| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katerina Naka K, Patra Vezyraki, Alexandros Kalaitzakis, Stelios Zerikiotis, Lampros Michalis, Charalampos Angelidi. Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice. Cell stress & chaperones. vol 19. issue 6. 2015-06-30. PMID:24748476. |
the study in primary embryonic cell lines showed that the apoptosis after incubation with dox was reduced in cells overexpressing hsp70 (tg/tg), while the apoptotic pathway that was activated by dox administration involved activated protein factors such as p53, bax, caspase-9, caspase-3, and parp-1. |
2015-06-30 |
2023-08-13 |
mouse |
| Shubhadeep Roychoudhury, Alexander V Sirotkin, Robert Toman, Adriana Kolesarov. Cobalt-induced hormonal and intracellular alterations in rat ovarian fragments in vitro. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. vol 49. issue 12. 2015-06-30. PMID:25310813. |
obtained results suggest co induced (1) inhibition in secretion of steroid hormone progesterone, (2) dose-dependent increase in the release of growth factor igf-i, and (3) decrease in the expression of markers of apoptosis (bax and caspase-3) of rat ovarian fragments. |
2015-06-30 |
2023-08-13 |
rat |
| Jessie Colin, Julie Garibal, Amandine Clavier, Sébastien Szuplewski, Yanick Risler, Cécile Milet, Sébastien Gaumer, Isabelle Guénal, Bernard Mignott. Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila. Genes & cancer. vol 6. issue 5-6. 2015-06-30. PMID:26124923. |
we have previously shown that the mammalian pro-apoptotic bcl-2 family member bax is very efficient in inducing apoptosis in drosophila, allowing the study of bax-induced cell death in a genetic animal model. |
2015-06-30 |
2023-08-13 |
drosophila_melanogaster |
| Tamer Said Abdelkader, Seo-Na Chang, Tae-Hyun Kim, Juha Song, Dong Su Kim, Jae-Hak Par. Exposure time to caffeine affects heartbeat and cell damage-related gene expression of zebrafish Danio rerio embryos at early developmental stages. Journal of applied toxicology : JAT. vol 33. issue 11. 2015-06-29. PMID:22886764. |
we studied the effect of caffeine on heartbeat, survival and the expression of cell damage related genes, including oxidative stress (hsp70), mitochondrial metabolism (cyclin g1) and apoptosis (bax and bcl2), at early developmental stages of zebrafish embryos. |
2015-06-29 |
2023-08-12 |
zebrafish |
| Xiao-Xi Guo, Qiao Guo, Yang Li, Seung Ki Lee, Xue-Ning Wei, Ying-Hua Ji. Ginsenoside Rh2 induces human hepatoma cell apoptosisvia bax/bak triggered cytochrome C release and caspase-9/caspase-8 activation. International journal of molecular sciences. vol 13. issue 12. 2015-06-29. PMID:23443079. |
in this manuscript we elucidate the molecular mechanism of g-rh2-induced apoptosis in human hepatoma sk-hep-1 cells by demonstrating that g-rh2 causes rapid and dramatic translocation of both bak and bax, which subsequently triggers mitochondrial cytochrome c release and consequent caspase activation. |
2015-06-29 |
2023-08-12 |
human |
| Thanh-Tuan Huynh, Yerra Koteswara Rao, Wei-Hwa Lee, Hsin-An Chen, T Do-Quyen Le, David T W Tzeng, Liang-Shun Wang, Alexander T H Wu, Yuh-Feng Lin, Yew-Min Tzeng, Chi-Tai Ye. Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 4. 2015-06-29. PMID:24434019. |
the present study showed that destruxin b (db) inhibits the proliferation and induces the apoptosis of hcc cells by decreasing the protein expression of anti-apoptotic bcl-2 and bcl-xl and increasing the expression of the proapoptotic protein bax. |
2015-06-29 |
2023-08-12 |
Not clear |
| Shiva Kant, Ajay Kumar, Sukh Mahendra Sing. Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms. Molecular and cellular biochemistry. vol 397. issue 1-2. 2015-06-29. PMID:25123669. |
bct inhibition also elevated the expression of cytochrome c, caspase-9, caspase-3, bax, reactive oxygen species, and nitric oxide along with inhibition of hsp-70 and bcl2, which regulate tumor cell survival and apoptosis. |
2015-06-29 |
2023-08-13 |
Not clear |
| Renhua Xu, Enbing Tian, Haiping Tang, Chongdong Liu, Qingtao Wan. Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. BioMed research international. vol 2014. 2015-06-29. PMID:25197664. |
importantly, proteomic and western blot analysis showed that apoptosis regulators bak and bax were upregulated in gossypol-treated cells, indicating that bcl-2 associated death pathway was activated. |
2015-06-29 |
2023-08-13 |
Not clear |
| Sang Eun Park, Won Tak Shin, Cheol Park, Su Hyun Hong, Gi-Young Kim, Sung Ok Kim, Chung Ho Ryu, Sang Hoon Hong, Yung Hyun Cho. Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases. Oncology reports. vol 32. issue 6. 2015-06-26. PMID:25241797. |
the induction of apoptosis by the eecr was associated with upregulation of death receptor 4 (dr4), dr5 and pro-apoptotic bax, as well as downregulation of anti-apoptotic survivin and bcl-2. |
2015-06-26 |
2023-08-13 |
human |
| Haibo Song, Fei Wu, Yuan Zhang, Yuzhu Zhang, Fang Wang, Miao Jiang, Zhongde Wang, Mingxiang Zhang, Shiwu Li, Lijun Yang, Xing Li Wang, Taixing Cui, Dongqi Tan. Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis. PloS one. vol 9. issue 10. 2015-06-26. PMID:25338001. |
it was also demonstrated that irisin reduced high glucose-induced apoptosis by up-regulating bcl-2 expression and down-regulating bax, caspase-9 and caspase-3 expression. |
2015-06-26 |
2023-08-13 |
human |
| Haibo Song, Fei Wu, Yuan Zhang, Yuzhu Zhang, Fang Wang, Miao Jiang, Zhongde Wang, Mingxiang Zhang, Shiwu Li, Lijun Yang, Xing Li Wang, Taixing Cui, Dongqi Tan. Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis. PloS one. vol 9. issue 10. 2015-06-26. PMID:25338001. |
in summary, these results suggested that irisin plays a novel role in sustaining endothelial homeostasis by promoting huvec proliferation via the erk signaling pathway and protects the cell from high glucose-induced apoptosis by regulating bcl-2,bax and caspase expression. |
2015-06-26 |
2023-08-13 |
human |
| Christian Roux, Céline Lesueur, Caroline Aligny, Carole Brasse-Lagnel, Damien Genty, Stéphane Marret, Annie Laquerrière, Soumeya Bekri, Bruno J Gonzale. 3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis. Cell transplantation. vol 23. issue 11. 2015-06-25. PMID:23849780. |
quantification of bax, mitochondrial integrity, caspase-3 cleavage, and caspase-3 immunolocalization and activity showed that 3-ma induced a significant decrease of gad67-gfp precursor apoptosis. |
2015-06-25 |
2023-08-12 |
mouse |
| Mei Yang, Chunsong Yang, Yuhua Pe. Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms. Bio-medical materials and engineering. vol 24. issue 6. 2015-06-24. PMID:25227106. |
finally, the expression levels of cell proliferation and apoptosis related proteins such as p21, bcl-2 and bax were determined by western blotting. |
2015-06-24 |
2023-08-13 |
Not clear |
| Mei Yang, Chunsong Yang, Yuhua Pe. Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms. Bio-medical materials and engineering. vol 24. issue 6. 2015-06-24. PMID:25227106. |
the proliferation inhibition and apoptosis of ec9706 cells mediated by sirt3 downregulation may be closely associated with the expression levels of p21, bcl-2 and bax proteins. |
2015-06-24 |
2023-08-13 |
Not clear |
| Jie Qiu, Xiao-Yu Zhou, Xiao-Guang Zhou, Yong Li, Rui Cheng, Hai-Ying Li. MicroRNA-210 knockdown contributes to apoptosis caused by oxygen glucose deprivation in PC12 cells. Molecular medicine reports. vol 11. issue 1. 2015-06-24. PMID:25323830. |
mir-210 knockdown increased cell apoptosis by inducing caspase activity and regulating the balance between bcl-2 and bax levels. |
2015-06-24 |
2023-08-13 |
Not clear |
| Jeong-Won Hwang, Young-Mi Baek, Ik-Soon Jang, Kyeong Eun Yang, Dong-Gi Lee, So-Jung Yoon, Jaerang Rho, Chong-Kwan Cho, Yeon-Weol Lee, Ki-Rok Kwon, Hwa-Seung Yoo, Jung-Suk Sung, Shin Kim, Jong-Wook Park, Byeong-Churl Jang, Jong-Soon Cho. An enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IκBα. Molecular medicine reports. vol 11. issue 1. 2015-06-24. PMID:25333578. |
an enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of kato3 human gastric cancer cells via modulation of bax, mtor, pkb and iκbα. |
2015-06-24 |
2023-08-13 |
human |
| Zhen Yuan, Lifeng Yang, Baian Chen, Ting Zhu, Mohammad Farooque Hassan, Xiaomin Yin, Xiangmei Zhou, Deming Zha. Protein misfolding cyclic amplification induces the conversion of recombinant prion protein to PrP oligomers causing neuronal apoptosis. Journal of neurochemistry. vol 133. issue 5. 2015-06-24. PMID:25810062. |
in addition, we found that this toxicity is the result of oligomer-induced apoptosis via regulation of bcl-2, bax, and caspase-3 in both wild-type and prp(-/-) cortical neurons. |
2015-06-24 |
2023-08-13 |
mouse |
| Zhen Yuan, Lifeng Yang, Baian Chen, Ting Zhu, Mohammad Farooque Hassan, Xiaomin Yin, Xiangmei Zhou, Deming Zha. Protein misfolding cyclic amplification induces the conversion of recombinant prion protein to PrP oligomers causing neuronal apoptosis. Journal of neurochemistry. vol 133. issue 5. 2015-06-24. PMID:25810062. |
this toxicity is the result of oligomers-induced apoptosis via regulation of bcl-2, bax, and caspase-3. |
2015-06-24 |
2023-08-13 |
mouse |
| Su-Feng Zhou, Jing Yuan, Meng-Yang Liao, Ni Xia, Ting-Ting Tang, Jing-Jing Li, Jiao Jiao, Wen-Yong Dong, Shao-Fang Nie, Zheng-Feng Zhu, Wen-Cai Zhang, Bing-Jie Lv, Hong Xiao, Qing Wang, Xin Tu, Yu-Hua Liao, Guo-Ping Shi, Xiang Chen. IL-17A promotes ventricular remodeling after myocardial infarction. Journal of molecular medicine (Berlin, Germany). vol 92. issue 10. 2015-06-23. PMID:24965614. |
additional studies in vitro indicated that il-17a induces neonatal cardiomyocyte (from c57bl/6 mice) apoptosis through the activation of p38, p53 phosphorylation, and bax redistribution. |
2015-06-23 |
2023-08-13 |
mouse |
| Yue-wen Chang, Yong-fang Zhao, Yue-long Cao, Wei Gu, Jian Pang, Hong-sheng Zha. Bufalin exerts inhibitory effects on IL-1β-mediated proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. Inflammation. vol 37. issue 5. 2015-06-22. PMID:24752615. |
moreover, bufalin induced apoptosis and mitochondrial damage of raflss, which was associated with bcl-2 downregulation, bax upregulation, mitochondrial cytochrome c release, and enhanced cleavages of caspase-3 and poly-(adp-ribose) polymerase. |
2015-06-22 |
2023-08-13 |
human |