| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| XueQing Guo, JunPing Zhang, XuPing Fu, Qing Wei, YingHua Lu, Yao Li, Gang Yin, YuMin Mao, Yi Xie, YaoCheng Rui, Kang Yin. Analysis of common gene expression patterns in four human tumor cell lines exposed to camptothecin using cDNA microarray: identification of topoisomerase-mediated DNA damage response pathways. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16368568. |
most of these common response genes were functionally related to cell proliferation or apoptosis, and some of them were involved in atm (ataxia-telangiectasia mutated) and atr (atm-and rad3 related) checkpoint pathways, jnk (c-jun n-terminal kinase) pathway, the survival phosphatidylinositol (pi) 3 kinase-akt-dependent pathway, mitochondrial cell death pathway, endoplasmic reticulum (er)-related cell death pathway, and to ubiquitin/proteasome dependent protein degradation pathway. |
2006-06-02 |
2023-08-12 |
human |
| Amanda S Coutts, Nicholas La Thangu. The p53 response during DNA damage: impact of transcriptional cofactors. Biochemical Society symposium. issue 73. 2006-05-25. PMID:16626298. |
dna damage induces the activity of p53, via damage sensors such as atm (ataxia telangiectasia mutated) and atr (ataxia telangiectasia-related), which leads to the transcriptional regulation of a variety of genes involved in cell cycle control and apoptosis. |
2006-05-25 |
2023-08-12 |
Not clear |
| Atan Gros. BID as a double agent in cell life and death. Cell cycle (Georgetown, Tex.). vol 5. issue 6. 2006-05-22. PMID:16582605. |
dna damage leads to the activation of atm and atr, which in turn either cause cell cycle arrest and dna repair or apoptosis. |
2006-05-22 |
2023-08-12 |
Not clear |
| Ludmila Jirmanova, Dmitry V Bulavin, Albert J Fornac. Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell cycle (Georgetown, Tex.). vol 4. issue 10. 2006-04-25. PMID:16138010. |
we have found that inhibition of atr and atm kinases with caffeine or chk1 with ucn-01, results in activation of a p38-dependent intra-s-phase checkpoint and activation of apoptosis in es cells. |
2006-04-25 |
2023-08-12 |
mouse |
| Bunsyo Shiotani, Masahiko Kobayashi, Masahiko Watanabe, Ken-Ichi Yamamoto, Takashi Sugimura, Keiji Wakabayash. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Molecular cancer research : MCR. vol 4. issue 2. 2006-04-18. PMID:16513843. |
these results thus suggest that pierisin-1 treatment primarily activates atr pathway and eventually activates atm pathway as a result of the induction of apoptosis. |
2006-04-18 |
2023-08-12 |
Not clear |
| Tatiana Garcia-Muse, Simon J Boulto. Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. The EMBO journal. vol 24. issue 24. 2006-02-08. PMID:16319925. |
here, we show that atl-1 (caenorhabditis elegans atr) and rad-5/clk-2 prevent mitotic catastrophe, function in the s-phase checkpoint and also cooperate with atm-1 in the checkpoint response to dsbs after ionizing radiation (ir) to induce cell cycle arrest or apoptosis via the cep-1(p53)/egl-1 pathway. |
2006-02-08 |
2023-08-12 |
caenorhabditis_elegans |
| Mark Livingstone, Hong Ruan, Jessica Weiner, Karl R Clauser, Peter Strack, Shengfang Jin, Amy Williams, Heidi Greulich, James Gardner, Monica Venere, Tamara A Mochan, Richard A DiTullio, Katarina Moravcevic, Vassilis G Gorgoulis, Anne Burkhardt, Thanos D Halazoneti. Valosin-containing protein phosphorylation at Ser784 in response to DNA damage. Cancer research. vol 65. issue 17. 2005-11-15. PMID:16140914. |
several in vivo substrates of atm and atr have been identified and almost all of them are involved in dna damage-induced cell cycle arrest and/or apoptosis. |
2005-11-15 |
2023-08-12 |
Not clear |
| Laura M McLaughlin, Bruce Dempl. Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. Cancer research. vol 65. issue 14. 2005-09-14. PMID:16024610. |
pretreatment with the pi3k family inhibitors also led to a switch from no-induced apoptosis to necrosis, which implicates a pi3k-related kinase such as ataxia telangiectasia mutated (atm) or atr (atm and rad3 related) in p53-dependent no-induced apoptosis. |
2005-09-14 |
2023-08-12 |
mouse |
| Hideshi Ishii, Taeko Inageta, Koshi Mimori, Toshiyuki Saito, Hiroki Sasaki, Masaharu Isobe, Masaki Mori, Carlo M Croce, Kay Huebner, Keiya Ozawa, Yusuke Furukaw. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 27. 2005-09-12. PMID:15983387. |
in response to stress, atr participates in the down-regulation of frag1 expression, leading to the induction of apoptosis through the release of rad9 from damaged chromatin during the s phase of the cell cycle, allowing rad9-bcl2 association and induction of proapoptotic bax protein. |
2005-09-12 |
2023-08-12 |
mouse |
| J L Andersen, E S Zimmerman, J L DeHart, S Murala, O Ardon, J Blackett, J Chen, V Planelle. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell death and differentiation. vol 12. issue 4. 2005-09-07. PMID:15650754. |
atr and gadd45alpha mediate hiv-1 vpr-induced apoptosis. |
2005-09-07 |
2023-08-12 |
human |
| J L Andersen, E S Zimmerman, J L DeHart, S Murala, O Ardon, J Blackett, J Chen, V Planelle. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell death and differentiation. vol 12. issue 4. 2005-09-07. PMID:15650754. |
our results support a model in which vpr-induced apoptosis is mediated via atr phosphorylation of brca1, and consequent upregulation of gadd45alpha. |
2005-09-07 |
2023-08-12 |
human |
| Simona Caporali, Sabrina Falcinelli, Giuseppe Starace, Maria Teresa Russo, Enzo Bonmassar, Josef Jiricny, Stefania D'Atr. DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322239. |
treatment of mmr-deficient cells with low tmz concentrations failed to activate atm and atr and to cause phosphorylation of chk1, chk2, and p53, as well as g(2)/m arrest and apoptosis. |
2004-11-03 |
2023-08-12 |
Not clear |
| Xian-min Meng, Li-guo Mi, Xiu-wen Zhao, Hui-qing Cao, Yun-lin Gao, Jin-feng Din. [Effect of antisense thrombin receptor and p21 double gene co-expression system on the proliferation and apoptosis in human aortic smooth muscle cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 24. issue 4. 2004-06-24. PMID:12905648. |
to focus on the study of the effect on proliferation and apoptosis of human aortic smooth muscle cells (asmc) by adeno-associated virus (aav) vector carrying antisense thrombin receptor (atr) and p21 double gene co-expression system. |
2004-06-24 |
2023-08-12 |
human |
| Kazuhiko Yamane, Kerri Taylor, Timothy J Kinsell. Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway. Biochemical and biophysical research communications. vol 318. issue 1. 2004-06-08. PMID:15110787. |
transfection of hela cells with small interfering rna (sirna) against the ataxia telangiectasia-related (atr) kinase or against the chk1 kinase destroyed the g2/m checkpoint and enhanced the apoptosis following 6-tg treatment. |
2004-06-08 |
2023-08-12 |
human |
| Zahid H Siddi. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene. vol 22. issue 47. 2003-11-21. PMID:14576837. |
its cytotoxic mode of action is mediated by its interaction with dna to form dna adducts, primarily intrastrand crosslink adducts, which activate several signal transduction pathways, including those involving atr, p53, p73, and mapk, and culminate in the activation of apoptosis. |
2003-11-21 |
2023-08-12 |
Not clear |
| Nicolas Foray, Didier Marot, Anastasia Gabriel, Voahangy Randrianarison, Antony M Carr, Michel Perricaudet, Alan Ashworth, Penny Jegg. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. The EMBO journal. vol 22. issue 11. 2003-07-17. PMID:12773400. |
we propose that brca1 facilitates the ability of atm and atr to phosphorylate downstream substrates that directly influence cell cycle checkpoint arrest and apoptosis, but that brca1 is dispensable for the phosphorylation of dna-associated atm and atr substrates. |
2003-07-17 |
2023-08-12 |
Not clear |
| Sarah Baatout, Hanane Derradji, Olivier Petitfour, Hanna von Suchodoletz, Max Mergea. [Mechanisms of radio-induced apoptosis]. Canadian journal of physiology and pharmacology. vol 80. issue 7. 2002-09-27. PMID:12184318. |
a second part is then devoted to the importance of p53 and of its regulators (atr, atm, dna-pkcs) in the process of radiation-induced apoptosis. |
2002-09-27 |
2023-08-12 |
Not clear |
| Atsushi Hirao, Alison Cheung, Gordon Duncan, Pierre-Marie Girard, Andrew J Elia, Andrew Wakeham, Hitoshi Okada, Talin Sarkissian, Jorge A Wong, Takashi Sakai, Elisa De Stanchina, Robert G Bristow, Toshio Suda, Scott W Lowe, Penny A Jeggo, Stephen J Elledge, Tak W Ma. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and cellular biology. vol 22. issue 18. 2002-09-27. PMID:12192050. |
ir-induced apoptosis was restored in chk2(-/-) thymocytes by reintroduction of the wild-type chk2 gene but not by a chk2 gene in which the sites phosphorylated by atm and ataxia telangiectasia and rad3(+) related (atr) were mutated to alanine. |
2002-09-27 |
2023-08-12 |
mouse |
| Atsushi Hirao, Alison Cheung, Gordon Duncan, Pierre-Marie Girard, Andrew J Elia, Andrew Wakeham, Hitoshi Okada, Talin Sarkissian, Jorge A Wong, Takashi Sakai, Elisa De Stanchina, Robert G Bristow, Toshio Suda, Scott W Lowe, Penny A Jeggo, Stephen J Elledge, Tak W Ma. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and cellular biology. vol 22. issue 18. 2002-09-27. PMID:12192050. |
atr may thus selectively contribute to p53-mediated apoptosis. |
2002-09-27 |
2023-08-12 |
mouse |
| Kazuhiko Yamane, Xianglin Wu, Junjie Che. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Molecular and cellular biology. vol 22. issue 2. 2002-01-29. PMID:11756551. |
similar to that of ataxia telangiectasia-related protein (atr), chk1, or hus1, downregulation of topbp1 leads to reduced cell survival, probably due to increased apoptosis. |
2002-01-29 |
2023-08-12 |
human |