| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael G Kemp, Aziz Sanca. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. The Journal of biological chemistry. vol 291. issue 17. 2016-11-03. PMID:26940878. |
these results therefore suggest that whereas dna polymerase stalling at dna lesions activates atr to protect cell viability and prevent apoptosis, the stalling of rna polymerases instead activates atr to induce an apoptotic form of cell death in non-cycling cells. |
2016-11-03 |
2023-08-13 |
human |
| Poorwa Awasthi, Marco Foiani, Amit Kuma. ATM and ATR signaling at a glance. Journal of cell science. vol 128. issue 23. 2016-09-09. PMID:26567218. |
although the role of both atm and atr in dna repair, cell cycle regulation and apoptosis have been well studied, both still remain in the focus of current research activities owing to their role in cancer. |
2016-09-09 |
2023-08-13 |
Not clear |
| Peter Solár, Gabriela Hrčková, Lenka Koptašíková, Samuel Velebný, Zuzana Solárová, Martin Bačko. Murine breast carcinoma 4T1 cells are more sensitive to atranorin than normal epithelial NMuMG cells in vitro: Anticancer and hepatoprotective effects of atranorin in vivo. Chemico-biological interactions. vol 250. 2016-08-17. PMID:26969521. |
moreover, flow cytometric and brdu incorporation analysis did not confirm the inhibited entry into s-phase of the cell cyle after atr incubation, and on the contrary, it induced apoptosis associated with the activation of caspase-3 and parp cleavage in 4t1 cells. |
2016-08-17 |
2023-08-13 |
mouse |
| Xing-Hua Liao, Li Zheng, Hong-Peng He, De-Liang Zheng, Zhao-Qiang Wei, Nan Wang, Jian Dong, Wen-Jian Ma, Tong-Cun Zhan. STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells. Cellular signalling. vol 27. issue 11. 2016-06-30. PMID:26261078. |
stat3 regulated atr via microrna-383 to control dna damage to affect apoptosis in a431 cells. |
2016-06-30 |
2023-08-13 |
human |
| Francesca Cottini, Teru Hideshima, Rikio Suzuki, Yu-Tzu Tai, Giampaolo Bianchini, Paul G Richardson, Kenneth C Anderson, Giovanni Tono. Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma. Cancer discovery. vol 5. issue 9. 2016-06-01. PMID:26080835. |
we identified a poor-prognosis subset of multiple myeloma with extensive chromosomal instability and replicative stress, which rely on atr to compensate for dna-replicative stress; conversely, silencing of atr or treatment with a specific atr inhibitor triggers multiple myeloma cell apoptosis. |
2016-06-01 |
2023-08-13 |
Not clear |
| Xiuying Jia, Dandan Wang, Nana Gao, Hui Cao, Hangjun Zhan. Atrazine Triggers the Extrinsic Apoptosis Pathway in Lymphocytes of the Frog Pelophylax nigromaculata in Vivo. Chemical research in toxicology. vol 28. issue 10. 2016-05-18. PMID:26382550. |
in summary, acute atr exposure damaged the lymphocytes, resulting in their apoptosis via an extrinsic signaling pathway. |
2016-05-18 |
2023-08-13 |
Not clear |
| Xiao-Yao Song, Jia-Nan Li, Yan-Ping Wu, Bo Zhang, Bai-Xiang L. Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System. International journal of molecular sciences. vol 16. issue 6. 2016-03-08. PMID:26075868. |
in this study, we investigated the autophagy and apoptosis induced by atr in dopaminergic neurons in vivo. |
2016-03-08 |
2023-08-13 |
rat |
| Xiao-Yao Song, Jia-Nan Li, Yan-Ping Wu, Bo Zhang, Bai-Xiang L. Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System. International journal of molecular sciences. vol 16. issue 6. 2016-03-08. PMID:26075868. |
furthermore, this induction may be regulated by the beclin-1 and bcl-2 autophagy and apoptosis pathways, and this may help to better understand the mechanism underlying the neurotoxicity of atr. |
2016-03-08 |
2023-08-13 |
rat |
| Kirsty Minto. DNA damage response: ATR prevents premature apoptosis. Nature reviews. Molecular cell biology. vol 16. issue 11. 2016-01-21. PMID:26449320. |
dna damage response: atr prevents premature apoptosis. |
2016-01-21 |
2023-08-13 |
Not clear |
| Shweta Sharma, Jayanta Sarkar, Chandana Haldar, Sudhir Sinh. Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes. PloS one. vol 9. issue 9. 2016-01-08. PMID:25259610. |
induction of mitochondrial apoptosis, er stress and autophagy dysregulation provide a new insight into the mechanism of atr immunotoxicity. |
2016-01-08 |
2023-08-13 |
mouse |
| Benjamin A Hilton, Zhengke Li, Phillip R Musich, Hui Wang, Brian M Cartwright, Moises Serrano, Xiao Zhen Zhou, Kun Ping Lu, Yue Zo. ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. Molecular cell. vol 60. issue 1. 2016-01-05. PMID:26387736. |
atr contains a bh3-like domain that allows atr-tbid interaction at mitochondria, suppressing cytochrome c release and apoptosis. |
2016-01-05 |
2023-08-13 |
Not clear |
| Shohei Miyata, Yasuaki Fukuda, Haruka Tojima, Keiichi Matsuzaki, Susumu Kitanaka, Hiroshi Sawad. Mechanism of the inhibition of leukemia cell growth and induction of apoptosis through the activation of ATR and PTEN by the topoisomerase inhibitor 3EZ, 20Ac-ingenol. Leukemia research. vol 39. issue 9. 2015-11-03. PMID:26194899. |
mechanism of the inhibition of leukemia cell growth and induction of apoptosis through the activation of atr and pten by the topoisomerase inhibitor 3ez, 20ac-ingenol. |
2015-11-03 |
2023-08-13 |
Not clear |
| Shohei Miyata, Yasuaki Fukuda, Haruka Tojima, Keiichi Matsuzaki, Susumu Kitanaka, Hiroshi Sawad. Mechanism of the inhibition of leukemia cell growth and induction of apoptosis through the activation of ATR and PTEN by the topoisomerase inhibitor 3EZ, 20Ac-ingenol. Leukemia research. vol 39. issue 9. 2015-11-03. PMID:26194899. |
these data suggest that 3ez, 20ac-ingenol-induced dna damage downregulates p-akt and upregulates atr leading to cell cycle arrest and increased apoptosis in ball-1 cells. |
2015-11-03 |
2023-08-13 |
Not clear |
| Janine O Ilagan, Aravind Ramakrishnan, Brian Hayes, Michele E Murphy, Ahmad S Zebari, Philip Bradley, Robert K Bradle. U2AF1 mutations alter splice site recognition in hematological malignancies. Genome research. vol 25. issue 1. 2015-09-28. PMID:25267526. |
u2af1 mutations cause differential splicing of hundreds of genes, affecting biological pathways such as dna methylation (dnmt3b), x chromosome inactivation (h2afy), the dna damage response (atr, fanca), and apoptosis (casp8). |
2015-09-28 |
2023-08-13 |
Not clear |
| Yuxia Cui, Stela S Palii, Cynthia L Innes, Richard S Paule. Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483091. |
atr depletion also inhibits ir-induced autophagy, regardless of the atm status, and enhances ir-induced apoptosis particularly when atm is deficient. |
2015-09-16 |
2023-08-13 |
human |
| Zhu Yuan, Wenhao Guo, Jun Yang, Lei Li, Meiliang Wang, Yi Lei, Yang Wan, Xinyu Zhao, Na Luo, Ping Cheng, Xinyu Liu, Chunlai Nie, Yong Peng, Aiping Tong, Yuquan We. PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25918161. |
gene silencing of chk1/2 rescues, whereas that of atm or atr does not affect, s phase arrest and apoptosis. |
2015-09-10 |
2023-08-13 |
human |
| Leonardo C Andrade-Lima, Luciana N Andrade, Carlos F M Menc. ATR suppresses apoptosis after UVB irradiation by controlling both translesion synthesis and alternative tolerance pathways. Journal of cell science. vol 128. issue 1. 2015-07-14. PMID:25380827. |
atr suppresses apoptosis after uvb irradiation by controlling both translesion synthesis and alternative tolerance pathways. |
2015-07-14 |
2023-08-13 |
human |
| Leonardo C Andrade-Lima, Luciana N Andrade, Carlos F M Menc. ATR suppresses apoptosis after UVB irradiation by controlling both translesion synthesis and alternative tolerance pathways. Journal of cell science. vol 128. issue 1. 2015-07-14. PMID:25380827. |
we observed that atr knockdown by sirna increased replication stress and promoted early induction of apoptosis following uvb irradiation in sv40-immortalized human cells, including cells from xp-v and xp-c patients. |
2015-07-14 |
2023-08-13 |
human |
| Bowen Li, Lingbin Sun, Jiali Cai, Chonggang Wang, Mengmeng Wang, Huiling Qiu, Zhenghong Zu. Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells. Journal of environmental sciences (China). vol 27. 2015-05-29. PMID:25597668. |
we further demonstrated that tbt induced cell apoptosis via the p53-mediated pathway, which was most likely activated by the ataxia telangiectasia mutated and rad-3 related (atr) protein kinase. |
2015-05-29 |
2023-08-13 |
human |
| Shobhan Gaddameedhi, Christopher P Selby, Michael G Kemp, Rui Ye, Aziz Sanca. The circadian clock controls sunburn apoptosis and erythema in mouse skin. The Journal of investigative dermatology. vol 135. issue 4. 2015-05-27. PMID:25431853. |
early-morning exposure to uv also produced maximal activation of ataxia telangiectasia mutated and rad3-related (atr)-mediated dna damage checkpoint signaling, including activation of the tumor suppressor p53, which is known to control the process of sunburn apoptosis. |
2015-05-27 |
2023-08-13 |
mouse |