| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Yin, Lu Lu, Dongtao Wang, Ying Shi, Ming Wang, Yanfeng Huang, Dexiu Chen, Cong Deng, Jiebin Chen, Peijia Lv, Yanjing Wang, Chengjie Li, Lian-Bo We. Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-31. PMID:27352334. |
to further confirm the effect of h2o2 on c2c12 cells, the protein expression of lc3 and rarp, which are the markers of autophagy and apoptosis, respectively, was analyzed by western blot, as well as the expression levels of p-p70s6k, p70s6k, bcl-2, bax, cyto-c, and caspase-3, to reveal the underlying mechanisms. |
2017-01-31 |
2023-08-13 |
Not clear |
| Liang Meng, Weidong Xu, Lihong Guo, Wenqi Ning, Xiandong Zen. Paeonol Inhibits the Proliferation, Invasion, and Inflammatory Reaction Induced by TNF-α in Vascular Smooth Muscle Cells. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-31. PMID:27352344. |
for apoptosis induced by paeonol, western blot analysis showed that cleaved caspase-3 and -9 were detected, and pro-apoptotic protein bax was up-regulated, whereas anti-apoptotic protein bcl-2 was down-regulated by paeonol in tnf-α-stimulated vsmcs. |
2017-01-31 |
2023-08-13 |
rat |
| Xiaoqing Wang, Dazhong Wang, Yumei Zha. Effect and Mechanism of Resveratrol on the Apoptosis of Lung Adenocarcinoma Cell Line A549. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-31. PMID:27352348. |
our study demonstrates that res inhibits proliferation and induces apoptosis of a549 cells through regulation of p53, bax, bcl-2, and cleaved caspase-3 expression. |
2017-01-31 |
2023-08-13 |
Not clear |
| Tinghong Ye, Shirui Zhu, Yongxia Zhu, Qiang Feng, Bing He, Yiong Xiong, Lifeng Zhao, Yiwen Zhang, Luoting Yu, Li Yan. Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-01-31. PMID:27470369. |
moreover, western blot analysis indicated that the occurrence of its apoptosis was associated with upregulation of cleaved caspases-3 and pro-apoptotic protein bax while downregulation of anti-apoptotic protein bcl-2. |
2017-01-31 |
2023-08-13 |
human |
| Haihui Zhang, Yanxiang Cheng, Xiaoping Luo, Yuqing Dua. Protective effect of procyanidins extracted from the lotus seedpod on immune function injury induced by extremely low frequency electromagnetic field. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-01-31. PMID:27470374. |
western blot determinated the levels of apoptosis genes including bcl-2, bax, bcl-cl, caspase-3 and caspase-9. |
2017-01-31 |
2023-08-13 |
mouse |
| Haihui Zhang, Yanxiang Cheng, Xiaoping Luo, Yuqing Dua. Protective effect of procyanidins extracted from the lotus seedpod on immune function injury induced by extremely low frequency electromagnetic field. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 82. 2017-01-31. PMID:27470374. |
and it may be hypothesized that elf-emf-induced apoptosis in splenocytes might occur via triggers the trans-activation of bax and activates caspases-3 and -9, which then cleaves the death substrates, leading to apoptosis in splenocytes of mice treated with elf-emf. |
2017-01-31 |
2023-08-13 |
mouse |
| Guanmin Meng, Kequn Chai, Xinda Li, Yongqiang Zhu, Weihua Huan. Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway. Chemico-biological interactions. vol 257. 2017-01-31. PMID:27474067. |
results revealed that luteolin exerted an anti-proliferation effect in a dose- and time-dependent manner in a549 lung adenocarcinoma cells, and induced apoptosis with a concomitant increase in the activation of caspases-3 and -9, diminution of bcl-2, elevation in bax expression, and the phosphorylation of mek and its down-stream kinase erk, as well as the activation of akt. |
2017-01-31 |
2023-08-13 |
Not clear |
| Rupamoni Thakur, Sudarshan Kini, Sillarine Kurkalang, Atanu Banerjee, Purba Chatterjee, Abhishek Chanda, Anupam Chatterjee, Dulal Panda, Ashis K Mukherje. Mechanism of apoptosis induction in human breast cancer MCF-7 cell by Ruviprase, a small peptide from Daboia russelii russelii venom. Chemico-biological interactions. vol 258. 2017-01-31. PMID:27613483. |
immunoblotting and quantitative real-time pcr (qrt-pcr) analyses suggested that ruviprase down-regulated the expression of anti-apoptotic protein bcl-2, increased cleavage of poly (adp-ribose) polymerase (parp) protein, and up-regulated the expression of pro-apoptotic protein bax, as well as executer protein caspase-7 to induced apoptosis in mcf-7 cells via intrinsic pathway. |
2017-01-31 |
2023-08-13 |
human |
| Tetiana Kochubei, Volodymyr Kitam, Oksana Maksymchuk, Oksana Piven, Lyubov Lukas. Possible mechanisms of Leukoagglutinin induced apoptosis in human cells in vitro. Cell biology international. vol 40. issue 12. 2017-01-31. PMID:27629532. |
furthermore, we proved that leukoagglutinin can induce apoptosis in cancer (hep-2) and non-cancer (4bl) cells, and observed that pha-l is able to induce apoptosis through the up-regulation of bax protein and activation of the effector caspase-3 and initiator caspase-8. |
2017-01-31 |
2023-08-13 |
human |
| Seon Min Woo, Taeg Kyu Kwo. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chemico-biological interactions. vol 260. 2017-01-31. PMID:27729209. |
jaceosidin induces apoptosis through bax activation and down-regulation of mcl-1 and c-flip expression in human renal carcinoma caki cells. |
2017-01-31 |
2023-08-13 |
human |
| Seon Min Woo, Taeg Kyu Kwo. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chemico-biological interactions. vol 260. 2017-01-31. PMID:27729209. |
cumulatively, our results suggest that jaceosidin induces apoptosis in renal carcinoma cells through bax activation and reduces mcl-1 and c-flip expression. |
2017-01-31 |
2023-08-13 |
human |
| Aabid Manzoor Shah, Abubakar Wani, Parvaiz H Qazi, Shakeel-U Rehman, Saleem Mushtaq, Shiekh Abid Ali, Aehtesham Hussain, Aiyatullah Shah, Asif Khurshid Qazi, Ubaid Sharif Makhdoomi, Abid Hamid, Ajay Kuma. Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells. Chemico-biological interactions. vol 256. 2017-01-30. PMID:27378626. |
biochemical evidence of apoptosis came from elevating the intracellular ros level that was accompanied by mitochondrial membrane potential loss, decreasing the expression profile of anti-apoptotic protein bcl-2, whereas it augments cleavage of caspase-3 and parp-1, activates caspase-8 and 9 with concomitant increase in expression of proapoptotic protein bax in a dose dependent manner. |
2017-01-30 |
2023-08-13 |
human |
| Yang Li, Xiaokang Liu, Dan Jiang, Yingjia Lin, Yushi Wang, Qing Li, Linlin Liu, Ying-Hua Ji. Betulin induces reactive oxygen species-dependent apoptosis in human gastric cancer SGC7901 cells. Archives of pharmacal research. vol 39. issue 9. 2017-01-27. PMID:27271333. |
mechanism study demonstrated that betulin induced apoptosis through mitochondrial bax and bak accumulation-mediated intrinsic apoptosis pathway. |
2017-01-27 |
2023-08-13 |
human |
| Yang Li, Xiaokang Liu, Dan Jiang, Yingjia Lin, Yushi Wang, Qing Li, Linlin Liu, Ying-Hua Ji. Betulin induces reactive oxygen species-dependent apoptosis in human gastric cancer SGC7901 cells. Archives of pharmacal research. vol 39. issue 9. 2017-01-27. PMID:27271333. |
the mitochondrial accumulation of bax and bak, as well as caspase activity, was also remarkably inhibited by nac treatment, indicating that ros are important signaling intermediates that lead to betulin-induced apoptosis by modulating multiple apoptosis-regulating proteins in sgc7901 cells. |
2017-01-27 |
2023-08-13 |
human |
| Wipada Duangprompo, Kalaya Aree, Arunporn Itharat, Pintusorn Hansaku. Effects of 5,6-Dihydroxy-2,4-Dimethoxy-9,10-Dihydrophenanthrene on G The American journal of Chinese medicine. vol 44. issue 7. 2017-01-27. PMID:27776429. |
moreover, hmp significantly increased the mrna and protein levels of proapoptotic bax as well as promoted subsequent caspase-9 activation and bid cleavage, indicating hmp-induced apoptosis via both intrinsic and extrinsic pathways. |
2017-01-27 |
2023-08-13 |
human |
| Rashmi Holur Kadirareddy, Sujana Ghanta Vemuri, Uma Maheswari Devi Palempall. Probiotic Conjugated Linoleic Acid Mediated Apoptosis in Breast Cancer Cells by Downregulation of NFκB. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 7. 2017-01-26. PMID:27509982. |
furthermore, outcome results indicated that the apoptosis was mediated by downregulation of the nf?b pathway which in turn acted through proteasome degradation of i?bα, inhibition of p65 nuclear translocation, release of cytochromec from mitochondria and finally overexpression of bax protein. |
2017-01-26 |
2023-08-13 |
human |
| Se-Hui Kang, In-Hu Hwang, Eunju Son, Chong-Kwan Cho, Jong-Soon Choi, Soo-Jung Park, Byeong-Churl Jang, Kyung-Bok Lee, Zee-Won Lee, Jong Hoon Lee, Hwa-Seung Yoo, Ik-Soon Jan. Allergen-Removed Rhus verniciflua Extract Induces Ovarian Cancer Cell Death via JNK Activation. The American journal of Chinese medicine. vol 44. issue 8. 2017-01-26. PMID:27848251. |
this subsequently increased bax activation, leading to marked arvs-induced apoptosis, whereas the jnk inhibitor sp600125 in arvs extract treated skov-3 cells strongly inhibited bax. |
2017-01-26 |
2023-08-13 |
Not clear |
| Se-Hui Kang, In-Hu Hwang, Eunju Son, Chong-Kwan Cho, Jong-Soon Choi, Soo-Jung Park, Byeong-Churl Jang, Kyung-Bok Lee, Zee-Won Lee, Jong Hoon Lee, Hwa-Seung Yoo, Ik-Soon Jan. Allergen-Removed Rhus verniciflua Extract Induces Ovarian Cancer Cell Death via JNK Activation. The American journal of Chinese medicine. vol 44. issue 8. 2017-01-26. PMID:27848251. |
bax subfamily proteins induced apoptosis through caspase-3. |
2017-01-26 |
2023-08-13 |
Not clear |
| Yan-Ming Xu, Dan-Dan Wu, Wei Zheng, Fei-Yuan Yu, Feng Yang, Yue Yao, Yuan Zhou, Yick-Pang Ching, Andy T Y La. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. vol 7. issue 5. 2017-01-24. PMID:26716417. |
moreover, there was an induction of proapoptotic protein bax, release of cytochrome c (cycs) from mitochondria, activation of caspase-3/9 (casp3/9); as well as decreased expression of cell cycle checkpoint proteins (tp53, p21, and p27) and several inhibitors of apoptosis proteins (iaps) [including ciap-1/2 (birc2/3), xiap (birc4), and survivin (birc5)]. |
2017-01-24 |
2023-08-13 |
human |
| Sin-Gu Jeong, Goang-Won Ch. Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion. Cell biochemistry and function. vol 34. issue 5. 2017-01-23. PMID:27212655. |
the oxidative stress-sensitive proteins ataxia-telangiectasia mutated and p53 were phosphorylated, and the expression of apoptosis molecules bax increased, and bcl-2 decreased in early passage mscs; however, the expression of the apoptotic molecules did less change in response to apoptotic stimulation in late-passage mscs, suggesting that the intrinsic apoptotic signalling pathway was not induced by oxidative stress in long-term-cultured mscs. |
2017-01-23 |
2023-08-13 |
human |