| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David J McConke. The integrated stress response and proteotoxicity in cancer therapy. Biochemical and biophysical research communications. vol 482. issue 3. 2017-05-23. PMID:28212730. |
phosphorylation of eif2α also promotes translation of atf4 and the expression of atf4 target genes that ameliorate proteotoxic stress but can also promote apoptosis. |
2017-05-23 |
2023-08-13 |
Not clear |
| Ritesh K Srivastava, Changzhao Li, Aftab Ahmad, Onika Abrams, Marina S Gorbatyuk, Kevin S Harrod, Ronald C Wek, Farrukh Afaq, Mohammad Atha. ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. Archives of biochemistry and biophysics. vol 609. 2017-05-09. PMID:27638049. |
atf4 regulates arsenic trioxide-mediated nadph oxidase, er-mitochondrial crosstalk and apoptosis. |
2017-05-09 |
2023-08-13 |
Not clear |
| Angelica M Merlot, Nurul H Shafie, Yu Yu, Vera Richardson, Patric J Jansson, Sumit Sahni, Darius J R Lane, Zaklina Kovacevic, Danuta S Kalinowski, Des R Richardso. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase. Biochemical pharmacology. vol 109. 2017-04-26. PMID:27059255. |
our results demonstrate that the cytotoxic chelator, dp44mt, which forms redox-active metal complexes, significantly: (1) increased er stress-associated pro-apoptotic signaling molecules (i.e., p-eif2α, atf4, chop); (2) increased ire1α phosphorylation (p-ire1α) and xbp1 mrna splicing; (3) reduced expression of er stress-associated cell survival signaling molecules (e.g., xbp1s and p58(ipk)); (4) increased cleavage of the transcription factor, atf6, which enhances expression of its downstream targets (i.e., chop and bip); and (5) increased phosphorylation of camkii that induces apoptosis. |
2017-04-26 |
2023-08-13 |
Not clear |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
in our study, l02 cells were treated with different concentrations of rfp for different time intervals, and cell apoptosis, the survival rate, and the gene and protein expression of grp78, perk, atf4, and chop were measured. |
2017-03-24 |
2023-08-13 |
Not clear |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
we found that rfp increased the cell apoptosis rate, decreased cell survival, and increased the protein and gene levels of grp78, perk, atf4 and chop in both a dose-dependent and a time-dependent manner. |
2017-03-24 |
2023-08-13 |
Not clear |
| Masaki R. Endoplasmic-reticulum stress pathway-associated mechanisms of action of proteasome inhibitors in multiple myeloma. International journal of hematology. vol 104. issue 3. 2017-03-16. PMID:27169614. |
low levels of xbp1, atf3, and atf4, which regulate upr and er stress-induced apoptosis, have been observed in poor responders to btz treatment, and three other genes, klf9, nampt, and cdk5, are associated with response to btz-containing therapy. |
2017-03-16 |
2023-08-13 |
Not clear |
| Jo Ishizawa, Kensuke Kojima, Dhruv Chachad, Peter Ruvolo, Vivian Ruvolo, Rodrigo O Jacamo, Gautam Borthakur, Hong Mu, Zhihong Zeng, Yoko Tabe, Joshua E Allen, Zhiqiang Wang, Wencai Ma, Hans C Lee, Robert Orlowski, Dos D Sarbassov, Philip L Lorenzi, Xuelin Huang, Sattva S Neelapu, Timothy McDonnell, Roberto N Miranda, Michael Wang, Hagop Kantarjian, Marina Konopleva, R Eric Davis, Michael Andreef. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Science signaling. vol 9. issue 415. 2016-11-10. PMID:26884599. |
atf4 induction through an atypical integrated stress response to onc201 triggers p53-independent apoptosis in hematological malignancies. |
2016-11-10 |
2023-08-13 |
mouse |
| Jo Ishizawa, Kensuke Kojima, Dhruv Chachad, Peter Ruvolo, Vivian Ruvolo, Rodrigo O Jacamo, Gautam Borthakur, Hong Mu, Zhihong Zeng, Yoko Tabe, Joshua E Allen, Zhiqiang Wang, Wencai Ma, Hans C Lee, Robert Orlowski, Dos D Sarbassov, Philip L Lorenzi, Xuelin Huang, Sattva S Neelapu, Timothy McDonnell, Roberto N Miranda, Michael Wang, Hagop Kantarjian, Marina Konopleva, R Eric Davis, Michael Andreef. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Science signaling. vol 9. issue 415. 2016-11-10. PMID:26884599. |
however, unlike the upr and isr, the increase in atf4 abundance in onc201-treated hematopoietic cells promoted apoptosis and did not depend on increased phosphorylation of eif2α. |
2016-11-10 |
2023-08-13 |
mouse |
| Ping-An Peng, Le Wang, Qian Ma, Yi Xin, Ou Zhang, Hong-Ya Han, Xiao-Li Liu, Qing-Wei Ji, Yu-Jie Zhou, Ying-Xin Zha. Valsartan protects HK-2 cells from contrast media-induced apoptosis by inhibiting endoplasmic reticulum stress. Cell biology international. vol 39. issue 12. 2016-10-13. PMID:26248489. |
the results showed that meglumine diatrizoate caused significant cell apoptosis by up-regulating the expression of er stress markers, including glucose-regulated protein 78 (grp78), activating transcription factor 4 (atf4), ccaat/enhancer-binding protein-homologous protein (chop) and caspase 12, in a time- and dose-dependent manner, which could be alleviated by preincubation with valsartan. |
2016-10-13 |
2023-08-13 |
mouse |
| Ze-Qun Jiang, Yan-Xia Ma, Mu-Han Li, Xiu-Qin Zhan, Xu Zhang, Ming-Yan Wan. 5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-α-injured L02 hepatocytes through regulating the PERK-eIF2α signaling pathway. Chinese journal of natural medicines. vol 13. issue 12. 2016-10-11. PMID:26721708. |
in addition, the knockdown of perk suppressed the expression of phospho-perk, phospho-eif2α, atf4, and chop, resulting in a significant decrease in cell apoptosis after the treatment with galn/tnf-α. |
2016-10-11 |
2023-08-13 |
human |
| T Narita, M Ri, A Masaki, F Mori, A Ito, S Kusumoto, T Ishida, H Komatsu, S Iid. Lower expression of activating transcription factors 3 and 4 correlates with shorter progression-free survival in multiple myeloma patients receiving bortezomib plus dexamethasone therapy. Blood cancer journal. vol 5. 2016-10-07. PMID:26636288. |
thus low basal expression of atf3 and atf4 may attenuate btz-induced apoptosis. |
2016-10-07 |
2023-08-13 |
Not clear |
| Xianfang Liu, Zhenghua Lv, Jidong Zou, Xiuxiu Liu, Juke Ma, Jinhua Wang, Na Sa, Peihang Jing, Wei X. Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma. American journal of cancer research. vol 6. issue 8. 2016-09-20. PMID:27648360. |
silencing either eif2α or atf4 by sirna transfection relieved afatinib-caused suppression of akt-mtor activity, attenuating mcl-1 down-regulation as well as subsequent apoptosis. |
2016-09-20 |
2023-08-13 |
Not clear |
| Pingdong Lin, Xiaping Weng, Fayuan Liu, Yuhuan Ma, Houhuang Chen, Xiang Shao, Wenwei Zheng, Xianxiang Liu, Hongzhi Ye, Xihai L. Bushen Zhuangjin decoction inhibits TM-induced chondrocyte apoptosis mediated by endoplasmic reticulum stress. International journal of molecular medicine. vol 36. issue 6. 2016-09-12. PMID:26497741. |
to further elucidate the mechanisms responsible for the inhibitory effects of bzd on tm‑induced chondrocyte apoptosis mediated by er stress, the mrna and protein expression levels of binding immunoglobulin protein (bip), x‑box binding protein 1 (xbp1), activating transcription factor 4 (atf4), c/ebp‑homologous protein (chop), caspase‑9, caspase-3, b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) were measured by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analysis. |
2016-09-12 |
2023-08-13 |
rat |
| Wioletta Rozpedek, Lukasz Markiewicz, J Alan Diehl, Dariusz Pytel, Ireneusz Majstere. Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease. Current medicinal chemistry. vol 22. issue 27. 2016-06-21. PMID:26282939. |
moreover, excessive, long-term stress conditions may contribute to inducing neuronal death by apoptosis as a result of the overactivated expression of pro-apoptotic proteins via atf4. |
2016-06-21 |
2023-08-13 |
Not clear |
| L R Palam, J Gore, K E Craven, J L Wilson, M Kor. Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma. Cell death & disease. vol 6. 2016-06-21. PMID:26469962. |
blocking the isr pathway in pccs with the isr inhibitor isrib or sirna-mediated depletion of atf4 resulted in enhanced gem-mediated apoptosis. |
2016-06-21 |
2023-08-13 |
mouse |
| Lili Liu, Bingyou Yang, Yupeng Cheng, Hongjin Li. Ameliorative Effects of Selenium on Cadmium-Induced Oxidative Stress and Endoplasmic Reticulum Stress in the Chicken Kidney. Biological trace element research. vol 167. issue 2. 2016-06-03. PMID:25805271. |
cd administration significantly increased the accumulation of cd, the malondialdehyde (mda) content, no production, inos activity, inos expression levels, expression levels of er stress-related genes (grp78, grp94, atf4, atf6, and ire) and the pro-apoptosis gene caspase 3, and the rate of apoptosis. |
2016-06-03 |
2023-08-13 |
human |
| Khalil El Karoui, Amandine Viau, Olivier Dellis, Alessia Bagattin, Clément Nguyen, William Baron, Martine Burtin, Mélanie Broueilh, Laurence Heidet, Géraldine Mollet, Anne Druilhe, Corinne Antignac, Bertrand Knebelmann, Gérard Friedlander, Frank Bienaimé, Morgan Gallazzini, Fabiola Terz. Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2. Nature communications. vol 7. 2016-05-23. PMID:26787103. |
mechanistically, we show that albumin induces tubular unfolded protein response via cytosolic calcium rise, which leads to tubular apoptosis by lipocalin 2 (lcn2) modulation through atf4. |
2016-05-23 |
2023-08-13 |
mouse |
| Annick Notte, Magali Rebucci, Maude Fransolet, Edith Roegiers, Marie Genin, Celine Tellier, Kassandra Watillon, Antoine Fattaccioli, Thierry Arnould, Carine Michiel. Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25724736. |
taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: atf4 activation regulates autophagy and inhibits apoptosis. |
2016-04-19 |
2023-08-13 |
human |
| Annick Notte, Magali Rebucci, Maude Fransolet, Edith Roegiers, Marie Genin, Celine Tellier, Kassandra Watillon, Antoine Fattaccioli, Thierry Arnould, Carine Michiel. Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25724736. |
however, while no link between the activation of these three er stress sensors and autophagy or apoptosis regulation could be evidenced, results showed that atf4 activation, which occurs independently of upr activation, was involved in taxol-induced autophagy completion. |
2016-04-19 |
2023-08-13 |
human |
| Clara Lucía León-Annicchiarico, Silvia Ramírez-Peinado, Dídac Domínguez-Villanueva, Anika Gonsberg, Theodore J Lampidis, Cristina Muñoz-Pined. ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells. The FEBS journal. vol 282. issue 18. 2016-04-12. PMID:26172539. |
atf4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells. |
2016-04-12 |
2023-08-13 |
Not clear |