| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dimitar S Jakimov, Vesna V Kojić, Lidija D Aleksić, Gordana M Bogdanović, Jovana J Ajduković, Evgenija A Djurendić, Katarina M Penov Gaši, Marija N Sakač, Suzana S Jovanović-Šant. Androstane derivatives induce apoptotic death in MDA-MB-231 breast cancer cells. Bioorganic & medicinal chemistry. vol 23. issue 22. 2016-08-18. PMID:26494582. |
higher expression of pro-apoptotic bax, downregulation of anti-apoptotic bcl-2 and cleavage of parp protein were confirmed in almost all treated samples, but the lack of caspase-3 activation suggested the induction of apoptosis in caspase-independent manner. |
2016-08-18 |
2023-08-13 |
human |
| Björn Oettinghaus, Donato D'Alonzo, Elisa Barbieri, Lisa Michelle Restelli, Claudia Savoia, Maria Licci, Markus Tolnay, Stephan Frank, Luca Scorran. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochimica et biophysica acta. vol 1857. issue 8. 2016-08-18. PMID:26997499. |
while bax, bak double deficient (dko) and apaf1(-/-) mouse embryonic fibroblasts (mefs) were less susceptible to apoptosis by bcl-2 family member bid, h(2)o(2), staurosporine and thapsigargin, drp1(-/-) mefs were protected only from bid and h(2)o(2). |
2016-08-18 |
2023-08-13 |
mouse |
| Neha Rani, Saurabh Bharti, Jagriti Bhatia, T C Nag, Ruma Ray, Dharamvir Singh Ary. Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation. Chemico-biological interactions. vol 250. 2016-08-17. PMID:26972669. |
additionally, chrysin significantly reduced apoptosis as indicated by augmented bcl-2 expression and decreased bax and caspase-3 expressions. |
2016-08-17 |
2023-08-13 |
rat |
| Ibrahim Y Abdelrahman, Reham Helwa, Hausein Elkashef, Nagwa H A Hassa. Induction of P3NS1 Myeloma Cell Death and Cell Cycle Arrest by Simvastatin and/or γ-Radiation. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 16. 2016-08-16. PMID:26514497. |
the cell viability, induction of apoptosis, cell death, cell cycling, generation of ros, and expression of p53, bax, bcl2, caspase3, parp1 and fas genes were estimated. |
2016-08-16 |
2023-08-13 |
Not clear |
| V Bastos, J M P Ferreira de Oliveira, D Brown, H Jonhston, E Malheiro, A L Daniel-da-Silva, I F Duarte, C Santos, H Oliveir. The influence of Citrate or PEG coating on silver nanoparticle toxicity to a human keratinocyte cell line. Toxicology letters. vol 249. 2016-08-16. PMID:27021274. |
cit30 agnps clearly induced apoptotic death, while cells exposed to peg30 agnps appeared to be at an earlier phase of apoptosis, supported by changes in bax, bcl2 and casp-3 expressions. |
2016-08-16 |
2023-08-13 |
human |
| Yanhua Jiang, Rongrong Fu, Jiangyue Zhao, Di Wu, Guang Qiao, Ruoxi Li, Jinsong Zhan. Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26328919. |
the present study compared uv-induced cell apoptosis, activation of caspase-3 and caspase-9 and changes in protein expression levels of b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax) and phosphorylated extracellular signal-regulated kinase in wild-type and eaf2-knockout mice. |
2016-08-15 |
2023-08-13 |
mouse |
| Yanhua Jiang, Rongrong Fu, Jiangyue Zhao, Di Wu, Guang Qiao, Ruoxi Li, Jinsong Zhan. Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26328919. |
further functional studies indicated that eaf2 can induce the activation of caspase-3 and caspase-9, increase the protein expression of the pro-apoptotic protein bax and inhibit the expression of the anti-apoptotic protein bcl-2; thereby, eaf2 promotes cell apoptosis and is implicated in the formation and development of cataracts. |
2016-08-15 |
2023-08-13 |
mouse |
| Thomas E Krahe, Alexandre E Medina, Crystal L Lantz, Cláudio C Filgueira. Hyperactivity and depression-like traits in Bax KO mice. Brain research. vol 1625. 2016-08-15. PMID:26363094. |
the bax gene is a member of the bcl-2 gene family and its pro-apoptotic bcl-associated x (bax) protein is believed to be crucial in regulating apoptosis during neuronal development as well as following injury. |
2016-08-15 |
2023-08-13 |
mouse |
| Jingjing Li, Kan Chen, Sainan Li, Tong Liu, Fan Wang, Yujing Xia, Jie Lu, Yingqun Zhou, Chuanyong Gu. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PloS one. vol 11. issue 4. 2016-08-15. PMID:27035150. |
in addition, intrinsic and extrinsic apoptosis mediated by bax, bid, bcl-2, bcl-xl and caspase 3, 8, and 9 were inhibited by fucoidan and the action was associated with the tradd/traf2 and jak2/stat1 signal pathways. |
2016-08-15 |
2023-08-13 |
mouse |
| Wenjuan Xu, Linlin Jing, Quanshi Wang, Chung-Chih Lin, Xiaoting Chen, Jianxin Diao, Yuanliang Liu, Xuegang Su. Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution. Oncotarget. vol 6. issue 30. 2016-08-12. PMID:26356820. |
here we report that the pgam5l, but not pgam5s is a prerequisite for the activation of bax and dephosphorylation of drp1 in arenobufagin and staurosporine induced intrinsic apoptosis. |
2016-08-12 |
2023-08-13 |
Not clear |
| Xiquan Ke, Yan Zhao, Xinlan Lu, Zhe Wang, Yuanyuan Liu, Mudan Ren, Guifang Lu, Dan Zhang, Zhenguo Sun, Zhipeng Xu, Jee Hoon Song, Yulan Cheng, Stephen J Meltzer, Shuixiang H. TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling. Oncotarget. vol 6. issue 32. 2016-08-12. PMID:26416455. |
we observed that tq inhibited tumor cell growth in vitro, where treatment with tq arrested the cell cycle in g1 by upregulating p21 and downregulating cyclind1 and cdk2 expression; moreover, tq induced apoptosis by decreasing expression of bcl-2 and increasing expression of bax. |
2016-08-12 |
2023-08-13 |
mouse |
| Yong Wang, Fenghong Huang, Liang Zhao, Di Zhang, Ou Wang, Xiaoxuan Guo, Feng Lu, Xue Yang, Baoping Ji, Qianchun Den. Protective Effect of Total Flavones from Hippophae rhamnoides L. against Visible Light-Induced Retinal Degeneration in Pigmented Rabbits. Journal of agricultural and food chemistry. vol 64. issue 1. 2016-08-11. PMID:26653970. |
tfh ameliorated the retinal oxidative stress (gsh-px, cat, t-aoc, and mda), inflammation (il-1β and il-6), angiogenesis (vegf), and apoptosis (bax, bcl2, and caspase-3) induced by light exposure. |
2016-08-11 |
2023-08-13 |
cat |
| Kejuan Li, Yue Yu, Shuang Sun, Ye Liu, Sukant Garg, Sunil C Kaul, Zhongfang Lei, Ran Gao, Renu Wadhwa, Zhenya Zhan. Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots. PloS one. vol 11. issue 3. 2016-08-11. PMID:27010955. |
furthermore, aqhar-induced apoptosis was mediated by increase in pro-apoptotic proteins including cleaved parp, caspases and bax. |
2016-08-11 |
2023-08-13 |
mouse |
| Lijie Ma, Wangping Li, Ruixuan Wang, Yandong Nan, Qingwei Wang, Wei Liu, Faguang Ji. Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis. International journal of oncology. vol 47. issue 4. 2016-08-10. PMID:26314326. |
it has been found that resveratrol inhibited the proliferation of h838 and h520 cells in a dose- and time-dependent manner, and apoptosis was increased in cells treated with resveratrol which was associated with the depolarization of mitochondrial membrane potential, release of cytochrome c from mitochondria to cytosol, and abnormal expression of bcl-2 and bax proteins. |
2016-08-10 |
2023-08-13 |
human |
| Lijie Ma, Wangping Li, Ruixuan Wang, Yandong Nan, Qingwei Wang, Wei Liu, Faguang Ji. Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis. International journal of oncology. vol 47. issue 4. 2016-08-10. PMID:26314326. |
above all, resveratrol enhanced the effects of cisplatin on inhibition of cancer cell proliferation, induction of cell apoptosis, depolarization of mitochondrial membrane potential, release of cytochrome c and regulation on expression of bcl-2 and bax. |
2016-08-10 |
2023-08-13 |
human |
| SweeKeong Yeap, Muhammad Nadeem Akhtar, Kian Lam Lim, Nadiah Abu, Wan Yong Ho, Seema Zareen, Kiarash Roohani, Huynh Ky, Sheau Wei Tan, Nordin Lajis, Noorjahan Banu Alithee. Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line. Drug design, development and therapy. vol 9. 2016-08-09. PMID:25733816. |
western blot analysis also indicated that the dhaqc (2) increased bax, p53, and cytochrome c levels in mcf-7 cells, which subsequently activated apoptosis as observed in annexin v/propidium iodide and cell cycle analyses. |
2016-08-09 |
2023-08-13 |
human |
| Jin-Ping Li, Yin-Xue Yang, Qi-Lun Liu, Zhi-Wei Zhou, Shu-Ting Pan, Zhi-Xu He, Xueji Zhang, Tianxin Yang, Si-Yuan Pan, Wei Duan, Shu-Ming He, Xiao-Wu Chen, Jia-Xuan Qiu, Shu-Feng Zho. The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells. Drug design, development and therapy. vol 9. 2016-08-09. PMID:25733818. |
danu significantly decreased the expression of b-cell lymphoma-extra-large (bcl-xl) and b-cell lymphoma 2 (bcl-2), but increased the expression of bcl-2-associated x protein (bax) and p53-upregulated modulator of apoptosis (puma), and promoted the cleavage of caspases 3 and 9. |
2016-08-09 |
2023-08-13 |
human |
| Noraziah Nordin, Nazia Abdul Majid, Najihah Mohd Hashim, Mashitoh Abd Rahman, Zalila Hassan, Hapipah Mohd Al. Liriodenine, an aporphine alkaloid from Enicosanthellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and blocking cell cycle progression. Drug design, development and therapy. vol 9. 2016-08-09. PMID:25792804. |
apoptosis was confirmed at the protein level, including bax, bcl-2, and survivin, while interruption of the cell cycle was used for final validation of apoptosis. |
2016-08-09 |
2023-08-13 |
human |
| Noraziah Nordin, Nazia Abdul Majid, Najihah Mohd Hashim, Mashitoh Abd Rahman, Zalila Hassan, Hapipah Mohd Al. Liriodenine, an aporphine alkaloid from Enicosanthellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and blocking cell cycle progression. Drug design, development and therapy. vol 9. 2016-08-09. PMID:25792804. |
confirmation of apoptosis at the protein level showed overexpression of bax and suppression of bcl-2 and survivin. |
2016-08-09 |
2023-08-13 |
human |
| Wei Chen, Zhiming Jiang, Xiaoying Zhang, Jianguo Feng, Yutian Lin. N‑acetyl-S-(p-chlorophenylcarbamoyl)cysteine induces mitochondrial-mediated apoptosis and suppresses migration in melanoma cells. Oncology reports. vol 34. issue 5. 2016-08-08. PMID:26351874. |
taken together, all the results presented in this study including apoptotic induction, activation of the caspase‑3 and ‑9 cascade, upregulation of bax, downregulation of mcl‑1, cyto c release from the mitochondria, mitochondrial membrane potential depletion, ros production and cytosolic calcium elevation demonstrated that nacc triggered apoptosis in the uacc‑62 cells via the mitochondrial‑dependent pathway. |
2016-08-08 |
2023-08-13 |
human |