| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Senft, A Weber, F Saathoff, C Berking, M V Heppt, C Kammerbauer, S Rothenfusser, S Kellner, Z Kurgyis, R Besch, G Häcke. In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins. Cell death & disease. vol 6. 2016-09-14. PMID:26610208. |
apoptosis depended on bak whereas bax was dispensable. |
2016-09-14 |
2023-08-13 |
human |
| D Senft, A Weber, F Saathoff, C Berking, M V Heppt, C Kammerbauer, S Rothenfusser, S Kellner, Z Kurgyis, R Besch, G Häcke. In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins. Cell death & disease. vol 6. 2016-09-14. PMID:26610208. |
activator bh3-only proteins were not required for apoptosis induction as apoptosis was unaltered in the absence of all bh3-only proteins known to activate bax or bak directly, bcl-2-interacting mediator of cell death, bh3-interacting domain death agonist and p53-upregulated modulator of apoptosis. |
2016-09-14 |
2023-08-13 |
human |
| Li-Min Zhang, Xiao-Chun Zhao, Wen-Bo Sun, Rui Li, Xiao-Jing Jian. Sevoflurane post-conditioning protects primary rat cortical neurons against oxygen-glucose deprivation/resuscitation via down-regulation in mitochondrial apoptosis axis of Bid, Bim, Puma-Bax and Bak mediated by Erk1/2. Journal of the neurological sciences. vol 357. issue 1-2. 2016-09-13. PMID:26152828. |
the results demonstrated that sevoflurane post-conditioning caused a marked decrease in cortical neuronal death secondary to ogd/r exposure through the downregulation of the mitochondrial apoptosis axis involving bid, bim, puma, bax, and bak that was mediated by the phosphorylation/activation of erk1/2. |
2016-09-13 |
2023-08-13 |
rat |
| YiMei Chen, Yanfang Zhang, Lin Li, Christian Hölsche. Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease. European journal of pharmacology. vol 768. 2016-09-13. PMID:26409043. |
drug treatment also increased levels of growth factor signaling molecule bax and reduced the apoptosis signaling molecule bcl-2. |
2016-09-13 |
2023-08-13 |
mouse |
| F Ke, S Grabow, G L Kelly, A Lin, L A O'Reilly, A Strasse. Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK. Cell death & disease. vol 6. 2016-09-13. PMID:26492371. |
it is well established that bax and bak play crucial, overlapping roles in the intrinsic pathway of apoptosis. |
2016-09-13 |
2023-08-13 |
mouse |
| Pingdong Lin, Xiaping Weng, Fayuan Liu, Yuhuan Ma, Houhuang Chen, Xiang Shao, Wenwei Zheng, Xianxiang Liu, Hongzhi Ye, Xihai L. Bushen Zhuangjin decoction inhibits TM-induced chondrocyte apoptosis mediated by endoplasmic reticulum stress. International journal of molecular medicine. vol 36. issue 6. 2016-09-12. PMID:26497741. |
to further elucidate the mechanisms responsible for the inhibitory effects of bzd on tm‑induced chondrocyte apoptosis mediated by er stress, the mrna and protein expression levels of binding immunoglobulin protein (bip), x‑box binding protein 1 (xbp1), activating transcription factor 4 (atf4), c/ebp‑homologous protein (chop), caspase‑9, caspase-3, b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) were measured by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analysis. |
2016-09-12 |
2023-08-13 |
rat |
| Tingting Yan, Yan Zhao, Xia Zhan. Acetaldehyde Induces Cytotoxicity of SH-SY5Y Cells via Inhibition of Akt Activation and Induction of Oxidative Stress. Oxidative medicine and cellular longevity. vol 2016. 2016-09-12. PMID:26649137. |
in this study, we investigated the cytotoxic effects of acetaldehyde in sh-sy5y cells and found that acetaldehyde induced apoptosis of sh-sy5y cells by downregulating the expression of antiapoptotic bcl-2 and bcl-xl and upregulating the expression of proapoptotic bax. |
2016-09-12 |
2023-08-13 |
Not clear |
| Mohan Shrestha, Pil-Hoon Par. p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 5. 2016-09-09. PMID:27610035. |
in addition, we also showed that knockdown of p53 restored suppression of caspase-3 activity by leptin through modulating bax expression and prevented leptin-induced cell cycle progression, implying the involvement of p53 signaling in the regulation of both apoptosis and cell cycle progression in cancer cells treated with leptin. |
2016-09-09 |
2023-08-13 |
Not clear |
| Zhen-Tao Mo, Wen-Na Li, Yu-Rong Zhai, Qi-Hai Gon. Icariin Attenuates OGD/R-Induced Autophagy via Bcl-2-Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-09-09. PMID:27610184. |
bcl-2 suppresses apoptosis by binding to bax and inhibits autophagy by binding to beclin-1 which is an autophagy related protein. |
2016-09-09 |
2023-08-13 |
Not clear |
| L Kong, X Zhou, Y Wu, Y Wang, L Chen, P Li, S Liu, S Sun, Y Ren, M Mei, X Wang, L Zhan. Targeting HOTAIR Induces Mitochondria Related Apoptosis and Inhibits Tumor Growth in Head and Neck Squamous Cell Carcinoma in vitro and in vivo. Current molecular medicine. vol 15. issue 10. 2016-09-08. PMID:26592246. |
protein expression analysis indicated that mitochondrial related cell death pathway (bcl-2, bax, caspase-3, cleaved caspase-3, cytochrome c) involved in hotair dependent apoptosis process. |
2016-09-08 |
2023-08-13 |
human |
| Yue Guan, Xiao-Xiao Wu, Jia-Lin Duan, Ying Yin, Chao Guo, Guo Wei, Yan-Hua Wang, Yan-Rong Zhu, Yan Weng, Miao-Miao Xi, Ai-Dong We. Effects and Mechanism of Combination of Rhein and Danshensu in the Treatment of Chronic Kidney Disease. The American journal of Chinese medicine. vol 43. issue 7. 2016-09-07. PMID:26503560. |
the combination also inhibited apoptosis by up-regulating bcl-2 and down-regulating bax. |
2016-09-07 |
2023-08-13 |
rat |
| Rui An, Lei Zhao, Cong Xi, Haixun Li, Guohong Shen, Haixiao Liu, Shumiao Zhang, Lijun Su. Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism. Basic research in cardiology. vol 111. issue 1. 2016-09-07. PMID:26671026. |
melatonin induced higher bcl-2 expression and lower bax expression, suggesting inhibition of apoptosis. |
2016-09-07 |
2023-08-13 |
rat |
| Anuradha Sehrawat, Shivendra V Sing. Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. Molecular carcinogenesis. vol 55. issue 5. 2016-09-06. PMID:25857724. |
prior studies from our laboratory have demonstrated a role for reactive oxygen species (ros)-dependent bax activation through the intermediary of c-jun n-terminal kinases in bitc-induced apoptosis in human breast cancer cells. |
2016-09-06 |
2023-08-13 |
mouse |
| Hye-Sook Seo, Jae Kyung Jo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Hyo In Kim, Soo-Yeon Kang, Kang Min Lee, Koong Won Nam, Namkyu Park, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu K. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. Bioscience reports. vol 35. issue 6. 2016-09-06. PMID:26500281. |
whereas, apigenin did not induce apoptosis via intrinsic mitochondrial apoptosis pathway since this compound did not decrease mitochondrial membrane potential without affecting the levels of b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax). |
2016-09-06 |
2023-08-13 |
Not clear |
| Z X Xia, Z X Li, M Zhang, L M Sun, Q F Zhang, X S Qi. CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway. Experimental and molecular pathology. vol 100. issue 2. 2016-09-06. PMID:26526492. |
carma3 knockdown increased cell apoptosis, as shown by flow cytometry, increased the mrna and protein expression levels of bax and caspase3, and downregulated bcl-2 in a549 and h1299 cells. |
2016-09-06 |
2023-08-13 |
Not clear |
| Thangavelu Soundara Rajan, Gina Rosalinda De Nicola, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzo. Anticancer activity of glucomoringin isothiocyanate in human malignant astrocytoma cells. Fitoterapia. vol 110. 2016-09-06. PMID:26882972. |
moringin showed to be effective in inducing apoptosis through p53 and bax activation and bcl-2 inhibition. |
2016-09-06 |
2023-08-13 |
human |
| b' M\\xc3\\xbccahit Se\\xc3\\xa7me, Canan Ero\\xc4\\x9flu, Yavuz Dodurga, G\\xc3\\xbclseren Ba\\xc4\\x9fc\\xc4\\xb. Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells. Gene. vol 585. issue 1. 2016-09-05. PMID:27032461.' |
oleuropein also induces apoptosis by inhibiting of bcl-2 and activating of bax,caspase-9 and caspase-3 gene expressions. |
2016-09-05 |
2023-08-13 |
Not clear |
| Fabien Llambi, Yue-Ming Wang, Bernadette Victor, Mao Yang, Desiree M Schneider, Sébastien Gingras, Melissa J Parsons, Janet H Zheng, Scott A Brown, Stéphane Pelletier, Tudor Moldoveanu, Taosheng Chen, Douglas R Gree. BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell. vol 165. issue 2. 2016-08-31. PMID:26949185. |
here, we report that bcl-2 ovarian killer (bok) is a bona fide yet unconventional effector of momp that can trigger apoptosis in the absence of both bax and bak. |
2016-08-31 |
2023-08-13 |
Not clear |
| Hong-Xia Zhang, Shan-Shan Jiang, Xiao-Fei Zhang, Zi-Qi Zhou, Qiu-Zhong Pan, Chang-Long Chen, Jing-Jing Zhao, Yan Tang, Jian-Chuan Xia, De-Sheng Wen. Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma. Oncotarget. vol 6. issue 33. 2016-08-30. PMID:26430962. |
ck2α-silenced resulted in significant apoptosis in cells that was demonstrated been associated with downregulation of expression of bcl-2, p-akt (ser473) and upregulation of expression of total p53, p-p53, bax, caspase3 and cleaved-caspase3 in hcc cells. |
2016-08-30 |
2023-08-13 |
mouse |
| Ling Han, Christian Hölscher, Guo-Fang Xue, Guanglai Li, Dongfang L. A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat. Neuroreport. vol 27. issue 1. 2016-08-30. PMID:26555034. |
furthermore, the expression of the apoptosis marker bax, the inflammation marker inos, and the survival marker bcl-2 was significantly increased. |
2016-08-30 |
2023-08-13 |
rat |