| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Bao, Ran Liu, Yonglu Wang, Fei Wang, Guohua Xia, Haijun Zhang, Xueming Li, Haixiang Yin, Baoan Che. PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway. International journal of nanomedicine. vol 10. 2016-04-21. PMID:25609961. |
meanwhile, cell apoptosis in the excised xenografts was measured by transferase-mediated dutp nick-end labeling assay, and the expression of apoptosis-related proteins, including bcl-2, bax, caspase-9, caspase-3, and cleaved-parp, was determined by western blotting analysis. |
2016-04-21 |
2023-08-13 |
Not clear |
| Jason Karch, Onur Kanisicak, Matthew J Brody, Michelle A Sargent, Demetria M Michael, Jeffery D Molkenti. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PloS one. vol 10. issue 6. 2016-04-21. PMID:26061004. |
during apoptosis the pro-death bcl-2 family members bax and bak induce mitochondrial outer membrane permeabilization (momp) to mediate cell death. |
2016-04-21 |
2023-08-13 |
mouse |
| Isabel C O Morais, Gustavo J S Pereira, M Orzáez, Roberta J B Jorge, Claudia Bincoletto, Marcos H Toyama, Helena S A Monteiro, Soraya S Smaili, Enrique Pérez-Payá, Alice M C Martin. L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. PloS one. vol 10. issue 7. 2016-04-21. PMID:26193352. |
mdck apoptosis induction was accompanied by ca2+ release from the endoplasmic reticulum, reactive oxygen species (ros) generation and mitochondrial dysfunction with enhanced expression of bax protein levels. |
2016-04-21 |
2023-08-13 |
rat |
| Ming Liu, Yumei Chen, Guixian Song, Bin Chen, Lihua Wang, Xing Li, Xiangqing Kong, Yahui Shen, Lingmei Qia. MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. Gene. vol 576. issue 1 Pt 2. 2016-04-21. PMID:26484393. |
we evaluated proliferation and cell cycle progression, detected morphological changes; apoptosis rate; bax, bcl2, gata binding protein 4 (gata4), cardiac troponin t (ctnt), and myocyte enhancer factor 2c (mef2c) expression; and caspase-3, -8, and -9 activity in mir-29c-overexpressing p19 cells, and investigated whether wnt4 was a mir-29c target. |
2016-04-21 |
2023-08-13 |
Not clear |
| Qing-Qing Liu, Feng-Feng Zhang, Fang Wang, Jing-Hua Qiu, Chun-Hua Luo, Guo-Yong Zhu, Ying-Fu Li. TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression. PloS one. vol 10. issue 5. 2016-04-20. PMID:25946186. |
taken together, tipe2 promoted lung cancer cell apoptosis through affecting apoptosis-related molecules caspase-3, caspase-9, bcl-2 and bax, possibly via regulating p38 and akt pathways, indicating that tipe2 might be a novel marker for lung cancer diagnosis and therapy. |
2016-04-20 |
2023-08-13 |
mouse |
| Yue-Bao Ning, Zhi-Qiang D. Role of c-Jun N-terminal kinase activation in apoptosis induced by removal of the growth factors. Cell biology international. vol 39. issue 5. 2016-04-19. PMID:25572129. |
together, il-3 deprivation of il-3-dependent cell line baf-3 induces a sustained jnk1 activation, followed by a decline of the ratio of bcl-xl to bax, leading to loss of dcm, and finally apoptosis. |
2016-04-19 |
2023-08-13 |
Not clear |
| I Porębska, M Kosacka, E Sobańska, E Wyrodek, R Jankowsk. Comparative Expression of Apoptotic Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma. Advances in experimental medicine and biology. vol 873. 2016-04-19. PMID:26022894. |
the goal of our study was a comparative evaluation of apoptosis regulators: p53, bcl-2, bax, cox-2, and survivin in lung adenocarcinoma (ac) and squamous cell carcinoma (scc). |
2016-04-19 |
2023-08-13 |
Not clear |
| Yufang Wang, Junping Lv, Yao Cheng, Jipei Du, Degao Chen, Chengtao Li, Ji Zhan. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PloS one. vol 10. issue 4. 2016-04-18. PMID:25860257. |
induction of apoptosis was caspase-dependent and appeared to be mediated by the mitochondrial pathway, in that it was associated with reduction in mitochondrial membrane potential and activation of bax and bak. |
2016-04-18 |
2023-08-13 |
human |
| Yufang Wang, Junping Lv, Yao Cheng, Jipei Du, Degao Chen, Chengtao Li, Ji Zhan. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PloS one. vol 10. issue 4. 2016-04-18. PMID:25860257. |
indeed, sirna knockdown of mcl-1 enhanced egb761-induced apoptosis, which was associated with increased activation of bax and bak. |
2016-04-18 |
2023-08-13 |
human |
| Chen Zhang, Jun Ma, Lihong Fan, Yulong Zou, Xiaoqian Dang, Kunzheng Wang, Jinhui Son. Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating. Tissue & cell. vol 47. issue 3. 2016-04-18. PMID:25891268. |
tunel staining and electron microscopy revealed that safranal treatment inhibited injury-induced apoptosis, and affected the expression of the apoptosis-related genes bax and bcl-2, which indicated an anti-apoptotic role after sci. |
2016-04-18 |
2023-08-13 |
rat |
| Hung-Yun Lin, Gennadi V Glinsky, Shaker A Mousa, Paul J Davi. Thyroid hormone and anti-apoptosis in tumor cells. Oncotarget. vol 6. issue 17. 2016-04-18. PMID:26041883. |
the hormone also decreases cellular abundance and activation of proteolytic caspases and of bax and causes increased expression of x-linked inhibitor of apoptosis (xiap). |
2016-04-18 |
2023-08-13 |
human |
| Hui Peng, Wenyu Zhong, Hong Zhao, Li Chen, Xiao Zhou, Feng Li, Weiwei Zhu, Guimei L. Lack of PGC-1α exacerbates high glucose-induced apoptosis in human umbilical vein endothelial cells through activation of VADC1. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-18. PMID:26191154. |
analysis of apoptotic markers (bcl-2, bax), intracellular ros and endoplasmic reticulum stress revealed that these mechanisms were not accounted for the effects of ad-shpgc-1α on apoptosis. |
2016-04-18 |
2023-08-13 |
human |
| Elham Rouhollahi, Soheil Zorofchian Moghadamtousi, Nawal Al-Henhena, Thubasni Kunasegaran, Mohadeseh Hasanpourghadi, Chung Yeng Looi, Sri Nurestri Abd Malek, Khalijah Awang, Mahmood Ameen Abdulla, Zahurin Mohame. The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats. Drug design, development and therapy. vol 9. 2016-04-18. PMID:26251570. |
upregulation of bax and downregulation of bcl-2 suggested the involvement of apoptosis in the chemopreventive effect of decpr. |
2016-04-18 |
2023-08-13 |
rat |
| Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Ch. Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells. Journal of microbiology (Seoul, Korea). vol 53. issue 7. 2016-04-15. PMID:26115996. |
to examine the molecular mechanisms of the inhibitory effect on huh7.5 cells, the effect of cme on cell apoptosis was measured using flow cytometry and the expressions of p53, bim, bax, parp, (cleaved) caspase-9, and (cleaved) caspase- 3 in huh 7.5 cells were detected by western blot assays. |
2016-04-15 |
2023-08-13 |
human |
| Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Ch. Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells. Journal of microbiology (Seoul, Korea). vol 53. issue 7. 2016-04-15. PMID:26115996. |
cme significantly increased early apoptosis and up-regulated the expression of bim, bax, cleaved parp, cleaved caspase 9 and cleaved caspase-3. |
2016-04-15 |
2023-08-13 |
human |
| Zhi-Lu Li, Chen Chen, Yuan Yang, Cheng Wang, Ting Yang, Xin Yang, Sheng-Chun Li. Gamma secretase inhibitor enhances sensitivity to doxorubicin in MDA-MB-231 cells. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-15. PMID:26191129. |
gsi-induced proliferation inhibition and apoptosis was achieved with an induction of pten and pro-apoptotic protein bax expression and suppression of notch-1, hes-1, cyclind1 and anti-apoptotic protein bcl-2. |
2016-04-15 |
2023-08-13 |
Not clear |
| Yue Jing, Gang Wang, Ying Ge, Minjie Xu, Shuainan Tang, Zhunan Gon. AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells. OncoTargets and therapy. vol 9. 2016-04-13. PMID:27073325. |
further, aa-pme induced apoptosis of human gastric cancer cells by affecting bcl-2, bax, c-myc, and caspase-3. |
2016-04-13 |
2023-08-13 |
human |
| Refilwe P Molatlhegi, Alisa Phulukdaree, Krishnan Anand, Robert M Gengan, Charlette Tiloke, Anil A Chuturgoo. Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line. PloS one. vol 10. issue 7. 2016-04-12. PMID:26134408. |
this resulted in dna damage (p < 0.0001), up-regulation of bax expression and caspase activity and induction of apoptosis in lung cancer cells. |
2016-04-12 |
2023-08-13 |
Not clear |
| Sandra-Annika Quast, Katja Steinhorst, Michael Plötz, Jürgen Eberl. Sensitization of Melanoma Cells for Death Ligand TRAIL Is Based on Cell Cycle Arrest, ROS Production, and Activation of Proapoptotic Bcl-2 Proteins. The Journal of investigative dermatology. vol 135. issue 11. 2016-04-12. PMID:26134947. |
activation of the proapoptotic bcl-2 protein bax and inhibition of apoptosis by bcl-2 overexpression or by the antioxidant n-acetyl cysteine underlined the critical involvement of mitochondrial apoptosis pathways and of ros, respectively. |
2016-04-12 |
2023-08-13 |
Not clear |
| T Srinivasa Reddy, Hitesh Kulhari, V Ganga Reddy, A V Subba Rao, Vipul Bansal, Ahmed Kamal, Ravi Shukl. Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents. Organic & biomolecular chemistry. vol 13. issue 40. 2016-04-12. PMID:26346902. |
the results indicate that the compounds induce apoptosis in u87mg cells via mitochondrial pathway through up-regulation of pro-apoptotic (bax) and down-regulation of anti-apoptotic (bcl-2) genes. |
2016-04-12 |
2023-08-13 |
Not clear |