| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongpeng Li, Lin Li, Haoyu Fu, Qing Yao, Lei Wang, Liguang Lo. Combined inhibition of PARP and ATR synergistically potentiates the antitumor activity of HER2-targeting antibody-drug conjugate in HER2-positive cancers. American journal of cancer research. vol 13. issue 1. 2023-02-13. PMID:36777513. |
effects of the her2-targeted adc, ds-8201, in combination with parpi (azd2281), a dna damage repair inhibitor that targets poly(adp-ribose) polymerase, and atri (bay1895344), which inhibits the serine/threonine kinase atr, were determined by assessing cell-growth inhibition, apoptosis and cell-cycle arrest, as well as using |
2023-02-13 |
2023-08-14 |
Not clear |
| Miki Suemura, Shusaku Shibutani, Hiroyuki Iwat. The endocytosis inhibitor dynasore induces a DNA damage response pathway that can be manipulated for enhanced apoptosis. Biochemical and biophysical research communications. vol 645. 2023-01-19. PMID:36657293. |
furthermore, an atr inhibitor sensitized the dynasore-induced apoptosis. |
2023-01-19 |
2023-08-14 |
Not clear |
| Vignesh Sundararajan, Tuan Zea Tan, Diana Lim, Yanfen Peng, Antje Margret Wengner, Natalie Yan Li Ngoi, Anand D Jeyasekharan, David Shao Peng Ta. Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition. The Journal of pathology. 2022-11-14. PMID:36373784. |
rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention toward targeting cell cycle checkpoint kinases (such as atr, chk1, wee1 and others) along the dna damage response and replicative stress response pathways, thereby allowing unrepaired dna damage to be carried forward towards mitotic catastrophe and apoptosis. |
2022-11-14 |
2023-08-14 |
Not clear |
| Weicai Huang, Zhen Han, Zepang Sun, Hao Feng, Liying Zhao, Qingyu Yuan, Chuanli Chen, Shitong Yu, Yanfeng Hu, Jiang Yu, Hao Liu, Guoxin Li, Yuming Jian. PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer. Cell death & disease. vol 13. issue 7. 2022-07-28. PMID:35902562. |
activation of atr is the necessary step for pak6 mediated hr repair to protect gc cells from oxaliplatin-induced apoptosis, and atr inhibitor (azd6738) could block the pak6-mediated hr repair, thereby reversing the resistance to oxaliplatin and even promoting the sensitivity to oxaliplatin regardless of high expression of pak6. |
2022-07-28 |
2023-08-14 |
Not clear |
| Francis M Barnieh, Goreti Ribeiro Morais, Herbie Garland, Paul M Loadman, Robert A Falcone. Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells. Biochemical pharmacology. 2022-05-22. PMID:35598808. |
we also explore synergism between ict2588 and atr inhibition, since colchicine, in addition to its vascular-disrupting properties, is known to induce g2/m arrest, dna damage, and trigger apoptosis. |
2022-05-22 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
atractylodin (atr) has anticancer effects on some tumor cells by inducing apoptosis, but its mechanism in lung cancer remains unclear. |
2022-05-14 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
results showed that the effect of atr on the apoptosis of a549 cells was negatively correlated with the change in mitochondrial membrane potential. |
2022-05-14 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
western blot analysis showed that atr regulated apoptosis induced by mitogen-activated protein kinase, signal transducer and activator of transcription 3, and nuclear factor kappa b signaling pathways. |
2022-05-14 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
results showed that atr can inhibit cell proliferation, induce cell apoptosis, induce cell cycle arrest, and inhibit the migration of a549 cells ( |
2022-05-14 |
2023-08-13 |
Not clear |
| Merve Yildirim, Ozgecan Kayalar, Ersan Atahan, Fusun Ozta. Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis. Journal of biochemical and molecular toxicology. 2022-04-13. PMID:35416377. |
the effects of atr on myofibroblast differentiation, apoptosis, and tgf-β and wnt/β-catenin signaling activations were examined by western blot analysis and flow cytometry in mrc5s. |
2022-04-13 |
2023-08-13 |
mouse |
| Merve Yildirim, Ozgecan Kayalar, Ersan Atahan, Fusun Ozta. Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis. Journal of biochemical and molecular toxicology. 2022-04-13. PMID:35416377. |
moreover, atr caused myofibroblast apoptosis via caspase-3 activation. |
2022-04-13 |
2023-08-13 |
mouse |
| Michel M Ouellette, Sumin Zhou, Ying Ya. Cell Signaling Pathways That Promote Radioresistance of Cancer Cells. Diagnostics (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35328212. |
however, radiation also concomitantly activates multiple prosurvival signaling pathways, which include those mediated by atm, atr, akt, erk, and nf-κb that promote dna damage checkpoint activation/dna repair, autophagy induction, and/or inhibition of apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Ganapathy Sriram, Lauren E Milling, Jung-Kuei Chen, Yi Wen Kong, Brian A Joughin, Wuhbet Abraham, Susanne Swartwout, Erika D Handly, Darrell J Irvine, Michael B Yaff. The injury response to DNA damage in live tumor cells promotes antitumor immunity. Science signaling. vol 14. issue 705. 2022-01-14. PMID:34665642. |
these immune-enhancing effects of dna damage did not correlate with immunogenic cell death markers or with the extent of apoptosis or necroptosis; instead, these effects were mediated by live injured cells with activation of the dna-pk, atr, nf-κb, p38 mapk, and ripk1 signaling pathways. |
2022-01-14 |
2024-04-07 |
mouse |
| Meiran Chu, Xinglan An, Daoyu Zhang, Qi Li, Xiangpeng Dai, Hao Yu, Ziyi L. Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint. Biochimica et biophysica acta. Molecular cell research. vol 1869. issue 2. 2021-12-10. PMID:34763028. |
combined treatment with 6-tg and dsf/cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-rad3-related kinase (atr), suggesting that dsf/cu promoted 6-tg-induced dna damage by suppressing atr protein kinases, therefore enhancing cell apoptosis. |
2021-12-10 |
2023-08-13 |
human |
| Shaohua Dou, Chao Yang, Danfeng Zou, Wa Da, Muqaddas Masood, Salah Adlat, Yang-Jin Baima, M I Nasser, Bin Li, Nan Jian. Atractylenolide II induces cell cycle arrest and apoptosis in breast cancer cells through ER pathway. Pakistan journal of pharmaceutical sciences. vol 34. issue 4. 2021-11-22. PMID:34799321. |
in this research, atractylenolide ii (atr ii) on apoptosis, cell cycle cells via er pathway in breast cancer (mda-mb-231 and mcf-7) cells are assessed. |
2021-11-22 |
2023-08-13 |
Not clear |
| Shaohua Dou, Chao Yang, Danfeng Zou, Wa Da, Muqaddas Masood, Salah Adlat, Yang-Jin Baima, M I Nasser, Bin Li, Nan Jian. Atractylenolide II induces cell cycle arrest and apoptosis in breast cancer cells through ER pathway. Pakistan journal of pharmaceutical sciences. vol 34. issue 4. 2021-11-22. PMID:34799321. |
our findings showed atr ii could inhibit breast cancer cell growth by apoptosis mainly through g2/m-phase cell cycle arrest. |
2021-11-22 |
2023-08-13 |
Not clear |
| Xiaojuan Zhang, Sisi Tian, Sara E Beese-Sims, Jingjie Chen, Nara Shin, Monica P Colaiácovo, Hyun-Min Ki. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. PLoS genetics. vol 17. issue 7. 2021-11-08. PMID:34329293. |
loss of amx-1 function activates the chk-1 kinase acting downstream of atr and leads to the accumulation of rad-51 foci and increased dna damage-dependent apoptosis in the germline. |
2021-11-08 |
2023-08-13 |
human |
| Xin-Yue Shang, Xiao-Qi Yu, Guo-Dong Yao, Shao-Jiang Son. Daphnegiravone D from Daphne giraldii induces cell death by targeting ATR in Hep3B cells. Bioorganic chemistry. vol 110. 2021-10-12. PMID:33730672. |
the results from go, kegg and ppi analysis showed that dna damage, cell cycle, apoptosis, dna repair related pathways changed and atr was exactly related to them. |
2021-10-12 |
2023-08-13 |
Not clear |
| Xin-Yue Shang, Xiao-Qi Yu, Guo-Dong Yao, Shao-Jiang Son. Daphnegiravone D from Daphne giraldii induces cell death by targeting ATR in Hep3B cells. Bioorganic chemistry. vol 110. 2021-10-12. PMID:33730672. |
furthermore, the knockdown of atr could increase apoptosis and reactive oxygen species (ros) which induced by dgd. |
2021-10-12 |
2023-08-13 |
Not clear |
| Hua Gan, Ming Qi, Chakpiu Chan, Pan Leung, Geni Ye, Yuhe Lei, Aiai Liu, Feifei Xue, Dongdong Liu, Wencai Ye, Dongmei Zhang, Lijuan Deng, Jiaxu Che. Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32468057. |
mechanistically, digitoxin caused dna double‑stranded breaks (dsbs), inhibited the cell cycle at the g2/m phase via the ataxia telangiectasia mutated serine/threonine kinase (atm)/atm and rad3‑related serine/threonine kinase (atr)‑checkpoint kinase (chk1)/checkpoint kinase 2 (chk2)‑cdc25c pathway and ultimately triggered mitochondrial apoptosis, which was characterized by the disruption of bax/bcl‑2, the release of cytochrome c and the sequential activation of caspases and poly(adp‑ribose) polymerase (parp). |
2021-05-05 |
2023-08-13 |
Not clear |