| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Wang, Z Chen, X Li, Y Tang, X Li, S Zhang, L Ma, X Huan. TSG-6 treatment promoted apoptosis in human fibroblasts of pathological scar. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 6. 2017-01-23. PMID:27262799. |
meanwhile, expression level of cell apoptosis related cytokine protein bax increased and cell proliferation related signal transduction pathways are blocked since the expression level of bcl-2 was decreased. |
2017-01-23 |
2023-08-13 |
human |
| Thantip Mitupatum, Kalaya Aree, Suthathip Kittisenachai, Sittiruk Roytrakul, Songchan Puthong, Sasichai Kangsadalampai, Panadda Rojpibulsti. mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 2. 2017-01-19. PMID:26925667. |
mrna expression of bax, bcl-2, p53, cathepsin b, caspase-3 and caspase-9 in the hepg2 cell line following induction by a novel monoclonal ab hep88 mab: cross-talk for paraptosis and apoptosis. |
2017-01-19 |
2023-08-13 |
Not clear |
| Thantip Mitupatum, Kalaya Aree, Suthathip Kittisenachai, Sittiruk Roytrakul, Songchan Puthong, Sasichai Kangsadalampai, Panadda Rojpibulsti. mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 2. 2017-01-19. PMID:26925667. |
the mrna expression results also suggested that the process triggered by hep88 mab involved up-regulation of tumor suppressor p53, pro-apoptotic bax, cathepsin b, caspase-3 and caspase-9, with a decrease of anti-apoptotic bcl-2 - thus confirming paraptosis and apoptosis programmed cell death. |
2017-01-19 |
2023-08-13 |
Not clear |
| Zhong-Kun Wang, Xue-Lei Zhou, Xiang-Bin Song, Dong-Ming Zhuang, Zhen-Yong Wang, Du-Bao Yang, Lin Wan. Alleviation of Lead-Induced Apoptosis by Puerarin via Inhibiting Mitochondrial Permeability Transition Pore Opening in Primary Cultures of Rat Proximal Tubular Cells. Biological trace element research. vol 174. issue 1. 2017-01-19. PMID:27116952. |
simultaneously, upregulation and downregulation of bcl-2 and bax with increased bcl-2/bax ratio due to pu administration further alleviated pb-induced mitochondrial apoptosis. |
2017-01-19 |
2023-08-13 |
rat |
| Suneetha Amara, Mu Zheng, Venkataswarup Tiriveedh. Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. Cell biochemistry and biophysics. vol 74. issue 3. 2017-01-19. PMID:27236294. |
however, oa efficiently reversed the high salt-mediated inhibition of cytochrome oxidase, caspase activity, and pro-apoptotic bax expression, thus suggesting that oa induced mitochondrial activity and enhanced apoptosis. |
2017-01-19 |
2023-08-13 |
Not clear |
| Hongbin Fan, Xiaoquan Li, Wei Wang, Qingwei Lai, Xiaohong Tang, Dianshuai Gao, Xiaoxing Yin, Tiejun X. Effects of NMDA-Receptor Antagonist on the Expressions of Bcl-2 and Bax in the Subventricular Zone of Neonatal Rats with Hypoxia-Ischemia Brain Damage. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-19. PMID:27352318. |
the effects of intraperitoneal injections of different drugs, namely mk-801 (0.5 mg/kg), nvp-aam077 (5 mg/kg), and ro25-6981 (5 mg/kg), on the expressions of anti-apoptotic protein bcl-2 and apoptosis protein bax in the subventricular zone were analyzed by immunohistochemical staining to explore the roles of nmda subunits (nr2a and nr2b) in hypoxic-ischemic. |
2017-01-19 |
2023-08-13 |
rat |
| Kanjana Assawasuparerk, Rapeepun Vanichviriyakit, Charoonroj Chotwiwatthanakun, Saksit Nobsathian, Thanakorn Rawangchue, Boonsirm Wittayachumnanku. Scabraside D Extracted from Holothuria scabra Induces Apoptosis and Inhibits Growth of Human Cholangiocarcinoma Xenografts in Mice. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 2. 2017-01-18. PMID:26925636. |
moreover, by quantitative real-time pcr, scabraside d effectively decreased bcl-2 while increasing bax and caspase-3 gene expression levels suggesting that the scabraside d could induce apoptosis in hucca cells. |
2017-01-18 |
2023-08-13 |
mouse |
| Qing-Qing Xu, Yi-Jun Xu, Cong Yang, Ying Tang, Lin Li, Hao-Bin Cai, Bo-Nan Hou, Hui-Fang Chen, Qi Wang, Xu-Guang Shi, Shi-Jie Zhan. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. BioMed research international. vol 2016. 2017-01-18. PMID:27556046. |
in addition, western blot was carried out to detect the expression of apoptosis related proteins (bcl-2, bax, and caspase-3). |
2017-01-18 |
2023-08-13 |
mouse |
| Zibiao Zhong, Qianchao Hu, Zhen Fu, Ren Wang, Yan Xiong, Yang Zhang, Zhongzhong Liu, Yanfeng Wang, Qifa Y. Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion. Artificial organs. vol 40. issue 6. 2017-01-17. PMID:26582147. |
renal apoptosis was detected by tunel staining, and the expression of aldh2, cleaved-caspase 3, bcl-2/ bax, mapk in renal tissue was detected by immunohistochemistry or western blot; 24 h after surgery, the concentration of cr in mp group was 355 ± 71μmol/l, in cs group was 511 ± 44 μmol/l (p < 0.05), while the bun was 15.02 ± 2.34 mmol/l in mp group, 22.64 ± 3.58 mmol/l in cs group (p < 0.05). |
2017-01-17 |
2023-08-13 |
Not clear |
| Pang-Hu Zhou, Wei Hu, Xiao-Bin Zhang, Wei Wang, Li-Jun Zhan. Protective Effect of Adrenomedullin on Rat Leydig Cells from Lipopolysaccharide-Induced Inflammation and Apoptosis via the PI3K/Akt Signaling Pathway ADM on Rat Leydig Cells from Inflammation and Apoptosis. Mediators of inflammation. vol 2016. 2017-01-17. PMID:27212810. |
adm pretreatment decreased apoptosis by significantly promoting bcl-2 and inhibiting bax, caspase-3, and parp expressions. |
2017-01-17 |
2023-08-13 |
rat |
| b' Tina Be\\xc4\\x8di\\xc4\\x87, Kanito Bilan, Snje\\xc5\\xbeana Marde\\xc5\\xa1i\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Mirna Saraga-Babi\\xc4\\x8. Spatiotemporal distribution of proliferation, proapoptotic and antiapoptotic factors in the early human limb development. Acta histochemica. vol 118. issue 5. 2017-01-16. PMID:27282649.' |
involvement of proliferation and apoptosis in the human limb development was analyzed electronmicroscopically and immunohistochemically in histological sections of 8 human embryos, 4(th) -10(th) week old, using apoptotic (caspase-3, aif, bax), anti-apoptotic (bcl-2) and proliferation (ki-67) markers, and tunel method. |
2017-01-16 |
2023-08-13 |
human |
| b' Tina Be\\xc4\\x8di\\xc4\\x87, Kanito Bilan, Snje\\xc5\\xbeana Marde\\xc5\\xa1i\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Mirna Saraga-Babi\\xc4\\x8. Spatiotemporal distribution of proliferation, proapoptotic and antiapoptotic factors in the early human limb development. Acta histochemica. vol 118. issue 5. 2017-01-16. PMID:27282649.' |
strong bcl-2 expression was observed in aer, subridge mesenchyme and phalanges, while bax expression charaterized limb areas undergoing apoptosis. |
2017-01-16 |
2023-08-13 |
human |
| b' Tina Be\\xc4\\x8di\\xc4\\x87, Kanito Bilan, Snje\\xc5\\xbeana Marde\\xc5\\xa1i\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Mirna Saraga-Babi\\xc4\\x8. Spatiotemporal distribution of proliferation, proapoptotic and antiapoptotic factors in the early human limb development. Acta histochemica. vol 118. issue 5. 2017-01-16. PMID:27282649.' |
spatio-temporal co-expresson of bcl-2 and bax indicates their role in suppression of apoptosis and selective stimulation of growth during human limb morphogenesis. |
2017-01-16 |
2023-08-13 |
human |
| Cynthia Celeste Castronuovo, María Luján Cuestas, José Raúl Oubiña, Verónica Lidia Mathe. Effect of several PEO-PPO amphiphiles on bax, bcl-2, and hTERT mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients. Biotechnology and applied biochemistry. vol 63. issue 2. 2017-01-11. PMID:25630439. |
effect of several peo-ppo amphiphiles on bax, bcl-2, and htert mrnas: an insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients. |
2017-01-11 |
2023-08-13 |
Not clear |
| Zhi-Yong Xu, Ming-Xue Zheng, Yan Zhang, Xiao-Zhen Cui, Sha-Sha Yang, Rui-Li Liu, Shan Li, Rou Xi, Xin Gong, Rui Ba. Dynamic changes in the main regulatory genes of mitochondrial permeability transition pore in Eimeria tenella host cells. Experimental parasitology. vol 171. 2017-01-11. PMID:27765656. |
primary chick embryo cecum epithelial cell culture techniques, spectrophotometer technology, hoechst-annexin v-pi apoptosis staining and elisa were used to detect the apoptosis rate and dynamic changes of bcl-2, bcl-xl, bax, bak, bid, bad, hk-ii, and atp content in e. tenella host cells at 4, 24, 48, 72, 96, and 120 h. |
2017-01-11 |
2023-08-13 |
chicken |
| Sebastian Czaplinski, Manuela Hugle, Valerie Stiehl, Simone Fuld. Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis. Oncotarget. vol 7. issue 8. 2017-01-09. PMID:26046302. |
this inactivation of antiapoptotic bcl-2 proteins promotes activation of bax and bak, cleavage of caspase-9 and -3 and caspase-dependent apoptosis. |
2017-01-09 |
2023-08-13 |
Not clear |
| Fei Liu, Duo Tong, Haoran Li, Mingming Liu, Jiajia Li, Ziliang Wang, Xi Chen. Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway. Oncotarget. vol 7. issue 8. 2017-01-09. PMID:26758421. |
here, we show that bufalin can inhibit cervical cancer cell proliferation, block cell cycle in g2/m phase, induce cellular apoptosis and reduce cell metastasis through stimulation of p21(waf/cip1), p27(cip/kip), bax and e-cadherin, and suppression of cyclin a, cyclin b1, cdk2, bcl-2, bcl-xl, mmp9 and snail1. |
2017-01-09 |
2023-08-13 |
human |
| Yan Liu, Tingting Bi, Wei Dai, Gang Wang, Liqiang Qian, Genhai Shen, Quangen Ga. Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 5. 2017-01-09. PMID:26892272. |
co-treatment with lupeol and 5-fu induced apoptosis through up-regulating the expressions of bax and p53 and down-regulating the expressions of survivin and bcl-2. |
2017-01-09 |
2023-08-13 |
mouse |
| Yushuang Ding, Hongge Wang, Jiajing Niu, Manyu Luo, Yangmei Gou, Lining Miao, Zhihua Zou, Ying Chen. Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells. International journal of molecular sciences. vol 17. issue 4. 2017-01-06. PMID:27089328. |
consequently, the g₁/s-cdk suppresser cdkn1b (p21) and pro-apoptotic proteins bax and activated caspase-3 were upregulated, while anti-apoptotic bcl-2 was downregulated, which were followed by cell cycle arrest at g₁ and marked apoptosis in atl-treated cancer but not non-cancer cells. |
2017-01-06 |
2023-08-13 |
human |
| Jin Hou, Fen Li, Xinhua Li, Qibing Mei, Man M. [Lily polysaccharide 1 enhances the effect of metformin on proliferation and apoptosis of human breast carcinoma cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 6. 2017-01-06. PMID:27371846. |
mcf-7 cell proliferation was determined using mtt assay; the apoptosis and cell cycle of mcf-7 cells were examined using annexin v-fitc/pi double staining combined with flow cytometry; western blotting was used to determine the content of bcl-2, bax, adenosine monophosphate-activated protein kinase (ampk) and phosphorated ampk (p-ampk) proteins. |
2017-01-06 |
2023-08-13 |
human |