| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingxian Liu, Qiwen Zeng, Hanming Chen, Jianzhao Liao, Yuman Bai, Qingyue Han, Na Qiao, Shuzhou Wang, Khalid Mehmood, Riaz Hussain, Bhutto Zohaib Ahmed, Zhaoxin Tang, Hui Zhang, Ying L. The hepatotoxicity of altrazine exposure in mice involves the intestinal microbiota. Chemosphere. vol 272. 2021-04-06. PMID:33485040. |
therefore, this study for the first time reports the variation in the gut microbiota, induction of process of apoptosis and autophagy in mice induced by atr. |
2021-04-06 |
2023-08-13 |
mouse |
| Bingxian Liu, Qiwen Zeng, Hanming Chen, Jianzhao Liao, Yuman Bai, Qingyue Han, Na Qiao, Shuzhou Wang, Khalid Mehmood, Riaz Hussain, Bhutto Zohaib Ahmed, Zhaoxin Tang, Hui Zhang, Ying L. The hepatotoxicity of altrazine exposure in mice involves the intestinal microbiota. Chemosphere. vol 272. 2021-04-06. PMID:33485040. |
moreover, results also revealed that atr induced apoptosis via disruption of apoptotic (bax, bcl2, and casp3) and autophagy (lc3/map1lc3a, beclin 1/becn1 and p62/sqstm1) genes. |
2021-04-06 |
2023-08-13 |
mouse |
| Wu-Li Zhao, Yan Xing, Cheng Ye, Yu-Han Qiu, Yi Li, Xiu-Jun Liu, Meng-Yan Wang, Chong-Wen Bi, Dan-Qing Song, Rong-Guang Sha. The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation. Acta pharmacologica Sinica. vol 41. issue 5. 2021-02-09. PMID:31932645. |
although previous studies have revealed that some sophoridine derivatives could induce dna breakage, the underlying mechanisms of inhibition of dna damage repair (atr inactivation) and the apoptosis independent of p53, have not been elucidated. |
2021-02-09 |
2023-08-13 |
Not clear |
| Mattias K Andersson, Giovanna Mangiapane, Paloma Tejera Nevado, Alexia Tsakaneli, Therese Carlsson, Gabriele Corda, Valentina Nieddu, Carla Abrahamian, Olesya Chayka, Lilam Rai, Michael Wick, Amanda Kedaigle, Göran Stenman, Arturo Sal. ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma. Oncogenesis. vol 9. issue 1. 2021-01-29. PMID:32001675. |
treatment with the clinical atr kinase inhibitor vx-970 induced apoptosis in myb-positive acc cells and growth inhibition in acc pdxs. |
2021-01-29 |
2023-08-13 |
human |
| Gun-Hwi Lee, Kyung-Chul Cho. Adverse effects of pesticides on the functions of immune system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 235. 2021-01-29. PMID:32376494. |
according to previous studies, pesticides such as atrazine (atr), organophophorus (op) compounds, carbamates, and pyrethroids were shown to inhibit the survival and growth of leukocytes by inducing apoptosis or cell cycle arrest and interfering with the specific immunological functions of each type of immune cells. |
2021-01-29 |
2023-08-13 |
Not clear |
| Soichiro S Ito, Yosuke Nakagawa, Masaya Matsubayashi, Yoshihiko M Sakaguchi, Shinko Kobashigawa, Takeshi K Matsui, Hitoki Nanaura, Mari Nakanishi, Fumika Kitayoshi, Sotaro Kikuchi, Atsuhisa Kajihara, Shigehiro Tamaki, Kazuma Sugie, Genro Kashino, Akihisa Takahashi, Masatoshi Hasegawa, Eiichiro Mori, Tadaaki Kirit. Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways. The Journal of biological chemistry. vol 295. issue 37. 2021-01-27. PMID:32675286. |
of note, the atr inhibition enhanced induction of dna double-strand breaks and apoptosis in 5-fu-treated cells. |
2021-01-27 |
2023-08-13 |
Not clear |
| Emily M Schleicher, Ashna Dhoonmoon, Lindsey M Jackson, Kristen E Clements, Coryn L Stump, Claudia M Nicolae, George-Lucian Moldova. Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors. PLoS genetics. vol 16. issue 11. 2021-01-07. PMID:33137164. |
importantly, we show that the mechanisms of resistance employed by these genes are varied, and include restoring dna replication fork progression, and prevention of atr inhibitor-induced apoptosis. |
2021-01-07 |
2023-08-13 |
Not clear |
| Shohei Miyata, Tomonori Nakamura, Susumu Kitanak. 3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation. Anticancer research. vol 40. issue 11. 2020-11-04. PMID:33109561. |
the topoisomerase 1 catalytic inhibitor 3ez, 20ac-ingenol specifically induces apoptosis through the activation of atr and the up-regulation of pten by enhancing the dna damage response (ddr) in human b lymphoma (ball-1) cells. |
2020-11-04 |
2023-08-13 |
human |
| Vibha Singh, Siddhant Bhoir, Rupesh V Chikhale, Javeena Hussain, Donard Dwyer, Richard A Bryce, Sivapriya Kirubakaran, Arrigo De Benedett. Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy. iScience. vol 23. issue 9. 2020-10-01. PMID:32905878. |
adt results in increased expression of tlk1b, a key kinase upstream of nek1 and atr and mediating the dna damage response that typically results in temporary cell-cycle arrest of androgen-responsive pca cells, whereas its abrogation leads to apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Wangta Liu, Chang-Yi Wu, Mei-Jei Lu, Yung-Jen Chuang, Eing-Mei Tsai, Steve Leu, I-Ling Lin, Chih-Jan Ko, Chien-Chih Chiu, Wen-Tsan Chan. The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling. Oxidative medicine and cellular longevity. vol 2020. 2020-09-17. PMID:32089770. |
the phenoxyphenol compound 4-hppp selectively induces antiproliferation effects and apoptosis in human lung cancer cells through aneupolyploidization and atr dna repair signaling. |
2020-09-17 |
2023-08-13 |
human |
| Seema Kumari, Murali G Mohan, G Shailender, Anil Kumar Badana, Rama Rao Mall. Synergistic enhancement of apoptosis by coralyne and paclitaxel in combination on MDA-MB-231 a triple-negative breast cancer cell line. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31172606. |
the expression of atm and atr a serine/threonine-protein kinase, ataxia telangiectasia and rad3-related protein were depleted with an increase in time from 24 to 48 hours in concurrent with increased levels of γh2ax indicating that dna damage routes cells to enter apoptosis. |
2020-09-14 |
2023-08-13 |
Not clear |
| Zay Yar Oo, Martina Proctor, Alexander J Stevenson, Deborah Nazareth, Madushan Fernando, Sheena M Daignault, Catherine Lanagan, Sebastian Walpole, Vanessa Bonazzi, Dubravka Škalamera, Cameron Snell, Nikolas K Haass, Jill E Larsen, Brian Gabriell. Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine. Molecular oncology. vol 13. issue 7. 2020-05-11. PMID:31044505. |
we demonstrate that hu effectively synergises with chk1, but not atr inhibition, in > 70% of melanoma and non-small-cell lung cancer cells assessed, resulting in apoptosis and complete loss of proliferative potential in vitro and in vivo. |
2020-05-11 |
2023-08-13 |
Not clear |
| Eve Combès, Augusto F Andrade, Diego Tosi, Henri-Alexandre Michaud, Flavie Coquel, Veronique Garambois, Delphine Desigaud, Marta Jarlier, Arnaud Coquelle, Philippe Pasero, Nathalie Bonnefoy, Jerome Moreaux, Pierre Martineau, Maguy Del Rio, Roderick L Beijersbergen, Nadia Vezzio-Vie, Celine Gongor. Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related ( Cancer research. vol 79. issue 11. 2020-03-23. PMID:30987998. |
combined application of the atr inhibitor ve-822 and oxaliplatin resulted in strong synergistic effects in six different colorectal cancer cell lines and their oxaliplatin-resistant subclones, promoted dna single- and double-strand break formation, growth arrest, and apoptosis. |
2020-03-23 |
2023-08-13 |
mouse |
| Wenxiu Qi, Xiaohao Xu, Manying Wang, Xiangyan Li, Chaonan Wang, Liping Sun, Daqing Zhao, Liwei Su. Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis. Biochemical pharmacology. vol 164. 2020-02-13. PMID:31014753. |
inhibition of wee1 sensitizes aml cells to atr inhibitor ve-822-induced dna damage and apoptosis. |
2020-02-13 |
2023-08-13 |
Not clear |
| Dan Wang, Rui Zhao, Yuan-Yuan Qu, Xin-Yu Mei, Xuan Zhang, Qian Zhou, Yang Li, Shao-Bo Yang, Zhi-Gui Zuo, Yi-Ming Chen, Yan Lin, Wei Xu, Chao Chen, Shi-Min Zhao, Jian-Yuan Zha. Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. Cell reports. vol 25. issue 2. 2019-12-18. PMID:30304680. |
mechanistically, mars preferentially bound to and modified ataxia-telangiectasia and rad3-related protein (atr), inhibited atr and its downstream effectors checkpoint kinase-1 and p53, and relieved cell-cycle arrest and decreased dna damage-induced apoptosis by disrupting the binding of atr-interacting protein to atr. |
2019-12-18 |
2023-08-13 |
mouse |
| Vaughn Thada, David Corte. Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation. The Journal of biological chemistry. vol 294. issue 21. 2019-12-09. PMID:30940728. |
dna damage response ser/thr kinases, including ataxia telangiectasia-mutated (atm) and rad3-related (atr), control cell cycle progression, dna repair, and apoptosis. |
2019-12-09 |
2023-08-13 |
Not clear |
| Vibha Singh, Praveen Kumar Jaiswal, Ishita Ghosh, Hari K Koul, Xiuping Yu, Arrigo De Benedett. Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors. International journal of cancer. vol 145. issue 4. 2019-12-03. PMID:30737777. |
following dna damage, addition of the tlk specific inhibitor, thioridazine (thd), impairs atr and chk1 activation, establishing the existence of a adt > tlk1 > nek1 > atr > chk1, ddr pathway, while its abrogation leads to apoptosis. |
2019-12-03 |
2023-08-13 |
Not clear |
| Mi Tian, Liu Qingzhen, Yu Zhiyang, Chen Chunlong, Duan Jiao, Lidong Zhang, Weiyan L. Attractylone attenuates sepsis-associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation. Journal of cellular biochemistry. 2019-11-20. PMID:30672013. |
the result showed that atr attenuated lps-induced cognitive impairment, neural apoptosis, inflammatory factors, and microglial activation. |
2019-11-20 |
2023-08-13 |
mouse |
| Emilie Lukášová, Martina Řezáčová, Alena Bačíková, Ludmila Šebejová, Jiřina Vávrová, Stanislav Kozube. Distinct cellular responses to replication stress leading to apoptosis or senescence. FEBS open bio. vol 9. issue 5. 2019-11-12. PMID:30982228. |
targeting checkpoint kinase 1 (chk1) or ataxia telangiectasia and rad3-related (atr)] led to apoptosis or senescence in four cancer cell lines differing in tp53 mutation status and expression of lamin a/c (la/c). |
2019-11-12 |
2023-08-13 |
Not clear |
| Kazumasa Komura, Yuki Yoshikawa, Teppei Shimamura, Goutam Chakraborty, Travis A Gerke, Kunihiko Hinohara, Kalyani Chadalavada, Seong Ho Jeong, Joshua Armenia, Shin-Yi Du, Ying Z Mazzu, Kohei Taniguchi, Naokazu Ibuki, Clifford A Meyer, Gouri J Nanjangud, Teruo Inamoto, Gwo-Shu Mary Lee, Lorelei A Mucci, Haruhito Azuma, Christopher J Sweeney, Philip W Kantof. ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. The Journal of clinical investigation. vol 128. issue 7. 2019-09-16. PMID:29863497. |
in kdm5d-deficient cells, blocking atr activity with an atr inhibitor enhanced dna damage, which led to subsequent apoptosis. |
2019-09-16 |
2023-08-13 |
Not clear |