscience reports. vol 35. issue 3. 2016-12-13. PMID:26182381. |
we found that fgl2 gene silencing inhibits apoptosis and improves heart function of streptozotocin (stz)-induced diabetes rats, the possible mechanism maybe that fgl2 gene silencing reduces the tumour necrosis factor (tnf)±levels, decreases the expression of b-cell lymphoma-2 (bcl2), bcl-2-associated x (bax), toll-like receptors 4 (tlr4) and p38 mitogen-activated protein kinase (mapk). |
2016-12-13 |
2023-08-13 |
rat |
| Feibo Xu, Jing Wang, Zheng Cao, Miao Song, Yang Fu, Yanzhu Zhu, Yanfei L. cAMP/PKA Signaling Pathway Induces Apoptosis by Inhibited NF-κB in Aluminum Chloride-Treated Lymphocytes In Vitro. Biological trace element research. vol 170. issue 2. 2016-12-13. PMID:26280903. |
lymphocytes apoptosis rate, intracellular camp content, pka, survivin, b cell lymphoma/leukemia-2 (bcl-2) and bcl-2-associated x protein (bax) mrna expressions, and the mrna and protein expressions of nuclear factor-κ-gene binding (nf-κb, p65) were detected, respectively. |
2016-12-13 |
2023-08-13 |
rat |
| Feibo Xu, Jing Wang, Zheng Cao, Miao Song, Yang Fu, Yanzhu Zhu, Yanfei L. cAMP/PKA Signaling Pathway Induces Apoptosis by Inhibited NF-κB in Aluminum Chloride-Treated Lymphocytes In Vitro. Biological trace element research. vol 170. issue 2. 2016-12-13. PMID:26280903. |
the results showed that apoptosis index of lymphocytes, camp content in intracellular and pka mrna expression were significantly upregulated, whereas nf-κb and survivin mrna expressions, nuclear nf-κb (p65) protein expression, and the ratio of bcl-2 and bax mrna expression were downregulated in the alcl3-treated groups compared with those in cg. |
2016-12-13 |
2023-08-13 |
rat |