| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arabinda Das, Rickey Miller, Philip Lee, Chrysanthe Alyssa Holden, Scott M Lindhorst, Jerry Jaboin, William A Vandergrift, Naren L Banik, Pierre Giglio, Abhay K Varma, Jeffery J Raizer, Sunil J Pate. A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 9. 2016-02-25. PMID:25864108. |
other events in apoptosis included downregulation of tetraspanin protein (tspan12), survival proteins (bcl-xl and mcl-1), and overexpression apoptotic factors (bax and caspase-3). |
2016-02-25 |
2023-08-13 |
human |
| Chun-Xiao Zhang, Long-Wei Ye, Ying Liu, Xiao-Ya Xu, Dan-Rui Li, Yan-Qing Yang, Lu-Lu Sun, Jie Yua. Antineoplastic activity of Newcastle disease virus strain D90 in oral squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 9. 2016-02-25. PMID:25877754. |
bax and bcl-2 also played a role in the apoptosis induced by d90. |
2016-02-25 |
2023-08-13 |
Not clear |
| Chao Yu, Zhiguo Zhou, Jun Wang, Jin Sun, Wei Liu, Yanan Sun, Bin Kong, Hong Yang, Shiping Yan. In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro. Journal of hazardous materials. vol 283. 2016-02-23. PMID:25464291. |
firstly, reactive oxygen species (ros) is generated induced by mno@sio2 nps, then p53 is activated followed by an increase in the bax and a decrease in the bcl-2, ultimately leading to g2/m phase arrest, increasing the activity of caspase-3 and inducing apoptosis. |
2016-02-23 |
2023-08-13 |
mouse |
| P Pawlak, E Warzych, M Hryciuk, D Lechnia. Transcript abundance, glutathione and apoptosis levels differ between porcine oocytes collected from prepubertal and cyclic gilts. Theriogenology. vol 84. issue 1. 2016-02-23. PMID:25865617. |
therefore, the aim of the present research was to analyze the transcript abundance of developmentally important genes (bmp15, gdf9, gsta2, atp5a1, eef1a1, bax, bcl2) followed by investigation of the glutathione and apoptosis level in oocytes of prepubertal and cyclic gilts. |
2016-02-23 |
2023-08-13 |
Not clear |
| Ai-yue Yu, Xiao-hong Sun, Xue-hong Liu, Jin Zhou, Lan Wan. [Effects of Citalopram on frontal cortical neurons' bax mRNA bcl-2 mRNA expression and cell apoptosis of rat after stress]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 31. issue 5. 2016-02-23. PMID:26827541. |
[effects of citalopram on frontal cortical neurons' bax mrna bcl-2 mrna expression and cell apoptosis of rat after stress]. |
2016-02-23 |
2023-08-13 |
rat |
| Ai-yue Yu, Xiao-hong Sun, Xue-hong Liu, Jin Zhou, Lan Wan. [Effects of Citalopram on frontal cortical neurons' bax mRNA bcl-2 mRNA expression and cell apoptosis of rat after stress]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 31. issue 5. 2016-02-23. PMID:26827541. |
to study the effects of citalopram on the mrna expression of bax and bel-2 in frontal cortical neurons and on cell apoptosis of rats after stress. |
2016-02-23 |
2023-08-13 |
rat |
| Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Mayte Blay, Anna Ardévol, Montserrat Pinen. Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats. International journal of food science. vol 2013. 2016-02-23. PMID:26904613. |
however, the administration of the extract enhances the cafeteria-induced increase in bax protein levels, suggesting increased apoptosis. |
2016-02-23 |
2023-08-13 |
rat |
| Darsan B Menon, V K Gopalakrishna. Terpenoids Isolated From the Shoot of Plectranthus hadiensis Induces Apoptosis in Human Colon Cancer Cells Via the Mitochondria-Dependent Pathway. Nutrition and cancer. vol 67. issue 4. 2016-02-22. PMID:25837437. |
the mechanism of apoptosis induction was studied by expression analysis of antiapoptotic bcl-2 and proapoptotic bax using rt-pcr and also by western blot analysis of proteins involved in the apoptotic pathway. |
2016-02-22 |
2023-08-13 |
human |
| Darsan B Menon, V K Gopalakrishna. Terpenoids Isolated From the Shoot of Plectranthus hadiensis Induces Apoptosis in Human Colon Cancer Cells Via the Mitochondria-Dependent Pathway. Nutrition and cancer. vol 67. issue 4. 2016-02-22. PMID:25837437. |
upregulation of caspase-3 activity and proapoptotic bax, and the downregulation of antiapoptotic bcl-2 and cox-2 confirmed that the apoptosis induction was via the mitochondria-dependent pathway. |
2016-02-22 |
2023-08-13 |
human |
| Diana Le Duc, Ana Spataru, Mihai Ceanga, Leon Zagrean, Torsten Schöneberg, Emil C Toescu, Ana-Maria Zagrea. Developmental exposure to ethanol increases the neuronal vulnerability to oxygen-glucose deprivation in cerebellar granule cell cultures. Brain research. vol 1614. 2016-02-22. PMID:25881894. |
in the ethanol-treated cerebellar granule neurons we find an increased expression of genes related to apoptosis (mapk8 and bax), but also of genes previously described as neuroprotective (dhcr24 and bdnf), which might suggest an actively maintained viability. |
2016-02-22 |
2023-08-13 |
mouse |
| Hu Shan, Rui Yan, Jiayu Diao, Lin Lin, Suqin Wang, Ming Zhang, Rong Zhang, Jin We. Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 31. 2016-02-22. PMID:26004897. |
in conclusion, the intrinsic, extrinsic pathways and the upstream regulators such as p53, bax, bcl-2, and bcl-x(l )were all involved in selenium deficiency-induced myocardial apoptosis. |
2016-02-22 |
2023-08-13 |
rat |
| Jianzhang Wu, Zhijian Cai, Xiaoyan Wei, Minxiao Chen, Shilong Ying, Lingyi Shi, Ren-Ai Xu, Fan He, Guang Liang, Xiuhua Zhan. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed research international. vol 2015. 2016-02-21. PMID:25977922. |
meanwhile, jz534 induced cell apoptosis and upregulated the expression of apoptosis-related proteins, including cleaved caspase-3, bax, and p53. |
2016-02-21 |
2023-08-13 |
Not clear |
| Ting Song, Xiaoyan Yu, Yubo Liu, Xiangqian Li, Gaobo Chai, Zhichao Zhan. Discovery of a small-molecule pBcl-2 inhibitor that overcomes pBcl-2-mediated resistance to apoptosis. Chembiochem : a European journal of chemical biology. vol 16. issue 5. 2016-02-19. PMID:25711460. |
s1-16 efficiently kills eee-bcl-2 (a t69e, s70e, and s87e mutant mimicking phosphorylation)-expressing hl-60 cells and high endogenously expressing pbcl-2 cells, by disrupting eee-bcl-2 or native pbcl-2 interactions with bax and bak, followed by apoptosis. |
2016-02-19 |
2023-08-13 |
Not clear |
| Farrokh Farhadi, Salar Jahanpour, Kameliya Hazem, Amirala Aghbali, Behzad Baradran, Seyyed Mahdi Vahid Pakde. Garlic ((Allium sativum)) Fresh Juice Induces Apoptosis in Human Oral Squamous Cell Carcinoma: The Involvement of Caspase-3, Bax and Bcl-2. Journal of dental research, dental clinics, dental prospects. vol 9. issue 4. 2016-02-18. PMID:26889365. |
garlic ((allium sativum)) fresh juice induces apoptosis in human oral squamous cell carcinoma: the involvement of caspase-3, bax and bcl-2. |
2016-02-18 |
2023-08-13 |
human |
| Farrokh Farhadi, Salar Jahanpour, Kameliya Hazem, Amirala Aghbali, Behzad Baradran, Seyyed Mahdi Vahid Pakde. Garlic ((Allium sativum)) Fresh Juice Induces Apoptosis in Human Oral Squamous Cell Carcinoma: The Involvement of Caspase-3, Bax and Bcl-2. Journal of dental research, dental clinics, dental prospects. vol 9. issue 4. 2016-02-18. PMID:26889365. |
the results of this study advanced that gfj induces apoptosis in the kb cells through increasing caspase-3 activity and bax:bcl2 ratio which could be attributed to its organo-sulfurcomponents. |
2016-02-18 |
2023-08-13 |
human |
| F T Lu, D C Ma, W Yan, J Guo, L H Ba. Antitumour activity of 3-nitropropionic acid from Phomopsis sp. and optimization of fermentation conditions. Letters in applied microbiology. vol 61. issue 2. 2016-02-17. PMID:25963711. |
through quantitative detection of the genes that are closely related to the bcl-2 signalling pathway, there was an increased expression of p53 and bax and a decreased expression of bcl-2, which indicated apoptosis in these cells. |
2016-02-17 |
2023-08-13 |
Not clear |
| Pengwei Lu, Huan Lin, Yuanting Gu, Lin Li, Hong Guo, Fang Wang, Xinguang Qi. Antitumor effects of crocin on human breast cancer cells. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26884946. |
we found that crocin can significantly inhibit the proliferation of mcf-7 cells, and induce their apoptosis through mitochondrial signaling pathways including the activation of caspase-8, upregulation of bax, the disruption of mitochondrial membrane potential (mmp), and the release of cytochrome c. the studies showed that crocin induced apoptosis of mcf-7 cells partially through caspase-8 mediated mitochondrial pathway. |
2016-02-17 |
2023-08-13 |
human |
| Guangfan Hai, Chong Zhang, Yanlong Jia, Suping Bai, Jinfen Han, Lanqing Guo, Taizhen Cui, Bingxuan Niu, Feng Huang, Yu Son. Anti-hepatoma activity of a novel compound glaucocalyxin H in vivo and in vitro. AAPS PharmSciTech. vol 16. issue 3. 2016-02-16. PMID:25374342. |
bcl2 and bax proteins played important roles in apoptosis and the disequilibrium between bcl2 and bax might result in apoptosis. |
2016-02-16 |
2023-08-13 |
mouse |
| Guangfan Hai, Chong Zhang, Yanlong Jia, Suping Bai, Jinfen Han, Lanqing Guo, Taizhen Cui, Bingxuan Niu, Feng Huang, Yu Son. Anti-hepatoma activity of a novel compound glaucocalyxin H in vivo and in vitro. AAPS PharmSciTech. vol 16. issue 3. 2016-02-16. PMID:25374342. |
taken together, glh can inhibit the growth of hepatoma cells in vivo and in vitro by inducing cell apoptosis due to the decreased bcl2 and increased bax proteins suggesting that glh could be a potential candidate as an anti-hepatoma agent for the therapeutic treatment of hepatoma. |
2016-02-16 |
2023-08-13 |
mouse |
| Hiroyuki Yamamoto, Kohzoh Ima. Microsatellite instability: an update. Archives of toxicology. vol 89. issue 6. 2016-02-16. PMID:25701956. |
gene targets of frameshift mutations caused by msi are involved in various cellular functions, including dna repair (msh3 and msh6), cell signaling (tgfbr2 and acvr2a), apoptosis (bax), epigenetic regulation (hdac2 and arid1a), and mirna processing (tarbp2 and xpo5), and a subset of msi+ crcs reportedly shows the mutated mirna machinery phenotype. |
2016-02-16 |
2023-08-13 |
Not clear |