| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae-Hwi Jang, Lesley Baerts, Yannick Waumans, Ingrid De Meester, Yoshito Yamada, Perparim Limani, Ignacio Gil-Bazo, Walter Weder, Wolfgang Jungraithmay. Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice. Clinical & experimental metastasis. vol 32. issue 7. 2015-12-15. PMID:26233333. |
autophagy markers (lc3, p62, and atf4) decreased, apoptosis increased (tunel, ph3/ki-76), and the cell cycle regulator pcdc2 was inhibited. |
2015-12-15 |
2023-08-13 |
mouse |
| Ann E Collier, Ronald C Wek, Dan F Spanda. Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response. The Journal of investigative dermatology. vol 135. issue 10. 2015-12-14. PMID:25950825. |
forced expression of atf4 and chop protein before uvb irradiation significantly enhanced apoptosis, suggesting that this portion of the isr is deleterious in keratinocytes following uvb. |
2015-12-14 |
2023-08-13 |
human |
| S Kikuchi, R Suzuki, H Ohguchi, Y Yoshida, D Lu, F Cottini, J Jakubikova, G Bianchi, T Harada, G Gorgun, Y-T Tai, P G Richardson, T Hideshima, K C Anderso. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. vol 29. issue 9. 2015-11-20. PMID:25801913. |
in this study, we hypothesized that hdac4 knockdown and/or inhibition could enhance apoptosis in mm cells under er stress condition by upregulating atf4, followed by chop. |
2015-11-20 |
2023-08-13 |
Not clear |
| S Kikuchi, R Suzuki, H Ohguchi, Y Yoshida, D Lu, F Cottini, J Jakubikova, G Bianchi, T Harada, G Gorgun, Y-T Tai, P G Richardson, T Hideshima, K C Anderso. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. vol 29. issue 9. 2015-11-20. PMID:25801913. |
as with hdac4 knockdown, tmp269 significantly enhanced cytotoxicity induced by cfz in mm cell lines, upregulating atf4 and chop and inducing apoptosis. |
2015-11-20 |
2023-08-13 |
Not clear |
| Sejeong Shin, Gwen R Buel, Laura Wolgamott, David R Plas, John M Asara, John Blenis, Sang-Oh Yoo. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell. vol 59. issue 3. 2015-11-04. PMID:26190261. |
sustained and extreme energetic stress promotes a switch to isoform-specific mek1/erk2 signaling, induction of gcn2/eif2α phosphorylation, and atf4 expression, which overrides perk/akt-mediated adaptation and induces apoptosis through atf4-dependent expression of pro-apoptotic factors including bid and trb3. |
2015-11-04 |
2023-08-13 |
Not clear |
| Souvik Dey, Carly M Sayers, Ioannis I Verginadis, Stacey L Lehman, Yi Cheng, George J Cerniglia, Stephen W Tuttle, Michael D Feldman, Paul J L Zhang, Serge Y Fuchs, J Alan Diehl, Constantinos Koumeni. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. The Journal of clinical investigation. vol 125. issue 7. 2015-09-16. PMID:26011642. |
here, we have shown that activating transcription factor 4 (atf4), a master transcriptional effector of the isr, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. |
2015-09-16 |
2023-08-13 |
human |
| Yun-Ying Huang, Xiong-Qin Huang, Li-Yan Zhao, Fang-Yun Sun, Wen-Liang Chen, Jie-Yi Du, Feng Yuan, Jie Li, Xue-Lian Huang, Jie Liu, Xiao-Fei Lv, Yong-Yuan Guan, Jian-Wen Chen, Guan-Lei Wan. ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25218423. |
clc-3 specific sirna attenuated palmitate-induced apoptosis and increased protein levels of grp78, atf4, chop and phosphorylation of jnk1/2, whereas had no effects on increased phospho-perk and phospho-eif2α protein expression. |
2015-09-04 |
2023-08-13 |
mouse |
| Li-Xin Jia, Wen-Mei Zhang, Hong-Jia Zhang, Tao-Tao Li, Yue-Li Wang, Yan-Wen Qin, Hong Gu, Jie D. Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. The Journal of pathology. vol 236. issue 3. 2015-08-25. PMID:25788370. |
excessive apoptosis (tunel staining) and er stress (atf4 and chop), along with inflammation, were present in taad samples from both mouse and human. |
2015-08-25 |
2023-08-13 |
mouse |
| C Humeres, J Montenegro, M Varela, P Ayala, R Vivar, A Letelier, I Olmedo, M Catalán, C Rivas, P Baeza, C Muñoz, L García, S Lavandero, G Díaz-Aray. 4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 8. 2015-08-18. PMID:25149584. |
neonate rat cf were treated with thapsigargin in presence or absence of 4-pba, and cell viability was evaluated by trypan blue exclusion and apoptosis by flow cytometry; whereas chop, bip, pdi, atf4 and procollagen protein levels were assessed by western blot. |
2015-08-18 |
2023-08-13 |
rat |
| Rozita Bagheri-Yarmand, Krishna M Sinha, Anupama E Gururaj, Zamal Ahmed, Yasmeen Q Rizvi, Su-Chen Huang, John E Ladbury, Oliver Bogler, Michelle D Williams, Gilbert J Cote, Robert F Gage. A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. The Journal of biological chemistry. vol 290. issue 18. 2015-07-16. PMID:25795775. |
knockdown of ret by shrna in medullary thyroid cancer-derived cells stimulated expression of activating transcription factor 4 (atf4), a master transcription factor for stress-induced apoptosis, through activation of its target proapoptotic genes noxa and puma. |
2015-07-16 |
2023-08-13 |
Not clear |
| Jun Lu, Hui-Yue Dong, Ling-Jing Lin, Qing-Hua Wang, Liang-Hu Huang, Jian-Ming Ta. [Palmitate induces apoptosis and endoplasmic reticulum stress in human umbilical cord-derived mesenchymal stem cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 6. 2015-05-16. PMID:24343717. |
the results showed that huc-mscs were homogeneously positive for msc markers; palmitate increased apoptosis of huc-mscs and activated xbp1 splicing, bip, grp94, atf4 and chop transcription. |
2015-05-16 |
2023-08-12 |
human |
| Q Jiang, F Li, K Shi, P Wu, J An, Y Yang, C X. Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells. Cell death & disease. vol 5. 2015-02-12. PMID:24874742. |
then, activated p38 further enhanced the docking of activating transcription factor 4 (atf4) onto the chop (ccaat/enhancer-binding protein homologous protein) promoter via eif2α to enhance apoptosis. |
2015-02-12 |
2023-08-13 |
Not clear |
| Yonju Ha, Arul K Shanmugam, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Sylvia B Smit. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and tissue research. vol 356. issue 1. 2014-11-18. PMID:24469320. |
we therefore used σr1(-/-) mice to investigate the expression of er stress genes (bip/grp78, atf6, atf4, ire1α) and proteins involved in apoptosis (bcl2, bax) and to examine the retinal transcriptome at young ages. |
2014-11-18 |
2023-08-12 |
mouse |
| Yi Zhang, Li Zhao, Xin Li, Yajing Wang, Jing Yao, Hu Wang, Fanni Li, Zhiyu Li, Qinglong Gu. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. Archives of toxicology. vol 88. issue 1. 2014-10-28. PMID:23835921. |
moreover, knocking down chop partly decreased the effect of v8-mediated apoptosis and activation of grp78, p-perk, p-eif2α, atf4 and chop modulated er stress triggered by v8. |
2014-10-28 |
2023-08-12 |
mouse |
| Allison Kupsco, Daniel Schlen. Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). Environmental science & technology. vol 48. issue 12. 2014-10-24. PMID:24856650. |
although significant changes in apoptosis were not observed, we witnessed up to 100 fold increases in transcripts of the endoplasmic reticulum (er) chaperone, immunoglobulin binding protein (bip) and trends toward increasing downstream signals, activating transcription factor 4 (atf4) and atf6 indicating potential contributions of the unfolded protein response to the effects of semet and hypersaline conditions. |
2014-10-24 |
2023-08-13 |
Not clear |
| Qiaoli Zheng, Jingjia Ye, Jiang Ca. Translational regulator eIF2α in tumor. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24609900. |
the atf4 is a transcription activator that can translocate into nucleus and upregulate genes involved in amino acid synthesis, redox balance, protein maturation, and degradation which lead to the activation of both autophagy and apoptosis. |
2014-10-06 |
2023-08-12 |
Not clear |
| Pengfei Zhang, Qiao Sun, Chenyang Zhao, Shukuan Ling, Qi Li, Yan-Zhong Chang, Yingxian L. HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308964. |
hdac4 protects cells from er stress induced apoptosis through interaction with atf4. |
2014-10-01 |
2023-08-12 |
Not clear |
| Pengfei Zhang, Qiao Sun, Chenyang Zhao, Shukuan Ling, Qi Li, Yan-Zhong Chang, Yingxian L. HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308964. |
er stress could promote cell apoptosis through the upregulation of atf4 levels and its target genes such as chop and trb3. |
2014-10-01 |
2023-08-12 |
Not clear |
| Pengfei Zhang, Qiao Sun, Chenyang Zhao, Shukuan Ling, Qi Li, Yan-Zhong Chang, Yingxian L. HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308964. |
these results demonstrated that hdac4 played an important role in the regulation of er stress-induced apoptosis through interacting with atf4 and inhibiting its transcriptional activity. |
2014-10-01 |
2023-08-12 |
Not clear |
| Olga Krizanova, Iveta Steliarova, Lucia Csaderova, Michal Pastorek, Sona Hudecov. Capsaicin induces apoptosis in PC12 cells through ER stress. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337105. |
these results were correlated with endoplasmic reticulum (er) stress markers chop, atf4 and x-box binding protein 1 (xbp1), as well as with apoptosis induction. |
2014-09-03 |
2023-08-12 |
rat |