| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeinab Saadatdoust, Ashok Kumar Pandurangan, Suresh Kumar Ananda Sadagopan, Norhaizan Mohd Esa, Amin Ismail, Mohd Rais Mustaf. Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway. The Journal of nutritional biochemistry. vol 26. issue 12. 2016-12-13. PMID:26355019. |
in addition, cocoa induces apoptosis by increased the expressions of bax and caspase 3 and decreased bcl-xl. |
2016-12-13 |
2023-08-13 |
mouse |
| Venkata Charepalli, Lavanya Reddivari, Sridhar Radhakrishnan, Ramakrishna Vadde, Rajesh Agarwal, Jairam K P Vanamal. Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. The Journal of nutritional biochemistry. vol 26. issue 12. 2016-12-13. PMID:26383537. |
pa, but not sulindac, suppressed levels of wnt pathway effector β-catenin (a critical regulator of csc proliferation) and its downstream proteins (c-myc and cyclin d1) and elevated bax and cytochrome c, proteins-mediating mitochondrial apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Hao Yu, Yong Yang, Qiaoyu Li, Tieliang Ma, Jun Xu, Taofeng Zhu, Jing Xie, Wenjiao Zhu, Zhihong Cao, Kun Dong, Jiancui Huang, Lei Ji. Ternary Dinuclear Copper(II) Complexes of a Reduced Schiff Base Ligand with Diimine Coligands: DNA Binding, Cytotoxic Cell Apoptosis, and Apoptotic Mechanism. Chemical biology & drug design. vol 87. issue 3. 2016-12-13. PMID:26427013. |
furthermore, cell apoptosis was detected by annexinv/pi flow cytometry and tunel assay and by western blotting to detect the protein expression of p53, bax, and bcl-2. |
2016-12-13 |
2023-08-13 |
human |
| Hao Yu, Yong Yang, Qiaoyu Li, Tieliang Ma, Jun Xu, Taofeng Zhu, Jing Xie, Wenjiao Zhu, Zhihong Cao, Kun Dong, Jiancui Huang, Lei Ji. Ternary Dinuclear Copper(II) Complexes of a Reduced Schiff Base Ligand with Diimine Coligands: DNA Binding, Cytotoxic Cell Apoptosis, and Apoptotic Mechanism. Chemical biology & drug design. vol 87. issue 3. 2016-12-13. PMID:26427013. |
all the three copper complexes can effectively induce apoptosis of the three human tumor cells, which was accompanied with upregulation of the expression of p53 and bax, while bcl-2 decreased. |
2016-12-13 |
2023-08-13 |
human |
| Jae Woong Han, Jae-Kyo Jeong, Sangiliyandi Gurunathan, Yun-Jung Choi, Joydeep Das, Deug-Nam Kwon, Ssang-Goo Cho, Chankyu Park, Han Geuk Seo, Jin-Ki Park, Jin-Hoi Ki. Male- and female-derived somatic and germ cell-specific toxicity of silver nanoparticles in mouse. Nanotoxicology. vol 10. issue 3. 2016-12-13. PMID:26470004. |
furthermore, an increase in mitochondrial-mediated apoptosis by cytochrome c release from mitochondria due to translocation of bax to mitochondria was observed. |
2016-12-13 |
2023-08-13 |
mouse |
| JeHoon Lee, Sakhila K Banu, John A McCracken, Joe A Aros. Early pregnancy modulates survival and apoptosis pathways in the corpus luteum in sheep. Reproduction (Cambridge, England). vol 151. issue 3. 2016-12-13. PMID:26585285. |
results indicate that: i) expressions of p-erk1/2, p-akt, β-catenin, nfκb -p65, -p50, -p52, p-src, p-β -arrestin, p-gsk3β, x-linked inhibitor of apoptosis protein (xiap), and p-creb proteins are suppressed during natural luteolysis; in contrast, their expressions are sustained or increased during establishment of pregnancy; ii) expressions of cleaved caspase-3, apoptosis inducing factor (aif), c-fos, c-jun, and egr-1 proteins are increased during natural luteolysis; in contrast, their expressions are decreased during establishment of pregnancy; and iii) expressions of bcl-2, bcl-xl, bad, and bax proteins are not modulated during natural luteolysis while expressions of bcl2 and bcl-xl proteins are increased during establishment of pregnancy in sheep. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ling Liu, Dongmei Wang, Jiangang Wang, Shuying Wan. The Nitric Oxide Prodrug JS-K Induces Ca(2+)-Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells. Journal of biochemical and molecular toxicology. vol 30. issue 4. 2016-12-13. PMID:26616367. |
meanwhile, carboxy-ptio and bapta-am treatment both attenuate js-k-induced apoptosis through upregulation of bcl-2, downregulation of bax, reduction of cyt c release from mitochondria to cytoplasm and inactivation of caspase-9/3. |
2016-12-13 |
2023-08-13 |
human |
| Chunmei Wang, Yuan Luo, Jie Lu, Yingchao Wang, Guangyao Shen. Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells. Journal of biochemical and molecular toxicology. vol 30. issue 4. 2016-12-13. PMID:26616494. |
meanwhile, the protein expression level of bc1-2, bax, cyclin a, cyclin b, and cyclin d1, which associated with apoptosis and cell cycle were analyzed by western blotting. |
2016-12-13 |
2023-08-13 |
Not clear |
| Chunmei Wang, Yuan Luo, Jie Lu, Yingchao Wang, Guangyao Shen. Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells. Journal of biochemical and molecular toxicology. vol 30. issue 4. 2016-12-13. PMID:26616494. |
results show that pd could effectively inhibit the growth, arrest cells in s phase, and induce apoptosis of acute monocytic leukemia cell line thp-1; meanwhile, expression of cyclin d1 and bc1-2 decreased significantly, and expression of bax and cyclin a increased notably. |
2016-12-13 |
2023-08-13 |
Not clear |
| Anupam Bishayee, Animesh Mandal, Piyali Bhattacharyya, Deepak Bhati. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutrition and cancer. vol 68. issue 1. 2016-12-13. PMID:26699876. |
thus, pe exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of bax and downregulation of bcl2 in concert with caspase cascades. |
2016-12-13 |
2023-08-13 |
rat |
| Jianlin Qiao, Yun Liu, Depeng Li, Yulu Wu, Xiaoqian Li, Yao Yao, Mingshan Niu, Chunling Fu, Hongchun Li, Ping Ma, Zhenyu Li, Kailin Xu, Lingyu Zen. Imbalanced expression of Bcl-xL and Bax in platelets treated with plasma from immune thrombocytopenia. Immunologic research. vol 64. issue 2. 2016-12-13. PMID:26712345. |
bcl-xl and bax play an opposite role in the regulation of apoptotic process with bcl-xl for cell survival and bax for cell apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jianlin Qiao, Yun Liu, Depeng Li, Yulu Wu, Xiaoqian Li, Yao Yao, Mingshan Niu, Chunling Fu, Hongchun Li, Ping Ma, Zhenyu Li, Kailin Xu, Lingyu Zen. Imbalanced expression of Bcl-xL and Bax in platelets treated with plasma from immune thrombocytopenia. Immunologic research. vol 64. issue 2. 2016-12-13. PMID:26712345. |
given the critical roles in the regulation of platelet apoptosis, whether bcl-xl or bax was involved in the pathogenesis of itp remains unknown. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jianlin Qiao, Yun Liu, Depeng Li, Yulu Wu, Xiaoqian Li, Yao Yao, Mingshan Niu, Chunling Fu, Hongchun Li, Ping Ma, Zhenyu Li, Kailin Xu, Lingyu Zen. Imbalanced expression of Bcl-xL and Bax in platelets treated with plasma from immune thrombocytopenia. Immunologic research. vol 64. issue 2. 2016-12-13. PMID:26712345. |
in conclusion, imbalanced expression of bcl-xl and bax might be associated with platelet apoptosis in itp and therapeutically targeting them might be a novel approach in the treatment of itp. |
2016-12-13 |
2023-08-13 |
Not clear |
| Roberto D V S Morais, Ralph G Thomé, Hélio B Santos, Nilo Bazzoli, Elizete Rizz. Relationship between bcl-2, bax, beclin-1, and cathepsin-D proteins during postovulatory follicular regression in fish ovary. Theriogenology. vol 85. issue 6. 2016-12-13. PMID:26719039. |
morphometric analysis of the immunolabeling revealed a more intense reaction for bcl-2 and beclin-1 (becn1) in pofs at 0 to 1 dps and for bax at 2 to 3 dps (p < 0.001), the later period being the peak of apoptosis of the follicular cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Abhijnan Chattopadhyay, Decha Pinkaew, Hung Q Doan, Reed B Jacob, Sunil K Verma, Hana Friedman, Alan C Peterson, Muge N Kuyumcu-Martinez, Owen M McDougal, Ken Fujis. Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. Scientific reports. vol 6. 2016-12-13. PMID:26726832. |
fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific dna-binding domain of the tumor suppressor protein and preventing it from transcriptionally activating bax. |
2016-12-13 |
2023-08-13 |
mouse |
| Yang Guo, Yating Deng, Zikun Huang, Qing Luo, Yiping Peng, Jie Chen, Hong Jiang, Jianqing Ye, Junming L. EBP50 induces apoptosis in macrophages by upregulating nitric oxide production to eliminate intracellular Mycobacterium tuberculosis. Scientific reports. vol 6. 2016-12-13. PMID:26729618. |
we showed that ebp50 overexpression significantly increased the expression of inos and generation of nitric oxide (no), and ebp50-induced apoptosis was no-dependent and mediated by bax and caspase-3. |
2016-12-13 |
2023-08-13 |
Not clear |
| A Jain, T Jain, P Kumar, M Kumar, S De, M Gohain, R Kumar, T K Datt. Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes. Domestic animal endocrinology. vol 55. 2016-12-13. PMID:26774556. |
fsh supplementation in in vitro maturation-medium resulted in a dose-dependent reduction in the expression of proapoptotic genes namely, bcl2-associated x protein (bax), cytochrome c, and caspase-3 and increase in the expression of antiapoptotic genes such as b-cell lymphoma 2 (bcl2) and x-linked inhibitor of apoptosis protein (xiap) in cumulus cells of mature oocyte. |
2016-12-13 |
2023-08-13 |
Not clear |
| You-Cui Wang, Guo-Ying Feng, Qing-Jie Xia, Yue Hu, Yang Xu, Liu-Lin Xiong, Zhi-Wei Chen, Hang-Ping Wang, Ting-Hua Wang, Xue Zho. Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26822976. |
together, endogenous snca play a crucial role in motor and sensory function regulation, in which, the underlying mechanism may be linked to the regulation of apoptosis associated with apoptotic gene (bax, bcl2) and neurotrophic factors expression (ngf, bdnf and nt3). |
2016-12-13 |
2023-08-13 |
rat |
| Latif Reshi, Horng-Cherng Wu, Jen-Leih Wu, Hao-Ven Wang, Jiann-Ruey Hon. GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 4. 2016-12-13. PMID:26833308. |
taken altogether, these results suggested that aquatic gsiv st kinase could induce apoptosis via upregulation of p53 and bax expression, resulting in mitochondrial disruption, which activated a downstream caspases-mediated cell death pathway. |
2016-12-13 |
2023-08-13 |
Not clear |
| Mingming Zhu, Cong Huang, Xiao Ma, Rui Wu, Weiwei Zhu, Xiaoting Li, Zhaofeng Liang, Feifei Deng, Jianyun Zhu, Wei Xie, Xue Yang, Ye Jiang, Shijia Wang, Jieshu Wu, Shanshan Geng, Chunfeng Xie, Caiyun Zhon. Modulation of miR-19 in Aluminum-Induced Neural Cell Apoptosis. Journal of Alzheimer's disease : JAD. vol 50. issue 4. 2016-12-13. PMID:26836165. |
in the present study, we showed that aluminum maltolate (al-malt), a lipophilic al complex which is a common component of human diet with the ability to facilitate the entry of al into the brain, induced apoptosis in human neuroblastoma sh-sy5y cells, along with downregulation of mir-19a/mir-19b, upregulation of mir-19-targeted pten, and alterations of its downstream apoptosis related proteins including akt, p53, bax, and bcl-2. |
2016-12-13 |
2023-08-13 |
human |