| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiaoli Zheng, Jingjia Ye, Jiang Ca. Translational regulator eIF2α in tumor. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24609900. |
the atf4 is a transcription activator that can translocate into nucleus and upregulate genes involved in amino acid synthesis, redox balance, protein maturation, and degradation which lead to the activation of both autophagy and apoptosis. |
2014-10-06 |
2023-08-12 |
Not clear |
| Pengfei Zhang, Qiao Sun, Chenyang Zhao, Shukuan Ling, Qi Li, Yan-Zhong Chang, Yingxian L. HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308964. |
hdac4 protects cells from er stress induced apoptosis through interaction with atf4. |
2014-10-01 |
2023-08-12 |
Not clear |
| Pengfei Zhang, Qiao Sun, Chenyang Zhao, Shukuan Ling, Qi Li, Yan-Zhong Chang, Yingxian L. HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308964. |
er stress could promote cell apoptosis through the upregulation of atf4 levels and its target genes such as chop and trb3. |
2014-10-01 |
2023-08-12 |
Not clear |
| Pengfei Zhang, Qiao Sun, Chenyang Zhao, Shukuan Ling, Qi Li, Yan-Zhong Chang, Yingxian L. HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308964. |
these results demonstrated that hdac4 played an important role in the regulation of er stress-induced apoptosis through interacting with atf4 and inhibiting its transcriptional activity. |
2014-10-01 |
2023-08-12 |
Not clear |
| Olga Krizanova, Iveta Steliarova, Lucia Csaderova, Michal Pastorek, Sona Hudecov. Capsaicin induces apoptosis in PC12 cells through ER stress. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337105. |
these results were correlated with endoplasmic reticulum (er) stress markers chop, atf4 and x-box binding protein 1 (xbp1), as well as with apoptosis induction. |
2014-09-03 |
2023-08-12 |
rat |
| Kazuya Takahashi, Fumihiko Furuya, Hiroki Shimura, Masahiro Kaneshige, Tetsuro Kobayash. Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24644288. |
in hfd-treated trα-deficient mice, atf4 was not induced, and apoptosis was enhanced compared with hfd-treated wt mice. |
2014-08-02 |
2023-08-12 |
mouse |
| Kazuya Takahashi, Fumihiko Furuya, Hiroki Shimura, Masahiro Kaneshige, Tetsuro Kobayash. Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24644288. |
these results indicate that endogenous trα plays an important role for the expression of atf4 and facilitates reduced apoptosis in pancreatic β-cells under er stress. |
2014-08-02 |
2023-08-12 |
mouse |
| Xiaobo Zhang, Seong-Ho Lee, Kyung-Won Min, Michael F McEntee, Jin Boo Jeong, Qingwang Li, Seung Joon Bae. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 12. 2014-07-31. PMID:24104354. |
moreover, the perk-eif2α-atf4 branch of the upr pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells, as silencing atf4 attenuates tolfenamic acid-induced apoptosis. |
2014-07-31 |
2023-08-12 |
mouse |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
activating transcription factor 4 (atf4) is a critical transcription factor in osteoblastogenesis and ers-induced apoptosis. |
2014-03-17 |
2023-08-12 |
rat |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
however, whether atf4 is involved in ers-mediated apoptosis contributing to vc remains unclear. |
2014-03-17 |
2023-08-12 |
rat |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
atf4 knockdown attenuated ers-induced apoptosis in calcified vsmcs. |
2014-03-17 |
2023-08-12 |
rat |
| Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Q. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis : an international journal on programmed cell death. vol 18. issue 9. 2014-03-17. PMID:23686245. |
our results demonstrate that atf4 was involved at least in part in the process of ers-mediated apoptosis contributing to vc. |
2014-03-17 |
2023-08-12 |
rat |
| Soledad Matus, Estefanía Lopez, Vicente Valenzuela, Melissa Nassif, Claudio Het. Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis. PloS one. vol 8. issue 7. 2014-02-13. PMID:23874395. |
atf4 is a key er stress transcription factor that plays a role in both adaptation to stress and the activation of apoptosis. |
2014-02-13 |
2023-08-12 |
mouse |
| Liang Wu, You-Yong Tian, Jing-Ping Shi, Wei Xie, Jian-Quan Shi, Jie Lu, Ying-Dong Zhan. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of candesartan cilexitil in the rotenone rat model of Parkinson's disease. Neuroscience letters. vol 548. 2014-02-07. PMID:23774475. |
moreover, candesartan cilexetil has been found to play a protective role via down-regulating the expression of activating transcription factor 4 (atf4), the ccaat-enhancer-binding protein (c/ebp) homologous protein (chop), and p53 upregulated modulator of apoptosis (puma). |
2014-02-07 |
2023-08-12 |
rat |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
selection of autophagy or apoptosis in cells exposed to er-stress depends on atf4 expression pattern with or without chop expression. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
thapsigargin-induced er-stress caused only apoptosis after ∼2 hr with ire1 phosphorylation, and grp78, atf4, and chop expressions. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
atf4-sirna completely inhibited the autophagy induced by naf or tunicamycin with suppressed atf4 protein and mrna expressions, and also inhibited apoptosis by thapsigargin with suppression of both atf4 and chop. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
on the other hand, chop-sirna activated autophagy in thapsigargin-induced er-stress with significant atf4 expression, and suppressed apoptosis with chop suppression. |
2013-10-29 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
these results showed that atf4 is the key signal for autophagy induced by er-stress, and that autophagy is switched to apoptosis by subsequent chop upregulation, suggesting that the changeover switch between autophagy and apoptosis is located between atf4 to chop in the perk pathway. |
2013-10-29 |
2023-08-12 |
Not clear |
| Qian Jiang, Feng Li, Kejian Shi, Pa Wu, Jiajia An, Yang Yang, Caimin X. ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells. FEBS letters. vol 587. issue 15. 2013-10-22. PMID:23792164. |
atf4 activation by the p38mapk-eif4e axis mediates apoptosis and autophagy induced by selenite in jurkat cells. |
2013-10-22 |
2023-08-12 |
Not clear |