| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guiqi Qin, ChuBiao Zhao, Lili Zhang, Hongyu Liu, Yingyao Quan, Liuying Chai, Shengnan Wu, Xiaoping Wang, Tongsheng Che. Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 8. 2016-01-04. PMID:25935454. |
compared with the modest inhibitory effects of silencing bax, silencing bak largely prevented dha-induced ΔΨm collapse and apoptosis though dha induced a commensurable activation of bax and bak, demonstrating a key role of the bak-mediated intrinsic apoptosis pathway. |
2016-01-04 |
2023-08-13 |
human |
| Guiqi Qin, ChuBiao Zhao, Lili Zhang, Hongyu Liu, Yingyao Quan, Liuying Chai, Shengnan Wu, Xiaoping Wang, Tongsheng Che. Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 8. 2016-01-04. PMID:25935454. |
silencing bim or noxa preferentially reduced dha-induced bak activation, while silencing puma preferentially reduced dha-induced bax activation, demonstrating that bim and to a lesser extent noxa act as upstream mediators to trigger the bak-mediated intrinsic apoptosis pathway. |
2016-01-04 |
2023-08-13 |
human |
| Lingxi Jiang, Dora Lai-Wan Kwong, Yan Li, Ming Liu, Yun-Fei Yuan, Yan Li, Li Fu, Xin-Yuan Gua. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. Carcinogenesis. vol 36. issue 10. 2016-01-04. PMID:26246424. |
as a chaperone of heat shock protein 70 (hsp70), hbp21 could inhibit interaction between hsp70 and bax, increased bax protein translocation from cytoplasm to mitochondria, and subsequently increased the release of cytochrome c into cytoplasm, and finally induced apoptosis. |
2016-01-04 |
2023-08-13 |
mouse |
| Meng-Liang Lin, Shih-Shun Chen, Tian-Shung W. Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408703. |
blockade of p53 expression by short-hairpin rna (shrna) suppressed oligomeric bcl-2-associated x protein (bax)/bcl-2 antagonist killer 1 (bak)-mediated mitochondrial apoptosis but did not inhibit lipid raft localization of cd95/fadd and pro-caspase-8 cleavage induced by tswu-br23. |
2016-01-04 |
2023-08-13 |
human |
| Jiujiao Gao, Qiu Yan, Shuai Liu, Xuesong Yan. Knockdown of EpCAM enhances the chemosensitivity of breast cancer cells to 5-fluorouracil by downregulating the antiapoptotic factor Bcl-2. PloS one. vol 9. issue 7. 2016-01-01. PMID:25019346. |
epcam knockdown enhanced the cytotoxic effect of 5-fu, promoting apoptosis by downregulating the expression of the anti-apoptotic protein bcl-2 and upregulating the expression of the pro-apoptotic proteins bax, and caspase3 via the erk1/2 and jnk mapk signaling pathways in mcf-7 cells. |
2016-01-01 |
2023-08-13 |
Not clear |
| Xingjie Ma, Minlu Huang, Zhenqiang Wang, Bingya Liu, Zhenggang Zhu, Chen L. ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis. Journal of Cancer. vol 7. issue 1. 2016-01-01. PMID:26722361. |
zhx1 induced g1/s arrest by decreasing cyclin d1 and cyclin e expression, and induced cell apoptosis by bcl2 downregulation and bax and cleaved caspase-3 upregulation. |
2016-01-01 |
2023-08-13 |
human |
| Xiling Du, Haipeng Wang, Fuhui Xu, Yongyi Huang, Zhixue Liu, Te Li. Enterovirus 71 induces apoptosis of SH‑SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression. Molecular medicine reports. vol 12. issue 1. 2015-12-31. PMID:25779425. |
furthermore, quantitative polymerase chain reaction and western blot analyses demonstrated that expression level of the apoptosis inhibitor bcl-2 was markedly reduced, but the expression levels of the apoptosis-promoting factors bax, caspase-7, caspase‑3 and active caspase-3 were markedly higher in the sh-sy5y cells 12-48 h after ev71 infection, compared with the non-infected cells. |
2015-12-31 |
2023-08-13 |
human |
| Lian-Mei Zhao, Yun-Long Jia, Ming Ma, Yu-Qing Duan, Li-Hua Li. Prevention effects of Schisandra polysaccharide on radiation-induced immune system dysfunction. International journal of biological macromolecules. vol 76. 2015-12-30. PMID:25709011. |
data showed that radiation-induced apoptosis of thymocytes could be reversed by sp through inducing upregulation of bcl-2 expression and downregulation of fas and bax levels. |
2015-12-30 |
2023-08-13 |
mouse |
| Yingying Feng, Xiaojie Xu, Yunjing Zhang, Jianhua Ding, Yonggang Wang, Xiaopeng Zhang, Zhe Wu, Lei Kang, Yingchun Liang, LiYing Zhou, Santai Song, Ke Zhao, Qinong Y. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. Scientific reports. vol 5. 2015-12-30. PMID:25800793. |
hpip inhibits crc cell apoptosis accompanied by the decreased levels of bax and pig3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor bcl2. |
2015-12-30 |
2023-08-13 |
mouse |
| Liang Liu, Lian-Fu Zuo, Jing Zuo, Jing Wan. Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25816175. |
in conclusion, art exerted concentration-dependent inhibitory activity against esophageal cancer in vivo and in vitro by inducing cell apoptosis and cell cycle arrest through affecting mitochondrial membrane potential, bcl-2, bax, caspase-3 and cdc25a. |
2015-12-30 |
2023-08-13 |
mouse |
| Jiaojiao Qin, Meilong Wu, Shu Yu, Xiaorong Gao, Jingjing Zhang, Xingyue Dong, Jinyan Ji, Yuxi Zhang, Lin Zhou, Qi Zhang, Fei Din. Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease. Toxicology letters. vol 238. issue 3. 2015-12-30. PMID:26276080. |
pre-treatment with pqq prevented cultured sh-sy5y cells from rotenone-induced apoptosis, accompanied by modulation of apoptosis-related proteins (bcl-2, bax and smac), restoration of the mitochondrial membrane potential, inhibition of intracellular reactive oxygen species (ros) production, suppression of tyrosine residues nitration, and dopamine redistribution. |
2015-12-30 |
2023-08-13 |
rat |
| Yan-Ling Wu, Li-Jie Xia, Jin-Yao Li, Fu-Chun Zhan. CecropinXJ inhibits the proliferation of human gastric cancer BGC823 cells and induces cell death in vitro and in vivo. International journal of oncology. vol 46. issue 5. 2015-12-29. PMID:25826779. |
annexin v/pi staining suggested that cecropinxj induced both early and late phases of apoptosis through activation of mitochondrial-mediated caspase pathway, upregulation of bax expression and downregulation of bcl-2 expression. |
2015-12-29 |
2023-08-13 |
mouse |
| Fabian D Liechti, Nicolas Stüdle, Regula Theurillat, Denis Grandgirard, Wolfgang Thormann, Stephen L Lei. The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PloS one. vol 9. issue 11. 2015-12-22. PMID:25409333. |
in the hippocampus, licl significantly reduced apoptosis and gene expression of bax and p53 while it increased expression of bcl-2. |
2015-12-22 |
2023-08-13 |
rat |
| Pei Ma, Sen Zhang, Xinlin Su, Guixing Qiu, Zhihong W. Protective effects of icariin on cisplatin-induced acute renal injury in mice. American journal of translational research. vol 7. issue 10. 2015-12-22. PMID:26692955. |
examination of molecules involving inflammation and apoptosis of the kidney revealed that treatment of icariin reduced expression of tnf-α, nf-κb, cleaved caspase-3, and bax, increased the expression of bcl-2. |
2015-12-22 |
2023-08-13 |
mouse |
| Xue-Tao Li, Rui-Jun Ju, Xiu-Ying Li, Fan Zeng, Ji-Feng Shi, Lei Liu, Cheng-Xiang Zhang, Meng-Ge Sun, Jin-Ning Lou, Wan-Liang L. Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells. Oncotarget. vol 5. issue 15. 2015-12-21. PMID:25153726. |
action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the bbb effectively; improving drug uptake by glioma cells and gscs; down-regulating the overexpressed abc transporters; inducing apoptosis of gscs via up-regulating apoptotic receptor/ligand (fas/fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (bax and bok), activating tumor suppressor protein (p53) and suppressing anti-apoptotic proteins (bcl-2 and mcl-1). |
2015-12-21 |
2023-08-13 |
mouse |
| Guo-Wei Wang, Chao Lv, Zhi-Ran Shi, Ren-Tao Zeng, Xue-Yun Dong, Wei-Dong Zhang, Run-Hui Liu, Lei Shan, Yun-Heng She. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PloS one. vol 9. issue 12. 2015-12-21. PMID:25502685. |
furthermore, our results revealed that induction of apoptosis through a mitochondrial pathway led to upregulation of bax, down-regulation of bcl-2, mitochondrial release of cytochrome c, reduction of mitochondrial membrane potential (mmp), and activation of caspase cascades (casp-9 and -3). |
2015-12-21 |
2023-08-13 |
human |
| Ferhat Hanikoglu, Aysegul Cort, Hakan Ozben, Aysegul Hanikoglu, Tomris Ozbe. Epoxomicin Sensitizes Resistant Osteosarcoma Cells to TRAIL Induced Apoptosis. Anti-cancer agents in medicinal chemistry. vol 15. issue 4. 2015-12-21. PMID:25666501. |
we determined the cytotoxic effects of epoxomicin and/or trail on these two types of os cells using dimethylthiazolyl 2,5 diphenyltetrazolium bromide (mtt) test and measured apoptosis markers such as pro-apoptotic bax levels and caspase-3, -8, -9 activities. |
2015-12-21 |
2023-08-13 |
Not clear |
| Nakwon Choe, Jin-Sook Kwon, Yong Sook Kim, Gwang Hyeon Eom, Young Keun Ahn, Yung Hong Baik, Hyun-Young Park, Hyun Koo. The microRNA miR-34c inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia by targeting stem cell factor. Cellular signalling. vol 27. issue 6. 2015-12-21. PMID:25683915. |
transient transfection of mir-34c to either vsmcs or a10 cells inhibited cell survival by inducing apoptosis, which was accompanied by an increase in expression of p21, p27, and bax. |
2015-12-21 |
2023-08-13 |
rat |
| Karolina Niska, Maria Jose Santos-Martinez, Marek Witold Radomski, Iwona Inkielewicz-Stepnia. CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 4. 2015-12-21. PMID:25701151. |
exposure of ht22 cells to cuonps resulted in: (1) increased cell death in a time- and concentration-dependent manner, with a lc50 of 25.9 μg/ml after 24 h; (2) decreased antioxidant/detoxification enzymes activities: glutathione peroxidase (gpx), superoxide dismutase (sod), glutathione s-tranferase (gst), and reduced glutathione (gsh) levels; (3) decreased gene expression of gpx and sod; (4) reactive oxygen species (ros) generation; (5) enhanced apoptosis; and (6) up-regulation of the pro-apoptotic genes bax, and down-regulation of anti-apoptotic genes bcl-2. |
2015-12-21 |
2023-08-13 |
mouse |
| Julien Prudent, Rodolfo Zunino, Ayumu Sugiura, Sevan Mattie, Gordon C Shore, Heidi M McBrid. MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death. Molecular cell. vol 59. issue 6. 2015-12-21. PMID:26384664. |
indeed, activated bax and bak can form functional channels in liposomes, bringing into question the contribution of mitochondrial dynamics in apoptosis. |
2015-12-21 |
2023-08-13 |
Not clear |