| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Zhu, M Y Zhao, X H Li, Q Fu, Z F Zhou, C F Huang, X S Zhang, H L Huang, Y Tan, J X Li, J N Li, S Huang, M Ashraf, C Lu, J M Chen, J Zhuang, H M Gu. Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury. Genetics and molecular research : GMR. vol 14. issue 3. 2016-07-06. PMID:26400280. |
compared with group a, bax was expressed less and bcl2 more in group b, and there was less apoptosis in group b. hypothermia preserves hind limb motor function and reduces neuronal death, thereby protecting rats from scii. |
2016-07-06 |
2023-08-13 |
rat |
| Rekha Jakhar, Souren Paul, Monika Bhardwaj, Sun Chul Kan. Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis. Cancer letters. vol 372. issue 1. 2016-07-06. PMID:26739061. |
consequently, apoptosis by bax translocation, cytochrome c release, and caspase activation were triggered. |
2016-07-06 |
2023-08-13 |
Not clear |
| Ting Zhang, Yuanyuan Hu, Meng Tang, Lu Kong, Jiali Ying, Tianshu Wu, Yuying Xue, Yuepu P. Liver Toxicity of Cadmium Telluride Quantum Dots (CdTe QDs) Due to Oxidative Stress in Vitro and in Vivo. International journal of molecular sciences. vol 16. issue 10. 2016-07-01. PMID:26404244. |
an increase in ros generation with a concomitant increase in the gene expression of the tumor suppressor gene p53, the pro-apoptotic gene bcl-2 and a decrease in the anti-apoptosis gene bax, suggested that a mitochondria mediated pathway was involved in cdte qds' induced apoptosis. |
2016-07-01 |
2023-08-13 |
mouse |
| Marta Woźniak, Kamila Duś-Szachniewicz, Piotr Ziółkowsk. Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line. International journal of molecular sciences. vol 16. issue 10. 2016-07-01. PMID:26445041. |
the aim of this study was to investigate the expression of igf-2 after 5-aminolevulinic acid (5-ala)-mediated-pdt in sw620 human colorectal cancer cells with evaluation of cell proliferation and apoptosis and to determine the effects of pdt on the igf-2 receptor (igf-2r), igf-2 binding protein-1 (igf-2bp-1) and the proapoptotic protein, bax. |
2016-07-01 |
2023-08-13 |
human |
| Ho-Yiu Wong, Kuen-daw Tsai, Yi-Heng Liu, Shu-mei Yang, Ta-Wei Chen, Jonathan Cherng, Kuo-Shen Chou, Chen-Mei Chang, Belen T Yao, Jaw-Ming Chern. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytotherapy research : PTR. vol 30. issue 2. 2016-07-01. PMID:26676220. |
the results show that 2-mca suppressed proliferation and induced apoptosis as indicated by an upregulation of pro-apoptotic bax and bak genes and downregulation of anti-apoptotic bcl-2 and bcl-xl genes, mitochondrial membrane potential loss, cytochrome c release, activation of caspase-3 and -9, and morphological characteristics of apoptosis, including plasma membrane blebbing and long comet tail. |
2016-07-01 |
2023-08-13 |
mouse |
| Ming Xu, Yufeng Xie, Weihua Sheng, Jingcheng Miao, Jicheng Yan. Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis. Technology in cancer research & treatment. vol 14. issue 5. 2016-06-30. PMID:24750000. |
we demonstrated that ad-ing4 induced significant growth inhibition and apoptosis, upregulated the expression of p21, p27 and bax, downregulated the bcl-2 expression and activated caspase-3 in mg-63 human osteosarcoma cells. |
2016-06-30 |
2023-08-13 |
mouse |
| Qiang Yun, Mingfang Jiang, Jun Wang, Xiangyu Cao, Xinfeng Liu, Sheng Li, Baomin L. Overexpression Bax interacting factor-1 protects cortical neurons against cerebral ischemia-reperfusion injury through regulation of ERK1/2 pathway. Journal of the neurological sciences. vol 357. issue 1-2. 2016-06-29. PMID:26253702. |
bax interacting factor-1 (bif-1), a multifunctional protein, can regulate cell apoptosis and autophagy. |
2016-06-29 |
2023-08-13 |
Not clear |
| Jinhua Jiang, Shenggan Wu, Xinju Liu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zha. Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish. Environmental toxicology and pharmacology. vol 40. issue 2. 2016-06-29. PMID:26318563. |
results demonstrated that the transcription patterns of many key genes involved in the hypothalamic-pituitary-gonadal/thyroid (hpg/hpt) axis (e.g., vtg1, erβ1, cyp19a and trα), cell apoptosis pathway (e.g., bcl2, bax, p53 and cas8), as well as innate immunity (e.g., cxcl-c1c, il-1β and tnfα) were affected in newly hatched zebrafish after exposure to acetochlor. |
2016-06-29 |
2023-08-13 |
cat |
| Xilin Baoleri, Chao Dong, Yang Zhou, Zhaojun Zhang, Xueliang Lu, Pengming Xie, Yongqi L. Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26238307. |
in addition, an mtt assay was performed to measure the inhibitory rate of the drug, flow cytometry was used to detect alterations in apoptosis and the cell cycle, and western blot analysis was used to detect bcl‑2 and bax protein expression levels. |
2016-06-27 |
2023-08-13 |
human |
| Zhen Huang, Ye Xu, Wei Pen. Colchicine induces apoptosis in HT‑29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26299305. |
furthermore, colchicine treatment induced a loss of Δψm, increased ros production, activated caspase‑3, upregulated bax expression and downregulated bcl‑2 expression, which evidenced the colchicine activity on apoptosis, potentially by acting via the intrinsic apoptotic signaling pathway. |
2016-06-27 |
2023-08-13 |
human |
| Olga Amelkina, Lina Zschockelt, Johanna Painer, Rodrigo Serra, Francisco Villaespesa, Beate C Braun, Katarina Jewgeno. Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx. PloS one. vol 10. issue 11. 2016-06-27. PMID:26599641. |
our factors of interest included agents of the intrinsic apoptosis pathway, i.e., pro-survival b-cell cll/lymphoma 2 (bcl2) and pro-apoptotic bcl2-associated x protein (bax), the executioner caspase-3 (casp3), as well as of the extrinsic pathway, i.e., pro-apoptotic receptor fas, and tumor necrosis factor (tnf) and its receptors (pro-apoptotic tnfrsf1a and pro-survival tnfrsf1b). |
2016-06-27 |
2023-08-13 |
cat |
| Ingiridur Skirnisdottir, Tomas Seidal, Helena Åkeru. Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 25. issue 7. 2016-06-23. PMID:26035126. |
the objective of this study was to compare immunohistochemical profile for the apoptosis regulators p53, c-myc, bax, puma, and pten and the cell cycle regulatory proteins p21 and p27, as well as clinical factors between types i and ii tumors. |
2016-06-23 |
2023-08-13 |
Not clear |
| Kuan Zeng, Bao Ping Deng, Hui-Qi Jiang, Meng Wang, Ping Hua, Hong-Wu Zhang, Yu-Bin Deng, Yan-Qi Yan. Prostaglandin E₁ protects bone marrow-derived mesenchymal stem cells against serum deprivation-induced apoptosis. Molecular medicine reports. vol 12. issue 4. 2016-06-23. PMID:26252504. |
furthermore, treatment with pge1 significantly reduced sd‑induced apoptosis, decreased the protein expression levels of bax and caspase‑3, and increased the expression levels of bcl‑2. |
2016-06-23 |
2023-08-13 |
Not clear |
| Li Li, Meng Xu, Bo Shen, Man Li, Qian Gao, Shou-Gang We. Moderate exercise prevents neurodegeneration in D-galactose-induced aging mice. Neural regeneration research. vol 11. issue 5. 2016-06-23. PMID:27335566. |
the ameliorative changes were likely induced by an upregulation of bcl-2 and brain-derived neurotrophic factor, the repression of apoptosis factors such as fas and bax, and an increase in the activity of glucose transporters-1 and 4. |
2016-06-23 |
2023-08-13 |
mouse |
| Jéssica Arribas, Esteban Giménez, Ricard Marcos, Antonia Velázque. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26216026. |
consistently, apoptosis was reduced in tbx15 transfected cells (p < 0.01) which also showed a decrease of the proapoptotic bax regulator and an increase of the antiapoptotic bcl2 and bcl-xl regulators. |
2016-06-21 |
2023-08-13 |
Not clear |
| Ana Teresa G Fernandes, Natália P Rocha, Elena Vendrame, Fabio Russomano, Beatriz J Grinsztejn, Ruth K Friedman, Amanda C Pinto, Evandro M Klumb, Elyzabeth Avvad, Jacyara Macedo, Otoniel Martínez-Maza, Maria da Gloria Bonecini-Almeid. Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26272263. |
apoptosis is regulated by different pathways involving genes that either promote (bcl2 gene) or inhibit (bax gene) cell death. |
2016-06-21 |
2023-08-13 |
human |
| Xingzhen Lao, Bin Li, Meng Liu, Chen Shen, Tingting Yu, Xiangdong Gao, Heng Zhen. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26283169. |
further, compared with tα1 treatment, tα1-irgd treatment of mcf-7 cells considerably increased the number of cells undergoing apoptosis, resulting in a dose-dependent inhibition of cancer cell growth, which was associated with a much better effect on up-regulation of the expression of bcl2-associated x protein (bax), caspase 9, etc. |
2016-06-21 |
2023-08-13 |
mouse |
| Vijay Kumar Veena, Ravindra Naik Popavath, Kamaraj Kennedy, Natarajan Sakthive. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacetylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10. Apoptosis : an international journal on programmed cell death. vol 20. issue 10. 2016-06-21. PMID:26283170. |
the dapg induced apoptosis in cancer cells by intrinsic and extrinsic pathways via the release of cytochrome-c, upregulation of bax and the activation of caspases and also, exhibited anti-inflammatory activity by the inhibition of lps-inflammed cell proliferation of macrophage (raw 264.7), monocytic cells (thp-1) and peripheral blood mononuclear cells (pbmcs). |
2016-06-21 |
2023-08-13 |
Not clear |
| Unnur Arna Thorsteinsdottir, Margret Thorsteinsdottir, Ian Henry Lamber. Protolichesterinic Acid, Isolated from the Lichen Cetraria islandica, Reduces LRRC8A Expression and Volume-Sensitive Release of Organic Osmolytes in Human Lung Epithelial Cancer Cells. Phytotherapy research : PTR. vol 30. issue 1. 2016-06-21. PMID:26549524. |
25% reduction in cell viability as well as 1.3-, 1.5- and 3.3-fold increase in the expression of lrrc8a, bax (regulator of apoptosis) and p21 (regulator of cell cycle progression), respectively. |
2016-06-21 |
2023-08-13 |
human |
| Maria Cosenza, Monica Civallero, Samantha Pozzi, Luigi Marcheselli, Alessia Bari, Stefano Sacch. The combination of bortezomib with enzastaurin or lenalidomide enhances cytotoxicity in follicular and mantle cell lymphoma cell lines. Hematological oncology. vol 33. issue 4. 2016-06-20. PMID:25394177. |
the significant increase of apoptosis was mediated by an increased ratio of pro-apoptotic proteins (bax, bad and bim) to anti-apoptotic proteins (bcl-2, bcl-xl and mcl-1), triggering the cleavage of caspases -3, -9, -8 and parp. |
2016-06-20 |
2023-08-13 |
Not clear |