| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huda H Al-Khalaf, Siti-Faujiah Hendrayani, Abdelilah Aboussekhr. ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:21976111. |
atr controls the p21(waf1/cip1) protein up-regulation and apoptosis in response to low uv fluences. |
2012-12-26 |
2023-08-12 |
human |
| Huda H Al-Khalaf, Siti-Faujiah Hendrayani, Abdelilah Aboussekhr. ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:21976111. |
furthermore, we present evidence that atr inhibits apoptosis in response to low fluences of uv light, through inhibiting the cleavage of caspase 3 and parp as well as the repression of the proapoptotic proteins bax and bak. |
2012-12-26 |
2023-08-12 |
human |
| Huda H Al-Khalaf, Siti-Faujiah Hendrayani, Abdelilah Aboussekhr. ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences. Molecular carcinogenesis. vol 51. issue 12. 2012-12-26. PMID:21976111. |
together, these results indicate that during the cellular response to low uvc fluences the atr protein kinase up-regulates p21(waf1/cip1) and inhibits apoptosis. |
2012-12-26 |
2023-08-12 |
human |
| Yukihiro Furusawa, Takashi Iizumi, Yoshisada Fujiwara, Mariame Ali Hassan, Yoshiaki Tabuchi, Takaharu Nomura, Takashi Kond. Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells. Ultrasonics sonochemistry. vol 19. issue 6. 2012-12-03. PMID:22571845. |
these findings revealed, for the first time, that us activates chk1 dependently on atr and the activated chk1 is involved in apoptosis of cells exposed to us. |
2012-12-03 |
2023-08-12 |
human |
| Tobias Sperka, Jianwei Wang, K Lenhard Rudolp. DNA damage checkpoints in stem cells, ageing and cancer. Nature reviews. Molecular cell biology. vol 13. issue 9. 2012-10-30. PMID:22914294. |
dna damage induces cell-intrinsic checkpoints, including p53 and retinoblastoma (rb), as well as upstream regulators (exonuclease 1 (exo1), ataxia telangiectasia mutated (atm), atr, p16(ink4a) and p19(arf)) and downstream targets (p21, puma (p53 upregulated modulator of apoptosis) and sestrins). |
2012-10-30 |
2023-08-12 |
Not clear |
| Hiroaki Inaba, Masae Kuboniwa, Hideyuki Sugita, Richard J Lamont, Atsuo Aman. Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts. Infection and immunity. vol 80. issue 8. 2012-10-10. PMID:22689813. |
the inhibition of atr prevented both g(1) arrest and apoptosis caused by p. gingivalis in htr-8 cells. |
2012-10-10 |
2023-08-12 |
human |
| Satoshi Tanida, Tsutomu Mizoshita, Keiji Ozeki, Hironobu Tsukamoto, Takeshi Kamiya, Hiromi Kataoka, Daitoku Sakamuro, Takashi Jo. Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment. International journal of surgical oncology. vol 2012. 2012-08-23. PMID:22778941. |
cisplatin forms inter- and intrastrand crosslinked dna adducts and its cytotoxicity is mediated by propagation of dna damage recognition signals to downstream pathways involving atr, p53, p73, and mitogen-activated protein kinases, ultimately resulting in apoptosis. |
2012-08-23 |
2023-08-12 |
Not clear |
| Robert A Forrest, Lonnie P Swift, Ada Rephaeli, Abraham Nudelman, Ken-Ichi Kimura, Don R Phillips, Suzanne M Cutt. Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation. Biochemical pharmacology. vol 83. issue 12. 2012-06-22. PMID:22414726. |
loss of atr was associated with abrogation of a drug-induced g(2)/m block and induction of mitotic catastrophe, while loss of atm was associated with drug-induced apoptosis in non-synchronised cells. |
2012-06-22 |
2023-08-12 |
Not clear |
| Wei-Hsin Chiu, Sheng-Jei Luo, Chia-Ling Chen, Jai-Hong Cheng, Chia-Yuan Hsieh, Chi-Yun Wang, Wei-Ching Huang, Wu-Chou Su, Chiou-Feng Li. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochemical pharmacology. vol 83. issue 9. 2012-05-21. PMID:22285910. |
unlike cisplatin, which causes dna damage in each phase of the cell cycle, vnr and nocodazole induced aberrant jnk-regulated dna damage in prometaphase; however, inhibiting atm (ataxia telangiectasia, mutated) and atr (atm and rad3-related) did not reverse mitotic arrest or apoptosis. |
2012-05-21 |
2023-08-12 |
Not clear |
| Zhongwei Zhou, Christopher Bruhn, Zhao-Qi Wan. Differential function of NBS1 and ATR in neurogenesis. DNA repair. vol 11. issue 2. 2012-05-18. PMID:22078264. |
here we show that a deletion of nbs1 or atr in the mouse central nervous system (cns) results in neurodevelopmental defects characterized by reduced proliferation and increased apoptosis in embryonic brains. |
2012-05-18 |
2023-08-12 |
mouse |
| Zhongwei Zhou, Christopher Bruhn, Zhao-Qi Wan. Differential function of NBS1 and ATR in neurogenesis. DNA repair. vol 11. issue 2. 2012-05-18. PMID:22078264. |
whereas most apoptosis in the nbs1-deleted cortex is restricted to the highly proliferating progenitors, atr knockout induces apoptosis in both proliferating and non-proliferating neural cells. |
2012-05-18 |
2023-08-12 |
mouse |
| Sung Hee Jang, Joo Weon Lim, Tomohiro Morio, Hyeyoung Ki. Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells. Free radical biology & medicine. vol 52. issue 3. 2012-05-17. PMID:22178412. |
the dna damage response (ddr) coordinates cell-cycle transitions, dna repair, and apoptosis through the activation of ataxia-telangiectasia-mutated (atm) and atm and rad3-related (atr) and their target proteins. |
2012-05-17 |
2023-08-12 |
Not clear |
| Prema S Rao, Arun Satelli, Majid Moridani, Marjorie Jenkins, U Subrahmanyeswara Ra. Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms. International journal of cancer. vol 130. issue 11. 2012-05-11. PMID:21792893. |
analysis of various proliferative signaling pathways indicated that luteolin-induced apoptosis involves reactive oxygen species generation, dna damage, activation of atr → chk2 → p53 signaling pathway, inhibition of nf-kb signaling pathway, activation of p38 pathway and depletion of antiapoptotic proteins. |
2012-05-11 |
2023-08-12 |
human |
| Yukihiro Furusawa, Takashi Iizumi, Yoshisada Fujiwara, Qing-Li Zhao, Yoshiaki Tabuchi, Takaharu Nomura, Takashi Kond. Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress. Apoptosis : an international journal on programmed cell death. vol 17. issue 1. 2012-05-07. PMID:22080164. |
the selective inhibitors of atr or chk1 abrogated hs-induced apoptosis in human leukemia jurkat cells whereas the inhibition of atm or chk2 caused only marginal effects. |
2012-05-07 |
2023-08-12 |
human |
| Gabriela Imreh, Helin Vakifahmetoglu Norberg, Stefan Imreh, Boris Zhivotovsk. Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. Journal of cell science. vol 124. issue Pt 17. 2012-02-29. PMID:21878502. |
in addition to p53 deficiency, the depletion of atm (ataxia telangiectasia mutated), but not atr (ataxia telangiectasia and rad3-related protein), protected against apoptosis and shifted cell death towards necrosis. |
2012-02-29 |
2023-08-12 |
Not clear |
| Xiaofeng Zhang, Mingqiu Wang, Shuying Gao, Rui Ren, Jing Zheng, Yang Zhan. Atrazine-induced apoptosis of splenocytes in BALB/C mice. BMC medicine. vol 9. 2012-01-23. PMID:22032520. |
this study presents on our investigation into the apoptosis of splenocytes in mice exposed to atr as we explore possible immunotoxic mechanisms. |
2012-01-23 |
2023-08-12 |
mouse |
| Masaoki Kawasumi, Bianca Lemos, James E Bradner, Renee Thibodeau, Yong-son Kim, Miranda Schmidt, Erin Higgins, Sang-wahn Koo, Aimee Angle-Zahn, Adam Chen, Douglas Levine, Lynh Nguyen, Timothy P Heffernan, Isabel Longo, Anna Mandinova, Yao-Ping Lu, Allan H Conney, Paul Nghie. Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 33. 2011-11-23. PMID:21844338. |
suppression of atr, or its downstream target checkpoint kinase 1 (chk1), selectively sensitizes dna-damaged and malignant cells to apoptosis. |
2011-11-23 |
2023-08-12 |
mouse |
| Kyungsoo Ha, Warren Fiskus, Rekha Rao, Ramesh Balusu, Sreedhar Venkannagari, Narasimha Rao Nalabothula, Kapil N Bhall. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Molecular cancer therapeutics. vol 10. issue 7. 2011-11-03. PMID:21566061. |
short hairpin rna-mediated depletion of atr also inhibited ir-induced p-atr and p-chk1, but increased γ-h2ax levels, sensitizing cancer cells to ir-induced apoptosis and loss of clonogenic survival. |
2011-11-03 |
2023-08-12 |
human |
| Weinong Han, Mei Ming, Yu-Ying H. Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21561856. |
inhibiting atr pathways by sirna targeting atr had little effect on uvb-induced apoptosis or akt activation, indicating that the inhibitory effect of caffeine on apoptosis and the akt pathway does not require the atr pathway. |
2011-09-09 |
2023-08-12 |
mouse |
| S O Abarikwu, E O Farombi, A B Pan. Biflavanone-kolaviron protects human dopaminergic SH-SY5Y cells against atrazine induced toxic insult. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 4. 2011-08-18. PMID:21333729. |
atr mediated nuclear changes associated with apoptosis; including nuclear fragmentation, condensation, dna laddering, and increased caspase-3 activity were blocked on addition of kv. |
2011-08-18 |
2023-08-12 |
human |