| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Beesetti, J Mavuluri, R P Surabhi, T M Oberyszyn, K Tober, R S Pitani, L D Joseph, G Venkatraman, S K Rayal. Transcriptional regulation of ataxia-telangiectasia and Rad3-related protein by activated p21-activated kinase-1 protects keratinocytes in UV-B-induced premalignant skin lesions. Oncogene. vol 36. issue 44. 2017-11-20. PMID:28692051. |
results from our analysis showed that pak1 overexpression, knockdown and pak1 knockout cell line models showed that pak1 confers protection to keratinocytes from uv-b-induced apoptosis and dna damage via atr. |
2017-11-20 |
2023-08-13 |
mouse |
| Andrea Celeghin, Silvia Giunco, Riccardo Freguja, Manuela Zangrossi, Silvia Nalio, Riccardo Dolcetti, Anita De Ross. Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells. Cell death & disease. vol 7. issue 12. 2017-10-09. PMID:28032863. |
the cell cycle arrest and apoptosis, consequent upon short-term tert inhibition, were associated with and likely dependent on the activation of the dna damage response (ddr), highlighted by the increased levels of γh2ax and activation of atm and atr pathways. |
2017-10-09 |
2023-08-13 |
Not clear |
| He-Guo Jiang, Ping Chen, Jin-Yu Su, Ming Wu, Hai Qian, Yi Wang, Jian L. Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells. Journal of cellular physiology. vol 232. issue 12. 2017-10-02. PMID:28075014. |
knockdown of rev3 synergizes with atr inhibition to promote apoptosis induced by cisplatin in lung cancer cells. |
2017-10-02 |
2023-08-13 |
Not clear |
| He-Guo Jiang, Ping Chen, Jin-Yu Su, Ming Wu, Hai Qian, Yi Wang, Jian L. Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells. Journal of cellular physiology. vol 232. issue 12. 2017-10-02. PMID:28075014. |
in this study, we show that rev3 knockdown combined with atr inhibition further enhance cytotoxicity of cisplatin in nsclc cells, including cisplatin-sensitive and -resistant cell lines, compared to individual knockdown of rev3 or atr, which are accompanied by markedly caspase-dependent apoptosis response, pronounced dna damage accumulation and severe impediment of interstrand crosslink (icl), and double strand break (dsb) repair. |
2017-10-02 |
2023-08-13 |
Not clear |
| Jun Yang, Xinyu Zhao, Mei Tang, Lei Li, Yi Lei, Ping Cheng, Wenhao Guo, Yu Zheng, Wei Wang, Na Luo, Yong Peng, Aiping Tong, Yuquan Wei, Chunlai Nie, Zhu Yua. The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells. Oncotarget. vol 8. issue 14. 2017-09-18. PMID:28423586. |
furthermore, puma induces dna breaks in γ-h2ax staining, and causes activation of dna damage-related kinases including atm, atr, dna-pkcs, chk1 and chk2, which are correlated with the apoptosis. |
2017-09-18 |
2023-08-13 |
Not clear |
| Patrick Y Lang, Gouri J Nanjangud, Marina Sokolsky-Papkov, Christine Shaw, Duhyeong Hwang, Joel S Parker, Alexander V Kabanov, Timothy R Gersho. ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation. Development (Cambridge, England). vol 143. issue 21. 2017-09-11. PMID:27803059. |
atr deletion in cerebellar granule neuron progenitors (cgnps) induced proliferation-associated dna damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. |
2017-09-11 |
2023-08-13 |
mouse |
| S V Muralidharan, J Bhadury, L M Nilsson, L C Green, K G McLure, J A Nilsso. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. vol 35. issue 36. 2017-08-31. PMID:26804177. |
bet bromodomain inhibitors synergize with atr inhibitors to induce dna damage, apoptosis, senescence-associated secretory pathway and er stress in myc-induced lymphoma cells. |
2017-08-31 |
2023-08-13 |
mouse |
| Ana Finzel, Andrea Grybowski, Jette Strasen, Elena Cristiano, Alexander Loewe. Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage. Molecular biology of the cell. vol 27. issue 15. 2017-08-30. PMID:27280387. |
it is mainly coordinated by the kinases atm, atr, and dna-pkcs, which control the repair of broken dna strands and relay the damage signal to the tumor suppressor p53 to induce cell cycle arrest, apoptosis, or senescence. |
2017-08-30 |
2023-08-13 |
Not clear |
| Vanessa Enriquez-Rios, Lavinia C Dumitrache, Susanna M Downing, Yang Li, Eric J Brown, Helen R Russell, Peter J McKinno. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123024. |
in contrast, atr coordinated the ddr during neurogenesis to direct apoptosis in cycling neural progenitors, whereas atm regulated apoptosis in both proliferative and noncycling cells. |
2017-08-01 |
2023-08-13 |
mouse |
| Ahrum Min, Seock-Ah Im, Hyemin Jang, Seongyeong Kim, Miso Lee, Debora Keunyoung Kim, Yaewon Yang, Hee-Jun Kim, Kyung-Hun Lee, Jin Won Kim, Tae-Yong Kim, Do-Youn Oh, Jeff Brown, Alan Lau, Mark J O'Connor, Yung-Jue Ban. AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells. Molecular cancer therapeutics. vol 16. issue 4. 2017-08-01. PMID:28138034. |
the aim of this study was to investigate the potential use of the atr inhibitor, azd6738, to treat gastric cancer.in snu-601 cells with dysfunctional atm, azd6738 treatment led to an accumulation of dna damage due to dysfunctional rad51 foci formation, s phase arrest, and caspase 3-dependent apoptosis. |
2017-08-01 |
2023-08-13 |
Not clear |
| Christine M M Hendriks, Jörg Hartkamp, Stefan Wiezorek, Anne-Dorothee Steinkamp, Giulia Rossetti, Bernhard Lüscher, Carsten Bol. Sulfoximines as ATR inhibitors: Analogs of VE-821. Bioorganic & medicinal chemistry letters. vol 27. issue 12. 2017-07-18. PMID:28479198. |
prolonged inhibition of atr by the analogs in a burkitt lymphoma cell line resulted in enhanced dna damage and a substantial amount of apoptosis. |
2017-07-18 |
2023-08-13 |
Not clear |
| Zhoushuai Qin, Zhiqiang Bai, Ying Sun, Xiaohong Niu, Wei Xia. PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints. Cell cycle (Georgetown, Tex.). vol 15. issue 24. 2017-06-28. PMID:27753536. |
the above cell-cycle arrest is reversible in an atr-dependent manner, as simultaneous inhibition of atr, but not atm, induces apoptosis. |
2017-06-28 |
2023-08-13 |
Not clear |
| Xin Li, Marilyn C Cornelis, Liming Liang, Fengju Song, Immaculata De Vivo, Edward Giovannucci, Jean Y Tang, Jiali Ha. A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma. Carcinogenesis. vol 37. issue 12. 2017-05-15. PMID:27797824. |
animal models have suggested that oral or topical administration of caffeine could inhibit ultraviolet-induced carcinogenesis via the ataxia telangiectasia and rad3 (atr)-related apoptosis. |
2017-05-15 |
2023-08-13 |
Not clear |
| Hee-Jun Kim, Ahrum Min, Seock-Ah Im, Hyemin Jang, Kyung Hun Lee, Alan Lau, Miso Lee, Seongyeong Kim, Yaewon Yang, Jungeun Kim, Tae Yong Kim, Do-Youn Oh, Jeffrey Brown, Mark J O'Connor, Yung-Jue Ban. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. International journal of cancer. vol 140. issue 1. 2017-05-08. PMID:27501113. |
atr is a master regulator of dna damage repair (ddr), signaling to control dna replication, dna repair and apoptosis. |
2017-05-08 |
2023-08-13 |
human |
| Yao Hu, Xiumei Lv, Jing Zhang, Xianli Men. Comparative Study on the Protective Effects of Salidroside and Hypoxic Preconditioning for Attenuating Anoxia-Induced Apoptosis in Pheochromocytoma (PC12) Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-05-03. PMID:27794583. |
results salidroside decreased the apoptosis and increased the viability of hypoxia-induced pc12 cells more effectively than hpc moreover, salidroside markedly stabilized mmp and intracellular ca2+, reduced or inhibited ldh and caspase-3 activity, and up-regulated bcl-2; csa and atr showed corresponding function. |
2017-05-03 |
2023-08-13 |
Not clear |
| Eun-Jin Lee, Youngsaeng Jang, Kwonyoon Kang, Da-Hyun Song, Rihyun Kim, Hee-Won Chang, Dong Eil Lee, Claire Ka-Eun Song, Bongkun Choi, Min-Ji Kang, Eun-Ju Chan. Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway. Environmental toxicology. vol 31. issue 8. 2017-02-16. PMID:25640594. |
atr exposure also led to inhibition of cell growth and induction of apoptosis in human jurkat t-cells. |
2017-02-16 |
2023-08-13 |
mouse |
| Eun-Jin Lee, Youngsaeng Jang, Kwonyoon Kang, Da-Hyun Song, Rihyun Kim, Hee-Won Chang, Dong Eil Lee, Claire Ka-Eun Song, Bongkun Choi, Min-Ji Kang, Eun-Ju Chan. Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway. Environmental toxicology. vol 31. issue 8. 2017-02-16. PMID:25640594. |
our results demonstrate that atr elicited an immunotoxic effect by inducing er stress-induced apoptosis in t-cells, therefore providing evidence for the molecular mechanism by which atr induces dysregulation of the immune system. |
2017-02-16 |
2023-08-13 |
mouse |
| Paulina Tokarz, Kai Kaarniranta, Janusz Blasia. Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases. Rejuvenation research. vol 19. issue 2. 2017-01-02. PMID:26214710. |
dna damage activates ataxia telangiectasia mutated (atm), ataxia telangiectasia and rad3-related (atr), breast cancer 1 (brca1), e2f transcription factor 1 (e2f1), and other proteins that regulate the cell cycle, dna damage repair, and apoptosis. |
2017-01-02 |
2023-08-13 |
Not clear |
| Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M Reaper, Oliver Mortusewicz, Sylvain A Jacques, Raoul V Kuiper, Niklas Schultz, Martin Scobie, Peter A Charlton, John R Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleda. Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Cell reports. vol 14. issue 2. 2016-11-09. PMID:26748709. |
indeed, we observe that replication stress induced by the chk1 inhibitor azd7762 results in replication catastrophe and apoptosis, when combined with the atr inhibitor ve-821 specifically in cancer cells. |
2016-11-09 |
2023-08-13 |
Not clear |
| Martin Andrs, Jan Korabecny, Eugenie Nepovimova, Daniel Jun, Zdenek Hodny, Kamil Kuc. Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy. Current cancer drug targets. vol 16. issue 3. 2016-11-08. PMID:26882028. |
atr activation triggers cell cycle checkpoints, dna repair and apoptosis, but also resistance of tumor cells to dna damaging agents, through stress support under replication stress. |
2016-11-08 |
2023-08-13 |
Not clear |