| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Hu, ZengMing Xia. Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 37. issue 3. 2016-08-08. PMID:26381132. |
formononetin induces apoptosis of human osteosarcoma cell line u2os by regulating the expression of bcl-2, bax and mir-375 in vitro and in vivo. |
2016-08-08 |
2023-08-13 |
human |
| Wei Hu, ZengMing Xia. Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 37. issue 3. 2016-08-08. PMID:26381132. |
this study investigates formononetin induction of apoptosis of human osteosarcoma cell line u2os by regulating bcl-2 and bax expression in vitro and in vivo. |
2016-08-08 |
2023-08-13 |
human |
| Yigao Wu, Wei Wang, Weilie Hu, Wenqing Xu, Ge Xiao, Qiwei Nie, Keyu Ouyang, Shuai Che. MicroRNA-205 suppresses the growth of adrenocortical carcinoma SW-13 cells via targeting Bcl-2. Oncology reports. vol 34. issue 6. 2016-08-08. PMID:26397843. |
further investigation into the mechanism found that activation of bcl-2 cleaved bax, releasing caspase-9 and -3 that are involved in the intrinsic apoptosis pathway, eventually inducing sw-13 cell apoptosis. |
2016-08-08 |
2023-08-13 |
Not clear |
| Rehab Hegazy, Abeer Salama, Dina Mansour, Azza Hassa. Renoprotective Effect of Lactoferrin against Chromium-Induced Acute Kidney Injury in Rats: Involvement of IL-18 and IGF-1 Inhibition. PloS one. vol 11. issue 3. 2016-08-08. PMID:26990190. |
tubular epithelial hyperplasia and apoptosis were demonstrated immunohistochemically by positive proliferating cell nuclear antigen (pcna), bax, and caspase-3 expression, respectively. |
2016-08-08 |
2023-08-13 |
rat |
| Ling Zhang, Shengtao Zhu, Xuesen Shi, Weihong Sh. The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. International journal of clinical and experimental pathology. vol 8. issue 8. 2016-08-03. PMID:26464652. |
the silence of p66(shc) in hct8 cells reduced the proliferation and accelerated the apoptosis, in addition, the expression of pro-apoptotic proteins caspase-3, caspase-9, bax was enhanced and the expression of anti-apoptotic protein bcl-2 was declined. |
2016-08-03 |
2023-08-13 |
Not clear |
| Jiayi Yang, Jianping Ning, Linlin Peng, Dan H. Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer. International journal of clinical and experimental pathology. vol 8. issue 8. 2016-08-03. PMID:26464676. |
this study aimed to explore the curcumin induced prostate cancer cell apoptosis and apoptosis related proteins bcl-2 and bax expression. |
2016-08-03 |
2023-08-13 |
mouse |
| Jiayi Yang, Jianping Ning, Linlin Peng, Dan H. Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer. International journal of clinical and experimental pathology. vol 8. issue 8. 2016-08-03. PMID:26464676. |
curcumin could inhibit pc-3 growth, decrease tumor volume, reduce tumor weight, and induce cell apoptosis under the skin of nude mice by up-regulating bax and down-regulating bcl-2. |
2016-08-03 |
2023-08-13 |
mouse |
| Yanjuan Hou, Shuangcheng Li, Ming Wu, Jinying Wei, Yunzhuo Ren, Chunyang Du, Haijiang Wu, Caili Han, Huijun Duan, Yonghong Sh. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. American journal of physiology. Renal physiology. vol 310. issue 6. 2016-08-03. PMID:26719366. |
ss-31 attenuated renal cell apoptosis and expression of bax and reversed the expression of bcl-2 in diabetic mice kidneys. |
2016-08-03 |
2023-08-13 |
mouse |
| Ishfaq Ahmed, Badal C Roy, Dharmalingam Subramaniam, Showkat Ahmad Ganie, Deep Kwatra, Dan Dixon, Shrikant Anant, Mohammad Afzal Zargar, Shahid Uma. An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. Carcinogenesis. vol 37. issue 4. 2016-08-03. PMID:26785732. |
the ar seed extract (ar extract) inhibited proliferation and colony formation in a dose- and time-dependent manner and promoted apoptosis as was evidenced by cleavage of parp and increased expression of bax accompanying reduced levels of bcl-xl protein in hct116 and sw480 cells, respectively. |
2016-08-03 |
2023-08-13 |
Not clear |
| Tetsuo Sato, Kazuko Kita, Chihomi Sato, Atsushi Kaned. Hochu‑ekki‑to (Bu‑zhong‑yi‑qi‑tang), a herbal medicine, enhances cisplatin‑induced apoptosis in HeLa cells. Molecular medicine reports. vol 12. issue 4. 2016-08-02. PMID:26239548. |
proteins associated with cell viability and apoptosis, including phosphorylated (p‑)akt, p53, b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax) and active caspase‑3 were analyzed by immunoblotting. |
2016-08-02 |
2023-08-13 |
Not clear |
| Huei-Yue Dai, Hui-Yu Chen, Wei-Chen Lai, Mien-Chie Hung, Long-Yuan L. Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma. Oncotarget. vol 6. issue 27. 2016-08-02. PMID:26247632. |
specifically, the combination of eafp-visa-bikdd plus dox markedly induced apoptosis via increased bax mitochondrial translocation and cytoplasmic cytochrome c release. |
2016-08-02 |
2023-08-13 |
mouse |
| Harish Chandra Pal, Ronald D Baxter, Katherine M Hunt, Jyoti Agarwal, Craig A Elmets, Mohammad Athar, Farrukh Afa. Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26299806. |
in addition, combination treatment resulted in enhanced (i) apoptosis, (ii) cleavage of caspase-3 and parp, (iii) expression of bax and bak, (iv) inhibition of bcl2 and mcl-1, and (v) inhibition of expression of pi3k, phosphorylation of mek1/2, erk1/2, akt and mtor. |
2016-08-02 |
2023-08-13 |
mouse |
| Pei-Hsun Sung, Hsin-Ju Chiang, Chih-Hung Chen, Yi-Ling Chen, Tien-Hung Huang, Yen-Yi Zhen, Meng-Wei Chang, Chu-Feng Liu, Sheng-Ying Chung, Yung-Lung Chen, Han-Tan Chai, Cheuk-Kwan Sun, Hon-Kan Yi. Combined Therapy With Adipose-Derived Mesenchymal Stem Cells and Ciprofloxacin Against Acute Urogenital Organ Damage in Rat Sepsis Syndrome Induced by Intrapelvic Injection of Cecal Bacteria. Stem cells translational medicine. vol 5. issue 6. 2016-08-02. PMID:27075767. |
protein expressions of apoptosis (bax, cleaved caspase 3 and poly[adp-ribose] polymerase 1, p21 protein [cdc42/rac]-activated kinase 2) and oxidative stress (oxidized protein, nadph oxidase (nox)-1, nox-2) in these organs showed an identical pattern compared with that of inflammation in all groups (all p < .001). |
2016-08-02 |
2023-08-13 |
rat |
| Zhimin Shi, Yan Li, Zhihai Liu, Jun Mi, Renxiao Wan. Theoretical Analysis of Fas Ligand-Induced Apoptosis with an Ordinary Differential Equation Model. Molecular informatics. vol 31. issue 11-12. 2016-08-02. PMID:27476734. |
it reveals the possible reasons for the transition between type-i and type-ii pathways and also provides some interesting predictions, such as the more decisive role of fas over bax in apoptosis pathway and a possible feedback mechanism between type-i and type-ii pathways. |
2016-08-02 |
2023-08-13 |
Not clear |
| Anup Singh Pathania, Santosh Kumar Guru, Nissar Ul Ashraf, Syed Riyaz-Ul-Hassan, Asif Ali, Sheikh Abdullah Tasduq, Fayaz Malik, Shashi Bhusha. A novel stereo bioactive metabolite isolated from an endophytic fungus induces caspase dependent apoptosis and STAT-3 inhibition in human leukemia cells. European journal of pharmacology. vol 765. 2016-08-01. PMID:26291658. |
it persuades apoptosis through both intrinsic and extrinsic pathways in above leukemic cell lines, which was evident through hoechst staining, annexin-v binding, cell cycle analysis, loss of mitochondrial membrane potential (Δψm), release of cytochrome c, bax, bid, over-expression of apical death receptors, activation of caspase-3,-8,-9 and parp (poly adp ribose polymerase) cleavage. |
2016-08-01 |
2023-08-13 |
human |
| Yuanxin Zhang, Zhiyao Hou, Yakun Ge, Kerong Deng, Bei Liu, Xuejiao Li, Quanshun Li, Ziyong Cheng, Ping'an Ma, Chunxia Li, Jun Li. DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for NIR-Responsive and Aptamer-Targeted Drug Delivery. ACS applied materials & interfaces. vol 7. issue 37. 2016-08-01. PMID:26325285. |
the underlying mechanism of apoptosis showed a strong synergistic inhibitory effect both on the expression of bcl-2, bcl-xl, mcl-1, and upregulated caspase 3/9 activity and on the expression level of bak and bax. |
2016-08-01 |
2023-08-13 |
Not clear |
| Wei-Lan Mo, Cheng-Zhi Chai, Jun-Ping Kou, Yong-Qing Yan, Bo-Yang Y. Sheng-Mai-San attenuates contractile dysfunction and structural damage induced by chronic intermittent hypoxia in mice. Chinese journal of natural medicines. vol 13. issue 10. 2016-08-01. PMID:26481374. |
mechanistically, the antioxidant effects of sms were demonstrated; sms was able to suppress mitochondrial apoptosis as indicated by the reduction of several pro-apoptotic factors (bax, cytochrome c, and cleaved caspase-3) and up-regulation of the anti-apoptosis factor bcl-2. |
2016-08-01 |
2023-08-13 |
mouse |
| Mei Ha, Li Wei, Xie Guan, Lianbing Li, Changjiang Li. p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity. Environmental pollution (Barking, Essex : 1987). vol 208. issue Pt B. 2016-08-01. PMID:26549752. |
activated p53 mediated hepatocyte apoptosis via the intrinsic mitochondrial pathway, inhibiting anti-apoptotic bcl-2 and bcl-xl and inducing pro-apoptotic bax, cytochrome c and caspases. |
2016-08-01 |
2023-08-13 |
human |
| Yuan Cui, Wei Liu, Wenping Xie, Wenlian Yu, Cheng Wang, Huiming Che. Investigation of the Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Apoptosis and Cell Cycle in a Zebrafish (Danio rerio) Liver Cell Line. International journal of environmental research and public health. vol 12. issue 12. 2016-08-01. PMID:26690195. |
cell apoptosis and cell cycle were detected by flow cytometry and the protein levels of p53, bcl-2, bax, caspase-3 and nf-κb p65 were determined by western blotting. |
2016-08-01 |
2023-08-13 |
zebrafish |
| Ling Li, Tongda Xu, Yinping Du, Defeng Pan, Wanling Wu, Hong Zhu, Yanbin Zhang, Dongye L. Salvianolic Acid A Attenuates Cell Apoptosis, Oxidative Stress, Akt and NF-κB Activation in Angiotensin-II Induced Murine Peritoneal Macrophages. Current pharmaceutical biotechnology. vol 17. issue 3. 2016-08-01. PMID:26873077. |
after cell identification, apoptosis was measured by dna strand break level with tdt-mediated dutp nick-end labeling (tunel) staining, and the expression of bcl-2 and bax. |
2016-08-01 |
2023-08-13 |
mouse |