| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leah Persaud, Jason Mighty, Xuelin Zhong, Ashleigh Francis, Marifer Mendez, Hilal Muharam, Stephen M Redenti, Dibash Das, Bertal Huseyin Aktas, Moira Sauan. IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells. International journal of molecular sciences. vol 19. issue 11. 2019-02-08. PMID:30424508. |
in particular, er stress-induced apoptosis is primarily regulated through the extent of eif2α phosphorylation and activating transcription factor 4 (atf4) action. |
2019-02-08 |
2023-08-13 |
human |
| Yifan Jia, Zeyu Li, Yang Feng, Ruixia Cui, Yanyan Dong, Xing Zhang, Xiaohong Xiang, Kai Qu, Chang Liu, Jingyao Zhan. Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress. Oxidative medicine and cellular longevity. vol 2018. 2019-01-22. PMID:30581532. |
in addition, the endoplasmic reticulum (er) stress-related glucose-regulated protein 78 (grp78)/activating transcription factor 4 (atf4)/c/ebp homologous protein (chop)/caspase-12 apoptosis signaling pathway was significantly suppressed in the clp + mrs group. |
2019-01-22 |
2023-08-13 |
mouse |
| Zhaohui Li, Jia Wu, Lei Shen. Ibrutinib improves the development of acute lymphoblastic leukemia by activating endoplasmic reticulum stress-induced cell death. Die Pharmazie. vol 73. issue 5. 2019-01-17. PMID:29724297. |
more importantly, once er-stress was suppressed by tauroursodeoxycholic acid (tudca), an er-stress inhibitor, the upregulation of bip, atf4, chop, cleaved-caspase3 and cleaved-parp after ibrutinib treatment was partially reversed, suggesting that induction of all cell apoptosis by ibrutinib was partially attributed to activation of er stress. |
2019-01-17 |
2023-08-13 |
Not clear |
| Zhang Zhao, Guo-Chang Liu, Wen F. Role of PERK-eIF2α signaling pathway in fetal male rats with hypospadias induced by di-n-butyl phthalate. The Kaohsiung journal of medical sciences. vol 34. issue 9. 2019-01-02. PMID:30173778. |
further, p-perk, p-eif2α and atf4 protein expressions and the ratio of lc3-ii/lc3-i were greatly increased in the gts of fetal rats, while apoptosis index (ai) and p62 protein expression were evidently decreased (all p < 0.05). |
2019-01-02 |
2023-08-13 |
rat |
| Caroline Demangel, Stephen Hig. Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease. Biology of the cell. vol 110. issue 11. 2018-12-17. PMID:30055020. |
prolonged exposure to mycolactone is normally cytotoxic, since it triggers stress responses activating the transcription factor atf4 and ultimately inducing apoptosis. |
2018-12-17 |
2023-08-13 |
Not clear |
| Sandeep C Chaudhary, Mohammad Waseem, Mehtab Rana, Hui Xu, Levy Kopelovich, Craig A Elmets, Mohammad Atha. Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1 Photochemistry and photobiology. vol 93. issue 4. 2018-12-11. PMID:28329421. |
in bcc and scc cells, naproxen-induced apoptosis and activated unfolded protein response (upr) signaling with increased expression of atf4, p-eif2α and chop. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qifei Wang, Guangzhen Wu, Xiangyu Che, Quanlin Li, Zhiwei Zhang, Qizhen Tan. Sorafenib induces renal cell carcinoma apoptosis Die Pharmazie. vol 73. issue 3. 2018-12-11. PMID:29544563. |
meanwhile, overexpression of atf4 was demonstrated to induce achn cell cycle arrest and cell apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qifei Wang, Guangzhen Wu, Xiangyu Che, Quanlin Li, Zhiwei Zhang, Qizhen Tan. Sorafenib induces renal cell carcinoma apoptosis Die Pharmazie. vol 73. issue 3. 2018-12-11. PMID:29544563. |
meanwhile, sorafenib-induced cell apoptosis may be dependent on the activation of atf4 since knockdown of atf4 partially reversed sorafenib-induced achn cell apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| X-Z Lu, Z-H Yang, H-J Zhang, L-L Zhu, X-L Mao, Y Yua. MiR-214 protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress and targeting ATF4. European review for medical and pharmacological sciences. vol 21. issue 21. 2018-08-07. PMID:29164589. |
mir-214 protects mc3t3-e1 osteoblasts against h2o2-induced apoptosis by suppressing oxidative stress and targeting atf4. |
2018-08-07 |
2023-08-13 |
Not clear |
| Janet M Menzie-Suderam, Payam Mohammad-Gharibani, Jigar Modi, Zea Ma, Rui Tao, Howard Prentice, Jang-Yen W. Granulocyte-colony stimulating factor protects against endoplasmic reticulum stress in an experimental model of stroke. Brain research. vol 1682. 2018-08-03. PMID:29277709. |
g-csf treatment significantly (p < .05) attenuated the expression of proteins involved in er stress apoptosis pathway; atf4, atf6, p-p38mapk, pjnk and chop. |
2018-08-03 |
2023-08-13 |
rat |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
taken together, these results suggest that phosphorylation of eif2α suppresses cisplatin‑induced p53 activation and apoptosis by attenuating oxidative stress via atf4-mediated ho-1 expression in hk-2 cells, as atf4 expression is usually dependent on the phosphorylation of eif2α and may also transcriptionally induce the expression of ho-1 in response to oxidative stress. |
2018-07-20 |
2023-08-13 |
human |
| Guanqun Ge, Yan Yan, Hui Ca. Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells. Biological & pharmaceutical bulletin. vol 40. issue 12. 2018-07-17. PMID:28966297. |
activating transcription factor 4 (atf4), ccaat/enhancer-binding protein homologous protein (chop), and caspase-4 were involved in g-rh2-induced apoptosis of h1299 cells. |
2018-07-17 |
2023-08-13 |
Not clear |
| Guanqun Ge, Yan Yan, Hui Ca. Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells. Biological & pharmaceutical bulletin. vol 40. issue 12. 2018-07-17. PMID:28966297. |
in addition, nac (n-acetylcysteine, a reactive oxygen species (ros) scavenger) treatment dramatically decreased ros generation in h1299 cells; both of nac and 4-pba (4-phenylbutyrate, a specific endoplasmic reticulum (er) stress inhibitor) administration impaired apoptosis and expression levels of atf4, chop and caspase-4 in g-rh2 incubated h1299 cells. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ritesh K Srivastava, Changzhao Li, Zhiping Weng, Anupam Agarwal, Craig A Elmets, Farrukh Afaq, Mohammad Atha. Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype. Scientific reports. vol 6. 2018-07-02. PMID:27725709. |
similar to its effects in murine epidermis, a dose- and time-dependent upregulation of ros, cytokines, upr proteins (grp78, p-perk, p-eif2α, atf4 and chop) and apoptosis were observed in pao-treated human skin keratinocytes nhek and hacat. |
2018-07-02 |
2023-08-13 |
human |
| Pingping Liang, Lin Zhong, Lei Gong, Jiahui Wang, Yujie Zhu, Weifeng Liu, Jun Yan. Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal‑regulated kinase 1/2 signaling pathway. International journal of molecular medicine. vol 40. issue 5. 2018-05-30. PMID:28949374. |
however, excessive er stress (tm ≥10 µm) activated the er stress-mediated apoptosis signaling pathways, including pkr-like er kinase (perk)-eukaryotic translational initiation factor 2α (eif2α)-activating transcription factor 4 (atf4)-ccaat/-enhancer-binding protein homologous protein (chop) and inositol-requiring kinase 1α (ire1α)-c-jun n-terminal kinases (jnk), as well as inhibited the expression of fgf21 and its primary receptors. |
2018-05-30 |
2023-08-13 |
rat |
| Xiaowen Gong, Hui Xie, Xiaoyong Li, Ji Wu, Yi Li. Bisphenol A induced apoptosis and transcriptome differences of spermatogonial stem cells in vitro. Acta biochimica et biophysica Sinica. vol 49. issue 9. 2018-05-23. PMID:28910977. |
among the cluster of degs associated with the kyoto encyclopedia of genes and genomes (kegg) apoptosis pathway, activating transcription factor 4 (atf4) and dna damage inducible transcript 3 (ddit3) genes were significantly up-regulated in bpa-treated sscs, which were proved by qpcr. |
2018-05-23 |
2023-08-13 |
mouse |
| Ravyn M Thompson, Dominik Dytfeld, Leticia Reyes, Reeder M Robinson, Brittany Smith, Yefim Manevich, Andrzej Jakubowiak, Mieczyslaw Komarnicki, Anna Przybylowicz-Chalecka, Tomasz Szczepaniak, Amit K Mitra, Brian G Van Ness, Magdalena Luczak, Nathan G Dollof. Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells. Oncotarget. vol 8. issue 22. 2018-03-26. PMID:28415782. |
mechanistically, cb-839 enhanced crflz-induced er stress and apoptosis, characterized by a robust induction of atf4 and chop and the activation of caspases. |
2018-03-26 |
2023-08-13 |
Not clear |
| Juhyun Song, Oh Yoen Ki. Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition. Nutrients. vol 9. issue 6. 2018-03-19. PMID:28604593. |
apoptosis cell death signaling markers (cleaved poly [adp-ribose] polymerase 1 (parp), p53, and bax) and er stress markers (phosphorylated eif2α (p-eif2α), atf4, chop, |
2018-03-19 |
2023-08-13 |
Not clear |
| Zhimeng Wu, Meiling Li, Wei Zheng, Qin Hu, Zhi Cheng, Fengjin Gu. Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. International journal of molecular medicine. vol 40. issue 1. 2018-03-16. PMID:28498443. |
silencing of both atf4 and perk inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. |
2018-03-16 |
2023-08-13 |
Not clear |
| Zhimeng Wu, Meiling Li, Wei Zheng, Qin Hu, Zhi Cheng, Fengjin Gu. Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. International journal of molecular medicine. vol 40. issue 1. 2018-03-16. PMID:28498443. |
on the whole, these findings reveal a new crucial combined effect of the silencing of perk and atf4 in modulating er stress‑mediated apoptosis during chondrocyte differentiation and proliferation. |
2018-03-16 |
2023-08-13 |
Not clear |