| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gan Wang, Vanitha Bhoopalan, David Wang, Le Wang, Xiaoxin X. The effect of caffeine on cisplatin-induced apoptosis of lung cancer cells. Experimental hematology & oncology. vol 4. 2015-05-04. PMID:25937999. |
caffeine can inhibit activities of both atm and atr, two important protein kinases involved in dna damage-induced cell cycle arrest and apoptosis. |
2015-05-04 |
2023-08-13 |
Not clear |
| Li-Hsin Chen, Pei-Ming Chu, Yi-Jang Lee, Pang-Hsien Tu, Chin-Wen Chi, Hsin-Chen Lee, Shih-Hwa Chio. Targeting protective autophagy exacerbates UV-triggered apoptotic cell death. International journal of molecular sciences. vol 13. issue 1. 2015-02-26. PMID:22312313. |
in conclusion, this study demonstrated that autophagy acts as a cytoprotective mechanism against uv-induced apoptosis and that autophagy induction accompanied with apoptosis at late stages is independent of atr activation. |
2015-02-26 |
2023-08-12 |
Not clear |
| Mohammad Rahman, Francesca Lovat, Giulia Romano, Federica Calore, Mario Acunzo, Erica Hlavin Bell, Patrick Nana-Sinka. miR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung. The Journal of biological chemistry. vol 289. issue 38. 2015-02-02. PMID:25092292. |
moreover, a pathway-based pcr expression array of genes demonstrated that mir-15b/16-2 overexpression significantly induced the expression of genes involved in atm/ataxia telangiectasia and rad-3-related (atr) signaling, apoptosis, the cell cycle, and dna repair pathways. |
2015-02-02 |
2023-08-13 |
human |
| Rachel Litman Flynn, Kelli E Cox, Maya Jeitany, Hiroaki Wakimoto, Alysia R Bryll, Neil J Ganem, Francesca Bersani, Jose R Pineda, Mario L Suvà, Cyril H Benes, Daniel A Haber, Francois D Boussin, Lee Zo. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science (New York, N.Y.). vol 347. issue 6219. 2015-01-26. PMID:25593184. |
inhibition of the protein kinase atr, a critical regulator of recombination recruited by rpa, disrupts alt and triggers chromosome fragmentation and apoptosis in alt cells. |
2015-01-26 |
2023-08-13 |
human |
| Filip Janku, Ahmed O Kaseb, Apostolia M Tsimberidou, Robert A Wolff, Razelle Kurzroc. Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. Oncotarget. vol 5. issue 10. 2015-01-23. PMID:24931142. |
detected molecular aberrations led to putative activation of the pi3k/akt/mtor pathway (n=3 [mtor, pik3ca, nf1]), wnt pathway (n=6 [ctnna1, ctnnb1]), mapk pathway (n=2 [map2k1, nras]), and aberrant dna repair mechanisms, cell cycle control and apoptosis (n=18 [atm, atr, bap1, ccnd1, cdkn2a, cdk4, fgf3, fgf4, fgf19, mcl1, mdm2, rb1, tp53]). |
2015-01-23 |
2023-08-13 |
Not clear |
| I I Suvorova, I V Kozhukharova, N N Nikol'skiĭ, V A Pospelo. [ATM/ATR signaling pathway activation in human embryonic stem cells after DNA damage]. Tsitologiia. vol 55. issue 12. 2015-01-02. PMID:25474902. |
atm and atr kinase are key sensors of dna double strands breaks and activate downstream signaling pathways involving checkpoints, dna repair and apoptosis. |
2015-01-02 |
2023-08-13 |
human |
| Ting Wang, Shu-chong Mei, Rong Fu, Hua-quan Wang, Zong-hong Sha. Expression of Shelterin component POT1 is associated with decreased telomere length and immunity condition in humans with severe aplastic anemia. Journal of immunology research. vol 2014. 2014-12-03. PMID:24892036. |
tnf-α and ifn-γ are found at high concentrations in saa patients and may be the effectors that trigger apoptosis through pot1 and atr. |
2014-12-03 |
2023-08-13 |
Not clear |
| Minkyung Bae, Joo Weon Lim, Hyeyoung Ki. Oxidative DNA Damage Response in Helicobacter pylori-Infected Mongolian Gerbils. Journal of cancer prevention. vol 18. issue 3. 2014-10-22. PMID:25337555. |
in the present study, we investigated the changes of hr dna repair proteins (ataxia-telangiectasia-mutated; atm, atm and rad3-related; atr), nhej repair proteins (ku70/80), cell cycle regulators (chk1, chk2), and apoptosis marker (p53/p-p53) were determined in h. pylori-infected mongolian gerbils. |
2014-10-22 |
2023-08-13 |
Not clear |
| Minkyung Bae, Joo Weon Lim, Hyeyoung Ki. Oxidative DNA Damage Response in Helicobacter pylori-Infected Mongolian Gerbils. Journal of cancer prevention. vol 18. issue 3. 2014-10-22. PMID:25337555. |
after 6 week, the expression levels of dna repair proteins (ku70/80, atm, atr), cell cycle regulators (chk1, chk2) and apoptosis marker (p-p53/p53) were increased in gastric mucosa of mongolian gerbils, which was suppressed by nac treatment. |
2014-10-22 |
2023-08-13 |
Not clear |
| Joost P M Melis, Raoul V Kuiper, Edwin Zwart, Joke Robinson, Jeroen L A Pennings, Conny T M van Oostrom, Mirjam Luijten, Harry van Stee. Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress. DNA repair. vol 12. issue 12. 2014-07-15. PMID:24084170. |
xpc has been linked to regulation of base excision repair (ber) activity, redox homeostasis and recruitment of atm and atr to damage sites, thereby possibly regulating cell cycle checkpoints and apoptosis. |
2014-07-15 |
2023-08-12 |
mouse |
| Bo Liu, Xin Che. The distinct signaling regulatory roles in the cortical atrophy and cerebellar apoptosis of newborn Nbn-deficient mice. Cellular and molecular neurobiology. vol 33. issue 8. 2014-07-08. PMID:23934213. |
in addition, jnk signaling and atr signaling are likely to converge to regulate the cerebellar apoptosis of newborn nbn-deficient mice. |
2014-07-08 |
2023-08-12 |
mouse |
| C Barckhausen, W P Roos, S C Naumann, B Kain. Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair. Oncogene. vol 33. issue 15. 2014-05-30. PMID:23604128. |
consequently, tp53 mutated cells are unable to repair icls, leading to prolonged atm, atr and checkpoint kinase 1 (chk1) activation, and finally apoptosis. |
2014-05-30 |
2023-08-12 |
mouse |
| Zhan Zhang, Huiyuan Lu, Fei Huan, Cromie Meghan, Xuejiao Yang, Yun Wang, Xichen Wang, Xinru Wang, Shou-Lin Wan. Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1. International journal of cancer. vol 134. issue 7. 2014-04-17. PMID:24114584. |
inhibition of atr (atr sirna or nu6027) reversely increased the apoptosis of p40 b-2a13 cells in parallel with the upregulation of bax, c-caspase 3 and c-parp, suggesting that atr plays an important role in maintaining cell survival via antiapoptosis. |
2014-04-17 |
2023-08-12 |
mouse |
| J Wang, J He, F Su, N Ding, W Hu, B Yao, W Wang, G Zho. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell death & disease. vol 4. 2014-02-25. PMID:23807228. |
repression of atr pathway by mir-185 enhances radiation-induced apoptosis and proliferation inhibition. |
2014-02-25 |
2023-08-12 |
human |
| J Wang, J He, F Su, N Ding, W Hu, B Yao, W Wang, G Zho. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell death & disease. vol 4. 2014-02-25. PMID:23807228. |
mir-185 enhances radiation-induced apoptosis and inhibition of proliferation by repressing atr pathway. |
2014-02-25 |
2023-08-12 |
human |
| Xiao Li, Ran Zhuo, Stanley Tiong, Francesca Di Cara, Kirst King-Jones, Sarah C Hughes, Shelagh D Campbell, Rachel Wevric. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555814. |
rather, caffeine-induced apoptosis in these mutants is exacerbated by inhibition of atm or atr checkpoint kinases but suppressed by rad51 depletion, suggesting a functional interaction involving homologous dna repair pathways that deserves further scrutiny. |
2014-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Yuichiro Nakata, Kosuke Nishi, Sogo Nishimoto, Takuya Sugahar. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway. The Journal of toxicological sciences. vol 38. issue 3. 2013-10-23. PMID:23665931. |
phosphorylation of p53 at ser15 was upregulated by activation of not only atr but also erk1/2 and p38, leading to increase of apoptosis. |
2013-10-23 |
2023-08-12 |
mouse |
| Sarah Sertic, Claudio Evolvi, Emanuela Tumini, Paolo Plevani, Marco Muzi-Falconi, Giuseppe Rotond. Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival. PloS one. vol 8. issue 3. 2013-09-30. PMID:23555860. |
this function prevents replication stress, atr hyper-signaling and, ultimately, apoptosis. |
2013-09-30 |
2023-08-12 |
human |
| Dipendra Gautam, Eileen Bridg. The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication. Journal of virology. vol 87. issue 15. 2013-09-18. PMID:23740981. |
mrn complex proteins localize to viral dna replication centers in e4 mutant-infected cells, and this complex is critical for activating the kinases ataxia-telangiectasia mutated (atm) and atm and rad3-related (atr), which phosphorylate numerous substrates important for dna repair, cell cycle checkpoint activation, and apoptosis. |
2013-09-18 |
2023-08-12 |
Not clear |
| Allan H Conney, Yao-Ping Lu, You-Rong Lou, Masaoki Kawasumi, Paul Nghie. Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis. Frontiers in oncology. vol 3. 2013-06-21. PMID:23785666. |
in studies with cultured primary human keratinocytes, inhibition of atr with sirna against atr inhibited chk1 phosphorylation and enhanced uvb-induced apoptosis. |
2013-06-21 |
2023-08-12 |
mouse |