| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina Keil, Maria T Meyer, David P Dannheisig, Lars D Maerz, Melanie Philipp, Astrid S Pfiste. Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events. Biochimica et biophysica acta. Molecular cell research. vol 1866. issue 5. 2019-09-04. PMID:30716409. |
we evaluated a potential signaling axis through the dna damage response kinases atm and atr and alternatively apoptosis as a potent driver of γh2a.x. |
2019-09-04 |
2023-08-13 |
human |
| Jie Wang, Lanyu Shen, Hong Hong, Jie Li, Hongtai Wang, Xiuzhen L. Atrasentan alleviates high glucose-induced podocyte injury by the microRNA-21/forkhead box O1 axis. European journal of pharmacology. vol 852. 2019-09-03. PMID:30876973. |
and, atr inhibited cell apoptosis and improved cell autophagic activity by downregulating mir-21 in hg-cultured podocytes. |
2019-09-03 |
2023-08-13 |
mouse |
| Jie Wang, Lanyu Shen, Hong Hong, Jie Li, Hongtai Wang, Xiuzhen L. Atrasentan alleviates high glucose-induced podocyte injury by the microRNA-21/forkhead box O1 axis. European journal of pharmacology. vol 852. 2019-09-03. PMID:30876973. |
we concluded that atr mitigated kidney injury in dn mice and alleviated hg-mediated apoptosis increase and autophagy inhibition in podocytes by regulating mir-21/foxo1 axis, further elucidating the molecular basis by which atr hampered dn progression. |
2019-09-03 |
2023-08-13 |
mouse |
| Jing Wang, Moussa Ide Nasser, Salah Adlat, Ming Ming Jiang, Nan Jiang, Li Ga. Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-08-15. PMID:30545141. |
as indicated by the results, atr ii could inhibit prostate cancer cell proliferation and promote du145 and lncap cell apoptosis through induced g2/m cell cycle arrest. |
2019-08-15 |
2023-08-13 |
human |
| Jing Wang, Moussa Ide Nasser, Salah Adlat, Ming Ming Jiang, Nan Jiang, Li Ga. Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-08-15. PMID:30545141. |
the cell apoptosis process induced by atr ii in both du145 and lncap cells was associated with its ability to inhibit androgen receptor (ar) with overexpression of protein inhibitor of activated stat-1 (pias1) and the repression of janus kinase (jak2) signaling pathways. |
2019-08-15 |
2023-08-13 |
human |
| A Lindemann, H Takahashi, A A Patel, A A Osman, J N Myer. Targeting the DNA Damage Response in OSCC with TP53 Mutations. Journal of dental research. vol 97. issue 6. 2019-06-24. PMID:29489434. |
the dna damage stabilizes p53 in part via the dna damage signaling pathway that involves sensor kinases, including atm and atr and effector kinases, such as chk1/2 and wee1, which leads to posttranscriptional regulation of a variety of genes involved in dna repair, cell cycle control, apoptosis, and senescence. |
2019-06-24 |
2023-08-13 |
human |
| Kun Wang, Yichen Ge, Chao Ni, Bomiao Cui, Jintao Du, Bo Zhang, Xiaoyu Hu, Jiao Chen, Liying Xiao, Chongkui Sun, Yan L. Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28607398. |
moreover, depletion of tcab1 caused both cell cycle arrest and apoptosis, and suppressed the activation of ataxia telangiectasia and rad3 related protein (atr) induced by ebv, resulting in accumulation of dna damage. |
2019-01-10 |
2023-08-13 |
Not clear |
| Shengchen Wang, Shufang Zheng, Qiaojian Zhang, Zijiang Yang, Kai Yin, Shiwen X. Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis. Environmental pollution (Barking, Essex : 1987). vol 243. issue Pt A. 2018-12-11. PMID:30193222. |
moreover, we found that in the nets process, atr downregulated the expression of the anti-apoptosis gene b-cell lymphoma-2 (bcl-2), increased the expression of the pro-apoptosis factors bcl-2-associated x (bax), cysteinyl aspartate specific proteinases (caspase3, 9), and anti-autophagy factor mammalian target of rapamycin (mtor), decreased the expression of autophagy-related protein light chain 3b (lc3b) and glucose transport proteins (glut1, 4), disturbed the activities of phosphofructokinase (pfk), pyruvate kinase (pkm), and hexokinase (hk) and limited reactive oxygen species (ros) levels, indicating that the reduced nets release was a consequence of increased apoptosis and diminished ros burst, autophagy and down-regulated glycolysis under atr treatment. |
2018-12-11 |
2023-08-13 |
human |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
3ez, 20ac-ingenol induces cell-specific apoptosis in cyclin d1 over-expression through the activation of atr and downregulation of p-akt. |
2018-11-05 |
2023-08-13 |
Not clear |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
we have previously used western blot analysis to show that the catalytic topoisomerase (topo) inhibitor, 3ez, 20ac-ingenol, induced dna damage response (ddr), which activated atr, downregulated p-akt through upregulation of pten level, and led to cell cycle arrest or apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
in this study, we used atr or pten sirna and observed that the specific cell arrest and apoptosis of ball-1 cells in ddr caused by 3ez, 20ac-ingenol was dependant on activation of atr and downregulation of nuclear p-akt through upregulation of pten. |
2018-11-05 |
2023-08-13 |
Not clear |
| Jun Ma, Xinyu Li, Yongwei Su, Jianyun Zhao, Daniel A Luedtke, Valeria Epshteyn, Holly Edwards, Guan Wang, Zhihong Wang, Roland Chu, Jeffrey W Taub, Hai Lin, Yue Wang, Yubin G. Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells. Scientific reports. vol 7. 2018-10-26. PMID:28176818. |
therefore, the cooperative induction of dna replication stress and damage by atr inhibition and cytarabine, and the ability of atr inhibition to abrogate the g2 cell cycle checkpoint both contributed to the synergistic induction of apoptosis and proliferation inhibition in aml cell lines. |
2018-10-26 |
2023-08-13 |
Not clear |
| Chris T Williamson, Rowan Miller, Helen N Pemberton, Samuel E Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J Ryan, Jeff Francis, Peter B Vermulen, Andrew R Reynolds, Philip M Reaper, John R Pollard, Alan Ashworth, Christopher J Lor. ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Nature communications. vol 7. 2018-09-25. PMID:27958275. |
in arid1a mutant tumour cells, inhibition of atr triggers premature mitotic entry, genomic instability and apoptosis. |
2018-09-25 |
2023-08-13 |
human |
| Jia Lin, Hua-Shan Zhao, Lei Qin, Xue-Nan Li, Cong Zhang, Jun Xia, Jin-Long L. Atrazine Triggers Mitochondrial Dysfunction and Oxidative Stress in Quail ( Coturnix C. coturnix) Cerebrum via Activating Xenobiotic-Sensing Nuclear Receptors and Modulating Cytochrome P450 Systems. Journal of agricultural and food chemistry. vol 66. issue 25. 2018-07-05. PMID:29865786. |
atr may initiate apoptosis by activating bcl-2, bax, and caspase3 protein expression but failed to induce autophagy (lc3b has not cleaved to lc3bi/ii). |
2018-07-05 |
2023-08-13 |
Not clear |
| Mahnoush Bahjat, Timon A Bloedjes, Amélie van der Veen, Guus de Wilde, Chiel Maas, Jeroen E J Guikem. Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay. Journal of visualized experiments : JoVE. issue 124. 2018-05-03. PMID:28654064. |
the ataxia-telangiectasia mutated kinase (atm), atm- and rad3-related kinase (atr) and the catalytic subunit of dna-dependent protein kinase (dna-pkcs) are among the first that are activated upon induction of dna damage, and are central regulators of a network that controls dna repair, apoptosis and cell survival. |
2018-05-03 |
2023-08-13 |
Not clear |
| Somsundar Veppil Muralidharan, Berglind Osk Einarsdottir, Joydeep Bhadury, Mattias F Lindberg, Jin Wu, Eric Campeau, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Lisa M Nilsson, Jonas A Nilsso. BET bromodomain inhibitors synergize with ATR inhibitors in melanoma. Cell death & disease. vol 8. issue 8. 2018-04-30. PMID:28796244. |
concomitant inhibition of bet proteins and atr of cultured melanoma cells resulted in similar effects as recently shown in lymphoma, such as induction of apoptosis and p62, implicated in autophagy, senescence-associated secretory pathway and er stress. |
2018-04-30 |
2023-08-13 |
mouse |
| Ming Wang, Gang Liu, Guo-Ping Shan, Bing-Bing Wan. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells. Cancer biotherapy & radiopharmaceuticals. vol 32. issue 6. 2018-04-23. PMID:28820634. |
the study investigated the ability of ataxia-telangiectasia mutated (atm)/rad3-related (atr) signaling pathway to influence the proliferation, apoptosis, and radiosensitivity of nasopharyngeal carcinoma (npc) cells. |
2018-04-23 |
2023-08-13 |
Not clear |
| Phillip R Musich, Zhengke Li, Yue Zo. Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation. Advances in experimental medicine and biology. vol 996. 2018-04-10. PMID:29124689. |
this review summarizes recent findings on the interplay between atr as a dna damage signaling kinase and as a novel ligand for intrinsic cell death proteins to delay damage-induced apoptosis, and on atr's regulation of xpa and the ner process for repair of uv-induced dna adducts. |
2018-04-10 |
2023-08-13 |
Not clear |
| Shuliang Zhou, Youde Xiao, Yafei Zhuang, Yinyin Liu, Hong Zhao, Hui Yang, Conghua Xie, Fuxiang Zhou, Yunfeng Zho. Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening. Oncology reports. vol 38. issue 1. 2018-04-04. PMID:28628186. |
knockdown of hmbox1 increased the apoptosis rate, decreased radiation-induced dna damage foci, and inhibited the expression of atm, atr, p-atm, p-atr and brca1 in the homologous recombination repair pathway. |
2018-04-04 |
2023-08-13 |
Not clear |
| Domenico Delia, Shuki Mizutan. The DNA damage response pathway in normal hematopoiesis and malignancies. International journal of hematology. vol 106. issue 3. 2018-03-08. PMID:28707218. |
at the heart of the ddr are the related signaling kinases atm, atr, and dna-pk, which regulate dna repair and associated events such as cell cycle checkpoints, chromatin remodeling, transcription, and ultimately apoptosis. |
2018-03-08 |
2023-08-13 |
Not clear |