| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junfen Ma, Xiaobing Guo, Shijie Zhang, Hongchun Liu, Jing Lu, Ziming Dong, Kangdong Liu, Liang Min. Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. Molecular medicine reports. vol 11. issue 6. 2015-12-03. PMID:25634603. |
tsa also induced cell apoptosis by enhancing the expression of pro‑apoptotic protein bax and decreasing the expression of anti‑apoptotic protein bcl‑2. |
2015-12-03 |
2023-08-13 |
Not clear |
| Yiping Wang, Zhaohui Hu, Bing Sun, Jiahong Xu, Jinfa Jiang, Ming Lu. Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury via Akt/endothelial nitric oxide synthase signaling and the B‑cell lymphoma/B‑cell lymphoma‑associated X protein pathway. Molecular medicine reports. vol 11. issue 6. 2015-12-03. PMID:25672441. |
in vitro investigations revealed that gsrg3 (10 mm) decreased nrc apoptosis through inhibiting the activation of caspase‑3 and caspase‑9, and increasing the expression levels of p‑akt, enos and the ratio of bcl‑2/bcl‑2‑associated x protein (bax). |
2015-12-03 |
2023-08-13 |
rat |
| Yang Wang, Ruo-Feng Yin, Jia-Song Ten. Wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of Bcl-2 and Bax in osteosarcoma cancer cells. International journal of clinical and experimental pathology. vol 8. issue 1. 2015-12-03. PMID:25755693. |
wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of bcl-2 and bax in osteosarcoma cancer cells. |
2015-12-03 |
2023-08-13 |
human |
| Khadka Sachita, Yongsoo Kim, Hyun-Ju Yu, Sung-Dae Cho, Jeong-Sang Le. In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines. Phytotherapy research : PTR. vol 29. issue 8. 2015-12-03. PMID:25903972. |
in addition, evodiamine decreased expression of myeloid cell leukemia (mcl-1) at the transcriptional modification, and knockdown of mcl-1 clearly resulted in an increase in expression of bax and active bax, resulting in induction of apoptosis. |
2015-12-03 |
2023-08-13 |
human |
| Cheppail Ramachandran, Karl-W Quirin, Enrique A Escalon, Ivonne V Lollett, Steven J Melnic. Therapeutic Effect of Supercritical CO2 Extracts of Curcuma Species with Cancer Drugs in Rhabdomyosarcoma Cell Lines. Phytotherapy research : PTR. vol 29. issue 8. 2015-12-03. PMID:25939344. |
ca also modulated the expression of genes associated with intrinsic pathway of apoptosis (bcl-2, bax, bak, and p53) and also inhibited the expression of genes associated with inflammation such as cox-2 and nf-κb. |
2015-12-03 |
2023-08-13 |
mouse |
| Marta Pérez-Hernández, Pablo Del Pino, Scott G Mitchell, María Moros, Grazyna Stepien, Beatriz Pelaz, Wolfgang J Parak, Eva M Gálvez, Julián Pardo, Jesús M de la Fuent. Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms. ACS nano. vol 9. issue 1. 2015-12-02. PMID:25493329. |
laser-irradiated "hot" nprs activate the intrinsic/mitochondrial pathway of apoptosis (programmed cell death), which is mediated by the nuclear-encoded proteins bak and bax through the activation of the bh3-only protein bid. |
2015-12-02 |
2023-08-13 |
mouse |
| Ailan Wang, Qingcui Liu, Jin Zhang, Rui Zhen. Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2/interleukin-10 and Bcl-2/Bax. International journal of clinical and experimental medicine. vol 8. issue 9. 2015-12-02. PMID:26629148. |
the present study is to investigate the effect of berberine on the expression of inflammatory factors interleukin (il)-2 and il-10, and the expression of apoptosis proteins bcl-2 and bax. |
2015-12-02 |
2023-08-13 |
rat |
| Soo Jung Kim, Kyung Hee Jung, Hong Hua Yan, Mi Kwon Son, Zhenghuan Fang, Ye-Lim Ryu, Hyunseung Lee, Joo Han Lim, Jun-Kyu Suh, JinHee Kim, Soyoung Lee, Sungwoo Hong, Soon-Sun Hon. HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation. Oncotarget. vol 6. issue 3. 2015-12-01. PMID:25483100. |
in addition, we found that hs-543 induced apoptosis with the loss of mitochondrial membrane potential by decreasing the expression of mcl-1 and survivin, together with increasing that of bax. |
2015-12-01 |
2023-08-13 |
Not clear |
| Natascia Cocchia, Annunziata Corteggio, Gennaro Altamura, Simona Tafuri, Silviana Rea, Isabella Rosapane, Alessandro Sica, Francesco Landolfi, Francesca Cian. The effects of superoxide dismutase addition to the transport medium on cumulus-oocyte complex apoptosis and IVF outcome in cats (Felis catus). Reproductive biology. vol 15. issue 1. 2015-12-01. PMID:25726378. |
the ovaries collected from 76 mixed-breed domestic queens were randomly assigned to the control or sod-treated groups and incubated for 3, 24, 48 or 72 h. the ovaries were then subjected to the following: (1) fixed in formalin to assess the incidence of apoptosis (fragmented dna in situ detection kit), (2) stored at -196°c in liquid nitrogen to evaluate the expression of the pro-apoptotic bax gene and the anti-apoptotic bcl-2 gene (rt-pcr), and (3) used to obtain the cumulus-oocyte complexes (cocs) in order to test the cell viability (carboxyfluorescein or trypan blue staining) and ivep. |
2015-12-01 |
2023-08-13 |
cat |
| F Yang, M Hu, Q Lei, Y Xia, Y Zhu, X Song, Y Li, H Jie, C Liu, Y Xiong, Z Zuo, A Zeng, Y Li, L Yu, G Shen, D Wang, Y Xie, T Ye, Y We. Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model. Cell death & disease. vol 6. 2015-11-30. PMID:25811798. |
in addition, western blot analysis demonstrated that the occurrence of its apoptosis was associated with activation of cleaved caspases-3 and bax, downregulation of bcl-2. |
2015-11-30 |
2023-08-13 |
Not clear |
| J Ngo, M Matsuyama, C Kim, I Poventud-Fuentes, A Bates, S L Siedlak, H-G Lee, Y Q Doughman, M Watanabe, A Liner, B Hoit, N Voelkel, S Gerson, P Hasty, S Matsuyam. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell death & disease. vol 6. 2015-11-30. PMID:25811803. |
previously, we found that ku70 also inhibits bax, a key mediator of apoptosis. |
2015-11-30 |
2023-08-13 |
mouse |
| Fangyi Chen, Rongbo Wu, Zhu Zhu, Wangping Yin, Min Xiong, Jianwei Sun, Miaozhong Ni, Guoping Cai, Xinchao Zhan. Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. Journal of molecular neuroscience : MN. vol 55. issue 4. 2015-11-27. PMID:25417142. |
the induction of apoptosis was prevented with reduction in expression level of bax and concomitant increase in b cell lymphoma 2 (bcl-2) level. |
2015-11-27 |
2023-08-13 |
rat |
| He Wang, Henghui Yin, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li, Yinghong Feng, Yi Zho. Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance. Oncotarget. vol 6. issue 5. 2015-11-25. PMID:25605018. |
furthermore, the caspase-9 and caspase-3 cascade was activated by the functional dox nanoparticles through upregulation of the pro-apoptotic proteins bax and bid and suppression of the antiapoptotic protein bcl-2, thereby enhancing apoptosis by acting on the mitochondrial signaling pathways. |
2015-11-25 |
2023-08-13 |
Not clear |
| Huibin Nie, Xia Xue, Jie Li, Xiangchun Liu, Shasha Lv, Guangju Guan, Haiying Liu, Gang Liu, Shanshan Liu, Zhixin Che. Nitro-oleic acid attenuates OGD/R-triggered apoptosis in renal tubular cells via inhibition of Bax mitochondrial translocation in a PPAR-γ-dependent manner. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 3. 2015-11-25. PMID:25766531. |
nitro-oleic acid attenuates ogd/r-triggered apoptosis in renal tubular cells via inhibition of bax mitochondrial translocation in a ppar-γ-dependent manner. |
2015-11-25 |
2023-08-13 |
Not clear |
| Farahnaz Ahmadi, Mahdi Mojarrab, Mahmoud Ghazi-Khansari, Leila Hosseinzade. A semipolar fraction of petroleum ether extract of Artemisia aucheri induces apoptosis and enhances the apoptotic response to doxorubicin in human neuroblastoma SKNMC cell line. Research in pharmaceutical sciences. vol 10. issue 4. 2015-11-25. PMID:26600860. |
the results indicated that f7 was able to induce apoptosis through mmp disruption, activation of caspases and increament of proapoptotic genes bax and smac/diablo. |
2015-11-25 |
2023-08-13 |
human |
| Triparagiri Ramanivas, Bottu Sushma, V Lakshma Nayak, Kunta Chandra Shekar, Ajay Kumar Srivastav. Design, synthesis and biological evaluations of chirally pure 1,2,3,4-tertrahydroisoquinoline analogs as anti-cancer agents. European journal of medicinal chemistry. vol 92. 2015-11-24. PMID:25615796. |
the apoptosis inducing properties were evaluated by dna fragmentation analysis, caspase-3 activity assay, annexin v-fitc assay and western blot analysis of proapoptotic protein, bax and antiapoptotic protein bcl-2. |
2015-11-24 |
2023-08-13 |
human |
| Kaimin Yu, Guochao Li, Weimin Feng, Lili Liu, Jiayu Zhang, Wei Wu, Lei Xu, Yanchun Ya. Chlorpyrifos is estrogenic and alters embryonic hatching, cell proliferation and apoptosis in zebrafish. Chemico-biological interactions. vol 239. 2015-11-24. PMID:26079056. |
the mrna expression levels of c-myc, cyclin d1, bax and bcl-2, which are closely related to cell proliferation and cell apoptosis, were disturbed by cpf in zebrafish embryos after exposure treated for 48h. |
2015-11-24 |
2023-08-13 |
zebrafish |
| Xiling Wei, Xingyu Zhu, Nan Hu, Xiuqin Zhang, Tianjiao Sun, Jiyang Xu, Xiaohong Bia. Baicalin attenuates angiotensin II-induced endothelial dysfunction. Biochemical and biophysical research communications. vol 465. issue 1. 2015-11-23. PMID:26239661. |
here, we shown that baicalin improved endothelial fuction impaired by ang ii through promoting endothelial-dependent vasodilation and suppressing the apoptosis of huvecs in which baicalin decreased the expression of bax and cleaved caspase-3, and increased bcl-2 expression. |
2015-11-23 |
2023-08-13 |
Not clear |
| Lingpeng Zhu, Jing Wang, Tingting Wei, Jin Gao, He He, Xiayun Chang, Tianhua Ya. Effects of Naringenin on inflammation in complete freund's adjuvant-induced arthritis by regulating Bax/Bcl-2 balance. Inflammation. vol 38. issue 1. 2015-11-20. PMID:25256150. |
he staining study demonstrated that cog and dex significantly suppressed pathological changes of joints tissues; tunel assay demonstrated that cog and dex induced apoptosis of aa via regulation of the protein expression of bcl-2 and bax. |
2015-11-20 |
2023-08-13 |
rat |
| Bin Liu, Yan-hong Zhang, Ying Jiang, Long-ling Li, Qian Chen, Guo-qian He, Xiao-dan Tan, Chang-qing L. Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke. International journal of biological sciences. vol 11. issue 3. 2015-11-20. PMID:25678854. |
gadd45b-rnai also significantly increased neuronal apoptosis as indicated by increased levels of bax and active caspase-3, and decreased levels of bcl-2. |
2015-11-20 |
2023-08-13 |
rat |