| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pattage Madushan Dilhara Jayatissa Fernando, Mei Jing Piao, Susara Ruwan Kumara Madduma Hewage, Hee Kyoung Kang, Eun Sook Yoo, Young Sang Koh, Mi Hee Ko, Chang Sik Ko, Sang Hee Byeon, Seung Ri Mun, Nam Ho Lee, Jin Won Hyu. Photo-protective effect of sargachromenol against UVB radiation-induced damage through modulating cellular antioxidant systems and apoptosis in human keratinocytes. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:26991844. |
furthermore, sc decreased uvb-induced bax, cleaved caspase-9, and cleaved caspase-3 protein levels, but increased that of bcl-2, which are well-known key mediators of apoptosis. |
2017-02-09 |
2023-08-13 |
human |
| Xichun Wang, Wei Xu, Mengxue Fan, Tingting Meng, Xiaofang Chen, Yunjing Jiang, Dianfeng Zhu, Wenjuan Hu, Jiajie Gong, Shibin Feng, Jinjie Wu, Yu L. Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:27017380. |
the effects of don were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (ldh) release, and apoptosis ratio in pc12 cells, and on (ii) the expression of key genes and proteins related to apoptosis, including bcl-2, bax, bid, cytochrome c (cyt c), apoptosis inducing factor (aif), cleaved-caspase9, and cleaved-caspase3. |
2017-02-09 |
2023-08-13 |
Not clear |
| Chao Deng, Changyun Ji, Weisen Qin, Xifeng Cao, Jialian Zhong, Yugu Li, Swaminath Srinivas, Youjun Feng, Xianbo Den. Deoxynivalenol inhibits proliferation and induces apoptosis in human umbilical vein endothelial cells. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:27037652. |
in addition, don also causes mitochondrial damage by decreasing the mitochondrial membrane potential and inducing apoptosis by up-regulation of apoptosis-related genes like caspase-3, caspase-9, and bax genes, and down-regulation of bcl-2 gene. |
2017-02-09 |
2023-08-13 |
human |
| Neha Rani, Saurabh Bharti, Ameesha Tomar, Amit Kumar Dinda, D S Arya, Jagriti Bhati. Inhibition of PARP activation by enalapril is crucial for its renoprotective effect in cisplatin-induced nephrotoxicity in rats. Free radical research. vol 50. issue 11. 2017-02-09. PMID:27571604. |
moreover, enalapril dose dependently inhibited cisplatin-induced inflammation (nf-κb/ikk-β/il-6/cox-2/tnf-α expressions), apoptosis (increased bcl-2 and reduced p53, cytochrome c, bax and caspase-3 expressions, and tunel/dapi positivity) and preserved the structural integrity of the kidney. |
2017-02-09 |
2023-08-13 |
rat |
| Verónica Bastos, José M P Ferreira-de-Oliveira, Joana Carrola, Ana L Daniel-da-Silva, Iola F Duarte, Conceição Santos, Helena Oliveir. Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line. Journal of environmental sciences (China). vol 51. 2017-02-09. PMID:28115130. |
at the concentrations used (11 and 5μg/ml corresponding to ic50 and ~ic10 levels, respectively) the amount of cells undergoing apoptosis was not significant and the apoptotic related genes bcl2 (anti-apoptotic gene) and bax (pro-apoptotic gene) were both downregulated. |
2017-02-09 |
2023-08-13 |
human |
| Y Wei, F J Yuan, W B Zhou, L Wu, L Chen, J J Wang, Y S Zhan. Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax. Genetics and molecular research : GMR. vol 15. issue 2. 2017-02-08. PMID:27420953. |
borax-induced apoptosis in hepg2 cells involves p53, bcl-2, and bax. |
2017-02-08 |
2023-08-13 |
Not clear |
| X Liu, X Zhang, K Ma, R Zhang, P Hou, B Sun, S Yuan, Z Wang, Z Li. Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 11. 2017-02-08. PMID:27755950. |
sah induced neural cell apoptosis, as demonstrated by high apoptotic index and increased expression of bax and caspase-3 proteins, as well as the reduced bcl-2 expression, which were reversed by matrine pretreatment. |
2017-02-08 |
2023-08-13 |
rat |
| A Molahosseini, M M Taghavi, Z Taghipour, A Shabanizadeh, F Fatehi, M Kazemi Arababadi, S H Eftekhar Vaghef. The effect of the ginger on the apoptosis of hippochampal cells according to the expression of BAX and Cyclin D1 genes and histological characteristics of brain in streptozotocin male diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 12. 2017-02-08. PMID:27894393. |
the effect of the ginger on the apoptosis of hippochampal cells according to the expression of bax and cyclin d1 genes and histological characteristics of brain in streptozotocin male diabetic rats. |
2017-02-08 |
2023-08-13 |
rat |
| A Molahosseini, M M Taghavi, Z Taghipour, A Shabanizadeh, F Fatehi, M Kazemi Arababadi, S H Eftekhar Vaghef. The effect of the ginger on the apoptosis of hippochampal cells according to the expression of BAX and Cyclin D1 genes and histological characteristics of brain in streptozotocin male diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 12. 2017-02-08. PMID:27894393. |
the aim of the present study was to determine the effect of ginger extract on apoptosis of the neurons of hippocampus, via evaluation of bax and cyclin d1 and also histological analysis, in male diabetic rats. |
2017-02-08 |
2023-08-13 |
rat |
| A Mohammadi, M M Yaghoobi, A GholamhoseynianNajar, B Kalantari-Khandani, H Sharifi, M Saravan. HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 12. 2017-02-08. PMID:27894402. |
to explore the possible mechanism of apoptosis induction by 17-aag and celecoxib combination, levels of bax and bcl-2 proteins were determined by western blotting. |
2017-02-08 |
2023-08-13 |
Not clear |
| Josef Roslan, Nelli Giribabu, Kamarulzaman Karim, Naguib Salle. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 86. 2017-02-08. PMID:28027533. |
distribution and expression levels of tnf-α and ikk-β (inflammatory markers), caspase-3, caspase-9, blc-2 and bax (apoptosis markers) in the heart were identified by immunohistochemistry and western blotting respectively. |
2017-02-08 |
2023-08-13 |
rat |
| Yunmao Huang, Wanyan Li, Danning Xu, Bingxin Li, Yunbo Tian, Linsen Za. Effect of Dietary Selenium Deficiency on the Cell Apoptosis and the Level of Thyroid Hormones in Chicken. Biological trace element research. vol 171. issue 2. 2017-02-07. PMID:26507440. |
these results suggested that dietary se deficiency exerts significant harmful effects on male reproductive organ and that the intrinsic and extrinsic pathways and the upstream regulators such as p53, bax, and bcl-2 were all involved in se deficiency-induced testicular apoptosis. |
2017-02-07 |
2023-08-13 |
chicken |
| Hyunwoo Jung, Jinhyung Bae, Sung Kwon Ko, Uy Dong Soh. Ultrasonication processed Panax ginseng berry extract induces apoptosis through an intrinsic apoptosis pathway in HepG2 cells. Archives of pharmacal research. vol 39. issue 6. 2017-02-07. PMID:27233905. |
furthermore, ugb induced apoptosis of hepg2 cells through bax activation and bcl-2 inhibition. |
2017-02-07 |
2023-08-13 |
human |
| M L Blagonravov, A Yu Korshunova, M M Azova, A A Bryk, V A Frolo. Expression of Bax Protein and Morphological Changes in the Myocardium in Experimental Acute Pressure Overload of the Left Ventricle. Bulletin of experimental biology and medicine. vol 161. issue 2. 2017-02-07. PMID:27383165. |
the expression of bax protein, marker of intracellular pathway of apoptosis initiation, in viable left ventricular cardiomyocytes and morphological changes in the myocardium in acute pressure overload of the left ventricle were studied in experiment on male rabbits. |
2017-02-07 |
2023-08-13 |
Not clear |
| Ashok Kumar, Baljinder Singh, Girish Mahajan, Parduman R Sharma, Sandip B Bharate, Mubashir J Mintoo, Dilip M Mondh. A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-07. PMID:27449046. |
4o treatment caused loss of mitochondrial membrane potential, cytochrome c release, upregulation of bax, downregulation of bcl-2, and cleavage of caspase-3, thereby showing activation of mitochondrial mediated apoptosis. |
2017-02-07 |
2023-08-13 |
mouse |
| Rosemary Viola Bosch, Miryam Paola Alvarez-Flores, Durvanei Augusto Maria, Ana Marisa Chudzinski-Tavass. Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-02-07. PMID:27470394. |
our results also show an up-regulation of bcl-2 and a down-regulation of bax protein levels, inhibition of cytochrome c release and a reduction in caspase-3 levels, all considered critical factors for apoptosis. |
2017-02-07 |
2023-08-13 |
human |
| Zhaoyun Liu, Kai Ding, Lijuan Li, Hui Liu, Yihao Wang, Chunyan Liu, Rong F. A novel histone deacetylase inhibitor Chidamide induces G0/G1 arrest and apoptosis in myelodysplastic syndromes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27541047. |
meanwhile,it also induced cell apoptosis by down-regulating bcl-2 and up-regulating cleaved caspase-3 and bax protein expression.the results of the present study demonstrates the potential utility of chidamide for the treatment of myelodysplastic syndromes. |
2017-02-07 |
2023-08-13 |
Not clear |
| Weishan Li, Binghua Jiang, Xianglin Cao, Yongjiang Xie, Ting Huan. Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways. Chemico-biological interactions. vol 261. 2017-02-07. PMID:27871895. |
we found that the concentrations of fluoride, malondialdehyde (mda) and reactive oxygen species (ros), gene expressions and activities of caspase-9 and caspase-3, and the gene expressions of bax were significantly decreased, while the activities of superoxide dismutase (sod) and glutathione peroxidase (gpx), the gene expression of bcl-2 were significantly increased in the lyc + naf-treated rats group; concentrations of mda and ros, gene expressions and activities of caspase-9 and caspase-3, and the gene expression of bax, and ameloblasts apoptosis rate were significantly decreased, while the activities of sod and gpx, the gene expression of bcl-2 were significantly increased in the lyc + naf-treated ameloblasts group. |
2017-02-07 |
2023-08-13 |
rat |
| Yongqin Zhang, Yun Zuo, Zhifeng Guan, Weidong Lu, Zheng Xu, Hao Zhang, Yan Yang, Meilin Yang, Hongcheng Zhu, Xiaochen Che. Salinomycin radiosensitizes human nasopharyngeal carcinoma cell line CNE-2 to radiation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26209294. |
the results showed that salinomycin induced apoptosis and g2/m arrest, increased bax and cleaved caspase3, decreased bcl-2 expression, and increased the formation of γ-h2ax nuclear foci. |
2017-02-06 |
2023-08-13 |
human |
| Xin Wang, Hongtao Liu, Xiaqing Zhang, Xiaojuan Li, Hao Gu, Heng Zhang, Ruitai Fa. G6PD downregulation triggered growth inhibition and induced apoptosis by regulating STAT3 signaling pathway in esophageal squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26250461. |
further investigation revealed that g6pd depletion contributed to the growth suppression in ec1 cells in vitro and ec1 cells xenografted nude mice in vivo, which was associated with the reduces of tumor weight and ki-67 proliferation index, triggered cell cycle arrest at g0/g1 phase coupled with obvious decreases of cyclin d1 and cdk4 protein levels, and induced cell apoptosis accompanied by the increases of caspase-3 activity and bax protein expression as well as the decrease of bcl-2 protein expression in ec1 cells. |
2017-02-06 |
2023-08-13 |
mouse |