| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xunqi Zhang, Yanxiao Han, Chenliu Fan, Yang Jiang, Wen Jiang, Chengyun Zhen. Epigallocatechin gallate induces apoptosis in multiple myeloma cells through endoplasmic reticulum stress induction and cytoskeletal disruption. International immunopharmacology. vol 141. 2024-08-19. PMID:39159563. |
subsequently, mrna sequencing of egcg-treated mm.1s cells revealed a significant upregulation of genes associated with endoplasmic reticulum stress (ers), including p-eif2α (phosphorylation-eukaryotic translation initiation factor 2 alpha), atf4 (activating transcription factor 4), chop (c/ebp homologous protein, ddit3), and puma (p53 upregulated modulator of apoptosis, bbc3), which were confirmed at the protein level by western blotting. |
2024-08-19 |
2024-08-22 |
mouse |
| Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xia. Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075912. |
we found that prolongation of oxygen-glucose deprivation activated the er stress pathway protein kinase-like endoplasmic reticulum kinase (perk)/eukaryotic translation initiation factor 2 subunit alpha (eif2α)-activating transcription factor 4 (atf4)-c/ebp homologous protein (chop), increased neuronal apoptosis, and induced autophagy. |
2024-07-30 |
2024-08-02 |
Not clear |
| Ruohan Cheng, Yihan Jiang, Yue Zhang, Mohammed Ismail, Luyong Zhang, Zhenzhou Jiang, Qinwei Y. Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity. Cell biology and toxicology. vol 40. issue 1. 2024-07-29. PMID:39073694. |
moreover, 4-phenylbutyric acid (4-pba), an ers inhibitor, was able to alleviate tp/lps-induced hepatotoxicity by reducing ers-related apoptosis protein expression (grp78, p-eif2α/eif2α, atf4, chop, cleaved caspase-3 and cleaved parp) and ros levels, with atf4 being an indispensable mediator. |
2024-07-29 |
2024-08-02 |
Not clear |
| Ruohan Cheng, Yihan Jiang, Yue Zhang, Mohammed Ismail, Luyong Zhang, Zhenzhou Jiang, Qinwei Y. Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity. Cell biology and toxicology. vol 40. issue 1. 2024-07-29. PMID:39073694. |
in summary, we propose that tp/lps may upregulate the activation of ers-associated apoptosis by inhibiting proteasome activity and enhancing ros production through atf4. |
2024-07-29 |
2024-08-02 |
Not clear |
| Ying Cui, Guang Yang, Hong Li, Jianying Sun, Xiaoman Liu, Xiaohan Xi. Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress. Biochemical and biophysical research communications. vol 730. 2024-07-12. PMID:38996786. |
in vitro experiments showed that the absence of nupr1 reduced the expression of atf4, chop, and cleaved caspase-12 in hippocampal neurons and inhibited the neuron apoptosis. |
2024-07-12 |
2024-07-15 |
mouse |
| Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui L. HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model. BMC musculoskeletal disorders. vol 25. issue 1. 2024-06-16. PMID:38879481. |
hdac4 represses er stress induced chondrocyte apoptosis by inhibiting atf4 and attenuates cartilage degeneration in an osteoarthritis rat model. |
2024-06-16 |
2024-06-18 |
human |
| Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui L. HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model. BMC musculoskeletal disorders. vol 25. issue 1. 2024-06-16. PMID:38879481. |
the present study evaluated whether the lack of histone deacetylase 4 (hdac4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (atf4) in human osteoarthritis (oa) cartilage degeneration. |
2024-06-16 |
2024-06-18 |
human |
| Huey-Liang Kuo, Haw-Ling Chuang, Chang-Mu Chen, Yu-Ya Chen, Yu-Syuan Chen, Ssu-Chia Lin, Pei-Yu Weng, Ting-Chun Liu, Pei-Yun Wang, Chun-Fa Huang, Siao-Syun Guan, Shing-Hwa Liu, Shun-Fa Yang, Cheng-Tien W. Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model. European journal of pharmacology. vol 977. 2024-06-08. PMID:38815787. |
furthermore, wogonin treatment mitigated endoplasmic reticulum (er) stress-associated molecular markers (grp78, grp94, atf4, chop, and the caspase cascade) and suppressed apoptosis. |
2024-06-08 |
2024-06-11 |
mouse |
| Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zh. ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844625. |
cell counting kit-8 (cck-8), clone formation, transwell, and flow cytometry assays were conducted to assess cell viability, clonogenicity, migration, invasion, cell cycle, and apoptosis, respectively, in the atf4 knockdown and overexpression sw480 cell lines. |
2024-06-06 |
2024-06-10 |
Not clear |
| Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zh. ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844625. |
atf4 knockdown promoted cell proliferation, invasion, and s-phase cell cycle and inhibited apoptosis in sw480 cells. |
2024-06-06 |
2024-06-10 |
Not clear |
| Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zh. ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer. Scientific reports. vol 14. issue 1. 2024-06-06. PMID:38844625. |
atf4 inhibited cc cell viability, clone formation ability, migration, and invasion and promoted apoptosis, possibly by regulating the expression of p-gcn2 and asns. |
2024-06-06 |
2024-06-10 |
Not clear |
| Young Yun Jung, Ninh The Son, Chakrabhavi Dhananjaya Mohan, Jairo Kenupp Bastos, Nguyen Dinh Luyen, Le Mai Huong, Kwang Seok Ah. Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP-1 expression, and the STAT3 pathway. IUBMB life. 2024-05-06. PMID:38708996. |
it also downmodulated the expression of alix (an intracellular inhibitor of paraptosis) and increased the expression of chop and atf4 (transcription factors that promote paraptosis) indicating that kf promotes apoptosis as well as paraptosis. |
2024-05-06 |
2024-05-08 |
Not clear |
| Huimin Liu, Ye Zheng, Shaoning Kan, Ming Hao, Huan Jiang, Shuangji Li, Rong Li, Yinyu Wang, Dongxu Wang, Weiwei Li. Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration. Heliyon. vol 10. issue 8. 2024-04-22. PMID:38644851. |
mt also promoted the expression of atf4, atf6, bip, bap31 and chop in crl-1623 cells leading to endoplasmic reticulum stress, and induced autophagy and apoptosis in crl-1623 cells. |
2024-04-22 |
2024-04-24 |
Not clear |
| Er-Ying Hao, Xue-Lu Liu, Xiang-Yu Chen, Han Xue, Bo-Fei Su, Yi-Fan Chen, De-He Wang, Lei Shi, Kang Bai, Fei Hou, Jian-Ku Hou, Hui-Ling Bao, Hui Che. Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. Poultry science. vol 103. issue 6. 2024-04-07. PMID:38583308. |
melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating atf4 to activate mtor signaling pathway in chickens. |
2024-04-07 |
2024-04-10 |
Not clear |
| Er-Ying Hao, Xue-Lu Liu, Xiang-Yu Chen, Han Xue, Bo-Fei Su, Yi-Fan Chen, De-He Wang, Lei Shi, Kang Bai, Fei Hou, Jian-Ku Hou, Hui-Ling Bao, Hui Che. Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. Poultry science. vol 103. issue 6. 2024-04-07. PMID:38583308. |
this study aimed to investigate whether mel inhibits ers and follicular granulosa cell apoptosis by regulating atf4 to activate mtor signaling pathway in chickens. |
2024-04-07 |
2024-04-10 |
Not clear |
| Er-Ying Hao, Xue-Lu Liu, Xiang-Yu Chen, Han Xue, Bo-Fei Su, Yi-Fan Chen, De-He Wang, Lei Shi, Kang Bai, Fei Hou, Jian-Ku Hou, Hui-Ling Bao, Hui Che. Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. Poultry science. vol 103. issue 6. 2024-04-07. PMID:38583308. |
then we explored whether melatonin protects follicular granulosa cells from ers-induced apoptosis through the mammalian target of rapamycin (mtor) signaling pathway by regulating atf4, we found that atf4 knockdown inhibited ers by decreasing the expression of ers-related genes and proteins and activating mtor signaling pathway by increasing the protein expression of p4e-bp1 and pt389-s6k (p<0.001), while these changes were promoted by tm+si-atf4+mel treatment (p<0.01). |
2024-04-07 |
2024-04-10 |
Not clear |
| Emeline Boët, Jean-Emmanuel Sarr. Targeting Metabolic Dependencies Fueling the TCA Cycle to Circumvent Therapy Resistance in Acute Myeloid Leukemia. Cancer research. vol 84. issue 7. 2024-04-01. PMID:38558131. |
in addition, onc-213 affected αkgdh, a pivotal nadh-producing enzyme of the tca cycle, to induce a mitochondrial stress response through atf4 activation that diminished the expression of the antiapoptotic protein mcl1, consequently promoting apoptosis of aml cells. |
2024-04-01 |
2024-04-04 |
Not clear |
| Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Cors. ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor. Biology. vol 13. issue 3. 2024-03-27. PMID:38534416. |
activating transcription factor 4 (atf4) plays a pivotal role in these pathways and controls the expression of many genes involved in redox processes, amino acid metabolism, protein misfolding, autophagy, and apoptosis. |
2024-03-27 |
2024-03-29 |
human |
| Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Cors. ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor. Biology. vol 13. issue 3. 2024-03-27. PMID:38534416. |
the role of atf4 in autophagy and apoptosis is explored as in the context of hiv-1 infection programmed cell deaths contribute to the depletion of cd4 t cells. |
2024-03-27 |
2024-03-29 |
human |
| Sokhna Haissatou Diaw, Sylvie Delcambre, Christoph Much, Fabian Ott, Vladimir S Kostic, Agata Gajos, Alexander Münchau, Simone Zittel, Hauke Busch, Anne Grünewald, Christine Klein, Katja Lohman. DYT-THAP1: exploring gene expression in fibroblasts for potential biomarker discovery. Neurogenetics. 2024-03-18. PMID:38498291. |
this included transcription factors and targets (atf4, cln3, eif2a, rrm1, yy1), genes involved in g protein-coupled receptor signaling (bdkrb2, lpar1), and a gene linked to apoptosis and dna replication/repair (cradd), which all showed higher expression levels in mmcs and nmcs than in controls. |
2024-03-18 |
2024-03-21 |
Not clear |