| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samaher Besbes, Massoud Mirshahi, Marc Pocard, Christian Billar. Strategies targeting apoptosis proteins to improve therapy of chronic lymphocytic leukemia. Blood reviews. vol 29. issue 5. 2016-06-01. PMID:25887155. |
recent results suggest that the development of bh3 mimetics capable of directly activating the apoptosis effectors bax and bak may also be envisaged. |
2016-06-01 |
2023-08-13 |
Not clear |
| Lu Zhao, Yi Feng, Aiwei Shi, Yujin Zong, Mingxi Wa. Apoptosis Induced by Microbubble-Assisted Acoustic Cavitation in K562 Cells: The Predominant Role of the Cyclosporin A-Dependent Mitochondrial Permeability Transition Pore. Ultrasound in medicine & biology. vol 41. issue 10. 2016-06-01. PMID:26164288. |
furthermore, mitochondrial dysfunction and apoptosis were significantly inhibited by cyclosporin a, a classic inhibitor of the mitochondrial permeability transition pore; however, the inhibitor of bax protein, bax-inhibiting peptide, could not suppress these effects. |
2016-06-01 |
2023-08-13 |
Not clear |
| Hui Chang, Juan-Juan Sheng, Lin Zhang, Zhi-Jie Yue, Bo Jiao, Jin-Sheng Li, Zhi-Bin Y. ROS-Induced Nuclear Translocation of Calpain-2 Facilitates Cardiomyocyte Apoptosis in Tail-Suspended Rats. Journal of cellular biochemistry. vol 116. issue 10. 2016-05-31. PMID:25820554. |
in summary, the above results suggest that iso increased noxs-derived ros which activated nuclear translocation of calpain-2, subsequently nuclear calpain-2 degraded camk ii δb which reduced the ratio of bcl-2 to bax, and finally the mitochondria apoptosis pathway was triggered in tail-suspended rat cardiomyocytes. |
2016-05-31 |
2023-08-13 |
rat |
| Gati Krushna Panigrahi, Ashish Yadav, Ashish Srivastava, Anurag Tripathi, S Raisuddin, Mukul Da. Mechanism of rhein-induced apoptosis in rat primary hepatocytes: beneficial effect of cyclosporine A. Chemical research in toxicology. vol 28. issue 6. 2016-05-31. PMID:25915446. |
at the molecular level, rhein-induced dna damage results in overexpression of γ-h2ax protein (2.5-fold), thereby causing enhancement of p53 (4.5-fold) and p21 (3.6-fold), leading to intrinsic pathway-mediated apoptosis involving bax, bcl2, cytochrome c, caspases 3 and 9, and poly-adp ribose polymerase. |
2016-05-31 |
2023-08-13 |
rat |
| Soumya C Iyer, Ashidha Gopal, Devaraj Halagowde. Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma. Molecular and cellular biochemistry. vol 407. issue 1-2. 2016-05-31. PMID:26104578. |
the analysis of gene expression revealed that myricetin inhibits pak1 by abrogating the ras-mediated signaling by decelerating wnt signaling, the downstream of erk/akt, thereby inducing intrinsic caspase-mediated mitochondrial apoptosis by downregulating the expression of anti-apoptotic bcl-2 and survivin and upregulating pro-apoptotic bax. |
2016-05-31 |
2023-08-13 |
Not clear |
| Brian H May, Shiqiang Deng, Anthony L Zhang, Chuanjian Lu, Charlie C L Xu. In silico database screening of potential targets and pathways of compounds contained in plants used for psoriasis vulgaris. Archives of dermatological research. vol 307. issue 7. 2016-05-31. PMID:26142738. |
all four tms contained compounds that had regulating effects on apoptosis regulator bax, apoptosis regulator bcl-2, caspase-3, tumor necrosis factor (tnf) or prostaglandin g/h synthase 2 (cox2). |
2016-05-31 |
2023-08-13 |
Not clear |
| Aihong Li, Lei Li, Xiaolei Sun, Yaohui Ni, Xin Chen, Aisong Guo, Xiaomei Che. Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats. Neurochemical research. vol 40. issue 8. 2016-05-27. PMID:26123482. |
furthermore, immunofluorescent staining revealed that mpv17 co-localized with p53, bax and active caspase-3 in neurons, suggesting its biological function in the process of neuronal apoptosis. |
2016-05-27 |
2023-08-13 |
rat |
| Lilly Magdalena Weiß, Manuela Hugle, Sarah Romero, Simone Fuld. Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells. International journal of cancer. vol 138. issue 2. 2016-05-27. PMID:26260582. |
this inactivation of anti-apoptotic bcl-2 family proteins in turn promotes activation of bax and bak, activation of caspase-9 and -3 and caspase-dependent apoptosis. |
2016-05-27 |
2023-08-13 |
Not clear |
| Lilly Magdalena Weiß, Manuela Hugle, Sarah Romero, Simone Fuld. Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells. International journal of cancer. vol 138. issue 2. 2016-05-27. PMID:26260582. |
overexpression of bcl-2 or simultaneous knockdown of bax and bak significantly rescue bi 6727/vcr-induced apoptosis, indicating that engagement of the mitochondrial pathway is critical for bi 6727/vcr-mediated apoptosis. |
2016-05-27 |
2023-08-13 |
Not clear |
| Zhiliang Wu, Thidarut Boonmars, Isao Nagano, Sirintip Boonjaraspinyo, Piyarat Srinontong, Panaratana Ratasuwan, Khuntikeo Narong, Phuangphaka Sadee Nielsen, Yoichi Maekaw. Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma. International journal of cancer. vol 138. issue 2. 2016-05-27. PMID:26312563. |
s100p knockdown also promoted cca cell apoptosis by up-regulating expression of apoptosis related factors, dr5, tradd, caspase 3 and bax, and increased the sensitivity of cca cells to the chemotherapeutic agents sunitinib and apigenin. |
2016-05-27 |
2023-08-13 |
Not clear |
| Yuki Nishida, Aya Maeda, Dhruv Chachad, Jo Ishizawa, Yi Hua Qiu, Steven M Kornblau, Shinya Kimura, Michael Andreeff, Kensuke Kojim. Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy. Cancer science. vol 106. issue 12. 2016-05-27. PMID:26450753. |
treatment with ptc-209 reduced protein level of bmi-1 and its downstream target mono-ubiquitinated histone h2a and triggered several molecular events consistent with the induction of apoptosis, this is, loss of mitochondrial membrane potential, caspase-3 cleavage, bax activation, and phosphatidylserine externalization. |
2016-05-27 |
2023-08-13 |
Not clear |
| Yixiang Han, Aifang Ye, Yan Zhang, Zhimin Cai, Wei Wang, Lan Sun, Songfu Jiang, Jianbo Wu, Kang Yu, Shenghui Zhan. Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin. PloS one. vol 10. issue 8. 2016-05-26. PMID:26308531. |
msi2 silencing induced apoptosis through down-regulation of bcl-2 expression and up-regulation of bax expression. |
2016-05-26 |
2023-08-13 |
Not clear |
| Bin-bin Wang, Xiao-hu Wang, Kai Liu, Shao-bo Sun, Peng Song, Ying-dong L. [Enhanced radiosensitivity of H22 ascitic tumor to 12C6+ ions radiation in ultra-filtration extract mixture from Astragalus mongholicus-treated mice]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 12. 2016-05-26. PMID:27169282. |
the body weights, abdomen circumference of the mice were measured and the mouse behavior was monitored every day; survival time was recorded to evaluate life extension effect; flow cytometry technique was used to detect h22 cell apoptosis and cell cycle; protein levels of p53, bax, bcl-2 and cleaved caspase-3 were analyzed by western blot; the single cell gel electrophoresis was used to detect the level of deoxyribonucleic acid damage (dna damage). |
2016-05-26 |
2023-08-13 |
mouse |
| Xiao-Fei Zhang, Qiu-Zhong Pan, Ke Pan, De-Sheng Weng, Qi-Jing Wang, Jing-Jing Zhao, Jia He, Qing Liu, Dan-Dan Wang, Shan-Shan Jiang, Hai-Xia Zheng, Lin Lv, Chang-Long Chen, Hong-Xia Zhang, Jian-Chuan Xi. Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma. Molecular carcinogenesis. vol 55. issue 1. 2016-05-24. PMID:25557723. |
silencing of ube4b expression by sirna inhibited the proliferation, colony formation, migration and invasion of hcc cells in vitro, and resulted in significant apoptosis that was associated with downregulation of expression of bcl-2 and upregulation of expression of total p53, p-p53, bax and cleaved-caspase3 in hcc cells. |
2016-05-24 |
2023-08-13 |
human |
| Saeideh Jafarinejad-Farsangi, Ali Farazmand, Mahdi Mahmoudi, Farhad Gharibdoost, Elham Karimizadeh, Farshid Noorbakhsh, Habibeh Faridani, Ahmad Reza Jamshid. MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. Autoimmunity. vol 48. issue 6. 2016-05-24. PMID:25857445. |
microrna-29a induces apoptosis via increasing the bax:bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. |
2016-05-24 |
2023-08-13 |
Not clear |
| Saeideh Jafarinejad-Farsangi, Ali Farazmand, Mahdi Mahmoudi, Farhad Gharibdoost, Elham Karimizadeh, Farshid Noorbakhsh, Habibeh Faridani, Ahmad Reza Jamshid. MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. Autoimmunity. vol 48. issue 6. 2016-05-24. PMID:25857445. |
transfection of both ssc and transforming growth factor-β (tgf-β) stimulated fibroblasts by mir-29a mimic, significantly decreased the expression of two anti-apoptotic members of the bcl-2 family, bcl-2 (p = 0.0005, p = 0.01) and bcl-xl (p = 0.0001, p = 0.006), resulted in enhanced bax:bcl-2 ratio and induced a high rate of apoptosis. |
2016-05-24 |
2023-08-13 |
Not clear |
| Teng Zong, Lidan Lai, Jia Hu, Meijun Guo, Mo Li, Lu Zhang, Chengxue Zhong, Bei Yang, Lei Wu, Dalei Zhang, Min Tang, Haibin Kuan. Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and development in pregnant mice. Journal of hazardous materials. vol 297. 2016-05-24. PMID:25935407. |
dehp administration disrupted labyrinth vascularization of placentas, and inhibited proliferation and induced apoptosis of placenta by the activation of caspase-3 and -8, up-regulation of bax and down-regulation of bcl-2 mrna and protein at gd 13. |
2016-05-24 |
2023-08-13 |
mouse |
| Yangyang Pan, Yan Cui, Abdul Rasheed Baloch, Jiangfeng Fan, Junfeng He, Guyue Li, Hongfei Zheng, Yifu Zhang, Peng Lv, Sijiu Y. Insulinlike growth factor I improves yak (Bos grunniens) spermatozoa motility and the oocyte cleavage rate by modulating the expression of Bax and Bcl-2. Theriogenology. vol 84. issue 5. 2016-05-24. PMID:26065339. |
in conclusion, this research reports that improvements in yak spermatozoa motility and the oocyte cleavage rate after the addition of igf-i may be a result of the reduction of spermatozoa apoptosis rates by modulating the expression of bax and bcl-2. |
2016-05-24 |
2023-08-13 |
Not clear |
| D Yugandhar, V Lakshma Nayak, Sivakumar Archana, Kunta Chandra Shekar, Ajay Kumar Srivastav. Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption. European journal of medicinal chemistry. vol 101. 2016-05-24. PMID:26163220. |
furthermore, western blot analysis suggested that these compounds up-regulate the levels of p53, p21, p27 and bax, and down-regulate the level of bcl-2 confirming the apoptosis inducing properties. |
2016-05-24 |
2023-08-13 |
human |
| Zhijun Wang, Danfeng Xu, Yi Gao, Yushan Liu, Jizhong Ren, Yacheng Yao, Lei Yin, Jie Chen, Sishun Gan, Xingang Cu. Immature Colon Carcinoma Transcript 1 Is Essential for Prostate Cancer Cell Viability and Proliferation. Cancer biotherapy & radiopharmaceuticals. vol 30. issue 7. 2016-05-24. PMID:26186090. |
knockdown of ict1 induced apoptosis through activation of poly adp-ribose polymerase and caspase 3, upregulation of bax expression, and downregulation of bcl-2 expression in du145 cells. |
2016-05-24 |
2023-08-13 |
human |