| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dandan Tong, Hui Qu, Xiangning Meng, Yang Jiang, Duanyang Liu, Shengqian Ye, He Chen, Yan Jin, Songbin Fu, Jingshu Gen. S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24970681. |
in contrast, in the sw620 cell line, the apoptosis induced by samc only affected tgf-β1 and smad7 signals, and promoted the expression of bax and bad and finally activated the mitochondrial apoptosis pathway protein caspase-9. |
2015-11-03 |
2023-08-13 |
Not clear |
| Ching-Chyuan Su, Jeff Yi-Fu Chen, Zhong-Hao Din, Jui-Hsin Su, Zih-Yan Yang, Yi-Jen Chen, Robert Y L Wang, Yu-Jen W. 13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression. Marine drugs. vol 12. issue 10. 2015-11-02. PMID:25342459. |
13-ac-induced apoptosis was confirmed through observation of a change in ΔΨm, up-regulated expression levels of bax and bad proteins, down-regulated expression levels of bcl-2, bcl-xl and mcl-1 proteins, and the activation of caspase-3, caspase-9, p38 and jnk. |
2015-11-02 |
2023-08-13 |
human |
| Rajeev Gupta, Subhendu Ghos. Bax and Bif-1 proteins interact on Bilayer Lipid Membrane and form pore. Biochemical and biophysical research communications. vol 463. issue 4. 2015-11-02. PMID:26051276. |
bax and bax interacting factor-1(bif-1) are cytosolic proteins, which translocate towards mitochondria during mitochondria-mediated apoptosis. |
2015-11-02 |
2023-08-13 |
Not clear |
| Perumal MadanKumar, Perumal NaveenKumar, Halagowder Devaraj, Sivasithamparam NiranjaliDevara. Morin, a dietary flavonoid, exhibits anti-fibrotic effect and induces apoptosis of activated hepatic stellate cells by suppressing canonical NF-κB signaling. Biochimie. vol 110. 2015-10-30. PMID:25577997. |
in fibrotic rats, morin treatment resulted in inhibition of canonical nf-κb signaling and induction of apoptosis, mainly by downregulating bcl-2, upregulating bax and cyt c and by activation of caspase-9 and caspase-3. |
2015-10-30 |
2023-08-13 |
human |
| Peyker Temiz, Gizem Akkaş, Nalan Neşe, Fazilet Uğur Duman, Cansu Karakaş, Yamaç Erha. Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. Turkish journal of medical sciences. vol 45. issue 4. 2015-10-30. PMID:26422859. |
determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, bcl-2, bax, bcl-xl, and cyclin d1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. |
2015-10-30 |
2023-08-13 |
Not clear |
| Neslihan Tekin, Mehmet C Ustuner, Fahrettin Akyuz, Cansu S Ozbayer, Ozlem Aydın, Kadriye Benkli, Dilek Burukoglu, Irfan Degirmenci, Hilmi Ozde. Apoptotic effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats. Molecular biology reports. vol 41. issue 8. 2015-10-28. PMID:24756331. |
in conclusion, [au(dppz)cl2]cl complex induced apoptosis by elevating levels of caspase 3, p53, bax, and dna fragmentation. |
2015-10-28 |
2023-08-13 |
rat |
| Xinwen Liu, Zhenguang Huang, Xiaoqin Zou, Yufang Yang, Yue Qiu, Yan We. Panax notoginseng saponins attenuates cisplatin-induced nephrotoxicity via inhibiting the mitochondrial pathway of apoptosis. International journal of clinical and experimental pathology. vol 7. issue 12. 2015-10-28. PMID:25674203. |
furthermore, pns reduced the rate of apoptosis, and the mechanism studies showed that pns inhibited the expression of bax and caspase 9, while increased the expression of bcl-2. |
2015-10-28 |
2023-08-13 |
rat |
| Mohamed A Haidara, Abdullah S Assiri, Mary A Youssef, Manal M Mahmoud, Eajaz Ahmed M S, Ahmed Al-Hakami, Harish C Chandramoorth. Differentiated mesenchymal stem cells ameliorate cardiovascular complications in diabetic rats. Cell and tissue research. vol 359. issue 2. 2015-10-27. PMID:25413785. |
the levels of pro-apoptotic makers p53 and bax were highly expressed in the diabetic groups indicating oxidative stress through ros induced by high cytosolic calcium skewing the cells towards apoptosis. |
2015-10-27 |
2023-08-13 |
rat |
| Zhi-Sheng Zhang, Dong-Yan Yang, Yan-Bo Fu, Lei Zhang, Qian-Ping Zhao, Gang L. Knockdown of CkrL by shRNA deteriorates hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis and survival inhibition Via Bax and downregulation of P-Erk1/2. Cell biochemistry and function. vol 33. issue 2. 2015-10-27. PMID:25703803. |
knockdown of ckrl by shrna deteriorates hypoxia/reoxygenation-induced h9c2 cardiomyocyte apoptosis and survival inhibition via bax and downregulation of p-erk1/2. |
2015-10-27 |
2023-08-13 |
human |
| Zhi-Sheng Zhang, Dong-Yan Yang, Yan-Bo Fu, Lei Zhang, Qian-Ping Zhao, Gang L. Knockdown of CkrL by shRNA deteriorates hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis and survival inhibition Via Bax and downregulation of P-Erk1/2. Cell biochemistry and function. vol 33. issue 2. 2015-10-27. PMID:25703803. |
in conclusion, these results confirmed that knockdown of crkl could deteriorate h/r-induced apoptosis and cell survival inhibition in rat-derived h9c2 cardiomyocytes via bax and downregulation of p-erk1/2. |
2015-10-27 |
2023-08-13 |
human |
| Erina Suzuki, Sabine Kajita, Hiroyuki Takahashi, Toshihide Matsumoto, Tomoko Tsuruta, Makoto Saegus. Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression. Laboratory investigation; a journal of technical methods and pathology. vol 95. issue 8. 2015-10-27. PMID:26030369. |
suppression of endogenous hnf-1β expression by sirna increased apoptosis in tov-21g cells, while treatment of hec251 cells (endometrial carcinoma cell line with extremely low endogenous hnf-1β expression) stably overexpressing exogenous hnf-1β with doxorubicin abrogated apoptosis of the cells, along with increased ratio of bcl-2 relative to bax. |
2015-10-27 |
2023-08-13 |
Not clear |
| Guiqi Qin, Liping Wu, Hongyu Liu, Yilin Pang, Chubiao Zhao, Shengnan Wu, Xiaoping Wang, Tongsheng Che. Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells. Experimental cell research. vol 336. issue 2. 2015-10-27. PMID:26163896. |
silencing bax but not bak significantly inhibited ars-induced apoptosis, demonstrating the key role of the bax-mediated intrinsic pathway. |
2015-10-27 |
2023-08-13 |
Not clear |
| Jin Hyoung Park, Soon-Suk Kang, Jae Yong Kim, Hungwon Tcha. The Antioxidant N-Acetylcysteine Inhibits Inflammatory and Apoptotic Processes in Human Conjunctival Epithelial Cells in a High-Glucose Environment. Investigative ophthalmology & visual science. vol 56. issue 9. 2015-10-27. PMID:26305534. |
we evaluated the effects of n-acetylcysteine (nac), which is known to inhibit reactive oxygen species (ros)-dependent apoptosis, on high glucose-induced ros, apoptosis, inflammation, and delayed-wounding closure in primary cultured human conjunctival epithelial cells (phcecs), and the regulatory effects of cleaved caspase-3, bax, nuclear factor κb (nf-κb), il-6, and tnf-α on these processes. |
2015-10-27 |
2023-08-13 |
human |
| Simin Sharifi, Jaleh Barar, Mohammad Saeid Hejazi, Nasser Samad. Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells. Advanced pharmaceutical bulletin. vol 5. issue 3. 2015-10-27. PMID:26504757. |
bax, bcl-xl, caspase-8 and 9 proteins are involved in induction of apoptosis. |
2015-10-27 |
2023-08-13 |
Not clear |
| Shan Gao, Jie Ding, Hai-Jun Xiao, Zhi-Qiang Li, Yan Chen, Xing-Sheng Zhou, Jing-E Wang, Jiang Wu, Wei-Ze Sh. Anti-inflammatory and anti-apoptotic effect of combined treatment with methylprednisolone and amniotic membrane mesenchymal stem cells after spinal cord injury in rats. Neurochemical research. vol 39. issue 8. 2015-10-26. PMID:24890008. |
the combination treatment with mp (50 mg/kg) and delayed transplantation of am-mscs after rat spinal cord injury, significantly reduced (1) myeloperoxidase activity, (2) the proinflammatory cytokines: tumor necrosis factor-α, interleukin (il)-1β, il-6, il-17, interferon-γ and (3) the cell apoptosis [terminal deoxynucleotidyl transferase, dutp nick end labeling (tunel) staining, and caspase-3, bax and bcl-2 expressions]; increased: (1) the levels of the anti-inflammatory cytokines (il-10 and transforming growth factor-β1) and (2) the survival rate of am-mscs in the injury site. |
2015-10-26 |
2023-08-13 |
rat |
| Y Liu, H V Clegg, P L Leslie, J Di, L A Tollini, Y He, T-H Kim, A Jin, L M Graves, J Zheng, Y Zhan. CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. Cell death and differentiation. vol 22. issue 6. 2015-10-26. PMID:25476776. |
chchd2 inhibits apoptosis by interacting with bcl-x l to regulate bax activation. |
2015-10-26 |
2023-08-13 |
Not clear |
| Y Liu, H V Clegg, P L Leslie, J Di, L A Tollini, Y He, T-H Kim, A Jin, L M Graves, J Zheng, Y Zhan. CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. Cell death and differentiation. vol 22. issue 6. 2015-10-26. PMID:25476776. |
mitochondrial outer membrane permeabilization (momp) is a critical control point during apoptosis that results in the release of pro-apoptotic mitochondrial contents such as cytochrome c. momp is largely controlled by bcl-2 family proteins such as bax, which under various apoptotic stresses becomes activated and oligomerizes on the outer mitochondrial membrane. |
2015-10-26 |
2023-08-13 |
Not clear |
| Y Liu, H V Clegg, P L Leslie, J Di, L A Tollini, Y He, T-H Kim, A Jin, L M Graves, J Zheng, Y Zhan. CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. Cell death and differentiation. vol 22. issue 6. 2015-10-26. PMID:25476776. |
furthermore, when chchd2 is absent from the mitochondria, the ability of bcl-xl to inhibit bax activation and to prevent apoptosis is attenuated, which results in increases in bax oligomerization, momp and apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Lavanya Yaidikar, Santhrani Thaku. Punicalagin attenuated cerebral ischemia-reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3. Molecular and cellular biochemistry. vol 402. issue 1-2. 2015-10-26. PMID:25555468. |
it also suppresses apoptosis through regulating, bcl-2, caspase-3, and bax protein expressions, perhaps another mechanism by which pg employs its neuroprotective action. |
2015-10-26 |
2023-08-13 |
rat |
| Lata Singh, Neelam Pushker, Neeru Saini, Seema Sen, Anjana Sharma, Sameer Bakhshi, Bhavna Chawla, Seema Kashya. Expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in human retinoblastoma. Clinical & experimental ophthalmology. vol 43. issue 3. 2015-10-22. PMID:25132102. |
regulation of apoptosis is a complex process that involves a number of genes, including bcl-2, bcl-x, bax and other bcl-2 family members. |
2015-10-22 |
2023-08-13 |
human |