| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeffrey J Rodvold, Kevin T Chiu, Nobuhiko Hiramatsu, Julia K Nussbacher, Valentina Galimberti, Navin R Mahadevan, Karl Willert, Jonathan H Lin, Maurizio Zanett. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Science signaling. vol 10. issue 482. 2018-03-12. PMID:28588081. |
however, ters-induced enhancement of cell survival was predominantly mediated by the upr kinase perk and a reduction in the abundance of the transcription factor atf4, which prevented the activation of the transcription factor chop and, consequently, the induction of apoptosis. |
2018-03-12 |
2023-08-13 |
mouse |
| Zhenjiang Liu, Huihui Gu, Lu Gan, Yatao Xu, Fei Feng, Muhammad Saeed, Chao Su. Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue. Oncotarget. vol 8. issue 6. 2018-02-26. PMID:28030827. |
further analysis revealed that sirt1 overexpression alleviated er stress-induced brown adipocyte apoptosis by inhibiting smad3 and atf4. |
2018-02-26 |
2023-08-13 |
mouse |
| Zhenjiang Liu, Huihui Gu, Lu Gan, Yatao Xu, Fei Feng, Muhammad Saeed, Chao Su. Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue. Oncotarget. vol 8. issue 6. 2018-02-26. PMID:28030827. |
our data also confirmed that sirt1 reduced early apoptotic cells and blocked the mitochondrial apoptosis pathway by directly interacting with atf4. |
2018-02-26 |
2023-08-13 |
mouse |
| Inge M N Wortel, Laurens T van der Meer, Michael S Kilberg, Frank N van Leeuwe. Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells. Trends in endocrinology and metabolism: TEM. vol 28. issue 11. 2018-02-26. PMID:28797581. |
however, under persistent stress conditions, atf4 promotes the induction of apoptosis. |
2018-02-26 |
2023-08-13 |
Not clear |
| Xiu-Mei Li, Jing Liu, Fang-Fang Pan, Dong-Dong Shi, Zhi-Guo Wen, Pei-Long Yan. Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway. PloS one. vol 13. issue 1. 2018-02-23. PMID:29324796. |
it is concluded based on our result that qa induces apoptosis and er stress just as qa-induced er stress pathway may mediate apoptosis by upregulating mrna expression levels of eif2α, atf4, ire1, xbp1, atf6, perk and chop in the hela cells. |
2018-02-23 |
2023-08-13 |
human |
| Hongze Chang, Feng Cai, Yan Zhang, Mintao Xue, Liang Liu, Anli Yang, Xiaodong Li. Early-stage autophagy protects nucleus pulposus cells from glucose deprivation-induced degeneration via the p-eIF2α/ATF4 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-20. PMID:28254665. |
interestingly, the p-eif2α/atf4 unfolded protein response pathway was activated in np cells deprived of glucose, and a deficiency in atf4 attenuated the activation of early-stage autophagy and increased apoptosis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Hongze Chang, Feng Cai, Yan Zhang, Mintao Xue, Liang Liu, Anli Yang, Xiaodong Li. Early-stage autophagy protects nucleus pulposus cells from glucose deprivation-induced degeneration via the p-eIF2α/ATF4 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-20. PMID:28254665. |
atf4 silencing also inhibited the late-stage accumulation of reactive oxygen species (ros) and apoptosis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Liming Yu, Buying Li, Meng Zhang, Zhenxiao Jin, Weixun Duan, Guolong Zhao, Yang Yang, Zhenhua Liu, Wensheng Chen, Siwang Wang, Jian Yang, Dinghua Yi, Jincheng Liu, Shiqiang Y. Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction. Apoptosis : an international journal on programmed cell death. vol 21. issue 7. 2018-02-05. PMID:27170343. |
recently, we demonstrated that melatonin reduced protein kinase rna (pkr)-like er kinase (perk)-eukaryotic initiation factor 2 alpha (eif2α)-activating transcription factor-4 (atf4)-mediated myocardial endoplasmic reticulum (er) stress and apoptosis during myocardial ischemia-reperfusion (mi/r) injury. |
2018-02-05 |
2023-08-13 |
mouse |
| Roi Isaac, Ido Goldstein, Noa Furth, Neta Zilber, Sarina Streim, Sigalit Boura-Halfon, Eytan Elhanany, Varda Rotter, Moshe Oren, Yehiel Zic. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell death and differentiation. vol 24. issue 1. 2018-01-16. PMID:27740623. |
this involves inhibitory phosphorylation of eukaryotic translation initiation factor 2α activity and increased expression of activating transcription factor-3 (atf3), atf4 and c/ebp homologous protein, followed by induction of apoptosis. |
2018-01-16 |
2023-08-13 |
human |
| Mei Zhang, Xiping Liu, Qinhao Wang, Yi Ru, Xin Xiong, Kaichun Wu, Libo Yao, Xia L. NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. FEBS letters. vol 591. issue 21. 2017-11-20. PMID:28948615. |
functionally, ndrg2 promotes ers-induced apoptosis partially through atf4 or chop. |
2017-11-20 |
2023-08-13 |
mouse |
| Xintong Jiang, Yantao Wei, Ting Zhang, Zhaotian Zhang, Suo Qiu, Xuezhi Zhou, Shaochong Zhan. Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress‑associated gene expression in retinal pigment epithelial cells. Molecular medicine reports. vol 15. issue 5. 2017-11-02. PMID:28358434. |
the present study investigated the effects of gsk2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (atf4), ccaat/enhancer‑binding protein homologous protein (chop) and vascular endothelial growth factor (vegf) in human retinal pigment epithelial (rpe) cells under endoplasmic reticulum (er) stress. |
2017-11-02 |
2023-08-13 |
human |
| Xun Yuan, Dhonghyo Kho, Jing Xu, Ambikai Gajan, Kongming Wu, Gen Sheng W. ONC201 activates ER stress to inhibit the growth of triple-negative breast cancer cells. Oncotarget. vol 8. issue 13. 2017-09-29. PMID:28423492. |
knockdown of atf4 impairs onc201-induced apoptosis of tnbc cells. |
2017-09-29 |
2023-08-13 |
Not clear |
| C Zhou, E Martinez, D Di Marcantonio, N Solanki-Patel, T Aghayev, S Peri, F Ferraro, T Skorski, C Scholl, S Fröhling, S Balachandran, D L Wiest, S M Syke. JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia. Leukemia. vol 31. issue 5. 2017-09-12. PMID:27840425. |
in addition, we observed that shrna-mediated inhibition of xbp1 or atf4 induces aml cell apoptosis and significantly extends disease latency in vivo tying the reduced survival mediated by jun inhibition to the loss of pro-survival upr signaling. |
2017-09-12 |
2023-08-13 |
Not clear |
| Jun Wang, Yunjie Li, Fangfang Ma, Huifeng Zhou, Rong Ding, Binbin Lu, Li Zou, Junxia Li, Rugang L. Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28720068. |
in addition, we found that ectopic par-4 co-localized with cell surface grp78 and induced high expression of the endoplasmic reticulum proteins atf4 and bax, which activated the endoplasmic reticulum apoptosis pathway. |
2017-07-26 |
2023-08-13 |
mouse |
| Zixuan Liu, Qiong Shi, Xiufang Song, Yuxin Wang, Yawen Wang, Erqun Song, Yang Son. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical research in toxicology. vol 29. issue 9. 2017-07-14. PMID:27484784. |
activating transcription factor 4 (atf4)-atf3-c/ebp homologous protein (chop) cascade shows an essential role in the er stress-induced sensitization of tetrachlorobenzoquinone-challenged pc12 cells to ros-mediated apoptosis via death receptor 5 (dr5) signaling. |
2017-07-14 |
2023-08-13 |
Not clear |
| Zixuan Liu, Qiong Shi, Xiufang Song, Yuxin Wang, Yawen Wang, Erqun Song, Yang Son. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical research in toxicology. vol 29. issue 9. 2017-07-14. PMID:27484784. |
blocking atf4, atf3, or chop signaling by gene silencing technology resulted in decreased cell apoptosis after exposure to tcbq. |
2017-07-14 |
2023-08-13 |
Not clear |
| Joseph C Gully, Valeriy G Sergeyev, Yogesh Bhootada, Hector Mendez-Gomez, Craig A Meyers, Sergey Zolotukhin, Marina S Gorbatyuk, Oleg S Gorbatyu. Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease. Neuroscience letters. vol 627. 2017-06-13. PMID:27233218. |
activating transcription factor 4 (atf4) is a member of the perk signaling pathway, which directly binds endoplasmic reticulum stress target genes and plays a crucial role in both adaptations to stress and activation of apoptosis. |
2017-06-13 |
2023-08-13 |
human |
| Ying Zong, Shijie Feng, Jinwei Cheng, Chenlin Yu, Guocai L. Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 2. 2017-06-06. PMID:28214891. |
up-regulated atf4 expression increases cell sensitivity to apoptosis in response to radiation. |
2017-06-06 |
2023-08-13 |
human |
| Yuta Komoike, Masato Matsuok. Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure. Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27634458. |
treatments of sh-sy5y cells with the chemical chaperone, 4-phenylbutyric acid and the ros scavenger, n-acetyl-cysteine reduced the aa-induced expression of atf4 protein and chop mrna, and resulted in the suppression of apoptosis. |
2017-05-31 |
2023-08-13 |
human |
| Ritesh K Srivastava, Changzhao Li, Yong Wang, Zhiping Weng, Craig A Elmets, Kevin S Harrod, Jessy S Deshane, Mohammad Atha. Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions. Toxicology and applied pharmacology. vol 308. 2017-05-23. PMID:27461142. |
sustained activation of atf4 by ato in macrophages induces apoptosis, while diminution of atf4 expression protects against ato-induced apoptotic cell death. |
2017-05-23 |
2023-08-13 |
mouse |