| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z T Gu, L Li, F Wu, P Zhao, H Yang, Y S Liu, Y Geng, M Zhao, L S. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports. vol 5. 2016-05-16. PMID:26105784. |
heat stress induced apoptosis is triggered by transcription-independent p53, ca(2+) dyshomeostasis and the subsequent bax mitochondrial translocation. |
2016-05-16 |
2023-08-13 |
Not clear |
| Z T Gu, L Li, F Wu, P Zhao, H Yang, Y S Liu, Y Geng, M Zhao, L S. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports. vol 5. 2016-05-16. PMID:26105784. |
furthermore, we demonstrated that generation of reactive oxygen species (ros) is a critical mediator in heat stress induced apoptosis and that the antioxidant mntbap significantly decreased heat stress induced p53 mitochondrial translocation and ca(2+) signal mediated mptp opening, as well as the subsequent bax mitochondrial translocation and activation of the caspase cascade. |
2016-05-16 |
2023-08-13 |
Not clear |
| Z T Gu, L Li, F Wu, P Zhao, H Yang, Y S Liu, Y Geng, M Zhao, L S. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports. vol 5. 2016-05-16. PMID:26105784. |
taken together, our results indicate that heat stress induces apoptosis through the mitochondrial pathway with ros dependent mitochondrial p53 translocation and ca(2+) dyshomeostasis, and the ensuing intro bax mitochondrial translocation as the upstream events involved in triggering the apoptotic process observed upon cellular exposure to heat stress. |
2016-05-16 |
2023-08-13 |
Not clear |
| H R Zhang, J H Peng, G Y Zhu, R X X. Neuroprotective effects of Bcl-2 overexpression on nerve cells of rats with acute cerebral infarction. Genetics and molecular research : GMR. vol 14. issue 3. 2016-05-16. PMID:26214450. |
we induced cerebral artery infarction using a suture-occlusion method and analyzed the cerebral expression levels of apoptosis-related genes (caspase-3, bax), total cerebral apoptosis, range of cerebral tissue infarction, and changes in nerve cell function after 72 h. the bcl-2-encoding lentivirus was well expressed in rat cerebral tissues. |
2016-05-16 |
2023-08-13 |
rat |
| Denis R Burton, Sofia Caria, Bevan Marshall, Michele Barry, Marc Kvansaku. Structural basis of Deerpox virus-mediated inhibition of apoptosis. Acta crystallographica. Section D, Biological crystallography. vol 71. issue Pt 8. 2016-05-12. PMID:26249341. |
here, it is reported that the deerpox virus inhibitor of apoptosis, dpv022, only engages a highly restricted set of death-inducing bcl-2 proteins, including bim, bax and bak, with modest affinities. |
2016-05-12 |
2023-08-13 |
Not clear |
| M F Maioral, L D S Bubniak, M A L Marzarotto, A C R De Moraes, P Leal, R Nunes, R A Yunes, M C Santos-Silv. Molecular Cytotoxic Mechanisms of 1-(3,4,5-Trihydroxyphenyl)-dodecylbenzoate in Human Leukemia Cell Lines. Indian journal of pharmaceutical sciences. vol 78. issue 1. 2016-05-12. PMID:27168690. |
thus, it is possible to conclude that 1-(3,4,5-trihydroxyphenyl)-dodecylbenzoate induces apoptosis by inhibiting the antiapoptotic protein bcl-2 and by increasing the release of aif, bax and p53. |
2016-05-12 |
2023-08-13 |
human |
| Ming Xu, Yufeng Xie, Weihua Sheng, Jingcheng Miao, Jicheng Yan. Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis. Technology in cancer research & treatment. vol 14. issue 4. 2016-05-10. PMID:25326586. |
we demonstrated that ad-ing4 induced significant growth inhibition and apoptosis, upregulated the expression of p21, p27 and bax, downregulated the bcl-2 expression and activated caspase-3 in mg-63 human osteosarcoma cells. |
2016-05-10 |
2023-08-13 |
mouse |
| Fangfang Cheng, Yanjing Yang, Li Zhang, Yudan Cao, Weifeng Yao, Yuping Tang, Anwei Din. A Natural Triterpene Derivative from Euphorbia kansui Inhibits Cell Proliferation and Induces Apoptosis against Rat Intestinal Epithelioid Cell Line in Vitro. International journal of molecular sciences. vol 16. issue 8. 2016-05-10. PMID:26274958. |
in addition, kansenone could up-regulate the apoptotic proteins bax, aif, apaf-1, cytochrome c, caspase-3, caspase-9, caspase-8, fasr, fasl, nf-κb, and tnfr1 mrna expression levels, and down-regulate the anti-apoptotic bcl-2 family proteins, revealing that kansenone induces apoptosis through both the death receptor and mitochondrial pathways. |
2016-05-10 |
2023-08-13 |
rat |
| Pengfei Xu, Yingjie Zhang, Yunye Liu, Qingyan Yuan, Liying Song, Mingyao Liu, Zhihang Liu, Yongbi Yang, Junyan Li, Deshan Li, Guiping Re. Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways. Toxicology and applied pharmacology. vol 290. 2016-05-10. PMID:26592322. |
besides, fgf-21 treatment caused activated hsc apoptosis with increasing expression of caspase-3, and decreased the ratio of bcl-2 to bax. |
2016-05-10 |
2023-08-13 |
mouse |
| Jun-Shan Mu, Hang Lin, Jian-Xin Ye, Min Lin, Xiao-Ping Cu. Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease. Molecular medicine reports. vol 12. issue 3. 2016-05-09. PMID:26016457. |
the expression levels of the endoplasmic reticulum (er) stress biomarker, glucose‑regulated protein 78 (grp78), and the mitochondrial apoptosis biomarkers, b‑cell lymphoma 2 (bcl‑2) and bcl‑2‑associated x protein (bax), were analyzed by western blotting. |
2016-05-09 |
2023-08-13 |
rat |
| Nahee Park, Hyoung Seok Baek, Young-Jin Chu. Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling. PloS one. vol 10. issue 8. 2016-05-09. PMID:26252009. |
we observed that embelin induced apoptosis of pc3 cells in a time-dependent manner correlated with decreased expression of bcl-2, bcl-xl, and mcl-1, increased translocation of bax into mitochondria, and a reduction in the mitochondrial membrane potential. |
2016-05-09 |
2023-08-13 |
human |
| Mohammad Adnan Siddiqui, Sushovita Mukherjee, Praveen Manivannan, Krishnamurthy Malath. RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1. International journal of molecular sciences. vol 16. issue 8. 2016-05-09. PMID:26263979. |
the caspase 3-cleaved c-terminal fragment of beclin-1 enhances apoptosis by translocating to the mitochondria along with proapoptotic protein, bax, and inducing release of cytochrome c to the cytosol. |
2016-05-09 |
2023-08-13 |
Not clear |
| Shize Li, Xuecheng Lv, Kaihua Zhai, Ruyan Xu, Yong Zhang, Songyao Zhao, Xiaoming Qin, Liujie Yin, Jiyu Lo. MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158385. |
microrna-7 inhibits neuronal apoptosis in a cellular parkinson's disease model by targeting bax and sirt2. |
2016-05-09 |
2023-08-13 |
Not clear |
| Shize Li, Xuecheng Lv, Kaihua Zhai, Ruyan Xu, Yong Zhang, Songyao Zhao, Xiaoming Qin, Liujie Yin, Jiyu Lo. MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158385. |
the altered molecular expressions downstream of bax and sirt2 are also involved in mir-7 regulation of the mpp(+)-triggered neuronal apoptosis. |
2016-05-09 |
2023-08-13 |
Not clear |
| Chia-Lo Chang, Pei-Hsun Sung, Cheuk-Kwan Sun, Chih-Hung Chen, Hsin-Ju Chiang, Tien-Hung Huang, Yi-Ling Chen, Yen-Yi Zhen, Han-Tan Chai, Sheng-Ying Chung, Meng-Shen Tong, Hsueh-Wen Chang, Hong-Hwa Chen, Hon-Kan Yi. Protective effect of melatonin-supported adipose-derived mesenchymal stem cells against small bowel ischemia-reperfusion injury in rat. Journal of pineal research. vol 59. issue 2. 2016-05-06. PMID:26013733. |
the ischemic mucosal damage score, the protein expressions of inflammation (tnf-α, nf-κb, mmp-9, mpo, and inos), oxidative stress (nox-1, nox-2, and oxidized protein), apoptosis (apaf-1, mitochondrial bax, cleaved caspase-3 and parp), mitochondrial damage (cytosolic cytochrome c) and dna damage (γ-h2ax) markers, as well as cellular expressions of proliferation (pcna), apoptosis (caspase-3, tunel assay), and dna damage (γ-h2ax) showed an identical pattern, whereas mitochondrial cytochrome c exhibited an opposite pattern compared to that of inflammation among all groups (all p < 0.001). |
2016-05-06 |
2023-08-13 |
rat |
| Chunshu Fang, Jingqing Zhang, Di Qi, Xiaoqing Fan, Jianchun Luo, Ling Liu, Qunyou Ta. Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells. PloS one. vol 9. issue 12. 2016-05-05. PMID:25506932. |
evo induced cell cycle arrest at g2/m phase, induced apoptosis by up-regulating the expression of caspase-12 and cytochrome c protein, and induced the expression of bax mrna and by down-regulating of the expression of bcl-2 mrna in both h446 and h1688 cells. |
2016-05-05 |
2023-08-13 |
human |
| Hayato Hikita, Takahiro Kodama, Satoshi Tanaka, Yoshinobu Saito, Yasutoshi Nozaki, Tasuku Nakabori, Satoshi Shimizu, Yoshito Hayashi, Wei Li, Minoru Shigekawa, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehar. Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damage in Hepatocytes That Contribute to Liver Tumorigenesis. Cancer prevention research (Philadelphia, Pa.). vol 8. issue 8. 2016-05-05. PMID:26038117. |
hepatic apoptosis, regeneration, accumulation of oxidative damages, and tumorigenesis observed in hepatocyte-specific mcl-1 knockout mice were substantially attenuated by further deficiency of bax or bid, suggesting that a balance of mitochondrial bcl-2 family proteins governs generation of oxidative stress and other pathologies. |
2016-05-05 |
2023-08-13 |
mouse |
| Utpal K Karmakar, Naoki Ishikawa, Kazufumi Toume, Midori A Arai, Samir K Sadhu, Firoj Ahmed, Masami Ishibash. Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium. Bioorganic & medicinal chemistry. vol 23. issue 15. 2016-05-04. PMID:26081757. |
compounds 1 and 5 enhanced the levels of apoptosis inducing proteins dr4, dr5, p53, chop, bax, cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9 and also decreased the levels of cell survival protein bcl-2 in trail-resistant ags cells in a dose-dependent manner. |
2016-05-04 |
2023-08-13 |
Not clear |
| Katelin E Ahlers, Bahri Karaçay, Leah Fuller, Daniel J Bonthius, Michael E Daile. Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration. Glia. vol 63. issue 10. 2016-05-03. PMID:25856413. |
alcohol-induced microglial activation and pro-inflammatory factor expression were largely abolished in bax null mice lacking neuroapoptosis, indicating that microglial activation is primarily triggered by apoptosis rather than the alcohol. |
2016-05-03 |
2023-08-13 |
mouse |
| Xuemin Zhang, Wenyu Hu, Fang Wu, Xue Yuan, Jian H. Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells. Canadian journal of physiology and pharmacology. vol 93. issue 8. 2016-05-03. PMID:26042337. |
further study revealed that shikonin regulates the activation of nuclear factor kappa b and phosphatidyl inositol 3-kinase signaling pathways; modulates the expression of cyclin d1, cyclin e, b-cell lymphoma 2, and bax; activates caspase-3 and caspase-9; induces cell cycle arrest; and promotes the apoptosis of vsmcs. |
2016-05-03 |
2023-08-13 |
rat |