| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongze Chang, Feng Cai, Yan Zhang, Mintao Xue, Liang Liu, Anli Yang, Xiaodong Li. Early-stage autophagy protects nucleus pulposus cells from glucose deprivation-induced degeneration via the p-eIF2α/ATF4 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-20. PMID:28254665. |
interestingly, the p-eif2α/atf4 unfolded protein response pathway was activated in np cells deprived of glucose, and a deficiency in atf4 attenuated the activation of early-stage autophagy and increased apoptosis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Hongze Chang, Feng Cai, Yan Zhang, Mintao Xue, Liang Liu, Anli Yang, Xiaodong Li. Early-stage autophagy protects nucleus pulposus cells from glucose deprivation-induced degeneration via the p-eIF2α/ATF4 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-20. PMID:28254665. |
atf4 silencing also inhibited the late-stage accumulation of reactive oxygen species (ros) and apoptosis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Liming Yu, Buying Li, Meng Zhang, Zhenxiao Jin, Weixun Duan, Guolong Zhao, Yang Yang, Zhenhua Liu, Wensheng Chen, Siwang Wang, Jian Yang, Dinghua Yi, Jincheng Liu, Shiqiang Y. Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction. Apoptosis : an international journal on programmed cell death. vol 21. issue 7. 2018-02-05. PMID:27170343. |
recently, we demonstrated that melatonin reduced protein kinase rna (pkr)-like er kinase (perk)-eukaryotic initiation factor 2 alpha (eif2α)-activating transcription factor-4 (atf4)-mediated myocardial endoplasmic reticulum (er) stress and apoptosis during myocardial ischemia-reperfusion (mi/r) injury. |
2018-02-05 |
2023-08-13 |
mouse |
| Roi Isaac, Ido Goldstein, Noa Furth, Neta Zilber, Sarina Streim, Sigalit Boura-Halfon, Eytan Elhanany, Varda Rotter, Moshe Oren, Yehiel Zic. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell death and differentiation. vol 24. issue 1. 2018-01-16. PMID:27740623. |
this involves inhibitory phosphorylation of eukaryotic translation initiation factor 2α activity and increased expression of activating transcription factor-3 (atf3), atf4 and c/ebp homologous protein, followed by induction of apoptosis. |
2018-01-16 |
2023-08-13 |
human |
| Mei Zhang, Xiping Liu, Qinhao Wang, Yi Ru, Xin Xiong, Kaichun Wu, Libo Yao, Xia L. NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. FEBS letters. vol 591. issue 21. 2017-11-20. PMID:28948615. |
functionally, ndrg2 promotes ers-induced apoptosis partially through atf4 or chop. |
2017-11-20 |
2023-08-13 |
mouse |
| Xintong Jiang, Yantao Wei, Ting Zhang, Zhaotian Zhang, Suo Qiu, Xuezhi Zhou, Shaochong Zhan. Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress‑associated gene expression in retinal pigment epithelial cells. Molecular medicine reports. vol 15. issue 5. 2017-11-02. PMID:28358434. |
the present study investigated the effects of gsk2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (atf4), ccaat/enhancer‑binding protein homologous protein (chop) and vascular endothelial growth factor (vegf) in human retinal pigment epithelial (rpe) cells under endoplasmic reticulum (er) stress. |
2017-11-02 |
2023-08-13 |
human |
| Xun Yuan, Dhonghyo Kho, Jing Xu, Ambikai Gajan, Kongming Wu, Gen Sheng W. ONC201 activates ER stress to inhibit the growth of triple-negative breast cancer cells. Oncotarget. vol 8. issue 13. 2017-09-29. PMID:28423492. |
knockdown of atf4 impairs onc201-induced apoptosis of tnbc cells. |
2017-09-29 |
2023-08-13 |
Not clear |
| C Zhou, E Martinez, D Di Marcantonio, N Solanki-Patel, T Aghayev, S Peri, F Ferraro, T Skorski, C Scholl, S Fröhling, S Balachandran, D L Wiest, S M Syke. JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia. Leukemia. vol 31. issue 5. 2017-09-12. PMID:27840425. |
in addition, we observed that shrna-mediated inhibition of xbp1 or atf4 induces aml cell apoptosis and significantly extends disease latency in vivo tying the reduced survival mediated by jun inhibition to the loss of pro-survival upr signaling. |
2017-09-12 |
2023-08-13 |
Not clear |
| Jun Wang, Yunjie Li, Fangfang Ma, Huifeng Zhou, Rong Ding, Binbin Lu, Li Zou, Junxia Li, Rugang L. Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28720068. |
in addition, we found that ectopic par-4 co-localized with cell surface grp78 and induced high expression of the endoplasmic reticulum proteins atf4 and bax, which activated the endoplasmic reticulum apoptosis pathway. |
2017-07-26 |
2023-08-13 |
mouse |
| Zixuan Liu, Qiong Shi, Xiufang Song, Yuxin Wang, Yawen Wang, Erqun Song, Yang Son. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical research in toxicology. vol 29. issue 9. 2017-07-14. PMID:27484784. |
activating transcription factor 4 (atf4)-atf3-c/ebp homologous protein (chop) cascade shows an essential role in the er stress-induced sensitization of tetrachlorobenzoquinone-challenged pc12 cells to ros-mediated apoptosis via death receptor 5 (dr5) signaling. |
2017-07-14 |
2023-08-13 |
Not clear |
| Zixuan Liu, Qiong Shi, Xiufang Song, Yuxin Wang, Yawen Wang, Erqun Song, Yang Son. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical research in toxicology. vol 29. issue 9. 2017-07-14. PMID:27484784. |
blocking atf4, atf3, or chop signaling by gene silencing technology resulted in decreased cell apoptosis after exposure to tcbq. |
2017-07-14 |
2023-08-13 |
Not clear |
| Joseph C Gully, Valeriy G Sergeyev, Yogesh Bhootada, Hector Mendez-Gomez, Craig A Meyers, Sergey Zolotukhin, Marina S Gorbatyuk, Oleg S Gorbatyu. Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease. Neuroscience letters. vol 627. 2017-06-13. PMID:27233218. |
activating transcription factor 4 (atf4) is a member of the perk signaling pathway, which directly binds endoplasmic reticulum stress target genes and plays a crucial role in both adaptations to stress and activation of apoptosis. |
2017-06-13 |
2023-08-13 |
human |
| Ying Zong, Shijie Feng, Jinwei Cheng, Chenlin Yu, Guocai L. Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 2. 2017-06-06. PMID:28214891. |
up-regulated atf4 expression increases cell sensitivity to apoptosis in response to radiation. |
2017-06-06 |
2023-08-13 |
human |
| Yuta Komoike, Masato Matsuok. Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure. Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27634458. |
treatments of sh-sy5y cells with the chemical chaperone, 4-phenylbutyric acid and the ros scavenger, n-acetyl-cysteine reduced the aa-induced expression of atf4 protein and chop mrna, and resulted in the suppression of apoptosis. |
2017-05-31 |
2023-08-13 |
human |
| Ritesh K Srivastava, Changzhao Li, Yong Wang, Zhiping Weng, Craig A Elmets, Kevin S Harrod, Jessy S Deshane, Mohammad Atha. Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions. Toxicology and applied pharmacology. vol 308. 2017-05-23. PMID:27461142. |
sustained activation of atf4 by ato in macrophages induces apoptosis, while diminution of atf4 expression protects against ato-induced apoptotic cell death. |
2017-05-23 |
2023-08-13 |
mouse |
| David J McConke. The integrated stress response and proteotoxicity in cancer therapy. Biochemical and biophysical research communications. vol 482. issue 3. 2017-05-23. PMID:28212730. |
phosphorylation of eif2α also promotes translation of atf4 and the expression of atf4 target genes that ameliorate proteotoxic stress but can also promote apoptosis. |
2017-05-23 |
2023-08-13 |
Not clear |
| Ritesh K Srivastava, Changzhao Li, Aftab Ahmad, Onika Abrams, Marina S Gorbatyuk, Kevin S Harrod, Ronald C Wek, Farrukh Afaq, Mohammad Atha. ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. Archives of biochemistry and biophysics. vol 609. 2017-05-09. PMID:27638049. |
atf4 regulates arsenic trioxide-mediated nadph oxidase, er-mitochondrial crosstalk and apoptosis. |
2017-05-09 |
2023-08-13 |
Not clear |
| Angelica M Merlot, Nurul H Shafie, Yu Yu, Vera Richardson, Patric J Jansson, Sumit Sahni, Darius J R Lane, Zaklina Kovacevic, Danuta S Kalinowski, Des R Richardso. Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase. Biochemical pharmacology. vol 109. 2017-04-26. PMID:27059255. |
our results demonstrate that the cytotoxic chelator, dp44mt, which forms redox-active metal complexes, significantly: (1) increased er stress-associated pro-apoptotic signaling molecules (i.e., p-eif2α, atf4, chop); (2) increased ire1α phosphorylation (p-ire1α) and xbp1 mrna splicing; (3) reduced expression of er stress-associated cell survival signaling molecules (e.g., xbp1s and p58(ipk)); (4) increased cleavage of the transcription factor, atf6, which enhances expression of its downstream targets (i.e., chop and bip); and (5) increased phosphorylation of camkii that induces apoptosis. |
2017-04-26 |
2023-08-13 |
Not clear |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
in our study, l02 cells were treated with different concentrations of rfp for different time intervals, and cell apoptosis, the survival rate, and the gene and protein expression of grp78, perk, atf4, and chop were measured. |
2017-03-24 |
2023-08-13 |
Not clear |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
we found that rfp increased the cell apoptosis rate, decreased cell survival, and increased the protein and gene levels of grp78, perk, atf4 and chop in both a dose-dependent and a time-dependent manner. |
2017-03-24 |
2023-08-13 |
Not clear |