| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Zhang, Gang Zhao, Yusi Guo, Harish Menghwar, Yingyu Chen, Huanchun Chen, Aizhen Gu. Mycoplasma bovis MBOV_RS02825 Encodes a Secretory Nuclease Associated with Cytotoxicity. International journal of molecular sciences. vol 17. issue 5. 2017-02-16. PMID:27136546. |
the apoptosis was confirmed by activated expression of phosphorylated nf-κb p65 and bax, and inhibition of iκβα and bcl-2. |
2017-02-16 |
2023-08-13 |
cattle |
| Palaniappan Sakthivel, Andivelu Ilangovan, Mahabir Prasad Kaushi. Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3-f]chromen-4(8H)-one based hybrids as potential mitochondrial apoptosis inducers. European journal of medicinal chemistry. vol 122. 2017-02-16. PMID:27376493. |
western blot analysis also revealed that these compounds persuade apoptosis through intrinsic pathway by up-regulating the pro-apoptotic protein bax and down-regulating the anti-apoptotic protein bcl-2. |
2017-02-16 |
2023-08-13 |
human |
| M A Behdani, R Hoshya. Phytochemical properties of Iranian organic saffron stigma: antioxidant, anticancer and apoptotic approaches. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 14. 2017-02-16. PMID:28145859. |
herb-induced apoptosis associated with increased expression of bax and decreased bcl2 gene leading eventually to a time-dependent increase in bax/bcl-2 ratio. |
2017-02-16 |
2023-08-13 |
Not clear |
| Tatsuo Tomit. Apoptosis in pancreatic β-islet cells in Type 2 diabetes. Bosnian journal of basic medical sciences. vol 16. issue 3. 2017-02-15. PMID:27209071. |
recently, hyperglycemia-induced β-cell apoptosis has been extensively studied on the balance of pro-apoptotic bcl-2 proteins (bad, bid, bik, and bax) and anti-apoptotic bcl family (bcl-2 and bcl-xl) toward apoptosis in vitro isolated islets and insulinoma cell culture. |
2017-02-15 |
2023-08-13 |
mouse |
| Zhan Shi, Xiang Li, Ding Wu, Run Tang, Renfu Chen, Song Xue, Xiaoqing Su. Silencing of HMGA2 suppresses cellular proliferation, migration, invasion, and epithelial-mesenchymal transition in bladder cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 6. 2017-02-14. PMID:26684800. |
in conclusion, we found that hmga2 knockdown markedly inhibited cell proliferation; this reduced cell growth was due to the high apoptosis rate of cells, as bcl-xl was diminished, whereas bax was upregulated. |
2017-02-14 |
2023-08-13 |
human |
| Xinran Chen, Ling Wang, Wei Wang, Lianmei Zhao, Baoen Sha. B7-H4 facilitates proliferation of esophageal squamous cell carcinoma cells through promoting interleukin-6/signal transducer and activator of transcription 3 pathway activation. Cancer science. vol 107. issue 7. 2017-02-14. PMID:27088889. |
additionally, compared with control cells, b7-h4 silenced cells showed higher apoptosis rates, bcl-2 and survivin upregulation, and bax downregulation. |
2017-02-14 |
2023-08-13 |
Not clear |
| Quanxin Gao, Qian Gao, Minghua Min, Chenjie Zhang, Shiming Peng, Zhaohong Sh. Ability of Lactobacillus plantarum lipoteichoic acid to inhibit Vibrio anguillarum-induced inflammation and apoptosis in silvery pomfret (Pampus argenteus) intestinal epithelial cells. Fish & shellfish immunology. vol 54. 2017-02-14. PMID:27179425. |
it also showed significant inhibitory effects on ehec-induced inflammation and apoptosis by modulating the expression of nf-κb (nuclear factor kappa b), iκb (inhibitor of nf-κb), bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), il-8 (interleukin 8) and tnf-α (tumor necrosis factor-α), and via inhibition of caspase-9 and caspase-3 activation. |
2017-02-14 |
2023-08-13 |
Not clear |
| Liping Zhu, Qingqiong Luo, Jianjun Bi, Jieying Ding, Shengfang Ge, Fuxiang Che. Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo. Chemico-biological interactions. vol 224. 2017-02-13. PMID:25450235. |
in addition, galangin induced apoptosis of hnscc cells, downregulating antiapoptotic protein bcl-2 and bcl-xl and upregulating proapoptotic protein bax and cleaved caspase 3. |
2017-02-13 |
2023-08-13 |
mouse |
| Xuerui Yan, Lin Wu, Bin Li, Xianjun Meng, Hanping Dai, Yanan Zheng, Junfan F. Cyanidin-3-O-glucoside Induces Apoptosis and Inhibits Migration of Tumor Necrosis Factor-α-Treated Rat Aortic Smooth Muscle Cells. Cardiovascular toxicology. vol 16. issue 3. 2017-02-13. PMID:26138096. |
our results illustrated that c3g pretreatment induced significant apoptosis in tnf-α-stimulated rasmcs in a dose-dependent way, which was accompanied with increased cleaved caspase-3, caspase-9 and bax and decreased bcl-2. |
2017-02-13 |
2023-08-13 |
mouse |
| Li Xiao Rui, Song Yu Shu, Wu Jing Jun, Chen Zi Mo, Sun Zheng Wu, Liu Shu Min, Lin Yuan, Peng Jin Yong, Song Zhi Cheng, Wang Shi Sheng, Tang Ze Ya. The dual induction of apoptosis and autophagy by SZC014, a synthetic oleanolic acid derivative, in gastric cancer cells via NF-κB pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-13. PMID:26547583. |
western blotting was performed to explore the expression of proteins associated with apoptosis (caspase 3, caspase 9, bax, bcl-2, and bcl-xl), autophagy (beclin 1 and atg 5), and nuclear factor-κb (nf-κb) signal pathway, respectively. |
2017-02-13 |
2023-08-13 |
Not clear |
| Li Xiao Rui, Song Yu Shu, Wu Jing Jun, Chen Zi Mo, Sun Zheng Wu, Liu Shu Min, Lin Yuan, Peng Jin Yong, Song Zhi Cheng, Wang Shi Sheng, Tang Ze Ya. The dual induction of apoptosis and autophagy by SZC014, a synthetic oleanolic acid derivative, in gastric cancer cells via NF-κB pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 4. 2017-02-13. PMID:26547583. |
caspase-dependent apoptosis induced by szc014 was confirmed to be associated with upregulation of bax and downregulation of bcl-2 and bcl-xl, while upregulation of beclin 1 and atg 5 was inferred to be involved in szc014-induced autophagy. |
2017-02-13 |
2023-08-13 |
Not clear |
| Ruxing Wang, Qian Xu, Lei Liu, Xiujun Liang, Luyang Cheng, Manli Zhang, Qingwen Sh. Antitumour activity of 2-dihydroailanthone from the bark of Ailanthus altissima against U251. Pharmaceutical biology. vol 54. issue 9. 2017-02-13. PMID:26956770. |
the western blot and rt-pcr assay showed that up-regulation of pro-apoptotic bax protein and down-regulation of anti-apoptotic bcl-2 protein as well as their mrna on u251 cells might be related to the apoptosis induction and proliferation inhibition. |
2017-02-13 |
2023-08-13 |
Not clear |
| Fang Chen, Bing Zhang, Yong Sun, Zeng-Xing Xiong, Han Peng, Ze-Yuan Deng, Jiang-Ning H. The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation. Nutrients. vol 8. issue 5. 2017-02-13. PMID:27120618. |
thus it was concluded that rh2-o induced apoptosis of hepg2 cells through activation of the lysosomal-mitochondrial apoptotic pathway involving the translocation of bax to the lysosome. |
2017-02-13 |
2023-08-13 |
cat |
| Jing Wang, Yue Zhang, Qiuzhen Zhu, Yulan Liu, Hao Cheng, Yuefan Zhang, Tiejun L. Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53. Environmental toxicology and pharmacology. vol 46. 2017-02-13. PMID:27525562. |
mtt assay, flow cytometry, hoechst 33258 staining, real-time pcr, and western blotting indicated that emodin pretreatment can effectively increase human umbilical venous endothelial cells (huvecs) viability and attenuate cell apoptosis; it also inhibited the expression of p53, bax, and caspase3 in huvecs after irradiation. |
2017-02-13 |
2023-08-13 |
mouse |
| Sumathi Thangarajan, Surekha Ramachandran, Priya Krishnamurth. Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair-Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax-Bad genes in male wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27690136. |
indeed, chrysin prevents apoptosis by upregulating the bcl-2 mrna expression and downregulating the pro-apoptotic (bax, bad) mrnas in 3-np induced condition. |
2017-02-13 |
2023-08-13 |
rat |
| Liu Xianchu, Professor Zheng Lan, Li Qiufang, Liu Yi, Ruan Xiangcheng, Hou Wenqi, Ding Yan. Naringin protects against lipopolysaccharide-induced cardiac injury in mice. Environmental toxicology and pharmacology. vol 48. 2017-02-13. PMID:27716530. |
lastly, treatment with naringin also significantly decreased the ratio of bax to bcl-2 to resist apoptosis in heart. |
2017-02-13 |
2023-08-13 |
mouse |
| Rantham Subramaniam Venkatesan, Abdul Majeeth Mohamed Sadi. Effect of morin-5'-sulfonic acid sodium salt on the expression of apoptosis related proteins caspase 3, Bax and Bcl 2 due to the mercury induced oxidative stress in albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 85. 2017-02-13. PMID:27919736. |
effect of morin-5'-sulfonic acid sodium salt on the expression of apoptosis related proteins caspase 3, bax and bcl 2 due to the mercury induced oxidative stress in albino rats. |
2017-02-13 |
2023-08-13 |
rat |
| Hui Yang, Ling Qiu, Li Zhang, Gaochao Lv, Ke Li, Huixin Yu, Minhao Xie, Jianguo Li. Platinum-zoledronate complex blocks gastric cancer cell proliferation by inducing cell cycle arrest and apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-09. PMID:26891667. |
the expressions of cell cycle regulators (p53, p21, cyclin d1, cyclin e, and cyclin-dependent kinase (cdk)2) and apoptosis-related proteins (bcl-2, bax, caspase-3, poly adp ribose polymerase (parp), and survivin) were regulated by the treatment of [pt(en)]2zl, resulting in the cell cycle arrest and apoptosis. |
2017-02-09 |
2023-08-13 |
human |
| Yanhua Fan, Hongyuan Lu, Li An, Changli Wang, Zhipeng Zhou, Fan Feng, Hongda Ma, Yongnan Xu, Qingchun Zha. Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:26923230. |
our findings suggested that the fraction e3 of e. sieboldianum could effectively inhibit the activity of aurora kinase and induce apoptosis via blocking cell cycle, up-regulating the expression of proapoptotic proteins including p53 and bax and reducing the expression of bcl-2. |
2017-02-09 |
2023-08-13 |
human |
| Mehrad Tavallai, Laurence Booth, Jane L Roberts, William P McGuire, Andrew Poklepovic, Paul Den. Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:26981780. |
over-expression of bcl-xl or knock down of bax, bim, bad or apoptosis inducing factor (aif) protected tumor cells. |
2017-02-09 |
2023-08-13 |
Not clear |