| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deping Han, Shuxiang Wang, Yanxin Hu, Yuanyuan Zhang, Xianggui Dong, Zu Yang, Jiankui Wang, Junying Li, Xuemei Den. Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson). PloS one. vol 10. issue 6. 2016-03-04. PMID:26047316. |
analysis of apoptotic cells and apoptosis-associated bax and bcl-2 proteins indicated that apoptosis is involved in degeneration of the thymus and bursa of fabricius. |
2016-03-04 |
2023-08-13 |
Not clear |
| Scott E Williams, Idoia Garcia, Andrew J Crowther, Shiyi Li, Alyssa Stewart, Hedi Liu, Kendall J Lough, Sean O'Neill, Katherine Veleta, Esteban A Oyarzabal, Joseph R Merrill, Yen-Yu Ian Shih, Timothy R Gersho. Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice. Development (Cambridge, England). vol 142. issue 22. 2016-03-04. PMID:26450969. |
co-deletion of aspm and either of the apoptosis regulators bax or trp53 (also known as p53) rescues the survival of neural progenitors and reduces the growth restriction imposed by aspm deletion. |
2016-03-04 |
2023-08-13 |
mouse |
| Suwen Yang, Shengrui Wang, Fengchao Sun, Mengmeng Zhang, Fengchang Wu, Fanfan Xu, Zhishan Din. Protective effects of puerarin against tetrabromobisphenol a-induced apoptosis and cardiac developmental toxicity in zebrafish embryo-larvae. Environmental toxicology. vol 30. issue 9. 2016-03-03. PMID:24596333. |
acridine orange staining results revealed that tbbpa exposure caused cardiomyocyte apoptosis and induced the expression of three proapoptotic genes: p53, bax, and caspase9. |
2016-03-03 |
2023-08-12 |
zebrafish |
| Huai-Cai Zeng, Qing-Zhi He, Yuan-Yuan Li, Cheng-Qiu Wu, Yi-Mou Wu, Shun-Qing X. Prenatal exposure to PFOS caused mitochondia-mediated apoptosis in heart of weaned rat. Environmental toxicology. vol 30. issue 9. 2016-03-03. PMID:24616003. |
apoptosis, as well as expression of apoptosis related genes associated with mitochondrial-mediated apoptosis pathway, including p53, bcl-2, bax, cytochrome c, caspase-9, and caspase-3 were analyzed in heart tissues from weaned (postnatal day 21, pnd 21) offspring. |
2016-03-03 |
2023-08-12 |
rat |
| Jianwei Zeng, Shiqiang Chen, Na Li, Liang Chen, Jiaosu Su, Guangjun Niu, Si Zhu, Yichi Lian. Sasanquasaponin from Camellia oleifera Abel. induces apoptosis via Bcl-2, Bax and caspase-3 activation in HepG2 cells. Molecular medicine reports. vol 12. issue 2. 2016-03-03. PMID:25937271. |
induces apoptosis via bcl-2, bax and caspase-3 activation in hepg2 cells. |
2016-03-03 |
2023-08-13 |
Not clear |
| S Sekaran, P Balaganapathy, R Parsanathan, S Elangovan, J Gunashekar, F A Bhat, A Jagadeesa. Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of first filial generation pubertal Wistar rats. Human & experimental toxicology. vol 34. issue 6. 2016-03-02. PMID:25352649. |
dehp-treated rats also showed increased oxidative stress by decreasing antioxidant levels in the scs; it disrupted sc tight junctional proteins occludin, claudin, junctional adhesion molecule, zona occludens protein-1 (zo-1), zona occludens protein-2 (zo-2), and afadin-6 (af-6), increased apoptosis by altering the apoptotic genes bax, cytochrome c, caspase-8, -9, -3 and antiapoptotic gene bcl-2. |
2016-03-02 |
2023-08-13 |
rat |
| Wan-Li Li, Wei Xiang, Ye Pin. Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection. Molecular medicine reports. vol 12. issue 2. 2016-03-02. PMID:25936661. |
b-cell lymphoma 2 (bcl-2) and bcl-2 associated x (bax) levels were measured, hoechst 33258 staining was performed to assess apoptosis, and superoxide dismutase (sod), tumor necrosis factor (tnf)-α and adenosine triphosphatase (atpase) levels were determined. |
2016-03-02 |
2023-08-13 |
Not clear |
| Wan-Li Li, Wei Xiang, Ye Pin. Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection. Molecular medicine reports. vol 12. issue 2. 2016-03-02. PMID:25936661. |
compared with the vehicle-treated groups, g1 and e2-treated groups exhibited elevated bcl-2 levels, decreased bax levels and cell apoptosis, significantly increased sod and atp levels and decreased tnf-α levels following ischemia-reperfusion. |
2016-03-02 |
2023-08-13 |
Not clear |
| Hamed Karimian, Mehran Fadaeinasab, Soheil Zorofchian Moghadamtousi, Maryam Hajrezaei, Mahboubeh Razavi, Sher Zaman Safi, Mahmood Ameen Abdulla, Hapipah Mohd Ali, Mohamad Ibrahim Noordi. Chemopreventive Activity of Ferulago angulate against Breast Tumor in Rats and the Apoptotic Effect of Polycerasoidin in MCF7 Cells: A Bioassay-Guided Approach. PloS one. vol 10. issue 5. 2016-03-01. PMID:25996383. |
falhe administration induced apoptosis in breast tumor cells, and this was confirmed by high expression levels of bax, p53 and caspase 3. |
2016-03-01 |
2023-08-13 |
rat |
| Hamed Karimian, Mehran Fadaeinasab, Soheil Zorofchian Moghadamtousi, Maryam Hajrezaei, Mahboubeh Razavi, Sher Zaman Safi, Mahmood Ameen Abdulla, Hapipah Mohd Ali, Mohamad Ibrahim Noordi. Chemopreventive Activity of Ferulago angulate against Breast Tumor in Rats and the Apoptotic Effect of Polycerasoidin in MCF7 Cells: A Bioassay-Guided Approach. PloS one. vol 10. issue 5. 2016-03-01. PMID:25996383. |
polycerasoidin induced mitochondrial-dependent apoptosis in breast cancer cells via caspase activation and changes in the mrna and protein expression of bax and bcl-2. |
2016-03-01 |
2023-08-13 |
rat |
| Yu-Rong Zhao, Wei Qu, Wen-Yuan Liu, Hao Hong, Feng Feng, Han Chen, Ning Xi. YGS40, an active fraction of Yi-Gan San, reduces hydrogen peroxide-induced apoptosis in PC12 cells. Chinese journal of natural medicines. vol 13. issue 6. 2016-03-01. PMID:26073340. |
cytotoxicity was determined by mtt (3, (4, 5-dimethylthiazole-2-yl) 2, 5-diphenyl-tetrazolium bromide) and lactate dehydrogenase (ldh) release assays; apoptosis was detected by annexin v/propidium iodide coupled staining and by determining caspase-3 activity and bax and bcl-2 protein levels. |
2016-03-01 |
2023-08-13 |
Not clear |
| Ceyda Crek, Ergul Mutlu Altundag, Betul Karademir, Semra Kocturk, Nesrin Kartal Ozer, Yavuz Tag. The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines. Free radical biology & medicine. vol 75 Suppl 1. 2016-03-01. PMID:26461322. |
the effect of resveratrol on signal transduction pathways and the role of pro-apoptotic bax protein on apoptosis in hct- 116 colon carcinoma cell lines. |
2016-03-01 |
2023-08-13 |
Not clear |
| Ceyda Crek, Ergul Mutlu Altundag, Betul Karademir, Semra Kocturk, Nesrin Kartal Ozer, Yavuz Tag. The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines. Free radical biology & medicine. vol 75 Suppl 1. 2016-03-01. PMID:26461322. |
the role of pro-apoptotic bax protein on the resveratrol related apoptosis, mitochondrial membrane potential and signal pathways has not been identified in colon carcinoma cells. |
2016-03-01 |
2023-08-13 |
Not clear |
| Ceyda Crek, Ergul Mutlu Altundag, Betul Karademir, Semra Kocturk, Nesrin Kartal Ozer, Yavuz Tag. The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines. Free radical biology & medicine. vol 75 Suppl 1. 2016-03-01. PMID:26461322. |
according to the flow cytometry, apoptosis ratio has been determined as 29.65% in the experimental group of bax positive cells, as 13.98% in the experimental group of bax negative cells. |
2016-03-01 |
2023-08-13 |
Not clear |
| Ceyda Crek, Ergul Mutlu Altundag, Betul Karademir, Semra Kocturk, Nesrin Kartal Ozer, Yavuz Tag. The effect of resveratrol on signal transduction pathways and the role of pro-apoptotic Bax protein on apoptosis in HCT- 116 colon carcinoma cell lines. Free radical biology & medicine. vol 75 Suppl 1. 2016-03-01. PMID:26461322. |
our data show that bax protein plays role in the apoptotic effect of resveratrol by altering mitochondrial membrane potential and mitochondrial membrane permeability, signal transduction and the absence of bax increase the sensitivity of hct-116 colon carcinoma cells to apoptosis. |
2016-03-01 |
2023-08-13 |
Not clear |
| Jianping Peng, Xiaoning Li, Dongshan Zhang, Jian-Kang Chen, Yunchao Su, Sylvia B Smith, Zheng Don. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney international. vol 87. issue 1. 2016-02-29. PMID:24963915. |
in vitro, high glucose-conditioned renal proximal tubular cells showed higher apoptosis and caspase activation following atp depletion and hypoxic injury, accompanied by a heightened mitochondrial accumulation of bax and release of cytochrome c. in response to injury, both glucose-conditioned renal proximal tubular cells and diabetic kidney tissues showed markedly higher p53 induction. |
2016-02-29 |
2023-08-13 |
mouse |
| Thouraya Ben Safta, Linda Ziani, Loetitia Favre, Lucille Lamendour, Gwendoline Gros, Fathia Mami-Chouaib, Denis Martinvalet, Salem Chouaib, Jerome Thier. Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 1. 2016-02-26. PMID:25404359. |
human gzmb preferentially induces target cell apoptosis by cleaving the proapoptotic bcl-2 family member bid, which, together with bax, induces mitochondrial outer membrane permeabilization. |
2016-02-26 |
2023-08-13 |
human |
| Feng Huang, Ming Huang, Hong Zhang, Chunjiang Zhang, Dequan Zhang, Guanghong Zho. Changes in apoptotic factors and caspase activation pathways during the postmortem aging of beef muscle. Food chemistry. vol 190. 2016-02-26. PMID:26212948. |
these results demonstrated that the mitochondrial pathway was one of the apoptosis pathways in pm beef muscle and that bax and hsp27 were two key regulation factors in apoptosis in pm beef muscle. |
2016-02-26 |
2023-08-13 |
Not clear |
| Shu-Mei Yang, Kuen-Daw Tsai, Ho-Yiu Wong, Yi-Heng Liu, Ta-Wei Chen, Jonathan Cherng, Kwang-Ching Hsu, Yao-Uh Ang, Jaw-Ming Chern. Molecular Mechanism of Cinnamomum verum Component Cuminaldehyde Inhibits Cell Growth and Induces Cell Death in Human Lung Squamous Cell Carcinoma NCI-H520 Cells In Vitro and In Vivo. Journal of Cancer. vol 7. issue 3. 2016-02-26. PMID:26918037. |
the results show that cua suppressed proliferation and induced apoptosis as indicated by an up-regulation of pro-apoptotic bax and bak genes and a down-regulation of anti-apoptotic bcl-2 and bcl-xl genes, mitochondrial membrane potential loss, cytochrome c release, activation of caspase 3 and 9, and morphological characteristics of apoptosis, including blebbing of the plasma membrane, nuclear condensation, fragmentation, apoptotic body formation, and comet with elevated tail intensity and moment. |
2016-02-26 |
2023-08-13 |
mouse |
| Yuan Peng, Xi Zhang, Yongfang Wang, Shasha Li, Junlei Wang, Long Li. Overexpression of toll-like receptor 2 in glomerular endothelial cells and podocytes in septic acute kidney injury mouse model. Renal failure. vol 37. issue 4. 2016-02-25. PMID:25715637. |
together, the current study indicates that tlr2 is overactivated in the glomerular endothelial cells and podocytes in septic aki mice, while the abundance of bax and caspase-3 were increased in the glomeruli of these mice, it may supply a clue that tlr2 induced these cell apoptosis in aki. |
2016-02-25 |
2023-08-13 |
mouse |