| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuanxiang Chen, Litao Qincao, Jingtao Xu, Sihao Du, Enping Huang, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicology letters. vol 240. issue 1. 2016-03-28. PMID:26524635. |
results showed that meth exposure induced cell apoptosis, increased puma protein levels, activated caspase-3 and parp, elevated bax and reduced bcl-2 expression, as well as increased the release of cyto c from mitochondria to the cytoplasm in both pc12 and sh-sy5y cells. |
2016-03-28 |
2023-08-13 |
Not clear |
| Chen Wang, Kazim Husain, Anying Zhang, Barbara A Centeno, Dung-Tsa Chen, Zhongsheng Tong, Säid M Sebti, Mokenge P Malaf. EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. The Journal of nutritional biochemistry. vol 26. issue 8. 2016-03-25. PMID:25997867. |
δ-tocotrienol-induced apoptosis is associated with consistent induction in the expression of the proapoptotic protein bcl-2-associated x protein (bax). |
2016-03-25 |
2023-08-13 |
Not clear |
| Chen Wang, Kazim Husain, Anying Zhang, Barbara A Centeno, Dung-Tsa Chen, Zhongsheng Tong, Säid M Sebti, Mokenge P Malaf. EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. The Journal of nutritional biochemistry. vol 26. issue 8. 2016-03-25. PMID:25997867. |
here, we provide evidence linking δ-tocotrienol-induced apoptosis in pancreatic cancer cells to egr-1 regulation of bax expression. |
2016-03-25 |
2023-08-13 |
Not clear |
| Chen Wang, Kazim Husain, Anying Zhang, Barbara A Centeno, Dung-Tsa Chen, Zhongsheng Tong, Säid M Sebti, Mokenge P Malaf. EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. The Journal of nutritional biochemistry. vol 26. issue 8. 2016-03-25. PMID:25997867. |
forced expression of egr-1 induces bax expression and apoptosis in pancreatic cancer cells. |
2016-03-25 |
2023-08-13 |
Not clear |
| Chen Wang, Kazim Husain, Anying Zhang, Barbara A Centeno, Dung-Tsa Chen, Zhongsheng Tong, Säid M Sebti, Mokenge P Malaf. EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. The Journal of nutritional biochemistry. vol 26. issue 8. 2016-03-25. PMID:25997867. |
in contrast, knockdown of δ-tocotrienol-induced egr-1 by small interfering rna attenuated δ-tocotrienol-induced bax expression and reduced δ-tocotrienol-induced apoptosis. |
2016-03-25 |
2023-08-13 |
Not clear |
| Sourabh Dwivedi, Quaiser Saquib, Abdulaziz A Al-Khedhairy, Javed Ahmad, Maqsood A Siddiqui, Javed Musarra. Rhamnolipids functionalized AgNPs-induced oxidative stress and modulation of toxicity pathway genes in cultured MCF-7 cells. Colloids and surfaces. B, Biointerfaces. vol 132. 2016-03-25. PMID:26057247. |
bax, bcl2, cyclin d1, dnaja1, e2f transcription factor 1, gpx1 and hspa4, associated with apoptosis signaling, proliferation and carcinogenesis, pro inflammatory and heat shock responses in rh-agnps treated cells. |
2016-03-25 |
2023-08-13 |
human |
| Xiaoyu Li, Junguo Ma, Jianji Wan. Cytotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by ionic liquid 1-methyl-3-octylimidazolium bromide. Ecotoxicology and environmental safety. vol 120. 2016-03-25. PMID:26099465. |
the transcriptions of p53 and bax were markedly up-regulated while bcl-2 was significantly down-regulated in hepg2 cells after [c8mim]br-exposure, suggesting that p53 and bcl-2 family may be involved in the cytotoxicity and apoptosis of hepg2 cells caused by [c8mim]br. |
2016-03-25 |
2023-08-13 |
human |
| Wenliang Ge, Qiyou Yin, Hua Xia. Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway. Journal of molecular neuroscience : MN. vol 56. issue 3. 2016-03-24. PMID:25740014. |
treatment of sk-n-be2 and imr-32 cells with 75 μΜ wogonin for 48 h significantly promoted apoptosis, the release of cytochrome c, altered the expression of certain members of bcl-2 family (bcl-2, bax and bid), and increased the activation of caspase-3, caspase-8, caspase-9, and parp-1, which demonstrated that the cytotoxic effect of wogonin in sk-n-be2 and imr-32 cells is mediated by mitochondrial dysfunction. |
2016-03-24 |
2023-08-13 |
human |
| Takuya Kumazawa, Kazuho Nishimura, Naohiro Katagiri, Sayaka Hashimoto, Yuki Hayashi, Keiji Kimur. Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. Scientific reports. vol 5. 2016-03-24. PMID:26044764. |
the acetylated p53 enhanced p21 and bax expression and induced apoptosis. |
2016-03-24 |
2023-08-13 |
Not clear |
| Wei Huang, Jie Liu, Xiangling Feng, Huan Chen, Liang Zeng, Guoling Huang, Weidong Liu, Lei Wang, Wei Jia, Jiawen Chen, Caiping Re. DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway. Medical oncology (Northwood, London, England). vol 32. issue 4. 2016-03-22. PMID:25779535. |
subsequently, the activation of mitochondrial apoptosis was verified by the increased expressions of bax, apaf1, cleave-caspases and cleave-parp, etc, and the decreased expressions of bcl-2, bcl-xl, mcl-1, survivin, etc, in 5-8f-dlc-1 cells. |
2016-03-22 |
2023-08-13 |
Not clear |
| Joana Soares, Liliana Raimundo, Nuno A L Pereira, Daniel J V A dos Santos, Maria Pérez, Glória Queiroz, Mariana Leão, Maria M M Santos, Lucília Saraiv. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins. Pharmacological research. vol 95-96. 2016-03-21. PMID:25814188. |
it was also shown that oxaz-1 potently triggered a p53-dependent mitochondria-mediated apoptosis, characterized by reactive oxygen species generation, mitochondrial membrane potential dissipation, bax translocation to mitochondria, and cytochrome c release, and exhibited a p53-dependent synergistic effect with conventional chemotherapeutic drugs. |
2016-03-21 |
2023-08-13 |
human |
| Wareeporn Wattanawongdon, Chariya Hahnvajanawong, Nisana Namwat, Sirimas Kanchanawat, Thidarut Boonmars, Patcharee Jearanaikoon, Chanwit Leelayuwat, Anchalee Techasen, Wunchana Seubwa. Establishment and characterization of gemcitabine-resistant human cholangiocarcinoma cell lines with multidrug resistance and enhanced invasiveness. International journal of oncology. vol 47. issue 1. 2016-03-21. PMID:25998688. |
using annexin v/propidium iodide staining, evasion of apoptosis via an intrinsic pathway was observed in both cell lines in association with upregulation of bcl-2 and downregulation of bax. |
2016-03-21 |
2023-08-13 |
human |
| Seung-Hwan Lee, Dong-Young Kim, Feifeng Jing, Hyesoon Kim, Chae-Ok Yun, Deok-Jong Han, Eun Young Cho. Del-1 overexpression potentiates lung cancer cell proliferation and invasion. Biochemical and biophysical research communications. vol 468. issue 1-2. 2016-03-21. PMID:26545781. |
neither treatment with recombinant human del-1 protein nor the introduction of adenovirus expressing del-1 altered the expression of the apoptosis regulators bax, puma and bcl-2. |
2016-03-21 |
2023-08-13 |
human |
| Tao Sun, Yanfei Jia, Dongjie Xia. Interference of STAT 5b expression enhances the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis. Oncology reports. vol 34. issue 1. 2016-03-18. PMID:25997700. |
mitochondrial proteins including bcl-2, bax, caspase-3 and caspase-9 were extracted using special kits for detecting mitochondrial pathway-related apoptosis proteins. |
2016-03-18 |
2023-08-13 |
Not clear |
| Seon Hee Kim, Yong Jung Kang, Bokyung Sung, Dong Hwan Kim, Hyun Sook Lim, Hye Rim Kim, Seong Jin Kim, Jeong-Hyun Yoon, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. MHY-449, a novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, mediates oxidative stress-induced apoptosis in AGS human gastric cancer cells. Oncology reports. vol 34. issue 1. 2016-03-18. PMID:25998412. |
in addition, it was found that mhy-449-induced apoptosis was accompanied by the upregulation of bax, p21(waf1/cip1), p27(kip1), and p53 and suppression of bcl-2. |
2016-03-18 |
2023-08-13 |
human |
| Daniela Puzzo, Antonella Bizzoca, Carla Loreto, Chiara A Guida, Walter Gulisano, Giuseppina Frasca, Maria Bellomo, Sergio Castorina, Gianfranco Gennarini, Agostino Palmer. Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25659859. |
the same mice undergo a decrease of neuronal apoptosis at the hippocampal level, which correlated to a decrease of active caspase-3; by contrast, procaspase-3 and bax as well as the anti-apoptotic and plasticity-related pathway bdnf/creb/bcl-2 were rather increased. |
2016-03-17 |
2023-08-13 |
mouse |
| Zhiyun Cao, Xuzheng Chen, Wei Lin, Jinyan Zhao, Liangpu Zheng, Hongzhi Ye, Lianming Liao, Jian D. Jiedu Xiaozheng Yin decoction inhibits hepatoma cell proliferation by inducing apoptosis via the mitochondrial-mediated pathway. Molecular medicine reports. vol 12. issue 2. 2016-03-16. PMID:25936398. |
following treatment of the hepg2 cells with ee-jxy for 24 h, cell viability, apoptosis, mitochondrial membrane potential, caspase enzyme activity and the expression levels of apoptotic-associated proteins (bcl-2 and bax) were detected by mtt, flow cytometry, elisa and western blotting respectively. |
2016-03-16 |
2023-08-13 |
mouse |
| Zhiyun Cao, Xuzheng Chen, Wei Lin, Jinyan Zhao, Liangpu Zheng, Hongzhi Ye, Lianming Liao, Jian D. Jiedu Xiaozheng Yin decoction inhibits hepatoma cell proliferation by inducing apoptosis via the mitochondrial-mediated pathway. Molecular medicine reports. vol 12. issue 2. 2016-03-16. PMID:25936398. |
furthermore, ee-jxy induced hepg2 cell apoptosis, as demonstrated by a loss of plasma membrane asymmetry and externalization of phosphatidylserine, collapse of mitochondrial membrane potential, activation of caspase-9 and caspase-3, and an increased ratio of pro-apoptotic bax to anti-apoptotic bcl-2. |
2016-03-16 |
2023-08-13 |
mouse |
| Hai-Bo Zhou, Jing-Ming Chen, Li-Ming Shao, Zhi-Gang Che. Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction. World journal of gastroenterology. vol 21. issue 27. 2016-03-15. PMID:26217086. |
to evaluate human pancreatic carcinoma cell line (panc-1) cells apoptosis and bcl-2 and bax expression induced by yin chen hao decoction (ychd). |
2016-03-15 |
2023-08-13 |
human |
| M A P C Piyathilaka, M M Pathmalal, K H Tennekoon, B G D N K De Silva, S R Samarakoon, S Chanthirik. Microcystin-LR-induced cytotoxicity and apoptosis in human embryonic kidney and human kidney adenocarcinoma cell lines. Microbiology (Reading, England). vol 161. issue Pt 4. 2016-03-14. PMID:25635275. |
similarly, fluorescence microscopic observations following acridine orange-ethidium bromide (ao/eb) staining confirmed that both cell types were undergoing apoptosis after treatment with mc-lr for 24 h. expression of three apoptosis-related genes, bax, survivin and p53, was analysed by quantitative reverse transcriptase pcr analysis. |
2016-03-14 |
2023-08-13 |
human |