| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Schmid, Francois Fay, Donna M Small, Jakub Jaworski, Joel S Riley, Diana Tegazzini, Cathy Fenning, David S Jones, Patrick G Johnston, Daniel B Longley, Christopher J Scot. Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine. Molecular therapy : the journal of the American Society of Gene Therapy. vol 22. issue 12. 2015-10-22. PMID:25200008. |
importantly, the combination of nanoparticle-induced dr5 clustering with camptothecin delivery overcomes resistance to dr5-induced apoptosis caused by loss of bax or overexpression of anti-apoptotic flip. |
2015-10-22 |
2023-08-13 |
Not clear |
| Li Chen, Yong Tao, Jing Feng, Yan Rong Jian. Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis. Journal of ophthalmology. vol 2015. 2015-10-22. PMID:26491547. |
furthermore, exogenous recombinant apelin effectively prevented hypoxia-induced apoptosis through downregulating active-caspase 3 expression and increasing the ratio of b cell lymphoma-2 (bcl-2)/bcl-2 associated x protein (bax) in pericytes. |
2015-10-22 |
2023-08-13 |
rat |
| Hwa-Young Lee, Geum-Hwa Lee, Anu Marahatta, Shun-Mei Lin, Mi-Rin Lee, Kyu Yun Jang, Kyung Min Kim, Hee Jae Lee, Jae-Won Lee, Tarique Rajasaheb Bagalkot, Young-Chul Chung, Yong-Chul Lee, Hyung-Ryong Kim, Han-Jung Cha. The protective role of Bax inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A. Scientific reports. vol 3. 2015-10-21. PMID:24292328. |
the anti-apoptotic protein bax inhibitor-1 (bi-1) is a regulator of apoptosis linked to endoplasmic reticulum (er) stress. |
2015-10-21 |
2023-08-12 |
mouse |
| Zhiyun Yu, Guifang Xie, Guangtong Zhou, Ye Cheng, Guangtao Zhang, Guangming Yao, Yong Chen, Yunqian Li, Gang Zha. NVP-BEZ235, a novel dual PI3K-mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells. Cancer letters. vol 367. issue 1. 2015-10-21. PMID:26188279. |
combination treatment with both tmz and nvp-bez235 resulted in synergistically inhibited glioma cell growth and induced apoptosis (combination index ci<1) in a subset of glioma cell lines, as shown in the increased levels of bax, and active caspase-3, and decreased level of bcl-2. |
2015-10-21 |
2023-08-13 |
mouse |
| Hongfang Jin, Angie Dong Liu, Lukas Holmberg, Manman Zhao, Siyao Chen, Jinyan Yang, Yan Sun, Shanshan Chen, Chaoshu Tang, Junbao D. The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury. International journal of molecular sciences. vol 14. issue 5. 2015-10-19. PMID:23698774. |
furthermore, cardiomyocyte apoptosis in the left ventricular tissues was augmented, left ventricular tissue bcl-2 expression was down-regulated, bax expression was up-regulated, mitochondrial membrane potential was significantly reduced, mptp opened, cytc release from mitochondrion into cytoplasm was significantly increased, and both caspase-9 and caspase-3 activities were increased. |
2015-10-19 |
2023-08-12 |
rat |
| Hongfang Jin, Angie Dong Liu, Lukas Holmberg, Manman Zhao, Siyao Chen, Jinyan Yang, Yan Sun, Shanshan Chen, Chaoshu Tang, Junbao D. The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury. International journal of molecular sciences. vol 14. issue 5. 2015-10-19. PMID:23698774. |
administration of an so2 donor, however, markedly improved heart function and relieved myocardial injury of the iso-treated rats; it lessened cardiomyocyte apoptosis, up-regulated myocardial bcl-2, down-regulated bax expression, stimulated mitochondrial membrane potential, closed mptp, and reduced cytc release as well as caspase-9 and caspase-3 activities in the left ventricular tissue. |
2015-10-19 |
2023-08-12 |
rat |
| Xing-Qi Li, Zhi-Gang Ouyang, Sheng-Hua Zhang, Hong Liu, Yue Shang, Yi Li, Yong-Su Zhe. Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction. Journal of neuro-oncology. vol 119. issue 1. 2015-10-19. PMID:24842385. |
as determined by western blot, apoptosis signal pathways in c6 cells and u87 cells were markedly affected by the synergistic alteration of p53, bax, procaspase 3, and bcd-2 expression. |
2015-10-19 |
2023-08-13 |
human |
| Shan-Shan Zhu, Yu-Sheng Zhang, Xie-Huang Sheng, Miao Xu, Si-Si Wu, Yue-Mao Shen, Yao-Jian Huang, Yi Wang, Yan-Qiu Sh. Deacetyl-mycoepoxydiene, isolated from plant endophytic fungi Phomosis sp. demonstrates anti-microtubule activity in MCF-7 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 69. 2015-10-19. PMID:25661342. |
additionally, dm-induced apoptosis was characterized with up-regulating caspase-3, bax, caspase-9, parp, and p21 while down-regulating bcl-2 activation. |
2015-10-19 |
2023-08-13 |
mouse |
| Linlin Zeng, Chen Hu, Fuqiang Zhang, Daniel C Xu, Mei-Zhen Cui, Xuemin X. Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively. The Journal of biological chemistry. vol 290. issue 30. 2015-10-19. PMID:26025363. |
a complete inhibition of ps1-induced apoptosis was achieved by knockdown of ps1-associated protein (psap), a mitochondrial proapoptotic protein that forms a complex with bax upon induction of apoptosis, in the presence of γ-secretase inhibitor. |
2015-10-19 |
2023-08-13 |
Not clear |
| Linlin Zeng, Chen Hu, Fuqiang Zhang, Daniel C Xu, Mei-Zhen Cui, Xuemin X. Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively. The Journal of biological chemistry. vol 290. issue 30. 2015-10-19. PMID:26025363. |
however, knockdown of bax or overexpression of bcl-2 resulted in complete inhibition of ps1-induced apoptosis. |
2015-10-19 |
2023-08-13 |
Not clear |
| Linlin Zeng, Chen Hu, Fuqiang Zhang, Daniel C Xu, Mei-Zhen Cui, Xuemin X. Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively. The Journal of biological chemistry. vol 290. issue 30. 2015-10-19. PMID:26025363. |
these two pathways converge on bax to activate mitochondria-dependent apoptosis. |
2015-10-19 |
2023-08-13 |
Not clear |
| Bing Liu, Divesh Bhatt, Zoltán N Oltvai, Joel S Greenberger, Ivet Baha. Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. Scientific reports. vol 4. 2015-10-16. PMID:25175563. |
our simulations show that the strength of p53 transcriptional activity and its coupling (or timing with respect) to mitochondrial pore opening are major determinants of cell fate: for systems where apoptosis is elicited via a p53-transcription-independent mechanism, direct activation of bax by p53 becomes critical to ir-induced-damage initiation. |
2015-10-16 |
2023-08-13 |
Not clear |
| Ke-qin Luo, Hui-bao Long, Bing-can X. Reduced apoptosis after acute myocardial infarction by simvastatin. Cell biochemistry and biophysics. vol 71. issue 2. 2015-10-16. PMID:25304741. |
edge myocardial infarction and myocardial cell apoptosis were analyzed using tunel assay, and bcl-2, bax, and caspase-3 protein levels were detected by western blot. |
2015-10-16 |
2023-08-13 |
Not clear |
| Ke-qin Luo, Hui-bao Long, Bing-can X. Reduced apoptosis after acute myocardial infarction by simvastatin. Cell biochemistry and biophysics. vol 71. issue 2. 2015-10-16. PMID:25304741. |
simvastatin can improve cardiac function after myocardial infarction and reduce apoptosis of myocardial cells, possibly by decreasing bax and caspase-3 expression and increasing the expression level of bcl-2. |
2015-10-16 |
2023-08-13 |
Not clear |
| Yong Peng, Congshan Guo, Yanhong Yang, Fenglin Li, Yanxia Zhang, Bin Jiang, Qingwang L. Baicalein induces apoptosis of human cervical cancer HeLa cells in vitro. Molecular medicine reports. vol 11. issue 3. 2015-10-16. PMID:25373554. |
the results demonstrated that baicalein inhibits the proliferation of hela cells and induces apoptosis in a caspase-3-dependent pathway, through downregulation of the b-cell lymphoma 2 (bcl-2) protein and upregulation of the bcl-2-associated x protein (bax), fas, fas ligand (fasl) and caspase-8. |
2015-10-16 |
2023-08-13 |
human |
| Yiming Wang, Hongming Zhang, Fangxian Chai, Xingde Liu, Michael Ber. The effects of escitalopram on myocardial apoptosis and the expression of Bax and Bcl-2 during myocardial ischemia/reperfusion in a model of rats with depression. BMC psychiatry. vol 14. 2015-10-16. PMID:25471226. |
the effects of escitalopram on myocardial apoptosis and the expression of bax and bcl-2 during myocardial ischemia/reperfusion in a model of rats with depression. |
2015-10-16 |
2023-08-13 |
rat |
| Yiming Wang, Hongming Zhang, Fangxian Chai, Xingde Liu, Michael Ber. The effects of escitalopram on myocardial apoptosis and the expression of Bax and Bcl-2 during myocardial ischemia/reperfusion in a model of rats with depression. BMC psychiatry. vol 14. 2015-10-16. PMID:25471226. |
our aim was therefore to explore the molecular mechanisms of escitalopram on myocardial apoptosis and the expression of bax and bcl-2 in a rat model of depression during myocardial ischemia/reperfusion (i/r). |
2015-10-16 |
2023-08-13 |
rat |
| Juan Xiao, Rongbing Yang, Lin Yang, Xiaohang Fan, Wenwei Liu, Wenbin Den. Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. Scientific reports. vol 5. 2015-10-16. PMID:25762107. |
kirenol treatment upregulated bax,downregulated bcl-2,and increased activation of caspase-3 and release of cytochrome c, indicating that a mitochondrial pathway was involved in kirenol induced apoptosis. |
2015-10-16 |
2023-08-13 |
mouse |
| Jun Bai, Yun Lei, Gai-li An, Li H. Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway. PloS one. vol 10. issue 3. 2015-10-16. PMID:25774669. |
additionally, western blotting assay showed that hdac6 silencing suppressed bcl-2 level and enhanced bax level, then activated caspase-9 and caspase-3, and further activated the release of cytochrome c from mitochondria to cytoplasm, finally induced cell apoptosis involving the mitochondrial pathway. |
2015-10-16 |
2023-08-13 |
human |
| Kimberly A Foster, Esther P Jane, Daniel R Premkumar, Alejandro Morales, Ian F Pollac. Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines. Journal of neuro-oncology. vol 120. issue 3. 2015-10-15. PMID:25139025. |
co-administration of abt-737 and saha induces apoptosis, mediated by noxa upregulation, bax activation and mitochondrial dysfunction in pten-intact malignant human glioma cell lines. |
2015-10-15 |
2023-08-13 |
human |