| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q X Paulson, R V Pusapati, S Hong, R L Weaks, C J Conti, D G Johnso. Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis. Oncogene. vol 27. issue 36. 2008-09-11. PMID:18469863. |
the absence of atm impaired apoptosis induced by e2f3a and treating k5 e2f3a transgenic mice with caffeine, an inhibitor of atm and rad3-related (atr), promoted skin tumor development. |
2008-09-11 |
2023-08-12 |
mouse |
| Karlene A Cimprich, David Corte. ATR: an essential regulator of genome integrity. Nature reviews. Molecular cell biology. vol 9. issue 8. 2008-08-12. PMID:18594563. |
the ataxia-telangiectasia mutated (atm) and atm and rad3-related (atr) protein kinases act as master regulators of the dna-damage response by signalling to control cell-cycle transitions, dna replication, dna repair and apoptosis. |
2008-08-12 |
2023-08-12 |
Not clear |
| Mario Falchetti, Calogero Saieva, Ramona Lupi, Giovanna Masala, Piera Rizzolo, Ines Zanna, Ketty Ceccarelli, Francesco Sera, Renato Mariani-Costantini, Gabriella Nesi, Domenico Palli, Laura Ottin. Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival. Human pathology. vol 39. issue 6. 2008-07-01. PMID:18440592. |
we also investigated the msi-h-related genetic changes by analyzing coding repeats within target genes involved in pathways that control cell growth (tgfbetarii, igfiir, riz, tcf4, dp2), apoptosis (bax, bcl10, fas, caspase5, apaf1), and dna repair genes (hmsh6, hmsh3, med1, rad50, blm, atr, brca2, mre11). |
2008-07-01 |
2023-08-12 |
Not clear |
| Vasco Oliveira, William J Romanow, Christoph Geisen, Diane M Otterness, Frank Mercurio, Hong Gang Wang, William S Dalton, Robert T Abraha. A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18326048. |
here, we report that small interfering rna-mediated depletion of hsmg-1, but not atm, atr, hupf1, or hupf2, in human u2os osteosarcoma cells markedly increases the magnitude and accelerates the rate of apoptosis induced by tumor necrosis factor-alpha (tnfalpha) stimulation. |
2008-06-17 |
2023-08-12 |
human |
| Navjotsingh Pabla, Shuang Huang, Qing-Sheng Mi, Rene Daniel, Zheng Don. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18162465. |
importantly, in the dna damage response, we demonstrate a critical role for atr, but not atm (ataxia telangiectasia mutated) or dna-pk (dna-dependent protein kinase), in cisplatin-induced p53 activation and apoptosis. |
2008-05-30 |
2023-08-12 |
mouse |
| Navjotsingh Pabla, Shuang Huang, Qing-Sheng Mi, Rene Daniel, Zheng Don. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18162465. |
blockade of atr with a dominant-negative mutant inhibits cisplatin-induced p53 activation and renal cell apoptosis. |
2008-05-30 |
2023-08-12 |
mouse |
| Hong Zhu, Min Huang, Fan Yang, Yi Chen, Ze-Hong Miao, Xu-Hong Qian, Yu-Fang Xu, Yu-Xin Qin, Hai-Bin Luo, Xu Shen, Mei-Yu Geng, Yu-Jun Cai, Jian Din. R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308047. |
moreover, using a topo ii catalytic inhibitor aclarubicin, ataxia-telangiectasia-mutated (atm)/atm- and rad3-related (atr) kinase inhibitor caffeine and topo ii-deficient hl-60/mx2 cells, we further showed that r16-triggered dna double-strand breaks, tumor cell cycle arrest, and apoptosis were in a topo ii-dependent manner. |
2007-11-09 |
2023-08-12 |
mouse |
| Jeannine R LaRocque, Diana L Dougherty, Sumreen K Hussain, Jeff Sekelsk. Reducing DNA polymerase alpha in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental defects. Genetics. vol 176. issue 3. 2007-09-27. PMID:17483406. |
reducing dna polymerase alpha in the absence of drosophila atr leads to p53-dependent apoptosis and developmental defects. |
2007-09-27 |
2023-08-12 |
drosophila_melanogaster |
| Jason L DeHart, Erik S Zimmerman, Orly Ardon, Carlos M R Monteiro-Filho, Enrique R Argañaraz, Vicente Planelle. HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system. Virology journal. vol 4. 2007-09-14. PMID:17559673. |
atr activation results in cell cycle arrest in g2 and induction of apoptosis. |
2007-09-14 |
2023-08-12 |
Not clear |
| Joshua L Andersen, Jason L DeHart, Erik S Zimmerman, Orly Ardon, Baek Kim, Guillaume Jacquot, Serge Benichou, Vicente Planelle. HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. PLoS pathogens. vol 2. issue 12. 2007-06-18. PMID:17140287. |
we previously identified the dna damage-signaling protein atr as the cellular factor that mediates vpr-induced g2 arrest and apoptosis. |
2007-06-18 |
2023-08-12 |
Not clear |
| Joshua L Andersen, Jason L DeHart, Erik S Zimmerman, Orly Ardon, Baek Kim, Guillaume Jacquot, Serge Benichou, Vicente Planelle. HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. PLoS pathogens. vol 2. issue 12. 2007-06-18. PMID:17140287. |
in support of the idea that checkpoint activation and apoptosis induction are functionally linked, we show that bax activation by vpr was ablated when atr or gadd45alpha was knocked down. |
2007-06-18 |
2023-08-12 |
Not clear |
| Bärbel Schröfelbauer, Yoshiyuki Hakata, Nathaniel R Landa. HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 10. 2007-04-24. PMID:17360488. |
in cells expressing vpr, the dna damage sensing kinase, atr, is activated, resulting in g(2) arrest and apoptosis. |
2007-04-24 |
2023-08-12 |
Not clear |
| Sujatha Kumar, Gerald E Dodson, Anthony Trinh, Joel R Puchalski, Randal S Tibbett. ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. Cell cycle (Georgetown, Tex.). vol 4. issue 11. 2007-02-12. PMID:16258278. |
atr activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. |
2007-02-12 |
2023-08-12 |
human |
| Sujatha Kumar, Gerald E Dodson, Anthony Trinh, Joel R Puchalski, Randal S Tibbett. ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. Cell cycle (Georgetown, Tex.). vol 4. issue 11. 2007-02-12. PMID:16258278. |
p53 induction in ml-1 cells was atr dependent and downregulation of p53 through rnai delayed hu-induced apoptosis. |
2007-02-12 |
2023-08-12 |
human |
| Sujatha Kumar, Gerald E Dodson, Anthony Trinh, Joel R Puchalski, Randal S Tibbett. ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. Cell cycle (Georgetown, Tex.). vol 4. issue 11. 2007-02-12. PMID:16258278. |
hu did not induce p53 or induce apoptosis in molt-3 leukemia cells, even though exposure to hu induced a comparable level of dna damage and robustly activated the atr pathway. |
2007-02-12 |
2023-08-12 |
human |
| Yasuhiko Terada, Yuko Yasud. Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. Molecular and cellular biology. vol 26. issue 21. 2007-01-30. PMID:16923959. |
vpr, the viral protein r of human immunodeficiency virus type 1, induces g(2) cell cycle arrest and apoptosis in mammalian cells via atr (for "ataxia-telangiectasia-mediated and rad3-related") checkpoint activation. |
2007-01-30 |
2023-08-12 |
human |
| Jinzhao Wang, Navjotsingh Pabla, Cong-Yi Wang, Weixin Wang, Patricia V Schoenlein, Zheng Don. Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53. American journal of physiology. Renal physiology. vol 291. issue 6. 2007-01-05. PMID:16849690. |
here, we show that atm, and not atr, was proteolytically cleaved into specific fragments of approximately 210 and 150 kda during cisplatin-induced tubular cell apoptosis. |
2007-01-05 |
2023-08-12 |
Not clear |
| Yeonsoo Joe, Jae-Hoon Jeong, Shutong Yang, Hyeog Kang, Noburu Motoyama, Pier Paolo Pandolfi, Jay H Chung, Myung K Ki. ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16891316. |
atr, pml, and chk2 play a role in arsenic trioxide-induced apoptosis. |
2006-11-27 |
2023-08-12 |
Not clear |
| Yeonsoo Joe, Jae-Hoon Jeong, Shutong Yang, Hyeog Kang, Noburu Motoyama, Pier Paolo Pandolfi, Jay H Chung, Myung K Ki. ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16891316. |
based on this, we propose that a pathway composed of atr, pml, chk2, and p53 plays a role in ato-mediated apoptosis, a notion that is consistent with the observation that chk2 is genetically intact and mutations in the p53 gene are extremely rare in apl. |
2006-11-27 |
2023-08-12 |
Not clear |
| Wenge Zhu, Anindya Dutt. An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Molecular and cellular biology. vol 26. issue 12. 2006-07-17. PMID:16738325. |
the g2/m checkpoint-mediated arrest of the cell cycle is critical for the prevention of both apoptosis and the accumulation of cells with rereplicated dna, because the loss of atr, brca1, or fanca promotes apoptosis and suppresses the accumulation. |
2006-07-17 |
2023-08-12 |
human |